Article
Oncology
Zhancheng Qiu, Weili Qi, Youwei Wu, Lingling Li, Chuan Li
Summary: This study examines the impact of public insurance status on the survival outcomes of HCC patients after liver resection in China. The results show that underinsured HCC patients have worse survival outcomes after liver resection. This may be due to the limited access to care for underinsured patients, but further exploration is needed for conclusive evidence.
Article
Clinical Neurology
Cathy Y. Yu, Timothy Blaine, Peter D. Panagos, Akash P. Kansagra
Summary: This study highlighted the demographic disparities in proximity to certified stroke care, with greater disparities observed in nonurban areas compared to urban areas. Higher proportions of elderly, American Indian, uninsured, or low-income populations in nonurban census tracts were found to be more distant from certified stroke care facilities.
Review
Oncology
Daniel Redondo-Sanchez, Dafina Petrova, Miguel Rodriguez-Barranco, Pablo Fernandez-Navarro, Jose Juan Jimenez-Moleon, Maria-Jose Sanchez
Summary: Lung cancer is a leading cause of cancer-related deaths worldwide. Lower socio-economic status (SES) is associated with higher risk and worse outcomes in lung cancer. People with lower SES have lower cancer survival due to barriers in receiving treatments, higher rates of comorbidities, and increased likelihood of emergency admissions. However, they are generally diagnosed at earlier stages. Broad implementation of lung cancer screening may change this scenario.
Article
Public, Environmental & Occupational Health
Bhed Ram, Ramna Thakur
Summary: In India, infectious diseases remain a major concern, while non-communicable diseases are also increasing, imposing a double burden on households. Analysis of data in India shows that infectious diseases are more prevalent among populations in rural areas, females, the 0-14 age group, Muslims, illiterates, large family households, and economically poor people. The per capita out-of-pocket expenditure on infectious diseases is INR 7.28 for inpatient care and INR 29.38 for outpatient care in India. The study emphasizes the need for effective implementation of policy measures, increased awareness of hygiene and disease transmission, immunization campaigns, subsidized medical facilities, and expanded access to quality primary healthcare facilities.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Oncology
Anjali Gupta, Chioma H. Omeogu, Jessica Y. Islam, Ashwini R. Joshi, Tomi F. Akinyemiju
Summary: This study found that area-level income and education are strongly associated with an advanced NSCLC diagnosis regardless of the facility type and among those with government and private insurance. 50% of NH Black patients were in the lowest income quartile, while only 17% of NH White patients were in this group.
Article
Environmental Sciences
Mehmet Demiral, Ozge Demiral
Summary: This study examines the effects of productive capacities in socio-economic factors on energy efficiency in a sample of 125 countries. The findings reveal varied driver and barrier influences of these factors on energy efficiency improvements, highlighting the importance of considering different factors in promoting energy efficiency. The results have significant implications for research and policy.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Ecology
Chevonne Reynolds, Caroline G. Howes
Summary: Urban biodiversity and its ecosystem services are distributed unevenly along socio-economic gradients. Socio-economic and urban landscape variables act as filters of bird species' functional traits, leading to differences in ecosystem service provision. However, urban green spaces in low-income areas support more birds of public interest but fewer birds that provide supporting ecosystem services. Tree cover and green space size have differing relationships with bird functional traits.
LANDSCAPE AND URBAN PLANNING
(2023)
Article
Oncology
Aman Opneja, Gino Cioffi, Asrar Alahmadi, Nelroy Jones, Tin-Yun Tang, Nirav Patil, David L. Bajor, Joel N. Saltzman, Amr Mohamed, Eva Selfridge, Ankit Mangla, Jill Barnholtz-Sloan, Richard T. Lee
Summary: The study found that the rate of using single agent anticancer therapy (SAACT) in the treatment of advanced hepatocellular carcinoma (aHCC) has gradually increased over time, leading to a significant improvement in overall survival. However, there are significant differences in treatment outcomes among patients based on facility type, insurance status, and income level.
Article
Substance Abuse
Inger Synnove Moan, Torleif Halkjelsvik
Summary: The study estimated the prevalence of alcohol-related presenteeism among Norwegian adults at 8.7%. Men and younger employees had a higher risk, as did those with higher education and income.
Review
Ecology
Laura Vang Rasmussen, Niels Fold, Rasmus Skov Olesen, Sheona Shackleton
Summary: Ecological infrastructure refers to natural functioning ecosystems that provide valuable services to people. Investments in ecological infrastructure primarily result in positive outcomes for short-term income and natural capital, with less frequent positive outcomes observed for other socioeconomic dimensions. Cases with high participant involvement in early implementation and utilizing multiple methods are more likely to achieve positive outcomes across various dimensions.
ECOSYSTEM SERVICES
(2021)
Article
Substance Abuse
Lindsey N. Potter, Chelsey R. Schlechter, Inbal Nahum-Shani, Cho Y. Lam, Paul M. Cinciripini, David W. Wetter
Summary: This study investigates whether the within-person associations of key risk and protective factors with smoking lapse varies by facets of socio-economic status (SES). The findings suggest that individuals from lower SES groups have a weaker influence of some risk factors on smoking lapse compared to higher SES groups.
Article
Public, Environmental & Occupational Health
Fiona C. Ingleby, Laura M. Woods, Iain M. Atherton, Matthew Baker, Lucy Elliss-Brookes, Aurelien Belot
Summary: The study reveals that there is a correlation between socio-economic status and cancer survival, with both individual and contextual factors contributing to inequalities in cancer outcomes.
Article
Multidisciplinary Sciences
Sofia Castro Lopes, Deborah Constant, Silvia Fraga, Nafissa Bique Osman, Daniela Correia, Jane Harries
Summary: Empowerment of women in Mozambique is influenced by various socio-economic, demographic, and behavioral factors, leading to different domains of empowerment such as beliefs about violence against women, decision-making, and control over sexuality and safe sex. This indicates the importance of considering context-specific characteristics in understanding and promoting women's empowerment.
Article
Oncology
Jingxuan Zhao, Xuesong Han, Leticia Nogueira, Stacey A. Fedewa, Ahmedin Jemal, Michael T. Halpern, K. Robin Yabroff
Summary: Previous studies have shown that uninsured patients in the United States are more likely to be diagnosed with late-stage cancer and have worse survival rates. This report provides comprehensive data on the association between health insurance coverage type and stage at diagnosis and long-term survival in individuals diagnosed with common cancers between 2010 and 2013.
CA-A CANCER JOURNAL FOR CLINICIANS
(2022)
Article
Surgery
Sacha C. Hauc, Jennifer Rodriguez, Aaron S. Long, Kirby Mateja, Layla M. Aboukhater, Jacqueline M. H. Ihnat, Alexandra Junn, Jacob Dinis, Sarah Phillips, Michael Alperovich
Summary: Race and socioeconomic factors are important predictors for access to complex reconstructive procedures and hospital-based outcomes in melanoma patients.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2022)
Article
Anesthesiology
E. Li
Summary: Surgical patients with peri-operative or recent SARS-CoV-2 infection are at increased risk of postoperative venous thromboembolism compared to those without a history of SARS-CoV-2. However, the optimal prophylaxis and treatment for venous thromboembolism in this patient population remains unknown. Venous thromboembolism is independently associated with 30-day mortality.
Article
Gastroenterology & Hepatology
Jule Leuz, Laura Brecht, Jacob Nattermann, Tim Glowka, Clemens Ballmann, Marcus Dahlem, Volker Schmitz
Summary: Dumping syndromes are common side effects after partial or total gastric resection, with diverse symptoms. Traditional therapy concepts, including personalized nutritional concepts and medication, may not always achieve desired results, prompting the need for individualized therapy concepts to restore patient's quality of life.
ZEITSCHRIFT FUR GASTROENTEROLOGIE
(2021)
Article
Surgery
Jana Enderes, Jessica Teschke, Martin von Websky, Steffen Manekeller, Joerg C. Kalff, Tim R. Glowka
Summary: The study shows that smokers have a lower incidence of delayed gastric emptying syndrome (DGE) after pancreatoduodenectomy and tolerate solid food intake more quickly. Smokers are typically younger, predominantly male, with a higher prevalence of pulmonary conditions and alcohol abuse.
Article
Biology
Jana Enderes, Christiane Pillny, Hanno Matthaei, Steffen Manekeller, Joerg C. Kalff, Tim R. Glowka
Summary: There is no difference in the occurrence and severity of delayed gastric emptying in obese patients compared to non-obese patients after pancreatic surgery. The mortality rate does not differ between the two groups.
Article
Medicine, General & Internal
Christiane Pillny, Jessica Teschke, Jana Enderes, Steffen Manekeller, Joerg C. Kalff, Tim R. Glowka
Summary: Delayed gastric emptying does not affect long-term survival in PDAC patients, although it prolongs hospital stay.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Taotao Zhou, Robert Mahn, Christian Moehring, Farsaneh Sadeghlar, Carsten Meyer, Marieta Toma, Barbara Kreppel, Markus Essler, Tim Glowka, Hanno Matthaei, Joerg C. Kalff, Christian P. Strassburg, Maria A. Gonzalez-Carmona
Summary: This report presents a case of a male patient with PD-L1-positive and BRCA2-mutated metastatic intrahepatic cholangiocarcinoma. The patient was treated with a combined therapy of PARP inhibitor olaparib and PD-1 antibody pembrolizumab, which achieved a long-lasting complete remission for over 15 months.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biology
Reiner Schneider, Patrick Leven, Shilpashree Mallesh, Mona Bresser, Linda Schneider, Elvio Mazzotta, Paola Fadda, Tim Glowka, Tim O. Vilz, Philipp Lingohr, Joerg C. Kalff, Fievos L. Christofi, Sven Wehner
Summary: IL1R1 signaling triggers enteric gliosis, resulting in macrophage activation and the development of postoperative ileus.
COMMUNICATIONS BIOLOGY
(2022)
Article
Medicine, General & Internal
James C. Glasbey, Tom E. F. Abbott, Adesoji Ademuyiwa, Adewale Adisa, Ehab AlAmeer, Sattar Alshryda, Alexis P. Arnaud, Brittany Bankhead-Kendall, M. K. Abou Chaar, Daoud Chaudhry, Ainhoa Costas-Chavarri, Miguel F. Cunha, Justine I. Davies, Anant Desai, Muhammed Elhadi, Marco Fiore, J. Edward Fitzgerald, Maria Fourtounas, Alex James Fowler, Kay Futaba, Gaetano Gallo, Dhruva Ghosh, Rohan R. Gujjuri, Rebecca Hamilton, Parvez Haque, Ewen M. Harrison, Peter Hutchinson, Gabriella Hyman, Arda Isik, Umesh Jayarajah, Haytham M. A. Kaafarani, Bryar Kadir, Ismail Lawani, Hans Lederhuber, Elizabeth Li, Markus W. Loffler, Maria Aguilera Lorena, Harvinder Mann, Janet Martin, Dennis Mazingi, Craig D. McClain, Kenneth A. McLean, John G. Meara, Antonio Ramos-De La Medina, Mengistu Mengesha, Ana Minaya, Maria Marta Modolo, Rachel Moore, Dion Morton, Dmitri Nepogodiev, Faustin Ntirenganya, Francesco Pata, Rupert Pearse, Maria Picciochi, Thomas Pinkney, Peter Pockney, Gabrielle H. van Ramshorst, Toby Richards, April Camilla Roslani, Sohei Satoi, Raza Sayyed, Richard Shaw, Joana Filipa Ferreira Simoes, Neil Smart, Richard Sulliva, Malin Sund, Sudha Sundar, Stephen Tabiri, Elliott H. Taylor, Mary L. Venn, Dakshitha Wickramasinghe, Naomi Wright, Sebastian Bernardo Shu Yip, Aneel Bhangu
Summary: This study developed and validated a novel index (SPI) to support the strengthening of local elective surgical systems and address growing backlogs. The findings showed that hospitals with a higher SPI were associated with an increased planned surgical volume ratio, independent of income status, COVID-19 burden, and hospital type. Annual self-assessment of surgical preparedness is recommended to identify areas for improvement and enhance the resilience of local surgical systems.
Article
Medicine, General & Internal
Jana Enderes, Christiane Pillny, Jens Standop, Steffen Manekeller, Joerg C. Kalff, Tim R. Glowka
Summary: In recent decades, there has been an increase in the rate of reoperations following pancreatoduodenectomy, mainly due to pancreaticogastrostomy dehiscence. Patients who underwent reoperations experienced higher rates of postoperative complications and mortality. Despite the increased rate of reoperations, it did not lead to a significant increase in mortality rate.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biology
Jana Enderes, Christiane Pillny, Hanno Matthaei, Steffen Manekeller, Joerg C. Kalff, Tim R. Glowka
Summary: Pancreatic cancer is a highly aggressive tumor with poor prognosis. Surgery combined with chemotherapy is the only chance for long-term survival, but it is a complex procedure with risks of complications. This study investigated the risk factors and treatment strategies for leakage of pancreatic fluid after surgery. The data showed that patients with leakage were younger, mainly male, with fewer comorbidities, higher body mass index, smaller tumor size, and softer pancreatic parenchyma. Treatment strategies included conservative treatment, drainage placement, endoscopic negative pressure therapy and surgery. Most patients received conservative treatment, resulting in shorter hospital stays.
Article
Gastroenterology & Hepatology
Jan Raabe, Kim M. Kaiser, Michael ToVinh, Claudia Finnemann, Philipp Lutz, Christoph Hoffmeister, Jenny Bischoff, Felix Goeser, Dominik J. Kaczmarek, Tim R. Glowka, Steffen Manekeller, Arthur Charpentier, Bettina Langhans, Hans Dieter Nischalke, Marieta Toma, Christian P. Strassburg, Ulrich Spengler, Ali T. Abdallah, Benjamin Kramer, Jacob Nattermann
Summary: In this study, researchers performed a detailed characterization of intrahepatic innate lymphoid cells (ILCs) in healthy and fibrotic livers, and identified a previously undescribed subset of ILC3-like cells that produce IL-13. These cells were enriched in human liver and increased in fibrotic livers. IL-13 production by ILC3 induced proinflammatory gene upregulation in hepatic stellate cells, suggesting a potential role in the modulation of chronic liver disease.
Review
Oncology
Christian Moehring, Freddy Jose Frontado Graffe, Alexandra Bartels, Farsaneh Sadeghlar, Taotao Zhou, Robert Mahn, Milka Marinova, Georg Feldmann, Peter Brossart, Tim R. Glowka, Joerg C. Kalff, Christian P. Strassburg, Maria A. Gonzalez-Carmona
Summary: The use of 5-FU/LV + nal-IRI as second- or third-line palliative treatment in patients with advanced pancreatic cancer showed similar overall survival, progression-free survival, and tolerance as randomized trials. Interestingly, it seemed to be beneficial even after exposure to non-liposomal irinotecan.
JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2023)
Article
Surgery
Jonas Henn, Patricia K. Wyzlic, Irene Esposito, Alexander Semaan, Vittorio Branchi, Carsten Klinger, Heinz J. Buhr, Ulrich F. Wellner, Tobias Keck, Philipp Lingohr, Tim R. Glowka, Steffen Manekeller, Joerg C. Kalff, Hanno Matthaei
Summary: This study aimed to compare the resection of pancreatic cystic lesions (PCL) in Germany with international guidelines and provide recommendations. Different types of PCL showed variations in surgical management and risks, which were associated with patient symptoms. Treatment strategies should be determined based on patient-specific factors and appropriate diagnostic means recommended in the guidelines.
LANGENBECKS ARCHIVES OF SURGERY
(2023)
Article
Surgery
Maria A. A. Willis, Sophia L. V. Soltau, Cornelius van Beekum, Nils Sommer, Tim R. R. Glowka, Joerg C. Kalff, Tim O. O. Vilz
Summary: Robot-assisted rectal resections are believed to overcome the challenges of laparoscopic rectal surgery through technical advantages, leading to better treatment outcomes. However, the results from published studies are heterogeneous. The analysis showed that robotic rectal resections were associated with longer operation times, while the other outcomes were minimally influenced by the surgical technique.
Review
Surgery
Cornelius J. van Beekum, Tim O. Vilz, Tim R. Glowka, Martin W. von Websky, Jorg C. Kalff, Steffen Manekeller
Summary: Mechanical perfusion is an innovative approach in liver transplantation, aiming to address the shortage of available organs. Hypothermic oxygenated perfusion and normothermic machine perfusion are two common methods that can mitigate ischemia-reperfusion injury, improve allograft quality, and reduce risks of complications in transplantation.
ANNALS OF TRANSPLANTATION
(2021)
Article
Oncology
Yuchao Liu, Zijia Liu, Liangyan Zhang, Yuelun Zhang, Ningchen Zhang, Yue Han, Le Shen
Summary: This study found an association between preoperative 6-min walk distance and postoperative complications in patients undergoing laparoscopic gastrointestinal cancer surgery.
Review
Oncology
Matteo Pavone, Rosa Autorino, Nicolo Bizzarri, Giuditta Chilorio, Vincenzo Valentini, Giacomo Corrado, Gabriella Ferrandina, Gabriella Macchia, Maria Antonietta Gambacorta, Giovanni Scambia, Denis Querleu
Summary: Ovarian transposition is an established method for protecting the ovaries from radiation, while surgical procedures for protecting the uterus are still under investigation. This study conducted a systematic review of uterine displacement techniques and performed dose simulation to assess the radiation dose received by the uterus. The results showed that the transposition approach was the most protective.
Article
Oncology
Silvia Ministrini, Maria Bencivenga, Federica Filippini, Gianni Mura, Carlo Milandri, Maria Antonietta Mazzei, Giulio Bagnacci, Mattia Berselli, Manlio Monti, Paolo Morgagni, Leonardo Solaini, Daniele Marrelli, Stefania Piccioni, Stefano De Pascale, Luigina Graziosi, Rossella Reddavid, Fausto Rosa, Claudio Belluco, Guido Tiberio
Summary: The Italian Research Group for Gastric Cancer developed a prospective database to evaluate the impact of a pragmatic attitude on the management of stage IV gastric cancer patients. The study found that different metastatic sites did not affect survival rates, but multiple metastatic sites were associated with worse survival. Patients who could undergo curative resection had better survival rates. A more accurate diagnostic workup and staging had a favorable impact on survival.
Article
Oncology
Luca Lambertini, Fabrizio Di Maida, Anna Cadenar, Samuele Nardoni, Antonio Andrea Grosso, Francesca Valastro, Pietro Spinelli, Riccardo Fantechi, Agostino Tuccio, Gianni Vittori, Andrea Mari, Lorenzo Masieri, Andrea Minervini
Summary: The aim of this study was to evaluate the functional outcomes of Florence intracorporeal neobladder (FloRIN) configuration technique performed with a stentless procedure. The results showed that the stentless procedure was associated with shorter console time and lower estimated blood loss compared to the stent group. There were no significant differences in terms of perioperative features and mid-term functional outcomes between the two groups.
Article
Oncology
Geun-Jeon Kim, Jooin Bang, Hyun-Il Shin, Sang-Yeon Kim, Dong -Il Sun
Summary: This study evaluated the outcome of tonsillar cancer managed with neoadjuvant chemotherapy followed by surgery. The results showed that neoadjuvant chemotherapy reduced tumor volume and pathological adverse features, significantly decreasing the need for adjuvant therapy. A greater reduction in tumor volume predicted a complete pathologic response. There was no significant difference in survival rates between the groups.
Article
Oncology
Alexandra Nassar, Stylianos Tzedakis, Ugo Marchese, Gaanan Naveendran, Remy Sindayigaya, Martin Gaillard, Francois Cauchy, Mickael Lesurtel, Brice Gayet, Olivier Soubrane, David Fuks
Summary: This study identified recurrence between the two stages and a larger tumor size in the future liver remnant as critical factors contributing to the failure of two-stage hepatectomy for bilobar colorectal liver metastases. These findings have important clinical implications for the selection and evaluation of TSH surgery.
Letter
Oncology
Michele Fiore, Gian Marco Petrianni, Gabriele D'Ercole, Pasquale Trecca, Sara Ramella
Review
Oncology
Harry Farrow, Oliver J. Pickering, James A. Gossage, Philip H. Pucher
Summary: The inclusion or exclusion of the thoracic duct in radical esophagectomy for esophageal cancer is a controversial issue. While removing the thoracic duct may increase lymph node yield, it may also lead to higher morbidity without any survival benefit.
Article
Oncology
Xiaokun Li, Siyuan Luan, Chi Zhang, Weili Kong, Xin Xiao, Haowen Zhang, Jianfeng Zhou, Yushang Yang, Yang Xu, Yong Qiang, Pinhao Fang, Yi Shen, Yong Yuan
Summary: This study proposes a new staging system based on ypTNM stage and cN status for early stage ESCC patients after nCRT. The new ypTNM-cN staging system demonstrates superior predictive ability and classification efficacy compared to the AJCC 8th ypTNM staging system. It provides new insights for accurately stratifying ypI stage ESCC patients.
