Article
Polymer Science
Prasong Srihanam, Wiriya Thongsomboon, Yodthong Baimark
Summary: The aim of this study was to modify PLLA-b-PEG-b-PLLA copolymer using low-cost CaCO3 filler to improve its material properties. The addition of CaCO3 enhanced the crystallinity and thermal stability of PLLA-b-PEG-b-PLLA matrix. SEM analysis showed stronger interfacial adhesion between PLLA-b-PEG-b-PLLA and CaCO3 compared to PLLA and CaCO3. Tensile testing revealed increased stress and modulus for PLLA-b-PEG-b-PLLA matrix with CaCO3, while these properties significantly decreased for PLLA matrix. Therefore, CaCO3 shows promise as an inexpensive filler for improving PLLA-b-PEG-b-PLLA bioplastics.
Article
Polymer Science
Prasong Srihanam, Yaowalak Srisuwan, Theeraphol Phromsopha, Apirada Manphae, Yodthong Baimark
Summary: In this study, the phase compatibility and mechanical properties of flexible poly(L-lactide)-b-poly(ethylene glycol)-b-poly(L-lactide) (PLLA-PEG-PLLA)/thermoplastic starch (TPS) blends were improved by adding citric acid (CA) as a compatibilizer. The crystallinity of PLLA-PEG-PLLA matrix was suppressed and the thermal stability was enhanced by CA modification of TPS. The compatibility between TPS and PLLA-PEG-PLLA phases was improved, and the blends exhibited increased tensile strength, elongation at break, and Young's modulus with higher CA content.
Article
Biochemistry & Molecular Biology
Yulia A. Kadina, Ekaterina V. Razuvaeva, Dmitry R. Streltsov, Nikita G. Sedush, Eleonora V. Shtykova, Alevtina I. Kulebyakina, Alexander A. Puchkov, Dmitry S. Volkov, Alexey A. Nazarov, Sergei N. Chvalun
Summary: Nanoparticles based on biocompatible mPEG(113)-b-P(D,L)LA(n) copolymers were prepared for the delivery of the anticancer agent oxaliplatin via a nanoprecipitation technique. It was found that an increase in the hydrophobic PLA block length resulted in larger nanoparticle size and decreased oxaliplatin loading content.
Article
Chemistry, Multidisciplinary
Ekkachai Martwong, Yvette Tran
Summary: The study reports on the synthesis and temperature-responsive properties of poly(PEGMA) hydrogel thin films. Surface-attached poly(PEGMA) hydrogel films were synthesized using a simple, versatile, and well-controlled thiol-ene click reaction method, with the transition temperature finely tunable by adjusting the number of PEG units. The LCST properties of the hydrogel films are not sensitive to salt, holding promise for applications in biology such as injectable hydrogels, drug delivery systems, microfluidic valves, and flow switches for biotechnologies.
Article
Pharmacology & Pharmacy
Xiangjun Meng, Zhi Zhang, Jin Tong, Hui Sun, John Paul Fawcett, Jingkai Gu
Summary: The in vivo fate of PEG-PLA was investigated in rats, showing that PEG-PLA is mainly excreted in urine as its PEG metabolite. This will help facilitate the scientific design and safety evaluation of PEG-PLA-based nanocarrier drug delivery systems.
ACTA PHARMACEUTICA SINICA B
(2021)
Article
Polymer Science
Balakondareddy Sana, Nancy Ferrentino, Taha Behroozi Kohlan, Yaqun Liu, Valdas Pasiskevicius, Anna Finne-Wistrand, Daniela Pappalardo
Summary: We have designed a light-sensitive polymer material that self-assembles into core-shell nanoparticles and releases encapsulated fluorescent dye upon light irradiation.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Chemistry, Physical
Yuanchao Pei, Wanjun Zhang, Yaxin Zhang, Jie Ma, Yang Zhao, Zhiyong Li, Jianji Wang, Ran Du
Summary: The design of thermal-responsive functional ionic liquids that can respond reversibly remains a challenge for the construction of smart systems. This study prepared a series of PEGylated ionic liquids and characterized their structures and thermal properties. The physicochemical properties, including density and viscosity, were measured and modeled. The results showed that these PEGylated ionic liquids exhibited good surface activity and low critical solution temperature phase behavior. The interaction between the ionic liquids and water molecules was analyzed to understand the mechanism of thermal-induced phase separation. This study provides valuable information for designing new thermoresponsive ionic liquids and their applications.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Engineering, Chemical
Mun Suk Seong, Hyun Jung Yu, Seong Yong Ha, Won Seok Chang, Hyung-Ju Kim, Jong Suk Lee
Summary: In this study, highly CO2-permeable membranes were obtained by blending micellar-structured poly(poly(ethylene glycol) methyl ether acrylate) (PPEGMEA) with poly(ether-block-amide) (Pebax). The blend membrane showed a significant enhancement in CO2 permeability while maintaining good CO2 selectivity and long-term separation performance.
JOURNAL OF MEMBRANE SCIENCE
(2022)
Article
Polymer Science
Ekaterina V. Kuznetsova, Nikita G. Sedush, Yulia A. Puchkova, Sergei V. Aleshin, Evgeny V. Yastremsky, Alexey A. Nazarov, Sergei N. Chvalun
Summary: In this study, stable and narrowly distributed polymeric nanoparticles based on biodegradable copolymers were prepared using a simple emulsion method. The aggregation behavior of the nanoparticles was found to be dependent on the hydrophobic block length of the copolymers. Docetaxel-loaded nanoparticles exhibited high stability and sustained release of the drug, with the release rate decreasing with increasing hydrophobic block length. The DTX-loaded P(D,L)LA(1230)-b-PEG(113) nanoparticles showed better anticancer performance compared to free DTX, and favorable freeze-drying conditions were established for the nanoparticles.
Article
Polymer Science
Huifang Xie, Xin Ma, Wenbin Lin, Shiting Dong, Qiang Liu, Yi Chen, Qunyu Gao
Summary: Linear dextrin (LD) was successfully prepared from waxy potato starch, and various LD products were separated based on their solubility. The formation of inclusion complexes between LD and insulin was analyzed using FT-IR, XRD, and CD, revealing that F-M-INS complexes had the best release effects.
Article
Chemistry, Physical
Mucahit Yilmaz, Mustafa Ersin Pekdemir, Ecem Ozen Oner
Summary: In this study, composites with shape memory properties were prepared by blending a polymer with lead element. The thermal stability of the polymer blend decreased with increasing lead percentage. The best shape memory properties were observed in the polymer blend containing 4% lead. The XRD results showed the characteristic cubic shape of lead in the composites. The highest degree of crystallinity was found in the polymer blend composite containing 16% lead. The gamma irradiation experiment demonstrated that the linear absorption capacity increased with increasing lead percentage.
RADIATION PHYSICS AND CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Irina M. Le-Deygen, Oxana E. Musatova, Victor N. Orlov, Nikolay S. Melik-Nubarov, Irina D. Grozdova
Summary: This study provides the first evidence of the interaction between PEG and HA in aqueous solutions. The binding of PEG to HA requires multiple free primary hydroxyls regularly distributed along the polysaccharide chain. Additionally, PEG-induced compaction of HA may be related to changes in plasma membrane properties and resealing of mechanical injuries.
Article
Thermodynamics
Kanika Bhakri, Nabaparna Chakraborty, K. C. Juglan, Harsh Kumar, Ravinder Sharma
Summary: The study examines the interlinkage between ethylene glycol (EG), diethylene glycol (DEG) and triethylene glycol (TEG) in aqueous gluconolactone mixtures using volumetric and acoustic approaches. The densities and sound velocity of ternary mixes of (water + gluconolactone + EG/DEG/TEG) were measured at different gluconolactone concentrations and temperatures. Various volumetric and acoustic properties, as well as pair-triplet interaction coefficients, were calculated to understand the mixture interactions and the structure-making/structure-breaking tendency of glycols in aqueous gluconolactone solutions.
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
(2023)
Article
Environmental Sciences
Hua Li, Yafei Duan, Hongbiao Dong, Jiasong Zhang
Summary: Immobilized microorganisms technology using a porous membrane composed of poly (lactic acid) (PLA) and poly (ethylene glycol) (PEG) has been investigated for wastewater treatment. The optimization of the membrane formulation was determined based on the morphology, mechanical properties, nitrate permeability, and biodegradability of the plane membranes. The encapsulation of denitrifying bacteria in the spherical membrane showed good denitrification performance in synthetic wastewater, with a high nitrate removal rate achieved in a short start-up time.
ENVIRONMENTAL TECHNOLOGY
(2023)
Article
Polymer Science
Johnel Giliomee, Lisa C. du Toit, Pradeep Kumar, Bert Klumperman, Yahya E. Choonara
Summary: The study focused on investigating the effects of crosslinking and concentration on a new library of low-concentration poly(Lys(60)-ran-Ala(40))-based hydrogels for potential wound healing applications. Controlled ring-opening polymerization (ROP) and precise hydrogel compositions were used to customize the physicochemical and biofunctional properties of the hydrogels, resulting in a desirable combination of properties for wound healing application.
Article
Pharmacology & Pharmacy
Natassa Pippa, Demetrios D. Chronopoulos, Dimitris Stellas, Rodrigo Fernandez-Pacheco, Raul Arenal, Costas Demetzos, Nikos Tagmatarchis
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2017)
Article
Pharmacology & Pharmacy
Konstantinos Gardikis, Marco Signorelli, Chiara Ferrario, Alberto Schiraldi, Maria Grazia Fortina, Sophia Hatziantoniou, Costas Demetzos, Dimitrios Fessasa
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2017)
Review
Biochemistry & Molecular Biology
Maria Chountoulesi, Nikolaos Naziris, Natassa Pippa, Costas Demetzos
JOURNAL OF LIPOSOME RESEARCH
(2018)
Article
Chemistry, Multidisciplinary
Natassa Pippa, Anastasia Meristoudi, Stergios Pispas, Costas Demetzos
JOURNAL OF NANOPARTICLE RESEARCH
(2017)
Article
Chemistry, Multidisciplinary
Natassa Pippa, Gregory Mountrichas, Stergios Pispas, Costas Demetzos, Gregory Sivolapenko
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
(2017)
Article
Thermodynamics
Aimilia Kyrili, Maria Chountoulesi, Natassa Pippa, Anastasia Meristoudi, Stergios Pispas, Costas Demetzos
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
(2017)
Article
Biochemistry & Molecular Biology
Papageorgiou Foteini, Natassa Pippa, Nikolaos Naziris, Costas Demetzos
JOURNAL OF LIPOSOME RESEARCH
(2019)
Article
Biochemistry & Molecular Biology
Natassa Pippa, Athanasios Skouras, Nikolaos Naziris, Francesca Biondo, Mattia Tiboni, Hector Katifelis, Maria Gazouli, Costas Demetzos, Luca Casettari
JOURNAL OF LIPOSOME RESEARCH
(2020)
Article
Biochemistry & Molecular Biology
Lydia Chatzinikoli, Natassa Pippa, Costas Demetzos
Summary: Elastic liposomes, composed of phospholipids and surfactants, are considered promising nanotechnological platforms for skin drug delivery. Physical stability studies show that elastic liposomes are more stable at low temperatures and prone to aggregation at high temperatures.
JOURNAL OF LIPOSOME RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Efstathia Triantafyllopoulou, Natassa Pippa, Costas Demetzos
Summary: This study examines the interactions between serum proteins and liposomes, specifically focusing on the role of surface charge and bilayer fluidity in protein corona formation. The results indicate that PEGylation plays a key role in reducing protein binding and potential toxicity.
JOURNAL OF LIPOSOME RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Katerina Xekouki, Nefeli Lagopati, Costas Demetzos, Maria Gazouli, Natassa Pippa
Summary: Nanovaccines based on lipids have been proven to be effective and preferred over conventional vaccines. This review focuses on describing the role, mechanisms, and advantages of nano vaccines, particularly liposomal nano vaccines and virus-lipid nanoparticles/virosomes. The physicochemical characteristics of these vaccines and their impact on the immune response and mechanism of action are also discussed.
JOURNAL OF LIPOSOME RESEARCH
(2023)