Review
Psychology, Clinical
Nathalia Garrido-Torres, Idalino Rocha-Gonzalez, Luis Alameda, Aurora Rodriguez-Gangoso, Ana Vilches, Manuel Canal-Rivero, Benedicto Crespo-Facorro, Miguel Ruiz-Veguilla
Summary: Research on drug-naive first-episode of psychosis patients showed a higher prevalence of metabolic syndrome, suggesting cardiovascular risk is underestimated in this population and not solely due to antipsychotic treatments. The study also highlighted the significant impact of ethnicity on metabolic parameters in psychosis patients.
PSYCHOLOGICAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Cornelia Larsson, Maria Lee, Tobias Lundgren, Sophie Erhardt, Carl M. Sellgren, Simon Cervenka, Jacqueline Borg, Sven Bolte, Helena Fatouros-Bergman
Summary: This study aimed to investigate whether individuals with first-episode psychosis (FEP) who are either antipsychotic drug-naive or briefly medicated have impaired facial affect recognition (FAR) compared to control participants, as well as whether psychotic symptoms are associated with FAR ability.
Article
Psychology, Clinical
Akiah Ottesen, W. T. Hegelstad, Inge Joa, Stein E. Opjordsmoen, Bjorn Rishovd Rund, Jan Ivar Rossberg, Erik Simonsen, Jan Olav Johannessen, Tor K. Larsen, Ulrik Helt Haahr, Thomas H. McGlashan, Svein Friis, Ingrid Melle
Summary: This longitudinal study compares symptom trajectories and remission in first-episode psychosis (FEP) with and without a history of childhood interpersonal trauma (CIT) over the first 2 years of treatment. The results indicate that antipsychotic medication is equally beneficial in achieving symptomatic remission, regardless of CIT. However, FEP patients with CIT experience more severe positive, depressive, and excited symptoms throughout the disease.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Fernanda Talarico, Gabriela Xavier, Vanessa Kiyomi Ota, Leticia M. Spindola, Pawan Kumar Maurya, Priscila Farias Tempaku, Patricia S. Moretti, Ary Gadelha, Mariane Noto, Cristiano Noto, Quirino Cordeiro, Rodrigo A. Bressan, Simone de Jong, Marcos L. Santoro, Gerome Breen, Sintia Belangero
Summary: Schizophrenia patients show altered DNA methylation age (DMA) and longer relative telomere length (RTL), indicating a decelerated aging process. However, no significant association was found between these aging markers and treatment response in antipsychotic-naive patients.
PSYCHONEUROENDOCRINOLOGY
(2021)
Article
Psychology, Clinical
Alex G. Segura, Gisela Mezquida, Albert Martinez-Pinteno, Patricia Gasso, Natalia Rodriguez, Lucia Moreno-Izco, Silvia Amoretti, Miquel Bioque, Antonio Lobo, Ana Gonzalez-Pinto, Alicia Garcia-Alcon, Alexandra Roldan-Bejarano, Eduard Vieta, Elena de la Serna, Alba Toll, Manuel J. Cuesta, Sergi Mas, Miquel Bernardo
Summary: Early intervention is crucial for preventing the progression of psychotic disorders. This study found that genetic susceptibility related to cognitive performance is associated with an increased risk of first-episode psychosis (FEP) and its clinical and cognitive progression. Additionally, genetic susceptibility for depression is associated with a worsening trajectory of executive function and general cognitive status.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Leah M. Fleming, Ann Catherine Lemonde, David Benrimoh, James M. Gold, Jane R. Taylor, Ashok Malla, Ridha Joober, Srividya N. Iyer, Martin Lepage, Jai Shah, Philip R. Corlett
Summary: Psychotic disorders are highly heterogeneous, and understanding the relationships between symptoms is crucial for understanding their underlying mechanisms. This study used dimensionality-reduction methods to analyze two unique samples and characterize the patterns of symptom organization. The results revealed clusters of disorganization symptoms, hallucinations/delusions, and negative symptoms, with specific themes and content sometimes co-occurring and sometimes not. These findings have important implications for treatment and research on the neurocomputational and pathophysiological mechanisms underlying delusions and hallucinations.
SCIENTIFIC REPORTS
(2023)
Article
Biology
Asael Lubotzky, Ilana Pelov, Ronen Teplitz, Daniel Neiman, Adama Smadja, Hai Zemmour, Sheina Piyanzin, Bracha-Lea Ochana, Kirsty L. Spalding, Benjamin Glaser, Ruth Shemer, Yuval Dor, Yoav Kohn
Summary: This study found significantly elevated levels of brain-derived cfDNA in the plasma of patients with a first psychotic episode, suggesting the potential use of brain-specific cfDNA methylation markers in early detection and monitoring of schizophrenia.
Review
Psychiatry
Julie Ramain, Philippe Conus, Philippe Golay
Summary: This study aimed to consolidate current knowledge on first-episode affective psychoses and identify areas for further investigation. The results showed heterogeneity in diagnosis-related grouping under the concept of affective psychoses, indicating a need for specialized intervention for patients with different psychopathological and neurocognitive profiles.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Psychiatry
TianHong Zhang, LiHua Xu, YanYan Wei, XiaoChen Tang, YeGang Hu, HuiRu Cui, YingYing Tang, Bin Xie, ChunBo Li, JiJun Wang
Summary: This study compared the effects of initiating antipsychotic drugs treatment in the clinical high risk of psychosis phase and the first episode of psychosis phase on symptomatic and functional outcomes after 2 years. It was found that initiating antipsychotic drugs treatment in the clinical high risk of psychosis phase may not be the preferred choice for long-term remission.
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
(2021)
Review
Medicine, General & Internal
Antonio Melillo, Edoardo Caporusso, Giulia Maria Giordano, Luigi Giuliani, Pasquale Pezzella, Andrea Perrottelli, Paola Bucci, Armida Mucci, Silvana Galderisi, Jean-Arthur Micoulaud Franchi
Summary: This review aims to explore the correlations between negative symptoms and deficits in neurocognition and social cognition in individuals with first-episode psychosis and at-risk populations. The available evidence suggests that negative symptoms are associated with executive functioning and theory of mind deficits in first-episode psychosis subjects, and with deficits in processing speed, attention, vigilance, and working memory in at-risk populations.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Immunology
V. L. Cropley, M. Kittel, M. Heurich, M. Focking, F. M. Leweke, C. Pantelis
Summary: The study found that alterations in the complement system may be a feature of the early psychosis phenotype. Complement protein levels in blood were higher in individuals with first-episode psychosis and clinical high-risk for psychosis, while levels in cerebrospinal fluid did not differ significantly between groups. Serum protein levels were correlated with symptom severity in first-episode psychosis. Further studies are needed to investigate complement proteins in cerebrospinal fluid and their changes with progression of psychotic illness.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Review
Endocrinology & Metabolism
Claudia Aymerich, Borja Pedruzo, Malein Pacho, Marta Laborda, Jon Herrero, Toby Pillinger, Robert A. McCutcheon, Daniel Alonso-Alconada, Marta Bordenave, Maria Martinez-Querol, Ainara Arnaiz, Javier Labad, Paolo Fusar-Poli, Miguel Angel Gonzalez-Torres, Ana Catalan
Summary: Alterations in prolactin and cortisol levels have been found in antipsychotic naive patients with first episode psychosis. This study aims to provide estimates for the standardized mean differences and inter-group variability of these hormone levels in this patient group compared to healthy controls.
PSYCHONEUROENDOCRINOLOGY
(2023)
Article
Psychology, Clinical
Pierluigi Selvaggi, Sameer Jauhar, Vasileia Kotoula, Fiona Pepper, Mattia Veronese, Barbara Santangelo, Fernando Zelaya, Federico E. Turkheimer, Mitul A. Mehta, Oliver D. Howes
Summary: This study found significantly lower frontal cortical blood flow in FEP patients before antipsychotic treatment. Additionally, the relative-to-global frontal cerebral blood flow measured before antipsychotic treatment may be associated with treatment response.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Neurosciences
Brian A. Coffman, Mark T. Curtis, Alfredo Sklar, Dylan Seebold, Dean F. Salisbury
Summary: Attentional control of auditory N100/M100 gain is reduced in individuals with first-episode psychosis (FEP). Persistent problems with executive modulation of auditory sensory activity may impact multiple aspects of psychosis. Our study found deficits in attentional M100 gain modulation in auditory cortex in FEP, and these deficits improved over time along with symptom severity.
HUMAN BRAIN MAPPING
(2023)
Article
Psychiatry
Robert A. McCutcheon, David Taylor, Jose Rubio, Joseph Nour, Toby Pillinger, Robin M. Murray, Sameer Jauhar
Summary: This study found that discontinuation of antipsychotic medication is associated with an increased risk of relapse in schizophrenia, which is related to receptor occupancy. Although the rate of discontinuation does not appear to affect relapse, gradual discontinuation strategies may facilitate easier reinstatement of antipsychotic medication in case of symptomatic worsening.
SCHIZOPHRENIA BULLETIN
(2023)