Article
Oncology
Fortunato Ciardiello, Davide Ciardiello, Giulia Martini, Stefania Napolitano, Josep Tabernero, Andres Cervantes
Summary: This review summarizes the progress in the clinical management of patients with metastatic colorectal cancer (mCRC) in the era of precision medicine. Molecular stratification, based on the current treatment algorithm, has been a significant step towards implementing more effective therapeutic approaches. Integrating tumor gene alterations with tumor and microenvironment gene and protein expression profiling, host immune competence, and applying dynamic changes to precision medicine-based continuum of care, could lead to the identification of individual prognostic and predictive parameters for choosing the most appropriate therapeutic program for each patient.
CA-A CANCER JOURNAL FOR CLINICIANS
(2022)
Article
Multidisciplinary Sciences
Qi Zhao, Feng Wang, Yan-Xing Chen, Shifu Chen, Yi-Chen Yao, Zhao-Lei Zeng, Teng-Jia Jiang, Ying-Nan Wang, Chen-Yi Wu, Ying Jing, You-Sheng Huang, Jing Zhang, Zi-Xian Wang, Ming-Ming He, Heng-Ying Pu, Zong-Jiong Mai, Qi-Nian Wu, Renwen Long, Xiaoni Zhang, Tanxiao Huang, Mingyan Xu, Miao-Zheng Qiu, Hui-Yan Luo, Yu-Hong Li, Dong-Shen Zhang, Wei-Hua Jia, Gong Chen, Pei-Rong Ding, Li-Ren Li, Zheng-Hai Lu, Zhi-Zhong Pan, Rui-Hua Xu
Summary: Through ultradeep whole-exome sequencing, we identified 46 significantly mutated genes associated with CRC and proposed a subtyping strategy that classifies CRC patients into four genomic subtypes with distinct clinical characteristics. Additionally, we found that mitochondrial DNA copy number is an independent factor for predicting the survival outcome of CRCs.
NATURE COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Stefan Titu, Vlad Alexandru Gata, Roxana Maria Decea, Teodora Mocan, Constantin Dina, Alexandru Irimie, Cosmin Ioan Lisencu
Summary: Exosomes are nanosized vesicles that play a role in various diseases, including cancer. They can mediate communication between cells and are involved in tumor growth, invasion, metastasis, angiogenesis, and immunomodulation. Exosomes in the bloodstream hold potential as a future tool for early cancer detection. Understanding exosomes is crucial for cancer progression and can provide useful information for diagnosis, treatment, and prevention of recurrence. Diagnostic tools based on exosomes may revolutionize cancer diagnosis and treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Genetics & Heredity
Wellington Dos Santos, Mariana Bisarro Dos Reis, Jun Porto, Ana Carolina de Carvalho, Marcus Matsushita, Gabriela Oliveira, Kari Syrjanen, Rui Manuel Reis, Denise Peixoto Guimaraes
Summary: This study characterized the mutation profile of colorectal cancer precursor lesions in a Brazilian population, revealing differences in the frequencies of mutations in genes such as APC, KRAS, TP53, and BRAF. These findings provide important insights into the biological history of colorectal cancer and support the potential use of these biomarkers in detecting precursor lesions during CRC screening in the Brazilian population.
BMC MEDICAL GENOMICS
(2022)
Article
Oncology
Ingrid M. M. Montes-Rodriguez, Hilmaris Centeno-Girona, Camila Rivera-Lynch, Noridza Rivera, Marcia Cruz-Correa
Summary: This study reports the mutational profile of colorectal cancer tumors in Puerto Ricans and compares it to other non-Hispanic and US Hispanic populations.
Article
Oncology
Mizunori Yaegashi, Takeshi Iwaya, Noriyuki Sasaki, Masashi Fujita, Zhenlin Ju, Doris Siwak, Tsuyoshi Hachiya, Kei Sato, Fumitaka Endo, Toshimoto Kimura, Koki Otsuka, Ryo Sugimoto, Tamotsu Sugai, Lance Liotta, Yiling Lu, Gordon B. Mills, Hidewaki Nakagawa, Satoshi S. Nishizuka
Summary: By conducting multiregional sequencing of colorectal tumours, founder mutations and truncal mutations were identified as personalized biomarkers for ctDNA assays. Frequent ctDNA monitoring can enable early relapse prediction and assessment of treatment efficacy.
BRITISH JOURNAL OF CANCER
(2021)
Review
Oncology
Nayeralsadat Fatemi, Sascha Tierling, Hamidreza Aboulkheyr Es, Maryam Varkiani, Ehsan Nazemalhosseini Mojarad, Hamid Asadzadeh Aghdaei, Joern Walter, Mehdi Totonchi
Summary: Colorectal cancer, the second leading cause of cancer death worldwide, is closely associated with epigenetic changes such as DNA methylation. Studies have shown that DNA methylation markers have high accuracy and reproducibility in noninvasive biosamples, making them promising for early diagnosis and personalized treatment of CRC. Further research and development of methylation biomarkers and detection methods are crucial for CRC diagnosis.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Review
Oncology
Evgeny Imyanitov, Ekaterina Kuligina
Summary: Molecular genetic analysis plays a crucial role in colorectal cancer management, guiding treatment choices such as targeted therapies and immune checkpoint inhibitors. The emerging technologies of liquid biopsy and next-generation sequencing are revolutionizing the landscape of CRC molecular diagnosis.
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Linwei Guo, Yunjin Wang, Wenxiao Yang, Chenchen Wang, Tian'an Guo, Jingcheng Yang, Zhiming Shao, Guoxiang Cai, Sanjun Cai, Liying Zhang, Xin Hu, Ye Xu
Summary: This study conducted tumor genetic testing and analysis on 869 Chinese patients with colorectal cancer (CRC). The results showed that single-gene somatic mutations in BRAF or RBM10 were associated with shorter progression-free survival in patients with metastatic CRC. Co-mutations of KRAS/AMER1 or KRAS/APC were found in the metastatic cohort, leading to poor response to bevacizumab. Moreover, pathogenic germline alterations in the DNA damage repair pathway were identified in a small percentage of patients, with secondary-hit events observed in a significant proportion of these tumors.
Review
Genetics & Heredity
Debyani Chakravarty, David B. Solit
Summary: Profiling tumors by next-generation sequencing has the potential to improve diagnostic accuracy, assess heritable cancer risk, and guide treatment selection. Through integrative analyses of tumor and germline variants, as well as identifying mutational signatures that influence therapy response, the clinical utility of cancer genomic profiling is being enhanced. Rapid technological innovation and reduced sequencing costs have enabled the profiling of hundreds of cancer-associated genes as part of routine cancer care.
NATURE REVIEWS GENETICS
(2021)
Review
Oncology
Katyana Amilca-Seba, Michele Sabbah, Annette K. Larsen, Jerome A. Denis
Summary: The mortality of colorectal cancer is linked to metastatic disease and undetectable micro-metastasis growth. Therapeutic strategies are efficient for locally advanced cancer but struggle to cure metastatic disease due to drug resistance and aggressive phenotype. Osteopontin is emerging as a valuable biomarker in various cancer types, including CRC, and shows potential as a therapeutic target.
Article
Multidisciplinary Sciences
Satoshi Ishikawa, Naohiro Nishida, Shiki Fujino, Takayuki Ogino, Hidekazu Takahashi, Norikatsu Miyoshi, Mamoru Uemura, Taroh Satoh, Hirofumi Yamamoto, Tsunekazu Mizushima, Yuichiro Doki, Hidetoshi Eguchi
Summary: Epithelial-mesenchymal transition (EMT) is a crucial phenotypic change during cancer metastasis, and the identification of 90 candidate EMT mediators that are predictive of survival in clinical samples suggests new therapeutic avenues for colorectal cancer.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Iiris Ukkola, Pirjo Nummela, Annamari Heiskanen, Matilda Holm, Sadia Zafar, Mia Kero, Caj Haglund, Tero Satomaa, Soili Kytola, Ari Ristimaki
Summary: All human cells have a complex glycan coating, and alterations in cell surface glycans are related to cancer progression and immune suppression. Colorectal cancer is a heterogeneous disease with different molecular subtypes, which have varying prognosis and therapy responses. Microsatellite instability and BRAF gene mutation, two important molecular markers, have been ignored in previous glycomics studies. Our analysis of the N-glycan profiles of colorectal cancers with different molecular subtypes revealed characteristic glycan profiles that may explain their tumorigenic properties.
Article
Oncology
Maria Gonzalez-Gonzalez, Maria Laura Gutierrez, Jose Maria Sayagues, Luis Munoz-Bellvis, Alberto Orfao
Summary: Sporadic colorectal cancer (sCRC) is the third leading cause of cancer death in the Western world, with approximately a quarter of patients presenting metastatic dissemination at the time of diagnosis. Patients with sCRC generally have a worse prognosis compared to those with primary colorectal tumors, and there are still many genetic alterations involved in the metastatic process that need to be further identified and studied.
SEMINARS IN CANCER BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Beatriz Armida Flores-Lopez, Maria de la Luz Ayala-Madrigal, Jose Miguel Moreno-Ortiz, Jorge Peregrina-Sandoval, Miguel Angel Trujillo-Rojas, Jose Luis Venegas-Rodriguez, Rosario Hernandez-Ramirez, Martha Alejandra Fernandez-Galindo, Melva Gutierrez-Angulo
Summary: This study identified genetic variants in tumor tissues from Mexican patients with colorectal cancer using massive parallel sequencing. The affected genes showed significance in disease, signal transduction, and immune system subsets, suggesting specific capabilities for survival, aggressiveness, or response to treatment in tumors.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)
