期刊
DYES AND PIGMENTS
卷 90, 期 2, 页码 119-122出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.dyepig.2010.12.008
关键词
Pentamethine; Carbocyanine; Fluorophore; Near infrared; Monofunctional; Symmetric
资金
- NIH [U01-HL080731, P50-CA086355]
A high-yield route to symmetric, conjugatable pentamethine carbocyanine dyes with far-red/near infrared (NIR) emission between 650 and 700 nm is reported. The dyes are prepared via condensation of indolium or benz[e]indolium inner salts with an alkyl carboxylic acid derivatized malonaldehyde dianil or alternatively in a one-pot reaction without isolation of the malonaldehyde intermediate. The fluorophores are water-soluble, have bright fluorescence emission, are easily prepared in good yield, and are promising candidates for use in a variety of biochemical and in vivo imaging applications. (C) 2011 Elsevier Ltd. All rights reserved.
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