Article
Food Science & Technology
Jia-Feng Chang, Chih-Yu Hsieh, Jian-Chiun Liou, Kuo-Cheng Lu, Cai-Mei Zheng, Mai-Szu Wu, Shu-Wei Chang, Ting-Ming Wang, Chang-Chin Wu
Summary: This study investigated the association between PCS, NHALP, and bone fracture risk in hemodialysis patients, finding that elevated levels of PCS and NHALP were intricately linked to an increased risk of bone fractures. A joint evaluation of both markers was deemed more comprehensive than assessing each independently in predicting skeletal events.
Article
Obstetrics & Gynecology
Akaninyene Eseme Ubom, Manu Vatish, Eytan R. Barnea
Summary: Preterm labor occurs in around 10% of pregnancies worldwide and efforts must be made to reduce morbidity and mortality. Access to neonatal intensive care is limited in LMICs and rural areas. The Prep-for-Labor triage method by FIGO can help identify low- and high-risk patients and guide appropriate management. The goal is to minimize morbidity and mortality associated with preterm labor and PPROM.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Obstetrics & Gynecology
Tamara Barna, Kalman F. F. Szucs, Annamaria Schaffer, Mohsen Mirdamadi, Judit Hajagos-Toth, Robert Gaspar
Summary: In this study, the combined application of beta(2)-mimetic terbutaline and magnesium sulfate (MgSO4) was found to have a significant uterus relaxant effect in pregnant rats. The administration of MgSO4 also reduced the tachycardia-inducing side effect of terbutaline.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Review
Oncology
Chengying Jiang, Fangke Hu, Jiazhen Li, Guangshen Gao, Xiaojing Guo
Summary: The purpose of this meta-analysis was to summarize the diagnostic value of serum alkaline phosphatase (ALP) and bone-specific isoforms (BAP) in metastatic breast cancer (BC), with a focus on bone metastases. High levels of ALP and BAP in serum were found to be associated with a higher detection rate of bone metastatic BC patients. Although not highly reliable, serum ALP and BAP still provide some useful information for early detection of BC metastases, especially bone metastases.
BREAST CANCER RESEARCH AND TREATMENT
(2023)
Review
Biochemistry & Molecular Biology
Saravanan Sekaran, Selvaraj Vimalraj, Lakshmi Thangavelu
Summary: TNAP is an essential enzyme involved in skeletal tissue mineralization and dephosphorylation of various physiological substrates. It plays vital roles in neuronal development, detoxification, anti-inflammatory processes, bile pH regulation, and maintaining the blood brain barrier. Understanding the mechanisms mediated by TNAP is crucial for minimizing off targeted effects and improving various pathological scenarios.
Article
Biochemistry & Molecular Biology
Grace Felciya Sekar Jeyakumar, Poornima Velswamy, Deebasuganya Gunasekaran, Nivethitha Panneerselvam Manimegalai, Kiran Manikantan Syamala, Uma Tiruchirappalli Sivagnanam
Summary: The irregular expression of bone matrix proteins during bone regeneration can result in deformities. In this study, a metal-organic composite [TQ-Sr-Fe] was developed to enhance bone mineralization. The composite showed a sheet-like structure and exhibited biocompatibility with cells. It promoted cell adhesion, proliferation, and osteoblastic differentiation, leading to increased calcium deposition and mineralization. Overall, the TQ-Sr-Fe composite has the potential to accelerate bone regeneration.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biotechnology & Applied Microbiology
Yan Chen, Tie Zhang, Qi Zhang, QingJian Lei, ShiJie Gao, KangWen Xiao, FeiFei Yan, Lin Cai
Summary: A composite bone cement, cubic crystalline magnesium-doped calcium sulfate/bioglass (MgCS/BG), was prepared and found to have increased compressive strength and good bioactivity. It promotes the adhesion and differentiation of mesenchymal stem cells, and enhances bone defect repair and new bone formation.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Endocrinology & Metabolism
Konstantinos Makris, Chagigia Mousa, Etienne Cavalier
Summary: Alkaline phosphatases are isoenzymes that catalyze the hydrolysis of organic phosphate esters in the extracellular space. Zinc and magnesium are important co-factors for their biological activity. They are found in various tissues, but most are derived from the liver and bone in the bloodstream. However, their exact physiological function remains largely unknown.
CALCIFIED TISSUE INTERNATIONAL
(2023)
Article
Endocrinology & Metabolism
Freja Pontan, Helena Hauta-alus, Saara Valkama, Jenni Rosendahl, Maria Enlund-Cerullo, Sture Andersson, Outi Makitie, Elisa Holmlund-Suila
Summary: This study investigated the concentrations of alkaline phosphatase (ALP) and the prevalence of hyperphosphatasemia in healthy children, and their association with vitamin D, growth, infections, and bone parameters. It was found that boys had higher ALP levels than girls, and hyperphosphatasemia was more common at 12 months. Hyperphosphatasemia was associated with body size, growth rate, and bone mineralization, but not with infections.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Endocrinology & Metabolism
Giuseppe Cannalire, Simone Pilloni, Susanna Esposito, Giacomo Biasucci, Anna Di Franco, Maria Elisabeth Street
Summary: Serum alkaline phosphatase (ALP) and its isoenzymes play a crucial role in reflecting bone metabolism. ALP increases mineralization and reduces the concentration of an inhibitor of mineral formation. Different isoenzymes of ALP are expressed in different tissues and the bone isoenzyme (B-ALP) is involved in bone turnover. ALP measurements are important in the diagnosis, differentiation, and follow-up of rickets.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Oncology
Ji-hoon Jung, Chae-Moon Hong, Il Jo, Shin-Young Jeong, Sang-Woo Lee, Jaetae Lee, Byeong-Cheol Ahn
Summary: This study aimed to evaluate whether serum alkaline phosphatase (ALP) can differentiate flare phenomenon from disease progression on bone scintigraphy in breast or prostate cancer patients with bone metastasis. The results suggest that ALP is a useful serologic marker to differentiate flare phenomenon from disease progression on bone scintigraphy in patients with bone metastasis.
Article
Pediatrics
Shintaro Hanaoka, Kouji Motokura, Seiichi Tomotaki, Mitsuyo Akita, Ryosuke Araki, Yutaro Tomobe, Takeru Yamauchi, Hiroko Tomotaki, Kougoro Iwanaga, Fusako Niwa, Junko Takita, Masahiko Kawai
Summary: This study aimed to compare the JSCC and IFCC methods, and find a conversion formula to measure serum ALP levels in neonates.
PEDIATRICS INTERNATIONAL
(2022)
Review
Nutrition & Dietetics
Mathias Haarhaus, Giuseppe Cianciolo, Simona Barbuto, Gaetano La Manna, Lorenzo Gasperoni, Giovanni Tripepi, Mario Plebani, Maria Fusaro, Per Magnusson
Summary: This narrative review summarizes recent clinical investigations and mechanisms linking alkaline phosphatase (ALP) and bone alkaline phosphatase (BALP) to inflammation, metabolic syndrome, vascular calcification, cardiovascular disease, and mortality. Further discussions include the association between ALP, vitamin K, bone metabolism, and fracture risk in patients with chronic kidney disease (CKD), as well as advancements in pharmacological strategies to modulate ALP expression in CKD-mineral and bone disorder (CKD-MBD).
Article
Obstetrics & Gynecology
Rebecca Chornock, Elissa Trieu, Tetsuya Kawakita, Brynley Dean, Rachael Overcash
Summary: This study aimed to evaluate the term neonatal outcomes after maternal magnesium sulfate (MgSO (4) ) treatment for seizure prophylaxis. A retrospective cohort study was conducted from January 2013 to December 2020, including all women with term singleton gestation requiring MgSO (4) treatment and their neonatal outcomes. The results showed that prolonged MgSO (4) treatment for 24 hours or more was associated with increased odds of term NICU admission due to neonatal lethargy.
AMERICAN JOURNAL OF PERINATOLOGY
(2023)
Article
Pediatrics
Emmanuelle Motte-Signoret, Marwa Jlassi, Ludivine Lecoq, Pierre-Yves Wachter, Amelie Durandy, Pascal Boileau
Summary: Very low birth weight (VLBW) neonates are at high risk of metabolic bone disease (MBD). This study aimed to find the easiest way to diagnose this disease early by identifying surrogate biomarkers before radiological signs appear. A 6-month observational study was conducted in a NICU, including all singleton VLBW neonates. Clinical and biological data, as well as nutritional intakes, were collected. Biological MBD (bMBD) was defined as alkaline phosphatase (ALP) levels above 600 IU/L at day of life 30 (DOL30), and a case-control analysis was performed. Out of 30 patients, 9 (30%) exhibited bMBD, all of whom had extremely low birth weight and were younger in gestational age and smaller in size at birth. There was no significant difference in nutritional intake between the bMBD and control groups. In the bMBD group, phosphatemia decreased since DOL3. ALP levels were already significantly elevated at DOL15, surpassing the normal range. Conclusions: Respectfully following nutritional guidelines does not completely prevent bMBD in high-risk patients. Early screening from DOL15, with ALP levels greater than 500 IU/L, could be sufficient for detecting upcoming MBD.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)