期刊
DRUGS OF THE FUTURE
卷 34, 期 4, 页码 291-295出版社
PROUS SCIENCE, SAU-THOMSON REUTERS
DOI: 10.1358/dof.2009.034.04.1360696
关键词
184072; trans-Resveratrol
资金
- GlaxoSmithKline Company (US)
The consumption of resveratrol, a naturally occurring polyphenol found in foods, has been associated with possible health benefits. These benefits are derived, in part, from activation of NAD-dependent deacetylase sirtuin-1 (SIRT1), an enzyme thought to control the aging process in multiple species To date, the activation of SIRT1 by resveratrol has been suboptimal due to its poor bioavailability, limiting the full treatment potential of SIRT1 activation We have developed a novel formulation of resveratrol, SRT5O1, with improved bioavailability The present report describes the safety and pharmacokinetic profile in animals and humans, as well as the glucose-lowering activity of once- and twice-daily dosing schedules of SRT5O1 In type 2 diabetic patients Our results demonstrate that SRT5O1 was safe and well tolerated in multiple preclinical toxicity studies and in clinical trials involving healthy normal volunteers and type 2 diabetes patients The efficacy seen in animal models of diabetes appears to be replicated in type 2 diabetic patients, and as such it shows promise as a novel treatment for diabetes.
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