Article
Environmental Sciences
Jie Meng, Wen-Xiong Wang, Li Li, Guofan Zhang
Summary: This study investigated the transportation mechanisms of ZIPs and ZnTs under different metal exposures, and the genetic effects of Zn accumulation in oysters. The research provides valuable biomarkers and genetic resources to evaluate environmental metal pollution.
ENVIRONMENTAL POLLUTION
(2021)
Review
Chemistry, Multidisciplinary
Hai-tao Yu, Juan Zhen, Ji-yan Leng, Lu Cai, Hong-lei Ji, Bradley B. Keller
Summary: Cadmium is a significant environmental pollutant linked to various health issues, while zinc has been shown to alleviate cadmium toxicity through mechanisms like direct competition for cellular uptake and induction of protective mechanisms. Future research directions on the role of zinc and metal transporters in reducing cadmium toxicity are discussed in this review.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Biochemistry & Molecular Biology
Ziyan Ruan, Youli Liu, Guangqiu Chang, Zhihua Lin, Qinggang Xue
Summary: In this study, two copper and zinc SOD family proteins were characterized in the Pacific oyster Crassostrea gigas. The results revealed the presence of a cytoplasmic CuZn-SOD molecule and molecular diversification of extracellular CuZn-SOD homologs in oysters.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Monica Nordberg, Gunnar F. Nordberg
Summary: This review summarizes the adverse effects of cadmium on human and animal health and emphasizes the importance of preventive measures. It specifically focuses on the role of metallothionein (MT) in cadmium toxicology and highlights the binding of cadmium to MT and the importance of the Cd/Zn ratio in kidney toxicity. The review calls for the application of these findings in risk assessment and preventive measures against cadmium exposures.
Article
Food Science & Technology
Dongyang Zhu, Zhen Yuan, Di Wu, Chao Wu, Hesham R. El-Seedi, Ming Du
Summary: Oyster proteins obtained from fresh oysters showed increased anti-diabetic and antioxidant effects after simulated gastrointestinal digestion. The α-glucosidase inhibitory activity, α-amylase inhibitory activity, DPPH radical scavenging activity, and ABTS radical scavenging activity of the oyster protein gastrointestinal digest were significantly increased. Additionally, the degree of hydrolysis, beta-turn structure, fluorescence intensity, free amino acid, and low molecular weight peptide content also increased during simulated gastrointestinal digestion.
FOOD SCIENCE AND HUMAN WELLNESS
(2023)
Article
Biochemistry & Molecular Biology
Ettore Priante, Edoardo Pietropoli, Elisabetta Piva, Gianfranco Santovito, Sophia Schumann, Paola Irato
Summary: The study aimed to evaluate the effects of zinc and the role of MTF-1 in cadmium-induced toxicity. The results suggest that zinc reduces cadmium content in co-treatments, possibly through competition for a common transporter. Additionally, zinc increases glutathione levels in co-treatments. MTF-1 is essential for the expression of MT-1.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Jing Liu, Ermeng Wang, Ziru Cheng, Yuan Gao, Chienmin Chen, Ru Jia, Zhi Luo, Lan Wang
Summary: Cadmium (Cd) is a carcinogenic environmental pollutant that harms male reproductive systems, but the mitigating effects of zinc (Zn) on Cd-induced toxicity have not been fully elucidated. This study investigated the effects of Zn supplementation on Cd-exposed freshwater crabs. Cd exposure caused Cd accumulation, Zn deficiency, decreased sperm survival rate, poor sperm quality, altered ultrastructure, increased apoptosis, and elevated metallothionein (MT) expression in the testis. However, Zn supplementation effectively alleviated these effects by preventing Cd accumulation, increasing Zn bioavailability, alleviating apoptosis, decreasing reactive oxygen species (ROS) levels, and restoring MT distribution. Furthermore, Zn also regulated the expression of apoptosis-related genes and proteins, metal transporter-related genes, and MT expression. These findings provide important insights for the development of mitigation strategies for Cd contamination or poisoning.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Environmental Sciences
Jing Tian, Yongjing Li, Huiru Fu, Liting Ren, Yameng He, Shangyu Zhai, Ben Yang, Qi Li, Nannan Liu, Shikai Liu
Summary: This study demonstrated the critical role of CYP17A1-like in Cd detoxification in Pacific oysters, providing a new perspective towards unraveling detoxification mechanisms of bivalves under heavy metal stress. The RNA interference experiments confirmed the importance of CYP17A1-like in Cd detoxification, leading to significant tissue damage in oysters and increased activities of antioxidant enzymes. Dual luciferase reporter assay revealed potential transcriptional regulation of CYP17A1-like by MTF-1 in oysters.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Environmental Sciences
Lina Chouchene, Kaouthar Kessabi, Marie-Madeleine Gueguen, Olivier Kah, Farzad Pakdel, Imed Messaoudi
Summary: This study provides new insights into the mechanisms of cadmium-induced toxicity in zebrafish larvae and the potential role of zinc in reversing these harmful effects. The results suggest that cadmium interferes with zinc metabolism, leading to its depletion and oxidative stress. However, supplementation of zinc can partially reverse the toxic effects of cadmium, possibly through its interaction with the toxic metal and improvement of oxidative status.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Ming Sun, Fanguang Hu, Tianming Wang, Tianwen Zhang, Yuanyuan Jing, Wen Guo, Qun Chen, Guangbin Liu
Summary: This study investigated the effects of temperature on the bioaccumulation and depuration processes of Crassostrea gigas exposed to Cd, as well as its molecular responses. The results showed that the concentration of Cd in different tissues varied at different temperatures, and both uptake rate and elimination rate were influenced by temperature. Additionally, the expression of metallothionein and P-glycoprotein also showed temperature-dependent changes.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
Monika Dhanji-Rapkova, Andrew D. Turner, Craig Baker-Austin, Jim F. Huggett, Jennifer M. Ritchie
Summary: A potent and heat-stable toxin, TTX, accumulates in various marine bivalve species, including Pacific oysters, with the highest concentrations found in the digestive gland. TTX levels vary significantly between different geographical locations and within populations of oysters, suggesting high variability in toxin distribution.
Article
Biochemistry & Molecular Biology
Jingya Yang, Lingxiong Li, Xiong Zhang, Shibo Wu, Xiaohui Han, Xiong Li, Jianchu Xu
Summary: This study investigated the Cd tolerance and potential mechanisms of Calotropis gigantea. The results showed that the roots and leaves of C. gigantea exhibited different responses to Cd stress, with the leaves activating various detoxification processes to cope with Cd.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Xuekai Zhang, Chao Fan, Jinlong Li, Xingzhi Zhang, Qiongzhen Li, Zhaoping Wang
Summary: This study analyzed the molecular processes in hybrids of Pacific oyster under hypoxia stress and identified significant differentially expressed genes related to cell survival and immune response.
FRONTIERS IN MARINE SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Nathalie Imbert-Auvray, Denis Fichet, Pierre-Edouard Bodet, Pascaline Ory, Rene Sabot, Philippe Refait, Marianne Graber
Summary: Cathodic protection using sacrificial galvanic anodes is commonly employed to prevent corrosion of metal structures in marine environments. However, the effects of the dissolved species and solid phases released by these anodes on marine organisms remain understudied. In this study, we examined the impact of Zinc and Al-Zn-In anodes on oysters through metabolomic analysis and chemical modelling. We identified several metabolites affected by the anodes, which play important roles in various biological processes. Furthermore, our novel approach combining chemical modelling and metabolomics shed light on the influence of Zinc in Al-Zn-In anodes.
Article
Biochemistry & Molecular Biology
Milena Sciskalska, Monika Oldakowska, Halina Milnerowicz
Summary: This study evaluated the changes in metallothionein concentration in the blood of patients with acute pancreatitis and healthy subjects. It also analyzed the impact of single-nucleotide polymorphisms on MT concentration and their association with metals and ceruloplasmin levels, as well as markers of inflammation and parameters describing the pro/antioxidative balance. The investigated polymorphisms in MT1A, MTIB, and MT2A genes appear to be important in maintaining homeostasis under oxidative stress conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Marine & Freshwater Biology
Huifeng Wu, Xiaoli Liu, Xingyan Zhang, Chenglong Ji, Jianmin Zhao, Junbao Yu
AQUATIC TOXICOLOGY
(2013)
Article
Environmental Sciences
Tim D. Williams, Ian M. Davies, Huifeng Wu, Amer M. Diab, Lynda Webster, Mark R. Viant, J. Kevin Chipman, Michael J. Leaver, Stephen G. George, Colin F. Moffat, Craig D. Robinson
Article
Limnology
You Liping, Ning Xuanxuan, Chen Leilei, Zhang Linbao, Zhao Jianmin, Liu Xiaoli, Wu Huifeng
CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY
(2014)
Article
Environmental Sciences
Lianzhen Li, Huifeng Wu, Cornelis A. M. van Gestel, Willie J. G. M. Peijnenburg, Herbert E. Allen
ENVIRONMENTAL POLLUTION
(2014)
Article
Environmental Sciences
Chenglong Ji, Jianmin Zhao, Huifeng Wu
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2014)
Article
Environmental Sciences
Yingying Zhang, Qing Wang, Yinglu Ji, Qian Zhang, Huifeng Wu, Jia Xie, Jianmin Zhao
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2014)
Article
Environmental Sciences
Chenglong Ji, Lei Wei, Jianmin Zhao, Huifeng Wu
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2014)
Article
Fisheries
Xiaoli Liu, Chenglong Ji, Jianmin Zhao, Huifeng Wu
FISH & SHELLFISH IMMUNOLOGY
(2013)
Article
Fisheries
Chunyan Wang, Jianmin Zhao, Changkao Mu, Qing Wang, Huifeng Wu, Chunlin Wang
FISH & SHELLFISH IMMUNOLOGY
(2013)
Article
Fisheries
Xiaoli Liu, Chenglong Ji, Jianmin Zhao, Qing Wang, Fei Li, Huifeng Wu
FISH & SHELLFISH IMMUNOLOGY
(2014)
Article
Plant Sciences
Huifeng Wu, Xiaoli Liu, Jianmin Zhao, Junbao Yu
JOURNAL OF PLANT GROWTH REGULATION
(2013)
Article
Biochemical Research Methods
Huifeng Wu, Chenglong Ji, Lei Wei, Jianmin Zhao, Hongjian Lu
JOURNAL OF PROTEOMICS
(2013)
Article
Biochemical Research Methods
Chenglong Ji, Huifeng Wu, Lei Wei, Jianmin Zhao, Hongjian Lu, Junbao Yu
JOURNAL OF PROTEOMICS
(2013)
Article
Environmental Sciences
Fei Li, Renmin Li, Xianhai Yang, Liping You, Jianmin Zhao, Huifeng Wu
MARINE POLLUTION BULLETIN
(2014)
Article
Endocrinology & Metabolism
Jianghua Feng, Jinquan Li, Huifeng Wu, Zhong Chen