Article
Fisheries
Dongyong Fu, Yadong Hu, Peng Chu, Tao Wang, Mingxu Chu, Yonghai Shi, Shaowu Yin, Yongxiang Zhu, Yaohui Wang, Zhenglong Guo
Summary: This study investigated the toxic effects of Cu-NPs and Cu2+ on Takifugu fasciatus, showing organ injuries, abnormal enzyme activities, and significant changes in the expression of TfCRT gene. Both Cu-NPs and Cu2+ had negative impacts on the health of T. fasciatus, with Cu-NPs exhibiting toxic effects similar to dissolved Cu.
AQUACULTURE REPORTS
(2021)
Article
Environmental Sciences
Tingting Ku, Mengmeng Zhou, Yanwen Hou, Yuanyuan Xie, Guangke Li, Nan Sang
Summary: The study found that low doses of tebuconazole mainly accumulated in the liver of mice, causing histopathological damage. Tebuconazole significantly dysregulated metabolizing enzymes, efflux transporters, and fatty acid metabolism-related genes in the liver, leading to liver hypertrophy and steatosis. Furthermore, excessive induction of ROS and oxidative stress partly accounted for the metabolic abnormalities mediated by tebuconazole.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Biochemistry & Molecular Biology
Ying Zheng, Yufei Wang, Mutang Zheng, Gang Wang, Hongfeng Zhao
Summary: This study revealed that pollution of Sulfamethoxazole (SMX) in water has potential toxic effects on the liver and gut microbiota of aquatic organisms, inducing histopathological damages, genetic expression alterations, disorder of fatty acid metabolism, and dysbiosis of intestinal microbiota.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2022)
Review
Oncology
Shannon M. Schroeder, Karen E. Matsukuma, Valentina Medici
Summary: Wilson disease is a rare condition characterized by copper accumulation in the liver and brain. Diagnosis and treatment of Wilson disease are crucial, but distinguishing it from other liver diseases remains challenging.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Fisheries
Ruidong Zhou, Guanju Wu, Letian Qu, Xiangqi Zhong, Yingli Gao, Zhujin Ding, Jianhe Xu, Xiangning Chen, Hanliang Cheng
Summary: Starvation significantly affects the intestinal structure and function of Synechogobius hasta, leading to decreased intestinal length, reduced enzyme activity, and altered intestinal cell structure. The expression levels of lipid metabolism-associated genes increase post-starvation, while some genes are downregulated in the intestine. Prolonged starvation disrupts the intestinal structure, weakens lipid deposition, and affects lipid metabolism.
AQUACULTURE RESEARCH
(2022)
Article
Endocrinology & Metabolism
Zhaoyue Zhang, Tara TeSlaa, Xincheng Xu, Xianfeng Zeng, Lifeng Yang, Gang Xing, Gregory J. Tesz, Michelle F. Clasquin, Joshua D. Rabinowitz
Summary: The liver relies on a unique cytosolic serine catabolic pathway for NADPH generation, while adipose tissue uses the pentose phosphate pathway. Acetyl-CoA for lipogenesis in liver is derived from acetate and lactate, whereas in adipose tissue glucose is the main substrate. Despite using the same enzymes, different substrates are utilized, highlighting the potential for tissue-specific pharmacological interventions.
Article
Fisheries
Xiangning Chen, Yili Xu, Xiangyu Cui, Siying Zhang, Xiangqi Zhong, Juntao Ke, Yuze Wu, Zhiyu Liu, Chaoqing Wei, Zhujin Ding, Jianhe Xu, Hanliang Cheng
Summary: This study investigated the effects of starvation on the muscular function, morphology, and regulatory signaling in javelin goby (Synechogobius hasta) and found significant changes in muscle metabolism and structure. Transcriptome analysis revealed the involvement of metabolism-related pathways. These findings provide reference data for optimizing feeding strategies in aquaculture.
AQUACULTURE NUTRITION
(2022)
Article
Food Science & Technology
Mingyu Yin, Ryosuke Matsuoka, Yinci Xi, Xichang Wang
Summary: The study found that phospholipids derived from egg yolk and soya bean exhibited significant antioxidant and lipid-lowering abilities in a high-fat-and-sucrose diet model, reducing liver burden and improving blood lipid and inflammation markers, with egg yolk phospholipids showing more effective therapeutic benefits.
Article
Multidisciplinary Sciences
Ann-Katrin Heymann, Karina Schnabel, Fabian Billenkamp, Susanne Buehler, Jana Frahm, Susanne Kersten, Liane Huether, Ulrich Meyer, Dirk von Soosten, Nares Trakooljul, Jens Peter Teifke, Sven Daenicke
Summary: The study found that GLY had no toxic effects on the liver of dairy cows, and blood parameters and histopathological evaluation were not influenced by GLY, but rather affected by time, CFP, or an interactive manner between time and CFP. Total bilirubin blood concentration was significantly influenced by an interaction between GLY and CFP with temporarily elevated concentrations in GLY(HC), while the biological relevance remained unclear. Gene expression analysis indicated 167 CFP-responsive genes, while seven genes showed altered expression in GLY groups compared to CON groups.
Review
Biochemistry & Molecular Biology
Francesco Bellanti, Aurelio Lo Buglio, Gianluigi Vendemiale
Summary: The prevalence of metabolism-associated fatty liver disease (MAFLD) is a global pandemic with high morbidity and mortality rates and increased socio-economic burden. Evidence shows that changes in gut microbiota affect the development and progression of MAFLD through metabolic pathways, immune response modulation, and pro-inflammatory signals activation. Additionally, metabolites produced by gut microbiota, such as short chain fatty acids and bile acids, play a role in regulating hepatic homeostasis through interactions with mitochondria. Recent research explores the potential of innovative treatment strategies, including prebiotics, probiotics, and metabolites, to modify gut microbiota composition and improve MAFLD by positively impacting mitochondrial function. This review summarizes the importance of mitochondria, discusses alterations in gut microbiota composition and metabolites in MAFLD, and highlights the potential effects of innovative treatments on modulating gut microbiota.
Article
Nutrition & Dietetics
Magdalena J. M. Marschall, Sarah M. Grundmann, Denise K. Gessner, Gaiping Wen, Erika Most, Klaus Eder, Robert Ringseis
Summary: This study aimed to investigate the potential of dietary insect meal from Hermetia illucens larvae to attenuate liver steatosis and hyperlipidemia in obese Zucker rats. The study conducted a 4-week trial with obese and lean Zucker rats, replacing a portion of casein protein in the diets of obese rats with protein from HI larvae meal. Results showed that the inclusion of HI larvae meal significantly reduced liver lipid accumulation and improved dyslipidemia markers in obese rats. These findings suggest the potential of HI larvae meal as a functional food for preventing obesity-related metabolic disorders.
Article
Gastroenterology & Hepatology
Zu-Yin Li, Gang Wu, Chen Qiu, Zhi-Jie Zhou, Yu-Peng Wang, Guo-He Song, Chao Xiao, Xin Zhang, Gui-Long Deng, Rui-Tao Wang, Yu-Long Yang, Xiao-Liang Wang
Summary: TM6SF2 plays a protective role in fatty liver, reducing hepatic lipid accumulation under high-fat diet conditions. Deficiency of TM6SF2 leads to dysregulated lipid metabolism and increased hepatic lipid deposition. Treatment with an acetyl-CoA carboxylase inhibitor (MK-4074) can alleviate the NAFLD phenotypes caused by TM6SF2 deficiency.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Environmental Sciences
Veronica P. Filippa, Emilce L. Tabares, Ana C. Castro-Guijarro, Juan G. Chediack, Fabricio D. Cid
Summary: The present study evaluated the effects of different Pb exposure times on the digestive system of eared doves. Blood delta-ALAD activity, histological and morphometric characteristics of the liver and small intestine were examined. The results showed that Pb exposure led to alterations in the liver and small intestine, indicating the potential dangerousness of environmental pollutants in wild animals.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Fanrong Zhao, Lei Zhang, Menglin Zhang, Jincan Huang, Jun Zhang, Yongsheng Chang
Summary: This study found that FGF9 expression was increased in the livers of diet-induced obese mice, and knockdown exacerbated the fatty liver phenotype while overexpression alleviated hepatic steatosis and improved insulin sensitivity. Mechanistically, FGF9 inhibits genes involved in lipogenesis and increases genes involved in fatty acid oxidation, reducing cellular lipid accumulation.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Binbin Li, Jiaxuan Liu, Xuan Xin, Lifen Zhang, Jiaming Zhou, Chunyan Xia, Weijian Zhu, Hongyu Yu
Summary: miR-34c plays a crucial role in hepatic stellate cell activation and liver fibrosis by targeting ACSL1 and regulating fatty acid synthesis.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)