Article
Environmental Sciences
Lars Barregard, Gerd Sallsten, Thomas Lundh, Johan Molne
Summary: This study found that even low levels of Cd exposure may cause mild tubular atrophy in the kidneys. There is also an association between kidney Hg and renal arteriosclerosis. The results are significant for understanding the effects of these toxic metals on the kidneys.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Xiaoming Zhou, Yijun Feng, Zonglin Gong
Summary: This study found associations between blood levels of heavy metal elements cadmium, lead, mercury, urinary total arsenic, dimethylarsinic acid and elevation of ALT in adults. The associations between blood lead and mercury with ALT elevation were only observed in women.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Food Science & Technology
Lu Ouyang, Qi Li, Shaoqi Rao, Rui Su, Yanhui Zhu, Guihua Du, Jie Xie, Fankun Zhou, Chang Feng, Guangqin Fan
Summary: Contaminated water and food are the main sources of lead, cadmium, and mercury in the human body, and their long-term and low-level ingestion can affect brain development and cognition. This study investigated the neurotoxic effects of exposure to a mixture of lead, cadmium, and mercury at different stages of brain development. The results showed that exposure during the critical period of brain development resulted in spatial memory deficits, while exposure during the late phase led to spatial memory abnormalities. However, exposure after brain maturation had no significant effects on cognitive function.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Environmental Sciences
Lijuan Xiong, Bin Zhou, Jamie L. Young, Kupper Wintergerst, Lu Cai
Summary: Cadmium exposure can induce testicular damage through ferroptosis, possibly due to iron accumulation and decreased expression of Nrf2, HO-1, SOD2, and SLC7A11.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Environmental Sciences
Ram B. Jain
Summary: The study revealed a negative association between blood cadmium concentrations and certain PFAAs, a positive association between blood lead concentrations and most PFAAs, and a positive association between blood total mercury concentrations and all PFAAs.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Jamie L. Young, Matthew C. Cave, Qian Xu, Maiying Kong, Jianxiang Xu, Qian Lin, Yi Tan, Lu Cai
Summary: Nonalcoholic fatty liver disease (NAFLD) is a major global public health concern, and this study explored the effects of early-life cadmium (Cd) exposure on diet-induced NAFLD. The results showed that different concentrations of Cd exposure altered the adverse health effects associated with a high-fat diet, including liver injury and lipid deposition. These findings contribute to a better understanding of the development of NAFLD.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
Review
Environmental Sciences
Soisungwan Satarug, Glenda C. Gobe, David A. Vesey
Summary: Dietary assessment reports and population surveillance programs have shown that chronic exposure to low levels of environmental cadmium adversely affects the health of both children and adults. This review assesses the current risk assessment model for cadmium and highlights alternative toxicity endpoints that are more relevant in deriving exposure limits. The review also discusses the association between low-dose cadmium exposure and reduced glomerular filtration rate and fertility, as well as the potential protective effects of selenium and zinc. Additionally, the review explores mitochondrial dysfunction as a potential mechanism underlying gonadal toxicities and infertility caused by cadmium.
Article
Public, Environmental & Occupational Health
Guihua Du, Fankun Zhou, Ouyang Lu, Kai Wang, Shaoqi Rao, Rui Su, Yanhui Zhu, Kechu Guo, Jinmei Xiao, Jie Xie, Qi Li, Chang Feng, Guangqin Fan
Summary: Environmental exposure to heavy metal mixture can cause harmful health effects. This study investigated how exposure to heavy metal mixture alters the metabolic dynamics of individual metals. The findings of this study are important for understanding the mechanism of the hazardous effects of heavy metal mixture exposure or revising guidelines for heavy metal exposure.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2023)
Review
Pediatrics
Mengmeng Ding, Shanshan Shi, Shuyan Qie, Jinglu Li, Xiaoming Xi
Summary: This study found that concentrations of cadmium, lead, arsenic, and mercury were significantly higher in individuals with Autism Spectrum Disorder (ASD) compared to healthy controls. The concentrations of these heavy metals varied in different regions, with higher levels observed in Asia and Europe. These findings support the implementation of policies to reduce heavy metal exposure, particularly among pregnant women and young children, in order to decrease the incidence of ASD.
FRONTIERS IN PEDIATRICS
(2023)
Article
Environmental Sciences
Yi Zhu, Yuanyuan Zhao, Xin-Xin Chai, Jiang Zhou, Meng-Jie Shi, Yurong Zhao, Youjia Tian, Xu-Meng Wang, Tian-Xing Ying, Qiao Feng, Jinghao Sheng, Chi Luo
Summary: In this study, we found that chronic low-dose exposure to cadmium promoted the development of nonalcoholic steatohepatitis (NASH) in mice. Mechanistically, chronic cadmium exposure reshaped the liver transcriptional landscape and altered fatty acid metabolic pathways, leading to reduced fatty acid desaturation, increased cell death, and inflammation.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Reproductive Biology
Anna Corry Gerald, Srividya Ganapathy, Jianmin Zhu, Yudan Wei
Summary: This cross-sectional study investigated the association between blood levels of endocrine-disrupting metals (cadmium, lead, and mercury) and serum estradiol levels in 1618 women. The results showed that increased levels of blood cadmium and lead were associated with increased and decreased levels of estrogen, respectively. Age-specific associations were observed, suggesting that the relationship between these metals and estrogen levels may vary among different age groups of women.
REPRODUCTIVE TOXICOLOGY
(2023)
Article
Medicine, General & Internal
Yuan Wei, Yuebin Lyu, Zhaojin Cao, Feng Zhao, Yingchun Liu, Chen Chen, Chengcheng Li, Heng Gu, Feng Lu, Jinhui Zhou, Bing Wu, Yang Liu, Juan Li, Xiaoming Shi
Summary: This study found that even low levels of exposure to cadmium and mercury (or non-industrial exposure) are associated with an increased risk of chronic kidney disease in the oldest population in China. However, there were no significant multiplicative or additive interactions found between cadmium and mercury levels in relation to the risk of chronic kidney disease.
CHINESE MEDICAL JOURNAL
(2022)
Article
Toxicology
Zhaojie Wang, Dongli Li, Lijun Mo, Shujun Liang, Xuemei Liao, Sihui Guo, Xingfen Yang, Qinzhi Wei
Summary: This study found that cadmium ions can promote autophagy and osteoclastogenesis in RAW264.7 cells by inhibiting the mTOR/p70S6K1 signaling pathway.
TOXICOLOGY LETTERS
(2022)
Review
Chemistry, Applied
Haining Zhang, Jinzhao Song, Sixin Wang, Qingxin Song, Hui Guo, Ziyong Li
Summary: Considering the harmful effects of heavy metal ions on the environment and human health, significant efforts have been made to develop new chemosensors for the detection of lead, cadmium, and mercury ions. Recently, chemosensors based on various macrocyclic segments have gained attention and have been extensively studied for their ability to sense heavy metals by controlling their coordination environments. This review discusses the recent advances in macrocycle-based chemosensors for lead, cadmium, and mercury ions, which are categorized into six categories based on their structural characteristics.
Article
Environmental Sciences
Marta Wacewicz-Muczynska, Katarzyna Socha, Jolanta Soroczynska, Marek Niczyporuk, Maria H. Borawska
Summary: The study aimed to assess the influence of dietary habits on the concentration of Cd, Pb and Hg in patients with psoriasis and vitiligo. Elevated levels of these toxic elements could increase oxidative stress and contribute to inflammation in the pathogenesis of skin disorders. Food habits have impact on the content of examined toxic metals in the blood of patients, which may be useful for composing the diet and prevention of psoriasis and vitiligo.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Veterinary Sciences
A. Lukacinova, J. Mojzis, R. Benacka, J. Keller, T. Maguth, P. Kurila, L. Vasko, O. Racz, F. Nistiar
ACTA VETERINARIA BRNO
(2008)
Article
Critical Care Medicine
Eugen Frisman, Oliver Racz, Anna Chmelarova
Article
Clinical Neurology
R. Morochovic, O. Racz, M. Kitka, S. Pingorova, P. Cibur, D. Tomkova, R. Lenartova
EUROPEAN JOURNAL OF NEUROLOGY
(2009)
Article
Agriculture, Dairy & Animal Science
A. Lukacinova, J. Mojzis, R. Benacka, O. Racz, F. Nistiar
JOURNAL OF ANIMAL AND FEED SCIENCES
(2008)
Article
Engineering, Environmental
Frantisek Nistiar, Oliver Racz, Agnesa Lukacinova, Beata Hubkova, Jaroslava Novakova, Eva Lovasova, Eva Sedlakova
JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART A-TOXIC/HAZARDOUS SUBSTANCES & ENVIRONMENTAL ENGINEERING
(2012)
Article
Engineering, Environmental
Agnesa Lukacinova, Roman Benacka, Eva Sedlakova, Eva Lovasova, Frantisek Nistiar
JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART A-TOXIC/HAZARDOUS SUBSTANCES & ENVIRONMENTAL ENGINEERING
(2012)
Article
Engineering, Environmental
Viera Almasiova, Katarina Holovska, Lucia Tarabova, Viera Cigankova, Agnesa Lukacinova, Frantisek Nistiar
JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART A-TOXIC/HAZARDOUS SUBSTANCES & ENVIRONMENTAL ENGINEERING
(2012)
Article
Medicine, Research & Experimental
Norbert Lukan, Oliver Racz, Ema Paulovicova, Lveta Mocnejova, Jozefina Petrovicova
MEDICAL SCIENCE MONITOR
(2012)
Article
Public, Environmental & Occupational Health
Jaroslava Novakova, Agnesa Lukacinova, Eva Lovasova, Iveta Cimbolakova, Oliver Racz, Frantisek Nistiar
TOXICOLOGY AND INDUSTRIAL HEALTH
(2015)
Article
Medicine, General & Internal
Eva Sedlakova, Oliver Racz, Eva Lovasova, Roman Benacka, Martin Kurpas, Anna Chmelarova, Jan Sedlak, Martin Studencan
CENTRAL EUROPEAN JOURNAL OF MEDICINE
(2009)
Article
Environmental Sciences
A. Lukacinova, R. Benacka, E. Lovasova, O. Racz, F. Nistiar
POLISH JOURNAL OF ENVIRONMENTAL STUDIES
(2008)
Article
Medicine, General & Internal
N. Lukan, I Lazurova, O. Racz, B. Kristofova, I Tkac
BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY
(2008)