期刊
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
卷 106, 期 -, 页码 136-145出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ecoenv.2014.02.018
关键词
Synthetic pyrethroid insecticides; Permethrin; Deltamethrin; DNA binding; Partial intercalation; Groove binding
资金
- Research and Technology, Kermanshah University of Medical Sciences
In this work, the interaction of two synthetic pyrethroid insecticides, permethrin (PER) and deltamethrin (DEL), with ct-DNA has been studied by cyclic voltammetry (CV), circular dichroism (CD), competitive fluorescence, atomic force microscopy (AFM), UV-vis spectroscopy, thermodynamic measurements, Fourier-transform infra-red (FT-IR), high performance liquid chromatography (HPLC) and two-layered ONIOM (our N-layered integrated molecular orbital+molecular mechanics) (DFT B3LYP, 6-31++G(d, p):UFF) molecular modeling methods. The last four methods were also utilized to study the binding of DEL with DNA. The results revealed that the PER may interact through partial intercalation and groove binding process while the PER only interacts through groove binding. Finally, the insecticides structure effect on interaction is discussed. (C) 2014 Elsevier Inc. All rights reserved.
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