Review
Environmental Sciences
Rebecca J. Brown, Grace H. Panter, Natalie Burden, Edward R. Salinas, Lennart Weltje, James R. Wheeler, Yvonne Wolf, Laurent Lagadic
Summary: This review examines the relationship between vitellogenin data and potential endocrine-disrupting properties of chemicals. It suggests that improvements in measurement methodologies and transparency in reporting of vitellogenin data are needed. However, it also demonstrates that in vitro mechanistic data can be used to predict in vivo vitellogenin response, highlighting the importance of such data in decision-making.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Fisheries
Pallath Muhammed Nuzaiba, Tincy Varghese, Subodh Gupta, Narottam Prasad Sahu, Prem Prakash Srivastava
Summary: The study showed that dietary genistein has an inducing effect on vitellogenesis in male carp, leading to enhanced estrogenic responses, increased testosterone levels, and reduced activity of steroidogenic enzymes, possibly causing a delay in maturation.
Article
Biochemistry & Molecular Biology
Zhifeng Ye, Tingting Zhao, Qianhao Wei, Haoran Lin, Yong Zhang, Shuisheng Li
Summary: This study investigated the expression of vitellogenin and estrogen receptors in the liver of orange-spotted grouper. The results showed that their expression levels increased significantly during the breeding season and were upregulated by estradiol (E-2) injection. ER beta 2 was found to mediate the E-2-induced expression of vitellogenin and ER alpha, and the transcriptional activity of ER alpha was enhanced through a classical ERE-dependent pathway. This study provides insights into the roles of ER subtypes in VTG expression and the efficient VTG production in orange-spotted grouper during the breeding season.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Juan P. Munoz, Rocio Araya-Osorio, Raul Mera-Adasme, Gloria M. Calaf
Summary: Recent reports have questioned the safety of glyphosate, the active ingredient in several herbicide formulations, suggesting that it may act as an endocrine disruptor by promoting estrogenic activity. This study aimed to investigate the mechanism by which glyphosate induces estrogenic effects using breast cancer cell line models. The results showed that high concentrations of glyphosate mimic the effects of estrogen, leading to the activation of estrogen receptor alpha and enhanced cell proliferation.
Article
Food Science & Technology
Yue Leng, Li Ren, Shu Niu, Tiehua Zhang, Jie Zhang
Summary: The metabolites of plasticizers did not show direct effects on the glucocorticoid receptor, but they could synergistically activate the receptor in combination with dexamethasone. The study found that monobutyl phthalate (MBP) in combination with dexamethasone enhanced the expression of specific genes and proteins regulated by the glucocorticoid receptor. The interactions between MBP and the glucocorticoid receptor were influenced by the chemical properties of MBP, with hydrophobic and hydrogen bonding interactions playing crucial roles in stabilizing the complex.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Environmental Sciences
Allan dos Santos Argolo, Giselle Gomes, Daniele Maia Bila
Summary: This study assessed the influence of physicochemical properties of contaminants and environmental matrix features on the Yeast Estrogen Screen (YES) assay. It was found that organic pollutants may interfere with the assay mechanism through enzymatic inhibition and also exhibit antiestrogenic activity. Organic matter characterization parameters, cytotoxicity, and antiestrogenic activity evaluation should be considered when interpreting the results.
Article
Pharmacology & Pharmacy
Aldana Moya, Daniela Tejedor, Mariana Manetti, Araceli Clavijo, Eduardo Pagano, Eliana Munarriz, Maria Florencia Kronberg
Summary: This study assessed the impact of exposure to five pesticides suspected of being endocrine disruptors on the reproductive development of the nematode Caenorhabditis elegans. The results showed that some of these pesticides may have estrogen-like endocrine disrupting activity, while others had lesser impact. This research contributes to the evaluation of environmental pollutants.
Article
Environmental Sciences
Rucong Liu, Kang Li, Guixiang Wang, Zhixin Jiang, Xubing Ba, Liping Liu
Summary: This study explored the effect of swimming on the synthesis of VTG in conger eel. The results showed that flowing water can inhibit the expression of VTG and Er genes in the liver, reduce the synthesis of VTG, and inhibit yolk accumulation during ovarian development in conger eel.
FRONTIERS IN MARINE SCIENCE
(2022)
Article
Immunology
Pablo Castejon, Isabel Cabas, Victoria Gomez, Elena Chaves-Pozo, Isabel Cerezo-Ortega, Miguel Angel Morinigo, Eduardo Martinez-Manzanares, Jorge Galindo-Villegas, Alfonsa Garcia-Ayala
Summary: Our study revealed the intrinsic relationship among estrogens, their associated receptors, and immunization in the ubiquitous fish immune regulation and the subtle but significant crosstalk with the gut endobolome.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Fisheries
Makito Kobayashi, Mai Kijima, Yuiko Matsuzuka, Youichi Hayakawa, Eri Iwata, Takeji Kimura
Summary: This study clarified the long-term effects of environmental estrogen on male reproductive activity in goldfish, leading to some fish exhibiting active spawning behavior without producing milt. This could result in a substantial decrease in population size of wild fish.
Article
Fisheries
Masoumeh Darvishi, Roghieh Safari, Seyed Hossein Hoseinifar, Ali Shabani, Maryam Dadar, Zahra Jarayedi, Marina Paolucci
Summary: The study found that after treatment with sub-lethal doses of Diazion, the expression of reproductive-related genes in female zebrafish significantly decreased, while the expression of immune and antioxidant related genes increased considerably. Ovarian morphology showed a decrease in oocyte development in groups treated with Diazion. Understanding the function and mechanism of action of Diazion on the female reproductive, immune, and oxidant status may provide new strategies to counteract its adverse effects.
AQUACULTURE REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Lea Clusan, Francois Ferriere, Gilles Flouriot, Farzad Pakdel
Summary: Breast cancer, the most common and deadliest cancer among women worldwide, is closely associated with estrogen signaling. Hormone therapy using antiestrogens is the standard treatment, but resistance inevitably occurs through various biological mechanisms. Understanding the estrogen pathway is crucial for the development of new therapies for hormone-dependent breast cancer. This mini-review summarizes the current literature on estrogen receptors in breast cancer, including their signalization, mechanisms of action, and clinical implications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
S. Sreelekshmi, K. Manish, M. C. Subhash Peter, R. Moses Inbaraj
Summary: This study investigated the effects of hypoxic and osmotic stress on neurotransmitters levels in the brain of zebrafish, revealing alterations in serotonin, epinephrine, and norepinephrine levels. The stressors also impacted the expression of reproductive signal genes, suggesting a potential role of neurotransmitters in regulating responses to acute stress in zebrafish brain.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2022)
Article
Environmental Sciences
Michael Niederwanger, Josef Wieser, Melanie Thaler, Agnes Felber, Katja Schmoelz, Wolfgang Mark, Erich Tasser, Rudiger Kaufmann, Bernd Pelster
Summary: The efflux of organic contaminants from sewage treatment plants and extensive pesticide use in vineyards and orchards have detrimental effects on fish species, particularly their endocrine system. This study investigated the effects of sewage treatment plant efflux and pesticide use on selected fish species in Austrian freshwater streams. Biomarkers related to endocrine disruption were identified, and mRNA expression levels were measured. The results showed increased mRNA expression in the tested fish species, indicating the presence of endocrine disrupting chemicals. This study provides important insights for further research on the effects of these chemicals on fish populations.
FRONTIERS IN ENVIRONMENTAL SCIENCE
(2022)
Article
Environmental Sciences
Mark Stanojevic, Marija Sollner Dolenc, Marjan Vracko
Summary: Endocrine-disrupting chemicals (EDCs) are exogenous substances that interfere with the normal function of the human endocrine system. These chemicals can affect specific nuclear receptors, such as androgen receptors (ARs) or estrogen receptors (ERα and ERβ), which play a crucial role in regulating complex physiological processes in humans. It is now more crucial than ever to identify EDCs and reduce exposure to them.