Article
Chemistry, Analytical
Ahmed Foudah, Faiyaz Shakeel, Mohammed H. Alqarni, Tariq M. Aljarba, Sultan Alshehri, Prawez Alam
Summary: This study developed a greener reverse-phase high-performance thin-layer chromatography with ultraviolet (HPTLC-UV) method for the simultaneous estimation of chlorzoxazone (CZN) and paracetamol (PCT) in commercial capsules and tablets. The proposed method showed excellent greenness profile and proved to be sensitive, accurate, precise, and robust for the simultaneous detection of CZN and PCT.
Article
Chemistry, Medicinal
Fernando J. Pereira, Aida Rodriguez-Cordero, Roberto Lopez, Luis C. Robles, A. Javier Aller
Summary: A rapid, simple, and sensitive isocratic RP-HPLC method with photodiode array detection was developed for the determination of paracetamol, caffeine, and tramadol in pharmaceutical formulations. An improved procedure for tramadol using a fluorescence detector system was also established.
Article
Pharmacology & Pharmacy
Freja Fredholt, Camilla Di Meo, Stine Sloth, Anette Mullertz, Ragna Berthelsen
Summary: This study aimed to investigate tablet disintegration by directly observing it in vivo and in vitro. Paracetamol tablets, including a standard conventional tablet and a rapidly absorbed tablet, were used as model systems. The disintegration process in the human stomach was visualized by administering the tablets attached to endoscopic camera capsules to fasted human volunteers. The obtained in vivo results were then replicated in an in vitro disintegration method. The study found that the viscosity of the simulated gastric fluid greatly influenced the disintegration time of the tested tablets. It is recommended to mimic gastric fluid viscosity during in vitro tablet disintegration studies.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2022)
Article
Engineering, Chemical
Seetharaman Rathinam, Lakshmi Karunanidhi Santhana
Summary: This work introduces three eco-friendly UV spectrophotometric methods for the simultaneous estimation of Paracetamol, Aceclofenac, and Eperisone Hydrochloride in pharmaceutical tablet formulation. The methods employed, including simultaneous equation method and multivariate chemometric methods, showed good accuracy and precision within permissible limits. These methods are suitable for routine quality control laboratories.
Article
Chemistry, Multidisciplinary
Heidi R. Abd El-Hadi, Basma M. Eltanany, Hala E. Zaazaa, Maya S. Eissa
Summary: In this research, a green HPLC method was used to monitor the impurities in drug substances, successfully separating toxic impurities and quantifying the target substances. The proposed method is more environmentally friendly than the traditional one and is suitable for impurity profiling.
SUSTAINABLE CHEMISTRY AND PHARMACY
(2023)
Article
Chemistry, Multidisciplinary
Lena Mareczek, Carolin Riehl, Meike Harms, Stephan Reichl
Summary: This study systematically analyzed the material properties of paracetamol-MCC blends and found that the initial material properties have a greater impact on the mechanical tablet properties than the processing route. It highlights the importance of material characterization for oral solid dosage forms.
PHARMACEUTICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Petra Meszaros, Sara Kovacs, Gyozo Kulcsar, Melinda Paskuj, Attila Almasi
Summary: Phenolic drug molecules can be metabolized by enterocytes in the small intestine, with conjugation reactions playing a significant role. Pathologic conditions such as hyperglycemia and diabetes can alter the metabolic pattern and lead to oxidative stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Letter
Chemistry, Multidisciplinary
K. S. Kokilambigai, K. S. Lakshmi
Summary: The paper presents a multicomponent UV spectrophotometric method for the determination of paracetamol, aceclofenac, and thiocolchicoside based on green analytical chemistry principles. This method is simple, economical, and environmentally friendly, with a wide linear range for each component.
GREEN CHEMISTRY LETTERS AND REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Saeed Ahmad, Alam Zeb, Sanaullah Khan
Summary: The study demonstrated that the aqueous extract of Medicago denticulata can protect against liver toxicity induced by paracetamol, showing potential for treating related toxicity.
JOURNAL OF FOOD BIOCHEMISTRY
(2021)
Article
Automation & Control Systems
Abbas Saadatmandi, Mahmoud Reza Sohrabi, Hasan Kabiri Fard
Summary: In this study, a fast, easy, inexpensive, and precise method combining UV-Vis spectrophotometry, continuous wavelet transform, and partial least squares multivariate calibration was developed for the simultaneous determination of paracetamol, diphenhydramine, and phenylephrine in tablet dosage form without extraction. The method was validated using synthetic mixtures and showed good performance.
CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS
(2023)
Article
Pharmacology & Pharmacy
Marcin Janiaczyk, Anna Jelinska, Aneta Wozniak-Braszak, Pawel Bilski, Maria Popielarz-Brzezinska, Magdalena Wachowiak, Mikolaj Baranowski, Szymon Tomczak, Magdalena Ogrodowczyk
Summary: The ionizing radiation stability of the nonsteroidal anti-inflammatory drugs diclofenac and aceclofenac was investigated, and it was found that they exhibit high radiation stability within a certain dose range, making them suitable for sterilization. The study also observed the influence of radiation on molecular dynamics and structure.
Article
Chemistry, Analytical
Ibrahim A. Naguib, Meral Majed, Maram Albogami, Maram Alshehri, Aseel Bukhari, Hadeel Alshabani, Izzeddin Alsalahat, Heba-Alla H. Abd-ElSalam
Summary: Green assessment of the analytical methods used for paracetamol analysis is crucial to ensure the safety of the environment and human health. HPLC methods were found to be reliable and feasible for the analysis of paracetamol in raw materials, drug products, and biological fluids. The greenest chromatographic methods for each category were proposed by Rao et al. (ESA = 76, AGREE = 0.62) and Modick et al. (ESA = 85, AGREE = 0.7) respectively. It is highly recommended to combine NEMI results with ESA and AGREE for comprehensive greenness assessment.
Article
Pharmacology & Pharmacy
Samuel Orubu, Richard A. Kendall, Yucheng Sheng, Catherine Tuleu
Summary: This study evaluated the taste-masking ability of milk in drug administration. It was found that milk could mask the taste of zinc sulfate in a mannitol-based formulation but not the taste of paracetamol. Samples without grittiness were more likely to be accepted as medicine.
Article
Biochemistry & Molecular Biology
Kannan Sridharan, Ali Mohamed Qader, Mustafa Hammad, Anfal Jassim, Diab Eltayeb Diab, Betsy Abraham, Hasan M. S. N. Hasan, Sheikh Abdul Azeez Pasha, Shamik Shah
Summary: This study investigated the prevalence of SNPs related to paracetamol metabolism in critically ill patients and those with chronic kidney disease. The results showed that SNPs led to alterations in metabolite concentrations and ratios, and patients with renal dysfunction had higher paracetamol concentrations.
Article
Chemistry, Analytical
Jan Schripsema, Ronald dos Santos Merlim, Lais Gonsalves Parvan, Helen SantAna dos Santos Ribeiro, Leonardo Dagnino Schripsema, Seldon Aleixo, Alexander Becht, Ulrike Holzgrabe, Denise Dagnino
Summary: The H-1 NMR spectra of paracetamol tablets were studied to analyze and quantify the excipients and minor components in the formulations. The spectra showed the presence of amide-iminol tautomers of paracetamol and the identification of seventeen different tablet components. Similarity calculations and differential NMR proved to be effective in analyzing trace components. This study highlights the limitations of multivariate data analysis and the strength of similarity calculations in NMR analysis.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2022)