4.7 Article

NMR-based characterization of the acute metabolic effects of weathered crude and dispersed oil in spawning topsmelt and their embryos

期刊

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
卷 78, 期 -, 页码 99-109

出版社

ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ecoenv.2011.11.009

关键词

Topsmelt; Toxicity; Dispersed oil; NMR; Metabolomics; Prudhoe Bay crude oil; Corexit 9500

资金

  1. California Department of Fish and Game Office of Spill Prevention and Response (OSPR) Trust
  2. Oiled Wildlife Care Network, Wildlife Health Center, UCD School of Veterinary Medicine

向作者/读者索取更多资源

Oil spill responders require information on the relative toxicity of dispersed and un-dispersed oil in order to make informed decisions regarding the use of chemical dispersants during spill events. Toxicity of the water-accommodated fraction (WAF) and the chemically-enhancec WAF (CEWAF; via the dispersant Corexit 9500) of weathered Prudhoe Bay crude oil was investigated using adult and embryonic topsmelt; topsmelt are an ecologically important atherinid in California bays and estuaries and an important indicator species. Following 96-h exposures, metabolite profiles wore measured using 1D H-1 nuclear magnetic resonance (NMR) spectroscopy and compared via principal component analysis. Similar metabolic profiles were obtained between WAF- and CEWAF-exposed adults and embryos. Although metabolic changes, for the adults lacked significance, significant increasing and decreasing metabolic changes were observed for embryos directly exposed. Furthermore, no mortality was observed for embryos, exposed to WAF and normal development occurred, whereas CEWAF exposed embryos lead to mortality and cardiovascular abnormalities. Observed toxicological information, specifically for developing fish, can aide resource managers in the relative risk of treating oil spills with dispersant. (C) 2011 Elsevier Inc. All rights reserved.

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