Article
Biophysics
Keke Zheng, Nobuhiro Yoda, Junning Chen, Zhipeng Liao, Jingxiao Zhong, Chi Wu, Boyang Wan, Shigeto Koyama, Keiichi Sasaki, Christopher Peck, Michael Swain, Qing Li
Summary: This study investigates bone remodelling responses to mandibulectomy by developing an algorithm that incorporates patient-specific longitudinal data. The study aims to simulate bone remodelling activity in the conjunction region with a fibula free flap reconstruction and compare the long-term outcomes of different fixation plate designs. The results show a decrease in overall bone density over time, except in the docking site where bone apposition occurs after a decrease in bone density. Different screw positioning does not significantly influence bone remodelling outcomes.
JOURNAL OF BIOMECHANICS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Haoliang Chen, Yongheng Li, Yawei Sun, Xin Chen, Yumei Pu, Guowen Sun
Summary: This study evaluated the changes in condylar position and morphology after mandibular reconstruction with condyle preservation. The results showed significant changes in condylar position on the ipsilateral side after reconstruction surgery, but no significant changes on the contralateral side. However, there was no statistically significant association between clinical characteristics and changes in condylar position and morphology.
CLINICAL ORAL INVESTIGATIONS
(2023)
Article
Surgery
Abraham Zavala, Juan F. Ore, Emiliana Rizo-Patron, Wieslawa De Pawlikowski
Summary: The study evaluated the long-term facial symmetry after mandible reconstruction using the vascularized fibula free flap in growing patients. The results showed that this technique could effectively maintain facial symmetry without the need for secondary procedures to enhance symmetry in the late postoperative period.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2022)
Article
Otorhinolaryngology
Brianna N. Harris, Shabnam Ghazizadeh, Rodrigo Bayon, Alexandra E. Kejner, Steven B. Cannady, Benjamin J. Greene, Andrew T. Huang, Joseph Curry, Keith E. Blackwell, Yadranko Ducic, Mark K. Wax
Summary: The study suggests that FFF in patients with prior knee replacement may be safe without increased risk of complications compared to baseline.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Article
Surgery
Alexandra C. Hatchell, Christiaan H. Schrag, Claire F. Temple-Oberle, Jennifer L. Matthews, C. David McKenzie, T. Wayne Matthews, Shamir P. Chandarana, Joseph C. Dort, Rasha Baaqeel
Summary: The study revealed that patients who have undergone fibula free flap harvest experience challenges related to ankle support and balance at the donor site, as well as functional difficulties impacting their quality of life. Multidisciplinary approaches for targeted rehabilitation after fibula free flap harvest should be explored to improve patients' quality of life.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2021)
Article
Surgery
Abraham Zavala, Juan F. Ore, Alfredo Broggi, Wieslawa De Pawlikowski
Summary: This study retrospectively reviewed 34 pediatric patients who underwent mandibular reconstruction using the vascularized fibula free flap, showing satisfactory outcomes with normal mouth opening and occlusion in most patients postoperatively. Complications were minimal in this patient population.
ANNALS OF PLASTIC SURGERY
(2021)
Article
Surgery
Alexander F. Mericli, Malke Asaad, Valerae O. Lewis, Patrick P. Lin, Christopher J. Goodenough, David M. Adelman, Scott D. Oates, Matthew M. Hanasono
Summary: This study evaluated outcomes of vascularized bone flap reconstruction for oncologic bony extremity defects and compared union rates based on different insetting methods. A retrospective review of patients who received fibula flap reconstruction after oncologic resection was conducted. The overall union rate was 91.7%, with a mean time to full weightbearing of 16 months for lower extremity reconstructions.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2023)
Article
Surgery
Yen -Shuo Lai, Yeu -Her Lai, Yao -Chou Lee
Summary: This study found that ensuring the proper location of skin within the oral cavity can reduce the risk of skin necrosis when using the fibula osteoseptocutaneous flap for mandibular and intraoral reconstructions.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2023)
Article
Oncology
Jochen Weitz, Alex Grabenhorst, Hannes Singer, Minli Niu, Florian D. Grill, Daniel Kamreh, Carolina A. S. Classen, Klaus-Dietrich Wolff, Lucas M. Ritschl
Summary: This study compared the application of auxiliary techniques in mandibular reconstruction. The use of adjustable resection/reconstruction aids and CAD/CAM assistance showed no significant differences in terms of feasibility, accuracy, and operative parameters. However, the adjustable aids had advantages of less preoperative planning time and lower costs per case, which may be more favorable for mandibular angle-to-angle reconstruction.
FRONTIERS IN ONCOLOGY
(2023)
Article
Otorhinolaryngology
Julie Lignon, Joanne Guerlain, Alexandre Bozec, Philippe Gorphe, Frederic Lauwers, Sebastien Vergez, Florian Jalbert, Emilien Chabrillac, Guillaume de Bonnecaze, Leonor Chaltiel, Agnes Dupret-Bories
Summary: This study aimed to assess the impact and cost-effectiveness of virtual surgical planning on fibula free flap mandibular reconstruction. The results show that while there was no significant difference in peri- and postoperative data between planned and non-planned surgeries, planned surgeries had a higher rate of centred occlusion. Further studies are needed to evaluate the long-term benefits of virtual surgical planning.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Lucas M. Ritschl, Thomas Muecke, Diandra Hart, Tobias Unterhuber, Victoria Kehl, Klaus-Dietrich Wolff, Andreas M. Fichter
Summary: This study aimed to evaluate the incidence of complications following mandibular reconstruction and analyze contributing factors. Skin perforation was most often detected in the reconstruction plate subgroup, with low BMI and total radiation dosage being the most relevant risk factors. Microvascular bone flaps were found to have fewer skin perforations overall, and BMI and expected radiation dosage should be considered when choosing a reconstructive technique.
CLINICAL ORAL INVESTIGATIONS
(2021)
Article
Biotechnology & Applied Microbiology
Philipp Ruf, Vincenzo Orassi, Heilwig Fischer, Claudius Steffen, Georg N. N. Duda, Max Heiland, Kilian Kreutzer, Sara Checa, Carsten Rendenbach
Summary: This study evaluated the primary fixation stability of CAD/CAM fixators and compared the performance of different types of fixators under biomechanical conditions. The results showed that CAD/CAM miniplates had higher mechanical strains, while CAD/CAM reconstruction plates resulted in higher strains. However, the stresses in the fixation systems were below the material yield stress, indicating that material failure would not be expected.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Surgery
Sho Yamakawa, Kenji Hayashida
Summary: In this study, the safety and efficacy of secondary mandibular reconstruction using FFF were evaluated and found to be comparable to primary reconstruction. Complete flap survival was achieved in the secondary reconstruction group, indicating that it can be a viable option for mandibular reconstruction.
Article
Materials Science, Multidisciplinary
Lingling Zheng, Dan Chen, Chao Wang, Liya Ai, Yongfeng Li, Min Hu, Raffaella Aversa, Lizhen Wang, Yubo Fan
Summary: This study compares the scaffold-driven double-barrel fibula flap method with the traditional method and investigates the biomechanical behavior of 3D-printed porous titanium scaffolds. The results show that the porous scaffolds effectively transmit mechanical stimulation and promote bone regeneration.
MATERIALS & DESIGN
(2023)
Article
Otorhinolaryngology
Quinn Dunlap, Hayden Hairston, James Reed Gardner, Joshua Hagood, Merit Turner, Deanne King, Jumin Sunde, Emre Vural, Mauricio Alejandro Moreno
Summary: This study compared the osteocutaneous radial forearm free flap and fibular free flap for maxillomandibular reconstruction, and found no significant difference in perioperative donor site morbidity between the two techniques.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
G. Bettini, G. Saia, S. Valsecchi, G. Bedogni, A. Sandi, A. Bedogni
Summary: This article presents a new technique for restoring iliac bone integrity using a customized titanium device designed by CAD/CAM in patients undergoing DCIA flap harvest. Post-surgery follow-up showed minimal complications and satisfactory long-term outcomes at the donor site, with all patients expressing satisfaction with the aesthetic result. The study recommends the use of this device in patients at high risk of herniation. Further research is needed to confirm the long-term stability of the device.
INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2021)
Article
Environmental Sciences
Giuseppina Campisi, Rodolfo Mauceri, Francesco Bertoldo, Giordana Bettini, Matteo Biasotto, Giuseppe Colella, Ugo Consolo, Olga Di Fede, Gianfranco Favia, Vittorio Fusco, Mario Gabriele, Antonio Lo Casto, Lorenzo Lo Muzio, Antonia Marciano, Marco Mascitti, Marco Meleti, Michele D. Mignogna, Giacomo Oteri, Vera Panzarella, Umberto Romeo, Andrea Santarelli, Paolo Vescovi, Claudio Marchetti, Alberto Bedogni
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2020)
Article
Oncology
Alberto Bedogni, Giordana Bettini, Giorgio Bedogni, Giorgia Menapace, Andrea Sandi, Fabio Michelon, Roberto Di Carlo, Piero Franco, Giorgia Saia
Summary: In this study, the safety and efficacy of REPLICA, a CAD/CAM-designed patient-specific titanium mandible, were evaluated in patients with mandibular defects not suitable for traditional reconstruction techniques. The primary outcome of absence of complications and improvement in oral function was achieved by the majority of patients, and quality of life data at 6 months showed positive results. Further research is needed to explore the full potential of REPLICA in different patient populations.
Article
Pathology
Riccardo Bonacina, Alice Indini, Gabriella Massazza, Eliana Rulli, Andrea Gianatti, Mario Mandala
Summary: Ameloblastoma is a rare odontogenic tumour with aggressive local behavior, often associated with BRAF V600 mutations. This study found that BRAF V600 mutated ameloblastomas are more common in younger patients, located in the mandible, and presented with unicystic variant. Local recurrence occurs in 30% of patients with ameloblastoma, and further studies are needed to understand the outcomes of this rare disease.
JOURNAL OF CLINICAL PATHOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Giuseppina Campisi, Rodolfo Mauceri, Francesco Bertoldo, Vittorio Fusco, Alberto Bedogni
Summary: MRONJ is a rare but severe complication associated with denosumab treatment, with a higher prevalence in cancer patients; new strategies for dental surgery using denosumab in osteoporosis patients have been proposed to reduce the risk of MRONJ.
HEAD & FACE MEDICINE
(2021)
Review
Environmental Sciences
Olga Di Fede, Federica Canepa, Vera Panzarella, Rodolfo Mauceri, Carmine Del Gaizo, Alberto Bedogni, Vittorio Fusco, Pietro Tozzo, Giuseppe Pizzo, Giuseppina Campisi, Antonio Galvano
Summary: The study found that compared to aggressive surgery alone, combined conservative surgery showed a statistically significant difference in the 6-month improvement rate. However, there was no significant difference in the 6-month total resolution rate between the two groups. Additionally, combining conservative surgery with various adjuvant non-invasive procedures was found to achieve partial or complete healing at all stages, with improved results and amelioration of many variables.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Letter
Dentistry, Oral Surgery & Medicine
Alberto Bedogn, Vittorio Fusco, Olga Di Fede, Giordana Bettini, Vera Panzarella, Rodolfo Mauceri, Giorgia Saia, Giuseppina Campisi
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2022)
Article
Oncology
Vittorio Fusco, Giuseppina Campisi, Alberto Bedogni
Summary: Antiresorptive drugs play a crucial role in the treatment of bone metastases in solid cancer patients. However, the choice of drugs and treatment options pose challenges in decision making. The underestimation of medication-related osteonecrosis of the jaw (MRONJ) risk and the need for long-term risk stratification based on actuarial data are important considerations. Surgical therapy also plays a significant role in improving the quality of life and survival of patients.
SUPPORTIVE CARE IN CANCER
(2022)
Review
Oncology
Rodolfo Mauceri, Rita Coniglio, Antonia Abbinante, Paola Carcieri, Domenico Tomassi, Vera Panzarella, Olga Di Fede, Francesco Bertoldo, Vittorio Fusco, Alberto Bedogni, Giuseppina Campisi
Summary: This study aims to provide guidance to healthcare providers in managing medication-related osteonecrosis of the jaw (MRONJ), with a focus on the role of dental hygienists. The study proposes an oral care protocol for primary prevention, secondary prevention, and MRONJ treatment, including specific guidelines and procedures for dental hygienists.
SUPPORTIVE CARE IN CANCER
(2022)
Letter
Oncology
Vittorio Fusco, Daniele Santini, Giuseppina Campisi, Francesco Bertoldo, Gaetano Lanzetta, Toni Ibrahim, Oscar Bertetto, Gianmauro Numico, Alfredo Addeo, Alfredo Berruti, Giordana Bettini, Giorgia Saia, Alberto Bedogni
JCO ONCOLOGY PRACTICE
(2020)
Article
Oncology
Yuchao Liu, Zijia Liu, Liangyan Zhang, Yuelun Zhang, Ningchen Zhang, Yue Han, Le Shen
Summary: This study found an association between preoperative 6-min walk distance and postoperative complications in patients undergoing laparoscopic gastrointestinal cancer surgery.
Review
Oncology
Matteo Pavone, Rosa Autorino, Nicolo Bizzarri, Giuditta Chilorio, Vincenzo Valentini, Giacomo Corrado, Gabriella Ferrandina, Gabriella Macchia, Maria Antonietta Gambacorta, Giovanni Scambia, Denis Querleu
Summary: Ovarian transposition is an established method for protecting the ovaries from radiation, while surgical procedures for protecting the uterus are still under investigation. This study conducted a systematic review of uterine displacement techniques and performed dose simulation to assess the radiation dose received by the uterus. The results showed that the transposition approach was the most protective.
Article
Oncology
Silvia Ministrini, Maria Bencivenga, Federica Filippini, Gianni Mura, Carlo Milandri, Maria Antonietta Mazzei, Giulio Bagnacci, Mattia Berselli, Manlio Monti, Paolo Morgagni, Leonardo Solaini, Daniele Marrelli, Stefania Piccioni, Stefano De Pascale, Luigina Graziosi, Rossella Reddavid, Fausto Rosa, Claudio Belluco, Guido Tiberio
Summary: The Italian Research Group for Gastric Cancer developed a prospective database to evaluate the impact of a pragmatic attitude on the management of stage IV gastric cancer patients. The study found that different metastatic sites did not affect survival rates, but multiple metastatic sites were associated with worse survival. Patients who could undergo curative resection had better survival rates. A more accurate diagnostic workup and staging had a favorable impact on survival.
Article
Oncology
Luca Lambertini, Fabrizio Di Maida, Anna Cadenar, Samuele Nardoni, Antonio Andrea Grosso, Francesca Valastro, Pietro Spinelli, Riccardo Fantechi, Agostino Tuccio, Gianni Vittori, Andrea Mari, Lorenzo Masieri, Andrea Minervini
Summary: The aim of this study was to evaluate the functional outcomes of Florence intracorporeal neobladder (FloRIN) configuration technique performed with a stentless procedure. The results showed that the stentless procedure was associated with shorter console time and lower estimated blood loss compared to the stent group. There were no significant differences in terms of perioperative features and mid-term functional outcomes between the two groups.
Article
Oncology
Geun-Jeon Kim, Jooin Bang, Hyun-Il Shin, Sang-Yeon Kim, Dong -Il Sun
Summary: This study evaluated the outcome of tonsillar cancer managed with neoadjuvant chemotherapy followed by surgery. The results showed that neoadjuvant chemotherapy reduced tumor volume and pathological adverse features, significantly decreasing the need for adjuvant therapy. A greater reduction in tumor volume predicted a complete pathologic response. There was no significant difference in survival rates between the groups.
Article
Oncology
Alexandra Nassar, Stylianos Tzedakis, Ugo Marchese, Gaanan Naveendran, Remy Sindayigaya, Martin Gaillard, Francois Cauchy, Mickael Lesurtel, Brice Gayet, Olivier Soubrane, David Fuks
Summary: This study identified recurrence between the two stages and a larger tumor size in the future liver remnant as critical factors contributing to the failure of two-stage hepatectomy for bilobar colorectal liver metastases. These findings have important clinical implications for the selection and evaluation of TSH surgery.
Letter
Oncology
Michele Fiore, Gian Marco Petrianni, Gabriele D'Ercole, Pasquale Trecca, Sara Ramella
Review
Oncology
Harry Farrow, Oliver J. Pickering, James A. Gossage, Philip H. Pucher
Summary: The inclusion or exclusion of the thoracic duct in radical esophagectomy for esophageal cancer is a controversial issue. While removing the thoracic duct may increase lymph node yield, it may also lead to higher morbidity without any survival benefit.
Article
Oncology
Xiaokun Li, Siyuan Luan, Chi Zhang, Weili Kong, Xin Xiao, Haowen Zhang, Jianfeng Zhou, Yushang Yang, Yang Xu, Yong Qiang, Pinhao Fang, Yi Shen, Yong Yuan
Summary: This study proposes a new staging system based on ypTNM stage and cN status for early stage ESCC patients after nCRT. The new ypTNM-cN staging system demonstrates superior predictive ability and classification efficacy compared to the AJCC 8th ypTNM staging system. It provides new insights for accurately stratifying ypI stage ESCC patients.
