Review
Pediatrics
Nicolas Dauby, Veronique Flamand
Summary: In utero exposure to maternal infections can affect infants' immune responses and increase susceptibility to post-natal infections and vaccines. The maternal environment, including microbiota and exposure to environmental microbes, also influences the infant's immune response and clinical phenotype after birth.
FRONTIERS IN PEDIATRICS
(2022)
Article
Obstetrics & Gynecology
Aditya Chhikara, James Hagadorn, Shabnam Lainwala
Summary: This study aimed to investigate the impact of maternal voice exposure on oral feeding in preterm infants. The results showed that exposure to maternal voice prior to enteral feeding significantly improved the proportions of oral feeding in preterm infants.
JOURNAL OF PERINATOLOGY
(2023)
Article
Pediatrics
Jessica Hirschel, Audrey Carlhan-Ledermann, Celine Ferraz, Laure-Anne Brand, Manuela Filippa, Edouard Gentaz, Fleur Lejeune, Olivier Baud
Summary: Prematurity is a major risk factor for perinatal stress and neonatal complications. This study examined the effects of maternal voice and tactile stimulation on the hormonal balance in mothers of preterm babies. The results showed that maternal voice alone had no effect on hormone levels, but when combined with tactile stimulation, it led to an increase in oxytocin levels, particularly in mothers of female neonates. These findings suggest that maternal voice with contingent tactile stimulation can potentially reduce parental stress following preterm delivery.
Article
Pediatrics
Christina L. Herrera, Priyanka S. Kadari, Jessica E. Pruszynski, Imran Mir
Summary: Maternal infection does not appear to be directly linked to neurodevelopmental impairment or death at 2 years of age in extremely preterm infants. However, acute histologic chorioamnionitis is associated with this outcome, suggesting the need for further research into the impact of infection and immune response on outcomes in extremely preterm infants.
PEDIATRIC RESEARCH
(2023)
Article
Nursing
Kartika Darma Handayani, Irwanto, Melinda Masturina, Risa Etika, Agus Harianto, Pieter J. J. Sauer
Summary: The study aimed to determine which assessment tool could better predict successful breastfeeding among late preterm infants. Results showed that maternal factors were more important for successful breastfeeding in this population compared to infant factors.
JOURNAL OF HUMAN LACTATION
(2021)
Article
Medicine, General & Internal
Camilla Fontana, Federica Marasca, Livia Provitera, Sara Mancinelli, Nicola Pesenti, Shruti Sinha, Sofia Passera, Sergio Abrignani, Fabio Mosca, Simona Lodato, Beatrice Bodega, Monica Fumagalli
Summary: Premature infants show hypomethylation of L1 promoter at birth, and an early intervention program can restore normal methylation levels and improve neurodevelopment in children. Mouse study suggests fine-tuning of L1 activity in perinatal brain, indicating a sensitive and vulnerable window for L1 epigenetic setting.
Article
Immunology
Brian L. Le, Renan Sper, Sandra C. A. Nielsen, Silvia Pineda, Quoc-Hung Nguyen, Ji-Yeun Lee, Scott D. Boyd, Tippi C. MacKenzie, Marina Sirota
Summary: Preterm labor is the leading cause of neonatal morbidity and mortality worldwide. The study found that preterm infants display immature features and clonal overlap with maternal TCR-beta clones. In preterm pregnancies, there is significantly higher clonal convergence between mother and baby pairs compared to term pregnancies.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Neurosciences
Manuela Filippa, Damien Benis, Alexandra Adam-Darque, Didier Grandjean, Petra S. Huppi
Summary: Understanding the impact of prematurity on language perception requires studying how early sensory experience affects brain development. EEG analysis showed that preterm infants have higher activation for stranger voices, while fullterm infants have higher activation for their mother's voice, indicating a difference in their perception of sound.
BRAIN AND COGNITION
(2023)
Review
Nursing
Shenglan Ding, Xiuhua Huang, Xue Li, Yi Shen, Lili Yang
Summary: Maternal voice has significant effects in reducing pain levels and stabilizing vital signs during painful procedures in preterm and full-term infants.
NURSING IN CRITICAL CARE
(2023)
Article
Pediatrics
Marie Camerota, Elisabeth C. McGowan, Brian S. Carter, Jennifer Check, Lynne M. Dansereau, Sheri A. DellaGrotta, Jennifer B. Helderman, Julie A. Hofheimer, Charles R. Neal, T. Michael O'Shea, Steven L. Pastyrnak, Lynne M. Smith, Barry M. Lester
Summary: This study found that prenatal risk phenotypes are associated with neurobehavioral impairment in children born very preterm. Infants born to mothers in the psychological risk group had increased risk of dysregulated neurobehavior at discharge and motor delay and externalizing problems at 24 months. Infants born to mothers in the physical risk group had increased risk of motor delay at 24 months.
JOURNAL OF PEDIATRICS
(2023)
Article
Construction & Building Technology
Chih-Fu Wei, Ching-Chun Lin, Meng-Shan Tsai, Yueliang L. Guo, Shio-Jean Lin, Hua-Fang Liao, Wu-Shiun Hsieh, Mei-Huei Chen, Pau-Chung Chen
Summary: Household incense burning exposure is associated with delays in neurodevelopment milestones among preterm infants, with different motor domains affected depending on the degree of prematurity. These associations are attenuated by the interaction between higher maternal educational status and household incense burning exposure status.
Article
Ophthalmology
Hannes Hudalla, Thomas Bruckner, Johannes Poeschl, Thomas Strowitzki, Ruben-J. Kuon
Summary: This study found that maternal smoking during pregnancy is an independent risk factor for the development of severe retinopathy of prematurity (ROP) in preterm infants born before 32 weeks of gestation. Other confirmed risk factors included low gestational age, low birth weight, and prolonged respiratory support.
Article
Medicine, General & Internal
Afif El-Khuffash, Adam J. Lewandowski, Amish Jain, Aaron Hamvas, Gautam K. Singh, Philip T. Levy
Summary: This study found that preterm infants with higher consumption of mother's own milk had enhanced cardiac performance at age 1 year, suggesting a favorable association between consumption of maternal breast milk and cardiac performance in preterm infants.
Article
Pediatrics
Francesca Gallini, Domenico Umberto De Rose, Maria Coppola, Maria Sofia Pelosi, Francesco Cota, Anthea Bottoni, Daniela Ricci, Domenico Marco Romeo, Teresa Spanu, Luca Maggio, Eugenio Mercuri, Giovanni Vento
Summary: This study aimed to evaluate the neurodevelopmental outcomes of preterm infants born to mothers with Ureaplasma/Mycoplasma colonization during pregnancy. The study found that infants exposed to colonization had poorer locomotor abilities compared to unexposed infants, while the incidences of cognitive and motor impairments were similar between the two groups.
FRONTIERS IN PEDIATRICS
(2022)
Article
Endocrinology & Metabolism
Lisa Middendorf, Alexandra Gellhaus, Antonella Iannaccone, Angela Koeninger, Anne-Kathrin Dathe, Ivo Bendix, Beatrix Reisch, Ursula Felderhoff-Mueser, Britta Huening
Summary: The sFlt-1/PlGF ratio does not predict the motor optimality score (MOS-R) in preterm infants, but low birth weight, which is correlated with an elevated ratio, has a negative effect on MOS-R outcome.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Oncology
Elisabetta Schiavello, Veronica Biassoni, Giovanna Gattuso, Marta Podda, Stefano Chiaravalli, Francesco Barretta, Manila Antonelli, Loris De Cecco, Emilia Pecori, Lorenza Gandola, Maura Massimino
Summary: This is a small series of homogeneously-treated DMG patients with H3K27M mutation. The treatment approach is similar to DIPG and the results obtained are comparable with those of DIPG patients. Therefore, these DMG patients should be included in registries and protocols of DIPG.
Article
Genetics & Heredity
Martina Rimoldi, Berardo Rinaldi, Roberta Villa, Jacopo Cerasani, Benedetta Beltrami, Maria Iascone, Rosamaria Silipigni, Simona Boito, Silvana Gangi, Lorenzo Colombo, Matteo Porro, Claudia Cesaretti, Maria Francesca Bedeschi
Summary: Coffin-Siris Syndrome (CSS) is a rare genetic condition characterized by nail and finger bone abnormalities, coarse facial features, excessive hair growth, developmental delay, intellectual disability, and growth impairment. This study presents two cases of CSS with congenital diaphragmatic hernia (CDH) and identifies different causative genetic variants. The occurrence of CDH did not predict CSS in these cases, but prompted genetic testing. This study provides further evidence of the association between CSS and CDH.
AMERICAN JOURNAL OF MEDICAL GENETICS PART A
(2023)
Article
Biochemistry & Molecular Biology
Giulia Rodari, Roberta Villa, Matteo Porro, Silvana Gangi, Maria Iascone, Francesca Elli, Federico Giacchetti, Eriselda Profka, Valentina Collini, Alberta Dall'Antonia, Maura Arosio, Giovanna Mantovani, Maria Francesca Bedeschi, Claudia Giavoli
Summary: This study reports two dizygotic twin girls with novel compound heterozygous deleterious variants of PRMT7 gene and describes their endocrine manifestations and short-term response to recombinant growth hormone treatment.
EUROPEAN JOURNAL OF HUMAN GENETICS
(2023)
Article
Oncology
Vincenzo Nasca, Francesco Barretta, Francesca Corti, Sara Lonardi, Monica Niger, Maria Elena Elez, Marwan Fakih, Priya Jayachandran, Aakash Tushar Shah, Massimiliano Salati, Elisabetta Fenocchio, Lisa Salvatore, Chiara Cremolini, Javier Ros, Margherita Ambrosini, Giacomo Mazzoli, Rossana Intini, Michael J. Overman, Rosalba Miceli, Filippo Pietrantonio
Summary: In this study of 331 patients with metastatic colorectal cancer treated with immune checkpoint inhibitors, it was found that certain immune-related adverse events (irAEs) could affect patient survival, with some having a protective effect and others having a harmful effect. The study proposed a simple model to evaluate the impact of irAEs on treatment outcomes.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Pediatrics
Gregorio P. Milani, Antonio Corsello, Peter J. Schulz, Marta Fadda, Maria Lorella Gianni, Ilaria Alberti, Anna Comotti, Paola Marchisio, Elena Chiappini, Diego Peroni
Summary: This study demonstrates the effectiveness of an educational intervention in changing medical students' conceptions and attitudes toward childhood fever in both the short and medium term.
Article
Genetics & Heredity
Beatrice Conti, Berardo Rinaldi, Martina Rimoldi, Roberta Villa, Maria Iascone, Silvana Gangi, Matteo Porro, Paola Francesca Ajmone, Anna Maria Colli, Fabio Mosca, Maria Francesca Bedeschi
Summary: Cornelia de Lange syndrome (CdLS) is a rare congenital neurodevelopmental disorder characterized by facial anomalies, short stature, developmental delay, gastrointestinal abnormalities, and limb defects. This report describes a familial case of CdLS-like presentation and identifies a likely pathogenic variant in the PHIP gene associated with Chung-Jansen syndrome. The findings suggest including PHIP among genes routinely analyzed in patients with CdLS spectrum.
AMERICAN JOURNAL OF MEDICAL GENETICS PART A
(2023)
Article
Obstetrics & Gynecology
Maria Lorella Gianni, Alessandra Consales, Daniela Morniroli, Giulia Vizzari, Fabio Mosca
Summary: One challenge for neonatologists is to ensure adequate growth and nutrition for premature infants. The INTERGROWTH-21st Preterm Postnatal Growth Standards provide evidence that preterm infants' growth differs from fetuses of the same age. Besides weight gain, the quality of growth, specifically lean mass apposition, should be considered. Mother's milk promotes growth and neurocognitive development of preterm infants, but fortification may be necessary to meet their nutritional needs during hospitalization. Continuing fortification after discharge may not provide clear benefits.
BREASTFEEDING MEDICINE
(2023)
Article
Oncology
Maura Massimino, Sabina Vennarini, Francesca Romana Buttarelli, Manila Antonelli, Francesca Colombo, Simone Minasi, Emilia Pecori, Paolo Ferroli, Carlo Giussani, Marco Schiariti, Elisabetta Schiavello, Veronica Biassoni, Alessandra Erbetta, Luisa Chiapparini, Olga Nigro, Luna Boschetti, Francesca Gianno, Evelina Miele, Piergiorgio Modena, Loris De Cecco, Bianca Pollo, Francesco Barretta
Summary: This study reports the experience, timing, and outcomes of re-irradiation for relapsed medulloblastoma. The results suggest that re-surgery and re-RT can prolong survival, and a significant fraction of patients with worse outcomes belong to the SHH subgroup.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Article
Dermatology
Andrea Maurichi, Francesco Barretta, Roberto Patuzzo, Rosalba Miceli, Gianfranco Gallino, Ilaria Mattavelli, Andrea Leva, Catherine Harwood, Daniele Bergamaschi, Tiffanie-Marie Borg, Michal Shimonovitz-Moore, Giuseppe Spadola, Elena Tolomio, Consuelo Barbieri, Paola Queirolo, Ausilia Maria Manganoni, Giovanni Pellacani, Vittoria Espeli, Cristina Mangas, Sandra Leoni-Parvex, Mara Cossa, Alessia Belotti, Barbara Valeri, Umberto Cortinovis, Mario Santinami
Summary: Narrower excision margins for T1 radial growth phase melanoma on the head and neck, including the face, are not associated with worse overall survival or increased local recurrence compared to wider margins. However, caution may be required in the presence of lentigo maligna melanoma.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Dermatology
Andrea Maurichi, Francesco Barretta, Roberto Patuzzo, Laura Sala, Rosalba Miceli, Gianfranco Gallino, Ilaria Mattavelli, Andrea Leva, Nicolo Simonotti, Bianca Taglione, Mara Cossa, Alessia Belotti, Barbara Valeri, Umberto Cortinovis, Mario Santinami
Summary: Melanoma guidelines recommend 10-mm surgical excision margins for T1 melanoma. However, this may not be feasible near critical anatomical locations. A comparison of wide (10-mm) and narrow (5-mm) excision margins for T1a melanoma near critical structures suggests that narrow excision may not be associated with an increased risk of local recurrence.
Article
Instruments & Instrumentation
Loic Le Guyader, Andrea Eschenlohr, Martin Beye, William Schlotter, Florian Doering, Cammille Carinan, David Hickin, Naman Agarwal, Christine Boeglin, Uwe Bovensiepen, Jens Buck, Robert Carley, Andrea Castoldi, Alessandro D'Elia, Jan-Torben Delitz, Wajid Ehsan, Robin Engel, Florian Erdinger, Hans Fangohr, Peter Fischer, Carlo Fiorini, Alexander Foehlisch, Luca Gelisio, Michael Gensch, Natalia Gerasimova, Rafael Gort, Karsten Hansen, Steffen Hauf, Manuel Izquierdo, Emmanuelle Jal, Ebad Kamil, Suren Karabekyan, Thomas Kluyver, Tim Laarmann, Tobias Lojewski, David Lomidze, Stefano Maffessanti, Talgat Mamyrbayev, Augusto Marcelli, Laurent Mercadier, Giuseppe Mercurio, Piter S. Miedema, Katharina Ollefs, Kai Rossnagel, Benedikt Roesner, Nico Rothenbach, Andrey Samartsev, Justine Schlappa, Kiana Setoodehnia, Gheorghe Sorin Chiuzbaian, Lea Spieker, Christian Stamm, Francesco Stellato, Simone Techert, Martin Teichmann, Monica Turcato, Benjamin Van Kuiken, Heiko Wende, Alexander Yaroslavtsev, Jun Zhu, Serguei Molodtsov, Christian David, Matteo Porro, Andreas Scherz
Summary: Femtosecond transient soft X-ray absorption spectroscopy (XAS) is a promising technique for studying out-of-equilibrium dynamics in material and energy research. This study presents a dedicated setup for soft X-rays at the European XFEL, which uses a beam-splitting zone plate to create three copies of the incoming beam for transmission measurement. Shot-by-shot analysis of transmission is enabled by simultaneously detecting the transmitted intensity through the excited and unexcited sample, as well as monitoring the incoming intensity. An imaging detector with high frame rate and sensitivity is employed for photon detection.
JOURNAL OF SYNCHROTRON RADIATION
(2023)
Letter
Pediatrics
Gregorio P. Milani, Antonio Corsello, Peter J. Schulz, Marta Fadda, Maria Lorella Gianni, Ilaria Alberti, Anna Comotti, Paola Marchisio, Elena Chiappini, Diego Peroni
Article
Oncology
Maria Danieli, Francesco Barretta, Stefano Radaelli, Marco Fiore, Claudia Sangalli, Marta Barisella, Elena Palassini, Rosalba Miceli, Anna Maria Frezza, Dario Callegaro, Paola Collini, Paolo Giovanni Casali, Silvia Stacchiotti, Alessandro Gronchi
Summary: This study explored the correlation between pathological and radiological response to preoperative treatments and outcome in surgically treated patients with myxofibrosarcoma and undifferentiated pleomorphic sarcoma. The results showed that the percentage of visible residual tumor had a greater impact on survival and disease-free survival than the size reduction of the tumor, especially in patients receiving neoadjuvant chemotherapy or radiotherapy.