Article
Chemistry, Analytical
Naser Hakimi, Mohammad Shahbakhti, Joern M. Horschig, Thomas Alderliesten, Frank Van Bel, Willy N. J. M. Colier, Jeroen Dudink
Summary: This study aimed to extract respiratory rate from neonatal NIRS signals to monitor the impact of breathing on cerebral hemodynamics. A novel algorithm called NRR was developed and showed high agreement with the reference respiratory rate (84.5%). The NRR algorithm outperformed existing methods in terms of accuracy and correlation.
Article
Medicine, General & Internal
Melinda Matyas, Mihaela Iancu, Monica Hasmasanu, Anca Man, Gabriela Zaharie
Summary: This study revealed that IVH, inotrope support, and episodes of apnea can lead to a decreased cerebral oxygen saturation in preterm newborns.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Engineering, Electrical & Electronic
Naser Hakimi, Jorn M. M. Horschig, Thomas Alderliesten, Mathijs Bronkhorst, Marianne J. J. Floor-Westerdijk, Frank van Bel, Willy N. J. M. Colier, Jeroen Dudink
Summary: This study proposes a novel algorithm, NIRS HR (NHR), for extracting heart rate from NIRS signals in neonates. The results show that the NHR algorithm has a higher correlation and lower error rate compared to existing algorithms.
IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT
(2023)
Article
Environmental Sciences
Eva-Maria Bonnelycke, Gordon D. Hastie, Kimberley A. Bennett, Jana M. Kainerstorfer, Ryan Milne, Simon E. W. Moss, Alexander Ruesch, Jingyi Wu, J. Chris McKnight
Summary: This study examined the effects of ketamine and midazolam on grey seals' physiological responses during prolonged anaesthesia trials using NIRS data. The results showed that both anesthetics led to apnoea in the seals, with an increase in Delta HHb while SpO(2) remained stable, indicating possible venous congestion. NIRS was found to be a valuable real-time monitoring tool for safe anaesthetic procedures in pinnipeds.
Article
Medicine, General & Internal
Jason Sutin, Rutvi Vyas, Henry A. Feldman, Silvina Ferradal, Chuan-Heng Hsiao, Lucca Zampolli, Lara J. Pierce, Charles A. Nelson, Sarah U. Morton, Susanne Hay, Mohamed El-Dib, Janet S. Soul, Pei-Yi Lin, Patricia E. Grant
Summary: The objective of this study was to evaluate the association between cerebral oxygen metabolism (CMRO2) and neurodevelopmental outcomes at 18 months in neonates with hypoxic ischemic encephalopathy (HIE), and to assess CMRO2 as a potential diagnostic for HIE. The study found that CMRO2 was significantly associated with cognitive and motor outcomes and outperformed conventional clinical evaluations in predicting these outcomes in mild to moderate HIE. This provides a promising, objective, physiologically-based diagnostic for HIE.
Article
Medicine, General & Internal
Ryosuke Takegawa, Kei Hayashida, Tai Yin, Rishabh C. Choudhary, Santiago J. Miyara, Houman Khalili, Muhammad Shoaib, Yusuke Endo, Emesto P. Molmenti, Lance B. Becker
Summary: Clinical studies have shown that the timing of decline in regional cerebral oxygen saturation (rSO(2)) after cardiac arrest and cardiopulmonary resuscitation can predict neurological outcomes. This study investigated the relationship between the timing of rSO(2) decline and brain injury severity in a rat model of cardiac arrest. The results suggest that the timing of rSO(2) decline can serve as a predictor of good neurological outcomes after cardiac arrest and cardiopulmonary resuscitation.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Pediatrics
Bi Ze, Lili Liu, Ge Sang Yang Jin, Minna Shan, Yuehang Geng, Congle Zhou, Tianqi Wu, Hong Wu, Xinlin Hou
Summary: The study revealed that normal neonates at high-altitude areas have significantly lower rSO(2) and cFTOE levels compared to those at low-altitude areas, possibly due to an increase in blood flow to the brain. Neonates with underlying diseases may have an increased risk of brain injury.
Review
Chemistry, Analytical
Maria Roldan, Panayiotis A. Kyriacou
Summary: Traumatic brain injury (TBI) occurs when sudden trauma causes damage to the brain, with secondary injuries potentially affecting cerebral oxygenation and autoregulation. Near-infrared spectroscopy (NIRS) is a potential noninvasive monitoring technique for assessing TBI early, based on chromophore absorption of infrared light.
Article
Cardiac & Cardiovascular Systems
William D. Watson, Peregrine G. Green, Andrew J. M. Lewis, Per Arvidsson, Giovanni Luigi De Maria, Hakan Arheden, Einar Heiberg, William T. Clarke, Christopher T. Rodgers, Ladislav Valkovic, Stefan Neubauer, Neil Herring, Oliver J. Rider
Summary: The study shows that even in nonischemic heart failure patients with severely impaired systolic function, the heart retains significant metabolic flexibility, including the ability to change substrate use to match arterial supply and workload changes. Increasing the uptake and oxidation of long-chain fatty acids is associated with improved myocardial energetics and contractility.
Article
Biotechnology & Applied Microbiology
Yoo Hwan Kim, Seung-Ho Paik, Youngmin Kim, Jaechul Yoon, Yong Suk Cho, Dohern Kym, Jun Hur, Wook Chun, Beop-Min Kim, Byung-Jo Kim
Summary: This study assessed the burn extent and depth in patients with burns using a custom-built 36-channel functional near-infrared spectroscopy system. Hemodynamic tissue signals measured during fNIRS showed significant differences between different burn categories, indicating that functional near-infrared spectroscopy can help with the early judgment of burn extent and depth by reflecting differences in the oxygen saturation levels in the skin.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Tim Hermans, Katherine Carkeek, Anneleen Dereymaeker, Katrien Jansen, Gunnar Naulaers, Sabine Van Huffel, Maarten De Vos
Summary: In neonates with hypoxic ischemic encephalopathy, the use of wavelet coherence between EEG power and rSO2 is a promising method for assessing neurovascular coupling. However, fluctuations in SpO2 limit the reliability of previous methods. To address this issue, partial wavelet coherence is proposed to eliminate the influence of SpO2. Furthermore, the study investigates the additional value of novel NVC biomarkers compared to traditional EEG and NIRS biomarkers for identifying brain injury.
SCIENTIFIC REPORTS
(2023)
Review
Biochemistry & Molecular Biology
Ilona Polvoy, Hecong Qin, Robert R. Flavell, Jeremy Gordon, Pavithra Viswanath, Renuka Sriram, Michael A. Ohliger, David M. Wilson
Summary: Deuterium Metabolic Imaging (DMI) is a method of metabolic imaging that involves labeling substrates and studying various metabolic processes in healthy and diseased states. Despite its low natural abundance, the short relaxation time of deuterium allows for rapid radiofrequency (RF) pulses and efficient image acquisition.
Review
Pediatrics
Christina H. Wolfsberger, Nina Hoeller, Ena Suppan, Bernhard Schwaberger, Berndt Urlesberger, Britt Nakstad, Gerhard Pichler
Summary: This systematic review explores the clinical use of pFOE in term and preterm neonates and the changes in pFOE values over time. The findings suggest that pFOE measured with NIRS in combination with venous occlusion can provide valuable insight into peripheral perfusion, oxygenation, and disturbances of microcirculation in neonates with different pathological findings.
FRONTIERS IN PEDIATRICS
(2022)
Article
Neurosciences
Susanna Tagliabue, Claus Lindner, Ivette Chochron da Prat, Angela Sanchez-Guerrero, Isabel Serra, Michal Kacprzak, Federica Maruccia, Olga Martinez Silva, Udo M. Weigel, Miriam de Nadal, Maria A. Poca, Turgut Durduran
Summary: The optical measurement of cerebral oxygen metabolism was evaluated and found to be reliable for monitoring cerebral signals during propofol-induced anesthesia.
Article
Pediatrics
Ena Pritisanac, Berndt Urlesberger, Bernhard Schwaberger, Gerhard Pichler
Summary: Limited data available currently suggest that fetal hemoglobin might affect peripheral muscle oxygen extraction but not cerebral oxygenation in preterm neonates. More studies are needed to reach a final conclusion, especially regarding the oxygenation changes driven by adult red blood cell transfusions.
FRONTIERS IN PEDIATRICS
(2021)
Article
Neurosciences
Feng Xu, Wenbo Li, Peiying Liu, Jun Hua, John J. Strouse, James J. Pekar, Hanzhang Lu, Peter C. M. van Zijl, Qin Qin
HUMAN BRAIN MAPPING
(2018)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jill B. De Vis, Hanzhang Lu, Harshan Ravi, Jeroen Hendrikse, Peiying Liu
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2018)
Article
Radiology, Nuclear Medicine & Medical Imaging
Deng Mao, Yang Li, Peiying Liu, Shin-Lei Peng, Jay J. Pillai, Hanzhang Lu
MAGNETIC RESONANCE IN MEDICINE
(2018)
Article
Radiology, Nuclear Medicine & Medical Imaging
Zhiliang Wei, Jiadi Xu, Peiying Liu, Lin Chen, Wenbo Li, Peter van Zijl, Hanzhang Lu
MAGNETIC RESONANCE IN MEDICINE
(2018)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jill B. De Vis, Shin-Lei Peng, Xi Chen, Yang Li, Peiying Liu, Sandeepa Sur, Karen M. Rodrigue, Denise C. Park, Hanzhang Lu
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2018)
Article
Critical Care Medicine
Jaclyn A. Stephens, Peiying Liu, Hanzhang Lu, Stacy J. Suskauer
JOURNAL OF NEUROTRAUMA
(2018)
Review
Neurosciences
Peiying Liu, Jill B. De Vis, Hanzhang Lu
Article
Neurosciences
Peiying Liu, Ying Qi, Zixuan Lin, Qiyong Guo, Xiaoming Wang, Hanzhang Lu
Article
Neurosciences
Jun Hua, Peiying Liu, Tae Kim, Manus Donahue, Swati Rane, J. Jean Chen, Qin Qin, Seong-Gi Kim
Article
Clinical Neurology
Samuel S. Shin, Vijai Krishnan, William Stokes, Courtney Robertson, Pablo Celnik, Yanrong Chen, Xiaolei Song, Hanzhang Lu, Peiying Liu, Galit Pelled
Article
Radiology, Nuclear Medicine & Medical Imaging
Zhiliang Wei, Lin Chen, Zixuan Lin, Dengrong Jiang, Jiadi Xu, Peiying Liu, Peter C. M. van Zijl, Hanzhang Lu
MAGNETIC RESONANCE IN MEDICINE
(2019)
Article
Biophysics
Yang Li, Peiying Liu, Yue Li, Hongli Fan, Pan Su, Shin-Lei Peng, Denise C. Park, Karen M. Rodrigue, Hangyi Jiang, Andreia V. Faria, Can Ceritoglu, Michael Miller, Susumu Mori, Hanzhang Lu
NMR IN BIOMEDICINE
(2019)
Article
Pediatrics
Anil N. Shetty, Ashley M. Lucke, Peiying Liu, Magdalena Sanz Cortes, Joseph L. Hagan, Zili D. Chu, Jill V. Hunter, Hanzhang Lu, Wesley Lee, Jeffrey R. Kaiser
PEDIATRIC RADIOLOGY
(2019)
Article
Neurosciences
Xirui Hou, Peiying Liu, Hong Gu, Micaela Chan, Yang Li, Shin-Lei Peng, Gagan Wig, Yihong Yang, Denise Park, Hanzhang Lu
Article
Neuroimaging
Kevin S. King, Min Sheng, Peiying Liu, Christopher D. Maroules, Craig D. Rubin, Ron M. Peshock, Roderick W. McColl, Hanzhang Lu
NEURORADIOLOGY JOURNAL
(2018)