Article
Biochemistry & Molecular Biology
Ruhul Quds, Zarmin Iqbal, Amin Arif, Riaz Mahmood
Summary: Mancozeb induces oxidative stress and impairs the antioxidant defense system in human erythrocytes, resulting in damage to cellular components and adverse effects on erythrocyte structure and function.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Marta Budkowska, Elzbieta Cecerska-Heryc, Zuzanna Marcinowska, Aldona Siennicka, Barbara Dolegowska
Summary: This study aimed to investigate the activity of several enzymes related to oxidative stress and the concentration of glutathione in the circadian rhythm. The results showed that the activity of these enzymes and the concentration of glutathione peaked at 2 a.m. during sleep. This suggests that the processes maintaining the redox balance are intensified during sleep, thus reducing oxidative stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Plant Sciences
Satish Kumar Sanwal, Parveen Kumar, Hari Kesh, Vijai Kishor Gupta, Arvind Kumar, Ashwani Kumar, Babu Lal Meena, Giuseppe Colla, Mariateresa Cardarelli, Pradeep Kumar
Summary: Salinity stress significantly reduces plant height, stem numbers, and tuber yield in potato varieties. Salt-tolerant genotypes exhibit better performance under salt stress due to a strong antioxidant defense system and osmotic adjustment, suggesting their potential for breeding new high-yielding, salt-tolerant lines. Specific physiological and biochemical traits were identified as predominant for tuber yield under salt stress, providing insights for further genetic and molecular studies on salt tolerance in potato.
Article
Environmental Sciences
Sukhchain Kaur, Neha Garg, Rubal Rubal, Monisha Dhiman
Summary: Heavy metal exposure is correlated with hypertension and is associated with altered lipid profiles, cardiac markers, oxidative stress markers, and heavy metal concentrations exceeding permissible limits.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Food Science & Technology
Cristiane de Freitas Rodrigues, Jean Ramos Boldori, Marcell Valandro Soares, Sabrina Somacal, Tatiana Emanuelli, Aryele Izaguirry, Francielli Weber Santos Cibin, Paula Rossini Augusti, Cristiane Casagrande Denardin
Summary: Goji berry juice exerts toxic effects on Caenorhabditis elegans, promoting premature aging. Further studies in mammals are needed before its consumption can be recommended.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Food Science & Technology
Chandra Sekhar Arigela, Giribabu Nelli, Siew Hua Gan, Kuttulebbai Nainamohamed Salam Sirajudeen, Kumarathevan Krishnan, Nurhanan Abdul Rahman, Visweswara Rao Pasupuleti
Summary: Bitter gourd honey (BGH) shows potential anti-oxidative, anti-inflammatory, and anti-apoptotic effects in the treatment of diabetes, reducing liver and kidney damage and increasing levels of antioxidant enzymes.
Article
Biochemistry & Molecular Biology
Jakub Rok, Zuzanna Rzepka, Mateusz Maszczyk, Artur Beberok, Dorota Wrzesniok
Summary: Minocycline, a semisynthetic tetracycline antibiotic, not only exhibits antibacterial activity but also shows antioxidative effects. Long-term use of minocycline may cause skin hyperpigmentation. Research indicates that minocycline induces oxidative stress in human melanocytes but can also increase cell viability and mitigate oxidative stress when exposed to hydrogen peroxide and UVA radiation. Additionally, the different impact of minocycline on CAT activity compared to other tetracyclines may be attributed to the binding site location.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Khadija Sossey Alaoui, Bernard Tychon, Sandrine Joachim, Alain Geffard, Katherine Nott, Sebastien Ronkart, Jean-Marc Porcher, Remy Beaudouin, Christelle Robert, Marie-Laure Fauconnier, Matthew Saive
Summary: The study aimed to assess the toxicity of a mixture of five pharmaceutical drugs using Fontinalis antipyretica as a bioindicator and bioaccumulator. Results showed that only carbamazepine and irbesartan were accumulated by the species, with bioaccumulation levels increasing with exposure time. Antioxidant enzymes were sensitive to the drug mixture, with higher activity observed in plants exposed to higher concentrations. Chlorophyll content decreased in exposed plants, but photosynthetic activity was restored after 5 months. Morphological characteristics were less impacted by the treatment.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Medicine, General & Internal
Shiva Ganjali, Reihaneh Keshavarz, Susan Hosseini, Atena Mansouri, Massimo R. Mannarino, Matteo Pirro, Tannaz Jamialahmadi, Amirhossein Sahebkar
Summary: This study revealed significant differences in oxidant/antioxidant markers between FH patients and healthy individuals, as well as between HoFH and HeFH patients. These differences may be strongly associated with plasma LDL-C levels.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Environmental Sciences
Yu Ji, Yanfang Ren, Chuan Han, Wenjia Zhu, Jinyu Gu, Junyu He
Summary: The research demonstrated that exogenous application of GB could improve plant growth and development of pakchoi under lead stress by enhancing antioxidative enzyme activities and reducing oxidative stress and lead accumulation.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Environmental Sciences
Mohammad Hasan Saberi, Seraj Bita
Summary: In this study, the immunotoxicity of silver nanoparticles on whiteleg shrimp was assessed by monitoring the activity of certain enzymes, as well as the changes in antioxidant capacity and oxidative damage markers. It was found that silver nanoparticles caused severe immunotoxicity in the hepatopancreas tissue of whiteleg shrimp through the suppression of certain enzymes and antioxidant capacity.
MARINE POLLUTION BULLETIN
(2023)
Article
Environmental Sciences
Yan Zhang, Ran Wen, Jialu Bao, Yinglan Gong, Xiaodan Wang
Summary: This study analyzed the mechanism of mancozeb-induced kidney injury by detecting kidney function indicators, combined with transcriptome and metabolome sequencing. The results showed that mancozeb impaired the kidney structure, increased creatinine and uric acid levels, and accumulated reactive oxygen species in the kidneys. The differentially expressed genes were enriched in the oxidative phosphorylation pathway. The metabolomic analysis identified the cGMP-PKG signaling pathway as the main altered pathway in mancozeb-induced nephrotoxicity.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Review
Biochemistry & Molecular Biology
Claudia Rebeca Rivera-Yanez, Porfirio Alonso Ruiz-Hurtado, Maria Isabel Mendoza-Ramos, Julia Reyes-Reali, Gina Stella Garcia-Romo, Glustein Pozo-Molina, Aldo Arturo Resendiz-Albor, Oscar Nieto-Yanez, Adolfo Rene Mendez-Cruz, Claudia Fabiola Mendez-Catala, Nelly Rivera-Yanez
Summary: Skin is the main external organ that needs protection from various harmful agents. There are skin disorders that lack effective and accessible treatment. Flavonoids from propolis have beneficial effects on skin diseases, with antioxidant and anti-inflammatory properties that help control and regulate cellular and biochemical changes caused by these diseases.
Article
Biotechnology & Applied Microbiology
Feng Liu, Rui Min, Jie Hong, Guangqin Cheng, Yongqian Zhang, Yulin Deng
Summary: The study investigated the impact of endogenous oxidative stress caused by submicromolar hydrogen peroxide in a mutant strain of E. coli. Through label-free quantitative proteomic analysis, 265 differentially expressed proteins were identified, activating DNA repair and cellular antioxidant signaling pathways. These findings highlight the role of oxidative signaling and the potential of mutant E. coli as a cell model for studying oxidative stress effects.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hanna Lesiewska, Alina Wozniak, Pawel Reisner, Krzysztof Czosnyka, Joanna Stachura, Grazyna Malukiewicz
Summary: Oxidative stress and depletion of antioxidant defenses may contribute to cataract incidence in patients under 60 years. This study measured antioxidant enzyme activity, vitamin concentrations, and oxidative stress markers in cataract patients and controls. The results showed lower activity of antioxidant enzymes and lower concentrations of vitamins A and E in cataract patients. Additionally, higher levels of lipid peroxidation and protein oxidation were observed, indicating increased oxidative stress in cataract patients. Supplementation with antioxidants could be beneficial for this group of patients.
Article
Cell Biology
Amal Idris Malik, Janet M. Storey, Kenneth B. Storey
Summary: The unfolded protein response (UPR) is involved in dealing with dehydration-induced disruption of protein processing in the tissues of African clawed frogs. Cellular stress markers and activating transcription factors related to UPR were upregulated in response to dehydration stress in frog tissues.
CELL STRESS & CHAPERONES
(2023)
Article
Chemistry, Multidisciplinary
Maria M. Bayliak, Oleh Demianchuk, Dmytro Gospodaryov, Vitalii A. Balatskyi, Volodymyr Lushchak
Summary: This study investigated the effects of essential amino acid l-arginine and ethanol on the physiological and biochemical parameters of fruit flies. The results showed that excessive l-arginine intake led to various changes in physiology and biochemistry, while ethanol intake increased resistance to starvation but decreased resistance to sodium nitroprusside. The combination of l-arginine and ethanol had interactive effects.
DRUG AND CHEMICAL TOXICOLOGY
(2023)
Article
Cell Biology
Isabelle A. MacLean, Anchal Varma, Kenneth B. Storey
Summary: This study investigated the dynamic nature of NADP-IDH during hibernation, revealing increased substrate affinity and protein phosphorylation levels. These changes suggest the ability of the organism to reduce energy consumption and enhance antioxidant activity during hibernation.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Cell Biology
Jacques Niles, Gurjit Singh, Kenneth B. Storey
Summary: Wood frogs, the most studied anuran for freeze tolerance, are able to survive in frigid temperatures due to their ability to produce glucose as a natural cryoprotectant. Under freezing, anoxia, and dehydration stresses, the liver and skeletal muscle of wood frogs activate the unfolded protein response (UPR) to enhance protein folding/refolding capacity and stabilize cellular proteins for survival. The ERAD pathway is also involved, with muscle showing preference for proteasomal degradation of misfolded proteins, while liver favors refolding of misfolded/unfolded proteins.
CELL STRESS & CHAPERONES
(2023)
Article
Biology
Saif Rehman, Hanane Hadj-Moussa, Liam Hawkins, Kenneth B. Storey
Summary: The wood frog can survive freezing temperatures by freezing part of its body water and entering a hypometabolic state. FOXO transcription factors are found to play a role in freeze tolerance and have an impact on the insulin pathway.
Article
Biochemistry & Molecular Biology
Sarah A. Breedon, Anchal Varma, Julian F. Quintero-Galvis, Juan Diego Gaitan-Espitia, Carlos Mejias, Roberto F. Nespolo, Kenneth B. Storey
Summary: The marsupial Monito del monte uses torpor to save energy and survive in cold and unpredictable environments. A study found that 14 microRNAs in the heart of Monito del monte showed significant differential expression during torpor. These differentially expressed microRNAs are predicted to regulate pathways related to cardiac function and tissue protection during torpor.
Article
Biochemistry & Molecular Biology
W. Aline Ingelson-Filpula, Hanane Hadj-Moussa, Kenneth B. B. Storey
Summary: The gray tree frog, which can freeze up to 42% of its body water during winter, exhibits rapid and reversible miRNA transcriptional regulation. Through miRNA sequencing analysis using RBiomirGS, we identified 11 miRNAs that are differentially regulated during freezing. These miRNAs play roles in downregulating signaling pathways, apoptosis, and nuclear processes while enhancing ribosomal biogenesis. Overall, miRNA induces energy conservation and prioritizes critical processes for freeze-tolerance survival.
CELL BIOCHEMISTRY AND FUNCTION
(2023)
Article
Entomology
Yani Yuan, Lihua Zhang, Ke Li, Yuehuan Hong, Kenneth B. Storey, Jiayong Zhang, Danna Yu
Summary: In this study, new mitogenomes of stick and leaf insects were sequenced, revealing novel mitochondrial structures and repeats. Phylogenetic analyses showed the relationships among different taxa in the Order Phasmatodea.
Article
Agriculture, Dairy & Animal Science
Yue-Huan Hong, Hai-Ming Huang, Lian Wu, Kenneth B. Storey, Jia-Yong Zhang, Yong-Pu Zhang, Dan-Na Yu
Summary: The mitochondrial genome of the endemic Chinese frog Hyla sanchiangensis was analyzed, and it showed typical gene arrangement and structure. Phylogenetic analysis revealed a close relationship between H. sanchiangensis and Hyla annectans and Hyla tsinlingensis. Positive selection in Hyla and Dryophytes is suggested to be a result of historical cold stress events, but further evidence is required to support this hypothesis.
Article
Biochemistry & Molecular Biology
Amanda M. S. Mattice, Anchal Varma, Kenneth B. Storey
Summary: The wood frog uses freeze tolerance to survive in cold environments. When exposed to freezing temperatures, the frog's body water can freeze, halting vital functions and causing damage. The study found that an enzyme called NADP-dependent isocitrate dehydrogenase (IDH) plays a role in antioxidant defense by maintaining the NADPH pool under stress conditions. The activity of IDH is regulated through reversible phosphorylation, with reduced phosphorylation observed in frozen and dehydrated frogs compared to controls.
Article
Genetics & Heredity
Yi-Jie Lin, Li-Hua Zhang, Yue Ma, Kenneth B. Storey, Dan-Na Yu, Jia-Yong Zhang
Summary: This study sequenced five mitogenomes from four species of Acanthopoidea and one species of Galinthiadoidea, revealing gene rearrangements in Acanthopoidea and tandem repeats in four mitogenomes. The study also discovered conserved block sequences within Acanthopoidea and reconstructed the phylogenetic tree of Mantodea based on four datasets.
Article
Biochemistry & Molecular Biology
Anchal Varma, Kenneth B. Storey
Summary: The regulation of citrate synthase (CS) in the liver of wood frogs during freezing was investigated. Results showed a significant decrease in the activity and catalytic efficiency of CS in the frozen frogs' liver, along with a decrease in phosphorylation levels. These results suggest that CS activity is suppressed and tricarboxylic acid (TCA) cycle flux is inhibited during freezing to support the frogs' survival in harsh winter conditions.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Agriculture, Dairy & Animal Science
Ling-Na Cai, Li-Hua Zhang, Yi-Jie Lin, Jing-Yan Wang, Kenneth B. Storey, Jia-Yong Zhang, Dan-Na Yu
Summary: This study identified the presence of ATP8 in the mitochondrial genome of Polypedates megacephalus for the first time, and detected duplications of ND5 genes and control regions. Furthermore, gene expression analysis revealed the crucial role of protein-coding mitochondrial genes and long non-coding RNAs in the molecular response to cold stress.
Article
Biochemistry & Molecular Biology
W. Aline Ingelson-Filpula, Kenneth B. Storey
Summary: This study analyzed the cardiac tissue of thirteen-lined ground squirrels during hibernation to identify miRNAs involved in hibernation regulation. The results revealed that these miRNAs activate the ErbB2 signaling pathway, affecting the MAPK and PI3K/Akt signaling pathways while decreasing the p53 signaling pathway and cell cycle-related processes. These findings provide insights into the important signaling pathways in the cardiac tissue during hibernation.
Article
Agriculture, Dairy & Animal Science
Jing-Yan Wang, Li-Hua Zhang, Yue-Huan Hong, Ling-Na Cai, Kenneth B. Storey, Jia-Yong Zhang, Shu-Sheng Zhang, Dan-Na Yu
Summary: The study reveals that Fejervarya kawamurai, a common anuran in Asian paddy fields, is sensitive to climate change. Different extreme temperatures result in significant transcriptional changes in mitochondrial genes of F. kawamurai, suggesting their ability to adapt to temperature fluctuations.