Article
Medicine, General & Internal
Alexia Polillo, George Foussias, Wei Wang, Aristotle N. Voineskos, Jacqueline Veras, Nicole Davis-Faroque, Albert H. C. Wong, Nicole Kozloff
Summary: This retrospective cohort study shows disparities in referral pathways and initial engagement in early psychosis intervention (EPI) services. Improving access to EPI services may facilitate recovery among youths and young adults with psychosis.
Article
Psychiatry
Michael Groff, Eric Latimer, Ridha Joober, Srividya N. Iyer, Norbert Schmitz, Sherezad Abadi, Amal Abdel-Baki, Nicola Casacalenda, Howard C. Margolese, G. Eric Jarvis, Ashok Malla
Summary: Cost-effectiveness study found that extending early intervention services (EIS) for psychosis may be more cost-effective for patients with a duration of untreated psychosis (DUP) of 12 weeks or less.
SCHIZOPHRENIA BULLETIN
(2021)
Article
Psychiatry
Sally S. Mustafa, Ashok Malla, Ridha Joober, Sherezad Abadi, Eric Latimer, Norbert Schmitz, G. Eric Jarvis, Howard C. Margolese, Nicola Casacalenda, Amal Abdel-Baki, Srividya N. Iyer
Summary: The study found that there was no significant difference in functional recovery between patients receiving extended early intervention or regular care after 2 years of early psychosis intervention. Longer periods of symptom remission and high school completion were positively associated with functional recovery, but one-third of patients were still unemployed or not in school at year 5. The lack of additional progress even in extended early intervention suggests the need for specific interventions targeting functional roles beyond the initial 2-year period.
ACTA PSYCHIATRICA SCANDINAVICA
(2022)
Article
Medicine, General & Internal
Armanda Freixo, Cecilia Abreu
Summary: Systemic sclerosis is a chronic and rare disease characterized by microcirculatory and immune alterations leading to fibrosis. Early diagnosis is crucial, and Raynaud's phenomenon and puffy fingers serve as red flags for referral to rheumatology.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Review
Psychology, Developmental
Anna Sunshine, Jon McClellan
Summary: Psychotic symptoms, such as hallucinations, delusions, and disorganized thinking and behaviors, are characteristic of schizophrenia but can occur in other psychiatric and medical conditions. Many children and adolescents experience psychotic-like symptoms, which may be linked to other psychopathology and past experiences. However, most youth reporting such symptoms do not have or develop schizophrenia or another psychotic disorder. Accurate assessment is crucial as different presentations have different diagnostic and treatment implications. This review focuses on the diagnosis and treatment of early onset schizophrenia, as well as the development of community-based first-episode psychosis programs and the importance of early intervention and coordinated care.
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
(2023)
Review
Medicine, General & Internal
Tomoyuki Hioki, Mayumi Komine, Mamitaro Ohtsuki
Summary: Psoriatic arthritis is a chronic inflammatory disorder that can cause deformities and joint damage, impacting quality of life. Early diagnosis and intervention are important to prevent permanent disability, but the clinical features overlap with other diseases, making early detection and intervention challenging.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Psychiatry
Julie Ramain, Philippe Conus, Philippe Golay
Summary: Affective psychoses share similarities in terms of sociodemographic variables, symptom progression, and outcomes, suggesting they can be grouped together for treatment strategies.
PSYCHIATRY RESEARCH
(2022)
Article
Health Care Sciences & Services
Laoise Renwick, Caitlin McWilliams, Olivia Schaff, Laura Russell, Susan Ramsdale, Rebecca Lauren Morris
Summary: This study used a robust, democratic process to determine the top priorities for research into early intervention in psychosis. The consensus was reached on 10 priority questions, which largely focused on access and engagement, information needs, and the influence of service-user priorities and beliefs on treatment choices and effectiveness. The study found that the priorities of service users, carers and healthcare professionals were aligned with researchers' and funders' priorities in some areas but misaligned in others.
HEALTH EXPECTATIONS
(2022)
Article
Medicine, General & Internal
Rozemarijn van der Gulden, Angelique A. Timmerman, Margaretha H. Sagasser, Anneke Kramer, Nynke Scherpbier-de Haan, Bart Thoonen, Sylvia Heeneman
Summary: This study explored the use of portfolios in supporting self-regulated learning during general practitioner specialty training. The findings showed that portfolio use did not effectively support self-regulated learning in this context, primarily due to conflicts arising from the dual purpose of portfolios for both learning and assessment.
Article
Clinical Neurology
Raphael O. Cerqueira, Carolina Ziebold, Daniel Cavalcante, Giovany Oliveira, Javiera Vasquez, Juan Undurraga, Alfonso Gonzalez-Valderrama, Ruben Nachar, Carlos Lopez-Jaramillo, Cristiano Noto, Nicolas Crossley, Ary Gadelha
Summary: This study compares patients with affective and non-affective psychosis (A-FEP and NA-FEP) in a Latin American sample. The findings suggest that characteristics of FEP patients could be utilized to enhance diagnosis and inform treatment decisions.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Multidisciplinary Sciences
Isaraporn Thepwongsa, Radhakrishnan Muthukumar, Poompong Sripa, Leon Piterman
Summary: Despite the availability of continuing medical education (CME) programmes on evidence-based diabetes care, there is still a lack of evidence-based best practice in actual GP practice. This study examined the uptake of online diabetes CME and its impact on GPs' attitudes and knowledge of Type 2 diabetes management. The findings highlight the need for mandatory CME to bridge the gap between evidence-based practice and actual GP practice.
Article
Computer Science, Artificial Intelligence
Fei Wang, Qi Liu, Enhong Chen, Zhenya Huang, Yu Yin, Shijin Wang, Yu Su
Summary: Cognitive diagnosis is widely applicable in scenarios where users' cognitive states need to be assessed. In this article, a general Neural Cognitive Diagnosis (NeuralCD) framework is proposed, which incorporates neural networks to learn the complex exercising interactions. Extensive experimental results show the effectiveness of NeuralCD framework with both accuracy and interpretability.
IEEE TRANSACTIONS ON KNOWLEDGE AND DATA ENGINEERING
(2023)
Article
Psychiatry
Vinod H. Srihari, Matcheri S. Keshavan
Summary: This article provides a conceptual history of modern early intervention services and briefly reviews the accomplishments of an international clinical and research community. It also offers proposals for how such services can participate in the next generation of progress, emphasizing the importance of bi-directional knowledge translation across basic, clinical, and policy domains.
SCHIZOPHRENIA BULLETIN
(2022)
Article
Psychiatry
Merle Schlief, Nathalie Rich, Luke Sheridan Rains, Helen Baldwin, Antonio Rojas-Garcia, Patrick Nyikavaranda, Karen Persaud, Ceri Dare, Paul French, Brynmor Lloyd-Evans, Mike Crawford, Jo Smith, James B. Kirkbride, Sonia Johnson
Summary: There is evidence of disparities in the provision of psychosis care among different ethnicities. This study investigated the variations in the receipt of Cognitive Behavioural Therapy for psychosis and family intervention among ethnic groups in Early Intervention in Psychosis teams in England. The results showed pervasive inequalities in receiving these interventions for almost all minoritized ethnic groups, highlighting the need for further research.
PSYCHIATRY RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Ignacio Sierra, Norberto Diaz-Diaz, Carlos Barranco, Rocio Carrasco-Villalon
Summary: This study aims to explore the application of artificial intelligence in early care, assisting with children's diagnosis and therapy allocation. By using various machine learning techniques on real data, the comparison with traditional diagnosis will be evaluated.
APPLIED SCIENCES-BASEL
(2022)
Review
Psychology, Clinical
San Lee, Keum Hwa Lee, Kyung Mee Park, Sung Jong Park, Won Jae Kim, Jinhee Lee, Andreas Kronbichler, Lee Smith, Marco Solmi, Brendon Stubbs, Ai Koyanagi, Louis Jacob, Andrew Stickley, Trevor Thompson, Elena Dragioti, Hans Oh, Andre R. Brunoni, Andre F. Carvalho, Joaquim Radua, Suk Kyoon An, Kee Namkoong, Eun Lee, Jae Il Shin, Paolo Fusar-Poli
Summary: Errors in data extraction may account for discrepancies in previous meta-analyses on the association between depression and inflammatory biomarkers.
PSYCHOLOGICAL MEDICINE
(2023)
Review
Psychology, Developmental
Gonzalo Salazar de Pablo, Carolina Pastor Jorda, Julio Vaquerizo-Serrano, Carmen Moreno, Anna Cabras, Celso Arango, Patricia Hernandez, Jeremy Veenstra-VanderWeele, Emily Simonoff, Paolo Fusar-Poli, Paramala Santosh, Samuele Cortese, Mara Parellada
Summary: This meta-analysis found that antipsychotics and medications used to treat ADHD were significantly better than placebo in improving emotional dysregulation and irritability in individuals with ASD. Specifically, risperidone and aripiprazole showed efficacy in short-term treatment. However, other drug classes did not show evidence of efficacy. Lower efficacy was associated with comorbid epilepsy.
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2023)
Article
Psychology, Clinical
Ana Catalan, Claudia Aymerich, Amaia Bilbao, Borja Pedruzo, Jose Luis Perez, Nerea Aranguren, Gonzalo Salazar de Pablo, Emily Hedges, Patxi Gil, Rafael Segarra, Ana Gonzalez-Pinto, Aranzazu Fernandez-Rivas, Lucia Inchausti, Philip McGuire, Paolo Fusar-Poli, Miguel Angel Gonzalez-Torres
Summary: COVID-19-related mortality and hospitalization rates were higher for patients with pre-existing psychotic disorders, while patients with affective disorders had lower rates.
PSYCHOLOGICAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Marco Solmi, Giovanni Croatto, Giada Piva, Stella Rosson, Paolo Fusar-Poli, Jose M. Rubio, Andre F. Carvalho, Eduard Vieta, Celso Arango, Nicole R. DeTore, Elizabeth S. Eberlin, Kim T. Mueser, Christoph U. Correll
Summary: Psychosocial interventions play an important role in schizophrenia and early psychosis. However, the literature on this topic is heterogeneous and contradictory. This umbrella review summarizes the findings from multiple meta-analyses comparing the effectiveness of different psychosocial interventions with standard treatment or other active interventions. The results suggest that early intervention services and cognitive behavioral therapy have significant effects on symptom reduction and functional improvement in early psychosis. For schizophrenia patients, cognitive behavioral therapy, psychoeducation, and any family interventions show positive effects on symptom reduction, relapse prevention, and functional improvement.
MOLECULAR PSYCHIATRY
(2023)
Review
Psychiatry
Rayanne John-Baptiste Bastien, Tao Ding, Alfonso Gonzalez-Valderrama, Lucia Valmaggia, James B. Kirkbride, Hannah E. Jongsma
Summary: There is a lack of reliable evidence on the incidence of non-affective psychotic disorders in low and middle-income countries (LMICs). A new, more equitable global mental health evidence base is urgently needed.
SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY
(2023)
Article
Psychology, Developmental
Lucy Adams, Nicoletta Adamo, Matthew J. Hollocks, Jennifer Watson, Aylana Brewster, Lucia Valmaggia, Emma Jewitt, Jodie Edwards, Maisie Krisson, Emily Simonoff
Summary: Remote psychological interventions have both challenges and benefits for individuals with autism spectrum disorder. A study interviewed autistic individuals and clinicians, finding that there are barriers and challenges to remote delivery, but also potential benefits for some individuals. Most participants supported the provision of hybrid delivery post-pandemic.
Article
Endocrinology & Metabolism
Giovanna Nordio, Rubaida Easmin, Alessio Giacomel, Ottavia Dipasquale, Daniel Martins, Steven Williams, Federico Turkheimer, Oliver Howes, Mattia Veronese, Sameer Jauhar, Maria Rogdaki, Robert McCutcheon, Stephen Kaar, Luke Vano, Grazia Rutigliano, Ilinca Angelescu, Faith Borgan, Enrico D'Ambrosio, Tarik Dahoun, Euitae Kim, Seoyoung Kim, Micheal Bloomfield, Alice Egerton, Arsime Demjaha, Ilaria Bonoldi, Chiara Nosarti, James Maccabe, Philip McGuire, Julian Matthews, Peter S. Talbot
Summary: In this study, a fully automated analytical framework for FDOPA PET neuroimaging data was evaluated. The framework showed good reproducibility and sensitivity to demographic and experimental variables. It represents an effective resource for standardized and robust quantification of dopamine synthesis capacity using FDOPA PET data.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Kate Merritt, Robert McCutcheon, Andre Aleman, Sarah Ashley, Katherine Beck, Wolfgang Block, Oswald J. N. Bloemen, Faith Borgan, Christiana Boules, Juan R. Bustillo, Aristides Capizzano, Jennifer Q. Coughlin, Anthony David, Camilo de la Fuente-Sandoval, Arsime Demjaha, Kara Dempster, Kim Do, Fei E. Du, Peter Falkai, Beata Galinska-Skok, Juergen Gallinat, Charles Gasparovic, Cedric E. Ginestet, Naoki Goto, Ariel Graff-Guerrero, Beng-Choon Ho, Oliver Howes, Sameer Jauhar, Peter Jeon, Tadafumi Kato, Charles A. Kaufmann, Lawrence S. Kegeles, Matcheri S. Keshavan, Sang-Young Kim, Bridget King, Hiroshi Kunugi, J. Lauriello, Pablo Leon-Ortiz, Edith Liemburg, Meghan Mcilwain, Gemma Modinos, Elias Mouchlianitis, Jun Nakamura, Igor Nenadic, Dost Ongur, Miho Ota, Lena E. Palaniyappan, Christos Pantelis, Tulsi F. Patel, Eric Plitman, Sotirios R. Posporelis, Scot Purdon, Juergen R. Reichenbach, Perry C. Renshaw, Francisco Reyes-Madrigal, Bruce A. Russell, Akira Sawa, Martin Schaefer, Dikoma C. Shungu, Stefan Smesny, Jeffrey Stanley, James G. Stone, Agata Szulc, Reggie Taylor, Katharine N. Thakkar, Jean J. Theberge, Philip Tibbo, Therese van Amelsvoort, Jerzy Walecki, Peter Williamson, Stephen Wood, Lijing Xin, Hidenori Yamasue, Philip K. McGuire, Alice Egerton
Summary: This study conducted meta-analyses and found that patients with schizophrenia have greater variability in glutamate metabolites compared to controls in various brain regions, and age and symptoms also influence individual variability.
MOLECULAR PSYCHIATRY
(2023)
Review
Clinical Neurology
Fiona Coutts, Nikolaos Koutsouleris, Philip McGuire
Summary: Precision psychiatry is an approach that aims to stratify individuals with psychotic disorders according to different clinical outcomes and tailor treatment to their individual needs. Currently, it is difficult to predict interindividual differences in outcomes of psychotic disorders solely on the basis of clinical assessment. Therefore, current research focuses on building models that integrate clinical information with a range of biological measures to predict outcomes.
NATURE REVIEWS NEUROLOGY
(2023)
Article
Multidisciplinary Sciences
Andre Zugman, Luz Maria Alliende, Vicente Medel, Richard A. I. Bethlehem, Jakob Seidlitz, Grace Ringlein, Celso Arango, Aurina Arnatkeviciute, Laila Asmal, Mark Bellgrove, Vivek Benegal, Miquel Bernardo, Pablo Billeke, Jorge Bosch-Bayard, Rodrigo Bressan, Geraldo F. Busatto, Mariana N. Castro, Tiffany Chaim-Avancini, Albert Compte, Monise Costanzi, Leticia Czepielewski, Paola Dazzan, Camilo de la Fuente-Sandoval, Marta Di Forti, Covadonga M. Diaz-Caneja, Ana Maria Diaz-Zuluaga, Stefan Du Plessis, Fabio L. S. Duran, Sol Fittipaldi, Alex Fornito, Nelson B. Freimer, Ary Gadelha, Clarissa S. Gama, Ranjini Garani, Clemente Garcia-Rizo, Cecilia Gonzalez Campo, Alfonso Gonzalez-Valderrama, Salvador Guinjoan, Bharath Holla, Agustin Ibanez, Daniza Ivanovic, Andrea Jackowski, Pablo Leon-Ortiz, Christine Lochner, Carlos Lopez-Jaramillo, Hilmar Luckhoff, Raffael Massuda, Philip McGuire, Jun Miyataaaa, Romina Mizrahi, Robin Murray, Aysegul Ozerdem, Pedro M. Pan, Mara Parellada, Lebogan Phahladira, Juan P. Ramirez-Mahalu, Ramiro Reckziegel, Tiago Reis Marques, Francisco Reyes-Madrigal, Annerine Roos, Pedro Rosa, Giovanni Salum, Freda Scheffler, Gunter Schumann, Mauricio Serpa, Dan J. Stein, Angeles Tepper, Jeggan Tiego, Tsukasa Ueno, Juan Undurraga, Eduardo A. Undurrag, Pedro Valdes-Sosaooo, Isabel Valliy, Mirta Villarrealu, Toby T. Winton-Brownrrr, Nefize Yalin, Francisco Zamorano, Marcus V. Zanetti, Anderson M. Winkler, Daniel S. Pine, Sara Evans-Lacko, Nicolas A. Crossley
Summary: Gender inequality has been linked to higher mental health risks and lower academic achievement for women globally. Differences in brain structure between men and women may be partially explained by unequal exposure to harsher conditions in gender-unequal countries, leading to worse outcomes for women. A meta-analysis of MRI scans from 139 samples across 29 countries revealed that women in gender-equal countries had no differences or even thicker cortical regions, while those in countries with greater gender inequality had thinner cortices. These findings highlight the potential negative impact of gender inequality on women's brains and the need for policies based on neuroscience for gender equality.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Clinical Neurology
Lucy A. Chester, Lucia R. Valmaggia, Matthew J. Kempton, Edward Chesney, Dominic Oliver, Emily P. Hedges, Elise Klatsa, Daniel Stahl, Mark van der Gaag, Lieuwe de Haan, Barnaby Nelson, Patrick McGorry, G. Paul Amminger, Anita Riecher-Rossler, Erich Studerus, Rodrigo Bressan, Neus Barrantes-Vidal, Marie-Odile Krebs, Birte Glenthoj, Merete Nordentoft, Stephan Ruhrmann, Gabriele Sachs, Philip McGuire
Summary: The aim of this study was to investigate the association between cannabis use and the incidence of psychotic disorders in individuals at clinical high risk of psychosis. The results showed no significant association between cannabis use and the transition to psychosis, persistence of symptoms, or functional outcome.
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2023)
Review
Psychology, Clinical
Simon Riches, Lawson Taylor, Priyanga Jeyarajaguru, Wim Veling, Lucia Valmaggia
Summary: This systematic review evaluates the feasibility, acceptability, and effectiveness of immersive technologies in promoting workplace wellbeing. The findings show that immersive VR environments can provide relaxation and stress reduction experiences that are helpful for workplaces, but more long-term data and controlled trials are needed to support the conclusions.
JOURNAL OF MENTAL HEALTH
(2023)
Article
Psychiatry
Simon Riches, Sarah L. Nicholson, Carolina Fialho, Jordan Little, Lava Ahmed, Harley Mcintosh, Ina Kaleva, Tom Sandford, Rebecca Cockburn, Clarissa Odoi, Lisa Azevedo, Ruxandra Vasile, James Payne -Gill, Helen L. Fisher, Catheleine van Driel, Wim Veling, Lucia Valmaggia, Freya Rumball
Summary: This study investigated the feasibility and acceptability of integrating a virtual reality relaxation clinic within acute psychiatric services. The findings suggest that virtual reality relaxation sessions can effectively reduce stress and improve psychological well-being for patients with acute psychiatric conditions. Furthermore, the implementation of virtual reality also resulted in a significant decrease in violent incidents and restrictive practices.
PSYCHIATRY RESEARCH
(2023)
Article
Nutrition & Dietetics
Sevgi Bektas, Ludovica Natali, Katie Rowlands, Lucia Valmaggia, Jerome Di Pietro, Hiba Mutwalli, Hubertus Himmerich, Janet Treasure, Valentina Cardi
Summary: The emotion of disgust plays a critical role in maintaining restrictive eating among individuals with anorexia nervosa. This study found that both food-specific trait and state disgust are associated with eating disorder psychopathology. Effective strategies are needed to attenuate food-specific disgust.
Article
Psychiatry
Maria Chiara Del Piccolo, Lucia Valmaggia, Claire Henderson, Tom J. Spencer, David Lewis, Sharon Fitzell, Sara Edwards, Carys Evans, Stefania Tognin
Summary: This study assessed the feasibility of implementing Individual Placement and Support (IPS) with a focus on educational and employment goals within a clinical service for individuals at clinical high risk (CHR) of psychosis. The findings suggest that IPS implementation within a CHR clinical team is feasible and may be a beneficial intervention for young people at CHR. Longer follow-up is needed to assess its impact on educational outcomes.
PSYCHIATRIC REHABILITATION JOURNAL
(2023)
