Article
Radiology, Nuclear Medicine & Medical Imaging
Ieun Yoon, Jae Seok Bae, Jeongin Yoo, Dong Ho Lee, Se Hyung Kim
Summary: Studies suggest that compared to MDCT alone, MDCT combined with [F-18]FDG PET/MRI can improve the diagnostic accuracy for preoperative M staging and resectability in patients with recurrent gastric cancer, with a significant advantage in evaluating M staging.
EUROPEAN RADIOLOGY
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Sangwon Han, Joon Young Choi
Summary: The systematic review and meta-analysis found that the use of F-18-FDG PET, PET/CT, or PET/MRI during the initial staging of breast cancer can significantly modify staging and treatment plans for patients. Factors such as age, initial stage, and histologic grade were identified as significant factors affecting the heterogeneity in changes in stage or management. Routine clinical use of PET imaging for initial staging of breast cancer may be beneficial based on current literature.
CLINICAL NUCLEAR MEDICINE
(2021)
Article
Oncology
Tomas Reinert, Alessandra Borba Anton de Souza, Mahira Lopes Rosa, Sabrina Richter Bedin, Carlos Henrique Barrios
Summary: Breast cancer is a complex disease, and accurate systemic staging is essential for evaluating patients. The likelihood of metastatic disease at diagnosis varies among patients and depends on various factors. Identifying patients with de novo stage IV breast cancer is crucial for prognosis and treatment implications.
CLINICAL BREAST CANCER
(2021)
Article
Oncology
Masahiko Kubo, Shogo Kobayashi, Kunihito Gotoh, Hirotoshi Takayama, Yoshifumi Iwagami, Daisaku Yamada, Yoshito Tomimaru, Hirofumi Akita, Takehiro Noda, Hiroki Kato, Eku Shimosegawa, Yuichiro Doki, Hidetoshi Eguchi
Summary: This study validated the usability of FDG-PET for biliary tract cancer lymph nodes and found that high FDG uptake is an adverse prognostic factor for postoperative outcomes in resectable BTC patients.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Kristine E. Fasmer, Ankush Gulati, Julie A. Dybvik, Kari S. Wagner-Larsen, Njal Lura, Oyvind Salvesen, David Forsse, Jone Trovik, Johanna M. A. Pijnenborg, Camilla Krakstad, Ingfrid S. Haldorsen
Summary: This study evaluated the diagnostic performance of four different preoperative imaging workups for predicting lymph node metastases in endometrial cancer. The results showed that selective use of [F-18]FDG-PET/CT in patients with high-risk MRI findings detected lymph node metastases better than MRI alone.
EUROPEAN RADIOLOGY
(2023)
Article
Medicine, General & Internal
Krishna K. Patel, Carole Decker, Christina M. Pacheco, Christine Fuss, Illham Boda, Kensey L. Gosch, Arthur McGhie, Randall C. Thompson, Brett W. Sperry, Timothy M. Bateman, John A. Spertus
Summary: This qualitative study aimed to design and test a patient-centered report for stress Myocardial Perfusion Imaging (MPI) test results. Key themes around patient experiences with the current MPI reporting and their desire for a more useful report were identified. The patient-centered report led to improved patient engagement and knowledge in a pilot survey.
Article
Radiology, Nuclear Medicine & Medical Imaging
Mirza S. Baig, Wais Habib, Veronica Attard, Ban Sharif, Daniel Lindsay, Bhavin Upadhyay, Asif Saifuddin
Summary: This study aimed to determine the prevalence of pulmonary metastases on re-staging chest CT at the time of first local recurrence of trunk or extremity soft tissue sarcoma. The results showed that pulmonary metastases were diagnosed in 23.9% of cases, most commonly associated with grade 3 STS and specific sub-types of tumors. This supports the recommendation for chest CT at the time of local recurrence in line with UK guidelines for sarcoma management.
EUROPEAN RADIOLOGY
(2021)
Article
Multidisciplinary Sciences
Sung Hoon Kim, Bong-Il Song, Hae Won Kim, Kyoung Sook Won, Young-Gil Son, Seung Wan Ryu, Yoo Na Kang
Summary: We developed and validated a new staging system for gastric cancer patients, which incorporates metabolic information from 18FDG PET/CT and tumor-node-metastasis staging. This new system provides more accurate prediction of disease-specific survival in gastric cancer patients.
SCIENTIFIC REPORTS
(2022)
Editorial Material
Oncology
Hannah M. Linden, David A. Mankoff
Summary: [F-18]fluoroestradiol (FES) PET is an FDA-approved imaging biomarker that predicts clinical benefit of endocrine therapy and measures target activity in drug development. A recent study showed that tumor heterogeneity of expression predicts clinical benefit, and serial FES monitoring can assess estrogen receptor blockade and posttreatment release.
CLINICAL CANCER RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Tim Akhurst, Mithat Gonen, Raymond E. Baser, Lawrence H. Schwartz, Scott Tuorto, Lynn A. Brody, Anne Covey, Karen T. Brown, Steven M. Larson, Yuman Fong
Summary: The study compared the utility of FDG-PET with CT and CTAP for preoperative staging of hepatic colorectal metastases. FDG-PET had a significant impact on treatment decisions for nearly one-third of patients, mainly due to detection of extrahepatic disease. However, it was found to have lower sensitivity for hepatic sites, especially for small liver tumors.
HEPATOBILIARY SURGERY AND NUTRITION
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Nils Martin Bruckmann, Julian Kirchner, Lale Umutlu, Wolfgang Peter Fendler, Robert Seifert, Ken Herrmann, Ann-Kathrin Bittner, Oliver Hoffmann, Svjetlana Mohrmann, Christina Antke, Lars Schimmoeller, Marc Ingenwerth, Katharina Breuckmann, Andreas Stang, Christian Buchbender, Gerald Antoch, Lino M. Sawicki
Summary: This study compared the diagnostic performance of different imaging techniques in detecting bone metastases in patients with primary breast cancer. [F-18]FDG PET/MRI and MRI alone showed significantly higher sensitivity and specificity than CT and bone scintigraphy; CT and bone scintigraphy had lower sensitivity in detecting bone metastases and were prone to false-positive results.
EUROPEAN RADIOLOGY
(2021)
Article
Oncology
Larissa F. Moreira, Thais C. Mussi, Marcelo L. da Cunha, Renee Z. Filippi, Ronaldo H. Baroni
Summary: This study assessed the accuracy of Ga-68-PSMA PET/CT for lymph nodes and bones in the primary stage of prostate cancer, and the results showed a high specificity and accuracy.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2022)
Article
Dermatology
D. Shan, N. Wu, Q. Wang, W. Ren, A. Zhu, L. Wang, Y. Liu, L. Sun, L. Guo, H. Xu
Summary: High-frequency ultrasound can aid in evaluating the extent of vertical invasion in extramammary Paget's disease (EMPD) by analyzing the pseudopodia morphology, helping to distinguish between invasive EMPD and in situ EMPD lesions.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2022)
Article
Oncology
Nicola Fossati, Gianluca Giannarini, Steven Joniau, Michiel Sedelaar, Prasanna Sooriakumaran, Martin Spahn, Morgan Roupret
Summary: This report presents a case of a 56-year-old man with newly diagnosed metastatic prostate cancer. The report discusses the staging, treatment plan, and important questions regarding the use of molecular imaging, local treatment in the metastatic setting, and the consideration of metastasis-directed therapy.
EUROPEAN UROLOGY ONCOLOGY
(2022)
Article
Medicine, General & Internal
Ramsha Iqbal, Lemonitsa H. Mammatas, Tuba Aras, Wouter V. Vogel, Tim van de Brug, Daniela E. Oprea-Lager, Henk M. W. Verheul, Otto S. Hoekstra, Ronald Boellaard, Catharina W. van der Houven van Oordt
Summary: The study revealed that FDG PET had a high rate of incorrect staging among patients with grade 1-2, ER+ breast cancer cases. Proper staging is crucial to avoid inappropriate treatment choices for better survival outcomes. Further prospective studies focusing on novel radiotracers are urgently needed.
Article
Oncology
Ariane A. van Loevezijn, Hillegonda A. O. Winter-Warnars, Genevieve S. Hernandez, Christiaan M. de Bloeme, Frederieke H. van Duijnhoven, Marie-Jeanne T. F. D. Vrancken Peeters
Summary: This study retrospectively selected early-stage breast cancer patients who underwent neoadjuvant systemic therapy (NST) and found that MRI could detect additional lesions in some patients, which could impact surgical treatment. Among them, 31% of patients had lesions detected in the ipsilateral breast, and 26% of patients underwent more extensive surgery after the detection of lesions on MRI.
BREAST CANCER RESEARCH AND TREATMENT
(2023)
Article
Oncology
Ariane A. A. van Loevezijn, Charissa S. S. Geluk, Marieke J. J. van den Berg, Erik D. D. van Werkhoven, Marie-Jeanne T. F. D. Vrancken Peeters, Frederieke H. H. van Duijnhoven, Marije J. J. Hoornweg
Summary: This study aimed to evaluate the surgical outcomes of immediate and delayed oncoplastic surgery (OPS). The study found that selecting delayed OPS allowed for re-excision of margins without dismantling the reconstruction, achieving excellent breast conservation rates.
BREAST CANCER RESEARCH AND TREATMENT
(2023)
Article
Oncology
Nansi Maliko, Thomas Schok, Nina Bijker, Michel W. J. M. Wouters, Luc J. A. Strobbe, Marije J. Hoornweg, Marie-Jeanne T. F. D. Vrancken Peeters
Summary: OPBCS is a major part of daily clinical practice of Dutch breast surgeons treating BC patients. A clear definition and standardization is necessary to improve the quality of BC care.
Article
Oncology
Sanne A. L. Bartels, Mila Donker, Coralie Poncet, Nicolas Sauve, Marieke E. E. Straver, Cornelis J. H. van de Velde, Robert E. E. Mansel, Charlotte Blanken, Lorenzo Orzalesi, Jean H. G. Klinkenbijl, Huub C. J. van der Mijle, Grard A. P. Nieuwenhuijzen, Sanne C. C. Veltkamp, Thijs van Dalen, Andreas Marinelli, Herman Rijna, Marko Snoj, Nigel J. J. Bundred, Jos W. S. Merkus, Yazid Belkacemi, Patrick Petignat, Dominic A. X. Schinagl, Corneel Coens, Geertjan van Tienhoven, Frederieke van Duijnhoven, Emiel J. T. Rutgers
Summary: This clinical trial compared axillary lymph node dissection (ALND) with axillary radiotherapy (ART) in patients with cT1-2, node-negative breast cancer. The study found that both modalities had comparable axillary control, but ART was associated with less morbidity. Additionally, patients in the ART group had a higher risk of developing second primary cancers.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Josephine M. N. L. Cardozo, Irene L. E. Andrulis, Stig E. Bojesen, Thilo M. Doerk, Diana M. A. Eccles, Peter A. J. Fasching, Maartje J. Hooning, Renske Keeman, Heli Nevanlinna, Emiel J. T. F. Rutgers, Douglas F. Easton, Per Hall, Paul D. P. J. Pharoah, Laura J. K. van't Veer, Marjanka K. Schmidt
Summary: A polygenic risk score (PRS) consisting of 313 common genetic variants (PRS313) is associated with risk of breast cancer and contralateral breast cancer. This study aimed to evaluate the association of the PRS313 with clinicopathologic characteristics of, and survival following, breast cancer. The results showed that PRS313 is associated with favorable tumor characteristics but not independently associated with prognosis. Rating: 8/10.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Letter
Surgery
Martine A. van Huizum, J. Joris Hage, Astrid N. Scholten, Emiel J. Rutgers
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2023)
Article
Surgery
Babette E. Becherer, Erik A. Heeg, Danny A. Young-Afat, Marie-Jeanne T. F. D. Vrancken Peeters, Hinne A. Rakhorst, Marc A. M. Mureau
Summary: In this population-based study in the Netherlands, the incidence of unplanned revision surgery was lower in immediate implant-based breast reconstruction using a direct-to-implant approach compared to a two-stage approach. Additionally, more breasts were reconstructed within the planned number of operations in the direct-to-implant group.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2023)
Article
Public, Environmental & Occupational Health
Jonathan Spoor, Marc A. M. Mureau, Juliette Hommes, Hinne Rakhorst, Anneriet E. Dassen, Hester S. A. Oldenburg, Yvonne L. J. Vissers, Esther M. Heuts, Linetta B. Koppert, Laura H. Zaal, Rene R. W. J. van der Hulst, Marie-Jeanne T. F. D. Vrancken Peeters, Eveline M. A. Bleiker, Flora E. van Leeuwen
Summary: This article introduces the Areola study, which aims to assess the risks of breast implant illness (BII) and autoimmune diseases in Dutch breast cancer survivors with silicone breast implants. The study design includes a retrospective cohort of breast cancer survivors who underwent implant-based reconstruction surgery between 2000 and 2015 in six major hospitals in the Netherlands. A comparison group of breast cancer survivors without breast implants and a group of women who received breast augmentation surgery will also be included. The study will collect data through a web-based questionnaire and link it with population-based databases to evaluate the prevalence, incidence, and risk factors of BII and autoimmune disorders.
ANNALS OF EPIDEMIOLOGY
(2023)
Editorial Material
Oncology
Annemiek K. E. van Hemert, Frederieke H. van Duijnhoven, Ariane A. van Loevezijn, Claudette E. Loo, Terry Wiersma, Emilie J. Groen, Marie-Jeanne T. F. D. Vrancken Peeters
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Annemiek K. E. van Hemert, Frederieke H. H. van Duijnhoven, Ariane A. A. van Loevezijn, Claudette E. E. Loo, Terry Wiersma, Emilie J. J. Groen, Marie-Jeanne T. F. D. Vrancken Peeters
Summary: The study aims to assess the residual disease in patients who had a favorable response on MRI and no residual disease detected through biopsy after neoadjuvant systemic treatment (NST) for breast cancer. The findings showed that substantial residual invasive disease remains in all molecular subtypes, suggesting the need for surgical excision until better imaging and biopsy techniques are developed.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Annemiek K. E. van Hemert, Josefien P. P. van Olmen, Liesbeth J. J. Boersma, John H. H. Maduro, Nicola S. S. Russell, Jolien Tol, Ellen G. G. Engelhardt, Emiel J. Th. Rutgers, Marie-Jeanne T. F. D. Vrancken Peeters, Frederieke H. H. van Duijnhoven
Summary: The purpose of this study is to show that omitting adjuvant radiotherapy in breast cancer patients with pCR after NST can result in low rates of local recurrence and good quality of life.
BREAST CANCER RESEARCH AND TREATMENT
(2023)
Review
Oncology
Marjanka K. Schmidt, Jennifer E. Kelly, Anne Bredart, David A. Cameron, Jana de Boniface, Douglas F. Easton, Birgitte Offersen, Fiorita Poulakaki, Isabel T. Rubio, Francesco Sardanelli, Rita Schmutzler, Tanja Spanic, Britta Weigelt, Emiel J. T. Rutgers
Summary: After a unilateral breast cancer diagnosis, more and more patients are choosing to have contralateral prophylactic mastectomy (CPM), the removal of the healthy breast. Breast cancer specialists need to provide guidance to women considering CPM. This manifesto discusses the challenges of CPM and offers recommendations to improve outcomes for women with unilateral breast cancer.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Oncology
Dinusha Veluponnar, Lisanne L. de Boer, Freija Geldof, Lynn-Jade S. Jong, Marcos Da Silva Guimaraes, Marie-Jeanne T. F. D. Vrancken Peeters, Frederieke van Duijnhoven, Theo Ruers, Behdad Dashtbozorg
Summary: During breast-conserving surgeries, accurate evaluation of tumor margins is challenging, leading to potential need for additional surgery or boost radiotherapy. The use of computer-aided delineation of tumor boundaries in ultrasound images shows promising results in predicting positive and close margins. There is a clinical need for an accurate and rapid margin assessment tool, and computer-aided ultrasound evaluation offers a potential solution.
Correction
Oncology
Marte C. C. Liefaard, Kat S. S. Moore, Lennart Mulder, Daan van den Broek, Jelle Wesseling, Gabe S. S. Sonke, Lodewyk F. A. Wessels, Matti Rookus, Esther H. H. Lips
BRITISH JOURNAL OF CANCER
(2023)
Article
Oncology
Yuchao Liu, Zijia Liu, Liangyan Zhang, Yuelun Zhang, Ningchen Zhang, Yue Han, Le Shen
Summary: This study found an association between preoperative 6-min walk distance and postoperative complications in patients undergoing laparoscopic gastrointestinal cancer surgery.
Review
Oncology
Matteo Pavone, Rosa Autorino, Nicolo Bizzarri, Giuditta Chilorio, Vincenzo Valentini, Giacomo Corrado, Gabriella Ferrandina, Gabriella Macchia, Maria Antonietta Gambacorta, Giovanni Scambia, Denis Querleu
Summary: Ovarian transposition is an established method for protecting the ovaries from radiation, while surgical procedures for protecting the uterus are still under investigation. This study conducted a systematic review of uterine displacement techniques and performed dose simulation to assess the radiation dose received by the uterus. The results showed that the transposition approach was the most protective.
Article
Oncology
Silvia Ministrini, Maria Bencivenga, Federica Filippini, Gianni Mura, Carlo Milandri, Maria Antonietta Mazzei, Giulio Bagnacci, Mattia Berselli, Manlio Monti, Paolo Morgagni, Leonardo Solaini, Daniele Marrelli, Stefania Piccioni, Stefano De Pascale, Luigina Graziosi, Rossella Reddavid, Fausto Rosa, Claudio Belluco, Guido Tiberio
Summary: The Italian Research Group for Gastric Cancer developed a prospective database to evaluate the impact of a pragmatic attitude on the management of stage IV gastric cancer patients. The study found that different metastatic sites did not affect survival rates, but multiple metastatic sites were associated with worse survival. Patients who could undergo curative resection had better survival rates. A more accurate diagnostic workup and staging had a favorable impact on survival.
Article
Oncology
Luca Lambertini, Fabrizio Di Maida, Anna Cadenar, Samuele Nardoni, Antonio Andrea Grosso, Francesca Valastro, Pietro Spinelli, Riccardo Fantechi, Agostino Tuccio, Gianni Vittori, Andrea Mari, Lorenzo Masieri, Andrea Minervini
Summary: The aim of this study was to evaluate the functional outcomes of Florence intracorporeal neobladder (FloRIN) configuration technique performed with a stentless procedure. The results showed that the stentless procedure was associated with shorter console time and lower estimated blood loss compared to the stent group. There were no significant differences in terms of perioperative features and mid-term functional outcomes between the two groups.
Article
Oncology
Geun-Jeon Kim, Jooin Bang, Hyun-Il Shin, Sang-Yeon Kim, Dong -Il Sun
Summary: This study evaluated the outcome of tonsillar cancer managed with neoadjuvant chemotherapy followed by surgery. The results showed that neoadjuvant chemotherapy reduced tumor volume and pathological adverse features, significantly decreasing the need for adjuvant therapy. A greater reduction in tumor volume predicted a complete pathologic response. There was no significant difference in survival rates between the groups.
Article
Oncology
Alexandra Nassar, Stylianos Tzedakis, Ugo Marchese, Gaanan Naveendran, Remy Sindayigaya, Martin Gaillard, Francois Cauchy, Mickael Lesurtel, Brice Gayet, Olivier Soubrane, David Fuks
Summary: This study identified recurrence between the two stages and a larger tumor size in the future liver remnant as critical factors contributing to the failure of two-stage hepatectomy for bilobar colorectal liver metastases. These findings have important clinical implications for the selection and evaluation of TSH surgery.
Letter
Oncology
Michele Fiore, Gian Marco Petrianni, Gabriele D'Ercole, Pasquale Trecca, Sara Ramella
Review
Oncology
Harry Farrow, Oliver J. Pickering, James A. Gossage, Philip H. Pucher
Summary: The inclusion or exclusion of the thoracic duct in radical esophagectomy for esophageal cancer is a controversial issue. While removing the thoracic duct may increase lymph node yield, it may also lead to higher morbidity without any survival benefit.
Article
Oncology
Xiaokun Li, Siyuan Luan, Chi Zhang, Weili Kong, Xin Xiao, Haowen Zhang, Jianfeng Zhou, Yushang Yang, Yang Xu, Yong Qiang, Pinhao Fang, Yi Shen, Yong Yuan
Summary: This study proposes a new staging system based on ypTNM stage and cN status for early stage ESCC patients after nCRT. The new ypTNM-cN staging system demonstrates superior predictive ability and classification efficacy compared to the AJCC 8th ypTNM staging system. It provides new insights for accurately stratifying ypI stage ESCC patients.
