Article
Multidisciplinary Sciences
Asim Shahzad, Mingzhou Qin, Mahmood Elahie, Muhammad Naeem, Tasmia Bashir, Humaira Yasmin, Muhammad Younas, Ahsan Areeb, Muhammad Irfan, Motsim Billah, Abdul Shakoor, Saman Zulfiqar
Summary: The study investigated the induced effect of Bacillus pumilus on maize plants in Cadmium contaminated soil. Results showed that inoculation with Bacillus pumilus helped maize plants resist cadmium stress, reducing losses in plant fresh weight and nutrient uptake.
SCIENTIFIC REPORTS
(2021)
Article
Environmental Sciences
Yuanliang Li, Hanming Chen, Jianzhao Liao, Keli Chen, Muhammad Tariq Javed, Na Qiao, Qiwen Zeng, Bingxian Liu, Jiangnan Yi, Zhaoxin Tang, Ying Li
Summary: Copper exposure may result in testicular toxicity, decrease hormone concentrations, increase copper levels, and promote antioxidant responses such as cell apoptosis and autophagy, ultimately leading to testicular dysfunction.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Sarita Pyatha, Haesoo Kim, Daeun Lee, Kisok Kim
Summary: Parkinson's disease is a neurodegenerative disorder that is associated with exposure to environmental toxins, particularly heavy metals. These metals contribute to the development and progression of the disease through proinflammatory responses, disruption of redox homeostasis, and induction of oxidative stress.
Article
Immunology
Reem S. Alruhaimi, Emad H. M. Hassanein, Mostafa K. Abd El-Aziz, Maisa Siddiq Abduh, Albandari Bin-Ammar, Emadeldin M. Kamel, Ayman M. Mahmoud
Summary: In this study, it was found that the melatonin receptor agonist agomelatine can protect against acute pancreatitis induced by cadmium by preventing inflammation, oxidative stress, and apoptosis, and by modulating the Nrf2/HO-1 pathway. Agomelatine enhanced the antioxidant capacity through the activation of the Nrf2/HO-1 pathway, while reducing inflammation and cellular damage.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Clemence Cheignon, Fabrice Collin, Laurent Sabater, Christelle Hureau
Summary: The study investigates the impact of oxidative stress on the assembly properties of the amyloid-beta (Aβ) peptide in Alzheimer's disease. Oxidized Aβ displayed smaller and ill-defined assemblies compared to the non-oxidized counterpart. It was able to slow down the formation of Aβ fibrils and formed weakly-structured aggregates in the presence of copper or zinc ions.
Article
Engineering, Environmental
Sifau A. Adejumo, Olujide Owoseni, Luis A. J. Mur
Summary: The uptake of heavy metals by agricultural crops presents a significant risk to human health. The application of compost and biochar in soil has been effective in reducing metal uptake by crop plants. However, their efficiency is influenced by environmental factors such as water and light intensity. This study found that combining organic amendments with reduced light intensity can enhance maize growth on contaminated soil, decrease lead uptake, and reduce oxidative stress. The combination of biochar and compost was more effective than their individual application in reducing soil lead concentration and lead uptake by maize plants.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2021)
Review
Biochemistry & Molecular Biology
R. G. Barber, Zoey A. Grenier, Jason L. Burkhead
Summary: This article discusses the impact of copper toxicity on the liver, suggesting that copper accumulation specifically affects zinc-dependent processes. Copper toxicity may have specific biochemical consequences that are not directly attributable to redox activity. Further research into copper toxicity in Wilson Disease and other copper-associated disorders is encouraged.
Article
Multidisciplinary Sciences
Madiha Khadim Hussain, Abida Aziz, Hafiza Mamona Allah Ditta, Muhammad Farooq Azhar, Ahmed M. El-Shehawi, Sajjad Hussain, Noman Mehboob, Mubshar Hussain, Shahid Farooq
Summary: The study found that foliar application of seed water extract of black cumin can mitigate the adverse impacts of Cadmium toxicity on maize growth, particularly showing better tolerance in the hybrid genotype.
Article
Cell Biology
Muhammad Aizaz, Ibrahim Khan, Sajjad Lubna, Sajjad Asaf, Saqib Bilal, Rahmatullah Jan, Abdul Latif Khan, Kyung-Min Kim, Ahmed AL-Harrasi
Summary: Modern irrigation practices and industrial pollution can lead to salinity and heavy metal contamination, adversely affecting crop productivity. This study explored the growth-promoting potentials of an endophytic fungal strain SL3 and compared it with exogenous IAA in salt and heavy metal stress conditions. Both IAA and SL3 positively influenced plant growth under normal and stressed conditions, with SL3 showing potential as a replacement for IAA in promoting plant growth in salt and heavy metal-affected regions.
Article
Engineering, Environmental
Xiaolei Wei, Christer Hogstrand, Guanghui Chen, Wuhong Lv, Yufeng Song, Yichuang Xu, Zhi Luo
Summary: This study found that Zn activated lipophagy, alleviating Cu-induced lipid accumulation by promoting deacetylation of Beclin1. This previously unidentified mechanism sheds light on the antagonistic effects of Cu and Zn on metabolism at environmentally relevant concentrations. The importance of combined exposure and the role of Beclin1 deacetylation in promoting lipophagy were highlighted in understanding the biological effects of heavy metals during environmental risk assessments.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Article
Environmental Sciences
Maria Aslam, Mbarki Sonia, Ghulam Abbas, Muhammad Shahid, Behzad Murtaza, Muhmmad Shafique Khalid, Saeed Ahmad Qaisrani, Hesham F. Alharby, Sameera A. Alghamdi, Basmah M. Alharbi, Yinglong Chen
Summary: Nickel tolerance and accumulation potential of two quinoa genotypes (Puno and Vikinga) were investigated in this study. Results showed that Puno exhibited greater tolerance to Ni compared to Vikinga, which was attributed to improved physiological responses and amelioration of oxidative stress. The study provides insights into understanding plant nickel tolerance and its potential application in Ni-contaminated soil remediation.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Sukhchain Kaur, Neha Garg, Rubal Rubal, Monisha Dhiman
Summary: Heavy metal exposure is correlated with hypertension and is associated with altered lipid profiles, cardiac markers, oxidative stress markers, and heavy metal concentrations exceeding permissible limits.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Environmental Sciences
Jamaan S. Ajarem, Ahmad K. Hegazy, Gamal A. Allam, Ahmed A. Allam, Saleh N. Maodaa, Ayman M. Mahmoud
Summary: This study evaluated the levels of heavy metals in Plantago ovata and domestic goats in the eastern region of Saudi Arabia, which were influenced by the petroleum industry. The results showed that the petroleum industry increased the levels of lead, cadmium, nickel, and vanadium in both the plant and animal samples, leading to liver and kidney injury, oxidative stress, and upregulation of pro-inflammatory and apoptosis markers.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Neurosciences
Beatriz Ferrer, Harshini Suresh, Alexey A. Tinkov, Abel Santamaria, Joao Batista Rocha, Anatoly Skalny, Aaron B. Bowman, Michael Aschner
Summary: Methylmercury is a global pollutant that damages the central nervous system, especially in vulnerable populations. Current therapeutic strategies for methylmercury poisoning are limited. Ghrelin has a protective effect against methylmercury-induced oxidative stress through upregulation of glutathione and induction of the NRF2/NQO1 pathway.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Rongrong Xu, Jianhao Peng, Puzhen Zhang, Chen Guo, Xieyuan Jiang, Shuai Lu, Yulin Kang, Qiujin Xu, Zhigang Li, Yongjie Wei
Summary: Exposure to heavy metals, particularly Cd and Pb released by e-waste, is associated with increased risk of cardiovascular diseases. Our study found that residents living near e-waste dismantling factories had higher plasma concentrations of heavy metals and increased levels of fibrinogen and activated coagulation factor X (FXa). The effects of Cd and Pb on coagulation were mediated by oxidative stress.
ENVIRONMENTAL TECHNOLOGY & INNOVATION
(2023)
Article
Pharmacology & Pharmacy
Maria Rosa Chitolina Schetinger, Tanara V. Peres, Leticia P. Arantes, Fabian Carvalho, Valderi Dressler, Graciela Heidrich, Aaron B. Bowman, Michael Aschner
Article
Immunology
Gessica Perin, Nathieli B. Bottari, Anielen D. Silva, Antonise M. Jaguezeski, Teane M. A. Gomes, Thalison F. Lopes, Maria Rosa C. Schetinger, Vera M. Morsch, Aleksandro S. Da Silva
MICROBIAL PATHOGENESIS
(2019)
Article
Immunology
Marcela C. S. Sousa, Gabriela M. Galli, Nathieli B. Bottari, Davi F. Alba, Karoline W. Leal, Thalison F. Lopes, Leticia Druzian, Maria Rosa C. Schetinger, Eduardo M. Gloria, Ricardo E. Mendes, Lenita M. Stefani, Aleksandro S. Da Silva
MICROBIAL PATHOGENESIS
(2020)
Review
Medicine, Research & Experimental
Karine Paula Reichert, Milagros Fanny Vera Castro, Charles Elias Assmann, Nathieli Bianchin Bottari, Vanessa Valeria Miron, Andreia Cardoso, Naiara Stefanello, Vera Maria Melchiors Morsch, Maria Rosa Chitolina Schetinger
Summary: This review focuses on the role of the purinergic system in diabetes and hypertension, highlighting changes in the expression of P1 and P2 receptors, as well as the activities of CD39, CD73, and ADA. It suggests that manipulating the purinergic axis at various levels could potentially prevent or exacerbate the development of diabetes and hypertension as a compensatory mechanism.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Cell Biology
Maria Luiza Mukai Franciosi, Millena Daher Medeiros Lima, Maria Rosa Chitolina Schetinger, Andreia Machado Cardoso
Summary: This review explores the potential role of purinergic signaling in COVID-19, focusing on purinergic receptors and components such as ATP, CD39, and CD73. It suggests therapeutic combination or association possibilities targeting purinergic system components as a useful tool for future research, aiming to unveil a novel option to treat COVID-19 patients.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Charles Elias Assmann, Grazielle Castagna Cezimbra Weis, Jessica Righi da Rosa, Beatriz da Silva Rosa Bonadiman, Audrei de Oliveira Alves, Maria Rosa Chitolina Schetinger, Euler Esteves Ribeiro, Vera Maria Melchiors Morsch, Ivana Beatrice Manica da Cruz
Summary: Nutraceuticals have been the subject of extensive research in recent years, with some showing promise in promoting certain health benefits. Certain Amazonian fruits and seeds may have potential beneficial impacts on the human nervous system, possibly due to the presence of various bioactive molecules.
NEUROCHEMISTRY INTERNATIONAL
(2021)
Article
Agronomy
Paulo Ademar Avelar Ferreira, Carlos Alberto Ceretta, Cledimar Rogerio Lourenzi, Lessandro De Conti, Carina Marchezan, Eduardo Girotto, Tadeu Luis Tiecher, Natalia Moreira Palermo, Leon-Etienne Parent, Gustavo Brunetto
Summary: No-till farming and manure application can help store carbon and improve soil quality, but organic fertilization poses risks to soil quality and the environment. Long-term N-based organic fertilization can increase crop yield but may lead to nutrient accumulation in the soil, threatening system sustainability.
Article
Agronomy
Cristiano Santos, Arcangelo Loss, Marisa de Cassia Piccolo, Eduardo Girotto, Marcos Paulo Ludwig, Julia Decarli, Jose Luiz Rodrigues Torres, Cledimar Rogerio Lourenzi, Gustavo Brunetto
Summary: This study found that long-term application of pig slurry can increase dry matter and soil carbon, nitrogen, and sulfur stocks in clayey Typic Hapludox in southern Brazil. The recommended pig slurry dose equivalent to 100 or 200 kg ha(-1) of nitrogen can achieve the same or higher effects compared to mineral fertilizer treatments.
Article
Chemistry, Analytical
Graciela M. Heidrich, Vinicius M. Neves, Naiara Stefanello, Vanessa V. Miron, Thauan F. Lopes, Sindy R. Krzyzaniak, Paola de A. Mello, Maria Rosa C. Schetinger, Dirce Pozebon, Valderi L. Dressler
Summary: Adult Wistar rats were exposed to lanthanum oxide nanoparticles (La(2)O(3)NPs) at different doses. Histological analysis revealed that higher doses of La2O3-NPs caused hepatic lesions in rats. However, the La2O3-NPs did not affect body weight, organ weight, and blood serum parameters. Increased reactive oxygen species (ROS) were found in the kidneys of rats treated with high dose of La2O3-NPs. Lanthanum was detected in organs but not in the blood.
BRAZILIAN JOURNAL OF ANALYTICAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Milagros Fanny Vera Castro, Charles Elias Assmann, Naiara Stefanello, Karine Paula Reichert, Tais Vidal Palma, Anielen Dutra da Silva, Vanessa Valeria Miron, Vitor Bastianello Mostardeiro, Vera Maria Melchiors Morsch, Maria Rosa Chitolina Schetinger
Summary: The study investigated the effects of caffeic acid (CA) on learning and memory tasks in diabetic rats. The researchers also assessed the impact of CA on the activities of specific enzymes and the density of certain receptors and inflammatory parameters in the cortex and hippocampus of diabetic rats. The results showed that CA improved learning and memory deficits, normalized enzyme activities, and modulated receptor density in the diabetic animals, suggesting its potential for treating cognitive deficits associated with the cholinergic and purinergic signaling pathways in diabetes. (c) 2023 Elsevier Inc. All rights reserved.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Cell Biology
Pedro Henrique Doleski, Fernanda Licker Cabral, Matheus Henrique Jantsch, Renan Silva Ebone, Stephen Adeniyi Adefegha, Daniela Bitencourt Rosa Leal, Maria Rosa Chitolina Schetinger
Summary: Plasma membrane anchored nucleotidases (E-ATPDases) play an important role in the hydrolysis and regulation of nucleotides in lymphocytes. The activities of E-ATPDases vary in different immune organs and resident subpopulations of lymphocytes. This study characterizes the E-ATPDases activities in bone marrow, thymus, and mesenteric lymph node lymphocytes of Wistar rats. The results suggest that the kinetic values of E-NTPDase activity in immune tissue lymphocytes could be an important therapeutic target for immune-related diseases.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Agriculture, Dairy & Animal Science
Vanessa Dazuk, Lara Tarasconi, Vitor Luiz Molosse, Bruno Giorgio Oliveira Cecere, Guilherme Luiz Deolindo, Joao Vitor Strapazzon, Nathieli Bianchi Bottari, Bianca Fagan Bissacotti, Maria Rosa Chitolina Schetinger, Laercio Sareta, Ricardo Evandro Mendes, Marcelo Vedovatto, Eduardo Micotti Gloria, Diovani Paiano, Gabriela Miotto Galli, Aleksandro Schafer Da Silva
Summary: This study aimed to determine the effects of adding vegetable biocholine (VB) to pigs' diets to minimize the negative effects caused by daily aflatoxin intake. Consuming aflatoxin-contaminated feed reduced feed consumption and weight gain in piglets and caused oxidative stress in their intestines and livers. However, VB supplementation did not improve performance but showed hepatoprotective potential when facing aflatoxin challenge.
Article
Biology
Vinicius Leobet Lunkes, Tais Vidal Palma, Charles Elias Assmann, Vitor Bastianello Mostardeiro, Maria Rosa Chitolina Schetinger, Vera Maria Melchiors Morsch, Cinthia Melazzo de Andrade
Summary: Cancer, especially melanoma skin cancer, is a major cause of death. Curcumin, extracted from the Curcuma longa plant, shows potential as an adjuvant therapy for melanoma by modulating the immune response, oxidative stress, and purinergic signaling cascade. This study found that vinblastine, a chemotherapeutic agent, may increase adenosine concentration in melanoma cells, while curcumin increases reactive oxygen species production and disrupts purinergic signaling. Therefore, curcumin may be a promising addition to melanoma treatment.
BRAZILIAN ARCHIVES OF BIOLOGY AND TECHNOLOGY
(2022)
Article
Immunology
Gabriela M. Galli, Luiz Gustavo Griss, Bruno F. Fortuoso, Anielen D. Silva, Mateus Fracasso, Thalisson F. Lopes, Maria Rosa S. Schetinger, Samanta Gundel, Aline F. Ourique, Christofe Carneiro, Ricardo E. Mendes, Marcel M. Boiago, Aleksandro S. Da Silva
MICROBIAL PATHOGENESIS
(2020)
Article
Biochemistry & Molecular Biology
Marilia Valvassori Rodrigues, Jessie Martins Gutierres, Fabiano Carvalho, Thauan Faccin Lopes, Vitor Antunes, Pauline da Costa, Maria Ester Pereira, Maria Rosa Chitolina Schetinger, Vera M. Morsch, Cinthia Melazzo de Andrade