Article
Cardiac & Cardiovascular Systems
Lin Na, Wenjing Cui, Xinqi Li, Jing Chang, Xin Xue
Summary: Using speckle tracking technology, this study investigated the effect of hypertriglyceridemia on the global longitudinal strain of the left ventricle in early stage coronary heart disease patients, and explored the value of myocardial strain in early identification of cardiac dysfunction. A cross-sectional study of 138 participants was conducted, and the myocardial strain parameters were compared between hypertriglyceridemia and normal triglyceride level groups, evaluating the effect of hypertriglyceridemia on early left ventricular global longitudinal strain impairment in coronary heart disease patients.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Medicine, General & Internal
Federica Ilardi, Antonello D'Andrea, Flavio D'Ascenzi, Francesco Bandera, Giovanni Benfari, Roberta Esposito, Alessandro Malagoli, Giulia Elena Mandoli, Ciro Santoro, Vincenzo Russo, Mario Crisci, Giovanni Esposito, Matteo Cameli
Summary: Left ventricular global longitudinal strain (GLS) and non-invasive myocardial work (MW) quantification are two new methods for assessing myocardial function, able to overcome limitations of previous methods and provide a more reliable evaluation of myocardial performance without load dependency.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Agriculture, Dairy & Animal Science
Ryohei Suzuki, Yunosuke Yuchi, Haruka Kanno, Takahiro Teshima, Hirotaka Matsumoto, Hidekazu Koyama
Summary: The endomyocardial form of restrictive cardiomyopathy (EMF-RCM), a primary disorder of the myocardium, is one of the diseases with poor prognosis in cats. Our study indicated that cats with EMF-RCM have reduced left ventricular myocardial function and certain right ventricular myocardial deformations compared to healthy cats. Myocardial function assessed by two-dimensional speckle-tracking echocardiography could reveal left and right myocardial dysfunction in cats with EMF-RCM.
Article
Medicine, General & Internal
Xiong Ye, Zhi Liu, Ying Ma, Ye Song, Lihua Hu, Jianwen Luo, Hui Xiao
Summary: A novel diaphragm deformation ultrasound imaging method was developed in this study using a NCC algorithm for real-time tracking of right diaphragm movements. Horizontal displacements were greater than vertical displacements, and global strain was found to be insensitive to the imaging plane.
FRONTIERS IN MEDICINE
(2021)
Article
Acoustics
N. H. M. van Oostrum, C. M. de Vet, S. B. Clur, D. A. A. van Der Woude, E. R. van den Heuvel, S. G. Oei, J. O. E. H. van Laar
Summary: This study aimed to obtain reference values for fetal global longitudinal strain (GLS) and GLS rate (GLSR) measured using 2D-STE and compare right and left ventricular values. The results showed that both ventricles exhibited a significant increase in GLS and GLSR values from the second trimester until delivery, with the right ventricular values being significantly higher than the left ventricular values.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Vito Di Terlizzi, Roberta Barone, Vincenzo Manuppelli, Michele Correale, Grazia Casavecchia, Giovanni Goffredo, Pierluigi Pellegrino, Alessandra Puteo, Riccardo Ieva, Matteo Di Biase, Natale Daniele Brunetti, Massimo Iacoviello
Summary: This study aimed to analyze the impact of heart rate changes on left and right ventricular longitudinal strain in participants with and without chronic heart failure (CHF). The results showed that as heart rate increased, there was a decrease in left ventricular longitudinal strain and an improvement in right ventricular longitudinal strain and right ventricular free wall longitudinal strain. Some participants exhibited deteriorations in right ventricular strain measures, which were associated with lower baseline right ventricular function and higher pulmonary systolic pressures.
APPLIED SCIENCES-BASEL
(2022)
Review
Hematology
Dimitrios Patsourakos, Constantina Aggeli, Yannis Dimitroglou, Sophia Delicou, Katerina Xydaki, Markos Koukos, Dimitrios Tsartsalis, Foteini Gialeli, Konstantinos A. Gatzoulis, Dimitrios Tousoulis, Konstantinos Tsioufis
Summary: Heart disease is a leading cause of morbidity and mortality in β-thalassemia major (β-TM) patients. Speckle tracking echocardiography (STE) has been used to identify myocardial dysfunction at an early stage. This review aims to gather and compare results from published studies evaluating myocardial strain in β-TM patients and propose recommendations based on these data. Thirty-five studies met the inclusion criteria and showed that myocardial strain was worse in β-TM patients compared to controls, indicating the potential utility of STE in early identification of myocardial dysfunction and screening for other cardiac conditions in β-TM patients.
ANNALS OF HEMATOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Jolanda Sabatino, Isabella Leo, Antonio Strangio, Sabrina La Bella, Nunzia Borrelli, Martina Avesani, Manjit Josen, Josefa Paredes, Enrico Piccinelli, Domenico Sirico, Valeria Pergola, Alain Fraisse, Salvatore De Rosa, Ciro Indolfi, Giovanni Di Salvo
Summary: This international multi-center study aimed to assess the feasibility and reliability of non-invasive myocardial work (MW) parameters in the pediatric population and provided normal reference ranges for these useful echocardiographic indices.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Medicine, General & Internal
Sergio Alejandro Gomez-Ochoa, Lyda Z. Rojas, Juliana Alexandra Hernandez-Vargas, Jorge Largo, Taulant Muka, Luis E. Echeverria
Summary: This systematic review analyzed the left ventricular longitudinal strain patterns using speckle tracking in different stages of Chagas disease. The study found that patients with chronic Chagas cardiomyopathy had significantly higher mean global longitudinal strain values compared to those with the indeterminate form, while no significant difference was observed between the indeterminate form patients and healthy controls. Segmental strain analyses showed that patients with the indeterminate form had worse strain values in certain segments compared to healthy controls.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Health Care Sciences & Services
Liliana Gozar, Mihaela Iancu, Horea Gozar, Anca Sglimbea, Andreea Cerghit Paler, Dorottya Gabor-Miklosi, Rodica Toganel, Amalia Fagarasan, Diana Ramona Iurian, Daniela Toma
Summary: The aim of this study was to compare the strain values of infants with severe and critical pulmonary stenosis (PS) with controls, both globally and regionally, and to assess the correlations between strain and conventional parameters. The results showed a significant difference in regional strain values between PS patients and controls. There were also significant changes in strain values from basal to apical location. However, there was no significant difference in strain values before and after intervention in PS patients. The study emphasizes the importance of using strain analysis, specifically RV global-4-chamber longitudinal strain, for evaluating RV function in infants with severe and critical PS.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Veterinary Sciences
Takahiro Saito, Ryohei Suzuki, Yunosuke Yuchi, Haru Fukuoka, Shuji Satomi, Takahiro Teshima, Hirotaka Matsumoto
Summary: In recent years, hypertrophic cardiomyopathy (HCM) in cats has become more common due to improvements in diagnostic techniques. This study compared myocardial function in HCM-affected cats with and without left ventricular outflow tract obstruction (DLVOTO) using speckle-tracking echocardiography. The results showed that LV myocardial function was more compromised in HCM-affected cats with DLVOTO, indicating the importance of DLVOTO in affecting LV function in HCM-affected cats.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Medicine, General & Internal
Liliana Gozar, Claudiu Marginean, Andreea Cerghit Paler, Dorottya Gabor-Miklosi, Daniela Toma, Mihaela Iancu, Rodica Toganel, Amalia Fagarasan
Summary: The study compared speckle-tracking peak global longitudinal (pGLS) and regional strain values in neonates with coarctation of aorta among control groups. Significant differences were found in segmental strain values at various segments of the heart, with pGLS also showing a significant difference between the studied groups. ROC analysis indicated that pGLS can be used as a reliable parameter for diagnosing CoA in neonates.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Chia-Te Liao, Han Siong Toh, Wei-Ting Chang, Chun-Ting Yang, Zhih-Cherng Chen, Hung-Jen Tang, Carol Strong
Summary: This study used speckle-tracking echocardiography to detect early cardiac impairment in Asian people living with HIV (PLWH) and investigated the associated risk factors. The results showed that hypertension and viral load are related to impaired myocardial strain. Therefore, timely antiretroviral therapy and hypertension control are crucial in preventing cardiovascular diseases in PLWH.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Medicine, General & Internal
Konstantinos Papadopoulos, Ozge Ozden Tok, Konstantina Mitrousi, Ignatios Ikonomidis
Summary: Assessing left ventricular contractility accurately is crucial in cardiac pathologies. The novel imaging tool called myocardial work, based on strain-blood pressure curves, provides detailed evaluation of LV function, incorporating pressure data for a more comprehensive assessment.
Article
Health Care Sciences & Services
Massimiliano Cantinotti, Pietro Marchese, Marco Scalese, Paola Medino, Vivek Jani, Eliana Franchi, Pak Vitali, Giuseppe Santoro, Cecilia Viacava, Nadia Assanta, Shelby Kutty, Martin Koestenberger, Raffaele Giordano
Summary: STE epsilon analysis revealed significant LV systolic impairment after surgery, with improvement thereafter but incomplete normalization at discharge. Differences between base and apex emerged, with apical segments showing relative hypercontractility after surgery. Slower recovery of LV epsilon values compared to LVEF suggests that STE epsilon analysis may be more accurate for follow-up of mild LV post-surgical impairment.
Article
Cardiac & Cardiovascular Systems
Rawan K. Rumman, Cameron Slorach, Wei Hui, Carmen Lopez, Guillermo Larios, Steve Fan, Anders Franco-Cereceda, Bart Loeys, Salah A. Mohamed, Harry Dietz, Seema Mital, Gregor Andelfinger, Luc Mertens, Michael Grattan
Summary: Children with BAV have differences in vascular function that are confined to their proximal aorta, even in normal functioning BAV. The observed differences in vascular function are likely multi-factorial, with contributions from abnormal regional flow and a potential localized primary aortopathy.
CANADIAN JOURNAL OF CARDIOLOGY
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Myunghyun M. Lee, Luc Mertens
CIRCULATION-CARDIOVASCULAR IMAGING
(2022)
Article
Cardiac & Cardiovascular Systems
Koyelle Papneja, Zachary M. Blatman, Ian D. Kawpeng, Jacqueline Wheatley, Hanne Osce, Boning Li, Myriam Lafreniere-Roula, Chun P. S. Fan, Cedric Manlhiot, Lee N. Benson, Luc Mertens
Summary: This study found that left ventricular remodeling occurs mainly within the first 3 years in children with predominantly residual aortic insufficiency after balloon aortic valvuloplasty (BAV), with no subsequent significant functional changes over the medium term. These findings improve our understanding of expected patient trajectories and may inform decisions on the timing of reintervention.
CIRCULATION-CARDIOVASCULAR IMAGING
(2022)
Review
Cardiac & Cardiovascular Systems
Devin Chetan, Luc L. Mertens
Summary: Recent advancements in fetal imaging, including echocardiography and MRI, have provided new opportunities for the diagnosis and treatment of coarctation of the aorta. The size of the aortic arch is found to be more important than its shape for optimal hemodynamics. Long-term outcomes suggest a higher mortality risk in coarctation patients, emphasizing the need for preventive measures and aggressive treatment of hypertension and vascular stiffening. Additionally, timely neurocognitive evaluation and intervention are crucial for neonatal patients undergoing repair.
CURRENT OPINION IN CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Alejandro A. Floh, Shubhadeep Das, Maruti Haranal, Peter C. Laussen, Lynn Crawford-Lean, Chun-Po S. Fan, Luc L. Mertens, Kyle Runeckles, Osami Honjo
Summary: The use of Del Nido cardioplegia (DNc) during pediatric cardiopulmonary bypass (CPB) was not associated with an increase in reported systemic ventricle dysfunction (sVD). However, DNc may potentially impact right ventricular function.
Article
Cardiac & Cardiovascular Systems
Sofie Dannesbo, Elisabeth Blixenkrone-Moeller, Christian A. Pihl, Anne-Sophie Sillesen, Ruth O. Voegg, Agnes S. Davidsen, Louise E. Lind, Dorthe L. Jeppesen, Charlotte Kruse, Betina Noerager, James K. Dodd, Finn S. Jorgensen, Anna A. Raja, Steven D. Colan, Luc Mertens, Vibeke E. Hjortdal, Niels Vejlstrup, Robert H. Anderson, Henning Bundgaard, Kasper Iversen
Summary: This study developed a new classification algorithm for interatrial communications in newborns using echocardiographic criteria. The algorithm showed high interobserver and intraobserver agreement in distinguishing between patency of the oval foramen and atrial septal defects. This algorithm may be valuable for both research and clinical practice.
CARDIOLOGY IN THE YOUNG
(2023)
Article
Cardiac & Cardiovascular Systems
Kristian Sorensen, Solveig Fadnes, Luc Mertens, Matthew Henry, Patrick Segers, Lasse Lovstakken, Siri Ann Nyrnes
Summary: This study developed and validated the calculation of intraventricular pressure difference (IVPD) using blood speckle-tracking (BST) in children and investigated its potential role in assessing diastolic function. The results showed that BST is highly feasible and provides information on diastolic suction and early filling in children with heart disease. The IVPD was significantly reduced in children with dilated cardiomyopathies (DCMs) and hypertrophic cardiomyopathies (HCMs) compared to controls.
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
(2023)
Article
Neurosciences
Julien Aguet, Nikan Fakhari, Minh Nguyen, Luc Mertens, Elod Szabo, Birgit Ertl-Wagner, Lynn Crawford, Christoph Haller, David Barron, Jerome Baranger, Olivier Villemain
Summary: Newborns with congenital heart disease undergoing cardiac surgery are at risk of neurodevelopmental impairment. This study used ultrafast power Doppler to assess cerebral blood volume (CBV) variations in neonates with hypoplastic left heart syndrome during surgery. The results showed that global CBV did not differ significantly before and after surgery. However, regional differences in CBV were observed during hypothermia, and CBV was correlated with cardiopulmonary bypass (CPB) flow rate. Patients with higher CBV variation had brain injury on post-operative imaging. This suggests that the measurement of CBV using ultrafast power Doppler can optimize cerebral perfusion during neonatal cardiac surgery.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Cardiac & Cardiovascular Systems
Safwat Aly, Luc Mertens, Mark K. Friedberg, Andreea Dragulescu
Summary: After the Fontan operation, there is a progressive decrease in myocardial deformation parameters. The progressive decrease in SV torsion is related to a decrease in apical rotation, which is more pronounced in single RVs. Decreased torsion is associated with increased markers of myocardial fibrosis and lower maximal exercise capacity.
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
(2023)
Article
Cardiac & Cardiovascular Systems
Aimen Malik, Jerome Baranger, Minh Bao Nguyen, Cameron Slorach, Wei Hui, Jose Carlos Villalobos Lizardi, Maelys Venet, Mark K. Friedberg, Luc Mertens, Olivier Villemain
Summary: This study aims to determine the normal range of myocardial stiffness in healthy children and young adults using shear-wave elastography (SWE) and explore the impact of left ventricular geometric characteristics on SWE. The results show that diastolic myocardial stiffness increases linearly with age and has a weaker correlation with myocardial and left ventricular geometric characteristics.
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
(2023)
Article
Cardiac & Cardiovascular Systems
Yohei Akazawa, Tao Fujioka, Kana Yazaki, Martina Strbad, Juergen Hoerer, Andreas Kuehn, Wei Hui, Cameron Slorach, Christoph Roehlig, Luc Mertens, Bart H. Bijnens, Manfred Vogt, Mark K. Friedberg
Summary: A study published in the Journal of the American Society of Echocardiography showed that mechanical dyssynchrony in the right ventricle is associated with remodeling, dysfunction, and impaired exercise capacity in Ebstein anomaly patients. Therefore, mechanical dyssynchrony may be a therapeutic target in selected patients.
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
(2023)
Article
Cardiac & Cardiovascular Systems
Rahna Rasouli, Jerome Baranger, Cameron Slorach, Wei Hui, Maelys Venet, Minh B. Nguyen, Matthew Henry, Josh Gopaul, Paul C. Nathan, Luc Mertens, Olivier Villemain
Summary: This study assessed the effect of anthracycline treatment on arterial stiffness in childhood cancer survivors using ultrafast ultrasound imaging. The results showed that there was no significant difference in demographic parameters, blood biomarkers, cardiovascular parameters, or pulse wave velocity between the survivors and healthy controls. Therefore, anthracycline treatment did not have a significant impact on local arterial stiffness in the left common carotid artery.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Computer Science, Interdisciplinary Applications
Nikan Fakhari, Julien Aguet, Minh Nguyen, Luc Mertens, David Barron, Christoph Haller, John G. Sled, Olivier Villemain, Jeirome Baranger
Summary: In this study, the variations of cerebral blood volume (CBV) in human neonates during cardiac surgery were measured using Ultrafast Power Doppler and freehand scanning. The study found significant variations of CBV during bypass and demonstrated the clinical translation of ultrafast power Doppler with diverging-waves and freehand scanning.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2023)
Correction
Pediatrics
Yingping Deng, Xiang Cao, Luc L. L. Mertens, Patrick J. J. McNamara
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Article
Pediatrics
Yingping Deng, Xiang Cao, Luc L. Mertens, Patrick J. McNamara
Summary: This study investigated the attitudes, training, and accreditation regarding targeted neonatal echocardiography (TnEcho) among Chinese neonatologists. The survey revealed that 35.1% of respondents used TnEcho in their neonatal intensive care units (NICUs). Most respondents valued the role of TnEcho in providing timely and longitudinal hemodynamic information. However, the lack of experienced practitioners and accredited training programs were perceived as major barriers to implementation.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
