Treating Chronic Pain: An Overview of Clinical Studies Centered on the Buprenorphine Option

Opioid-induced inhibition of the human 5-HT and noradrenaline transporters in vitro : link to clinical reports of serotonin syndrome

(2018) Anna Rickli et al.   BRITISH JOURNAL OF PHARMACOLOGY

Norbuprenorphine and respiratory depression: Exploratory analyses with new lyophilized buprenorphine and sublingual buprenorphine


(2018) John Strang et al.   INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS

Efficacy and safety of buprenorphine in peripheral nerve blocks

(2017) Alexander Schnabel et al.   EUROPEAN JOURNAL OF ANAESTHESIOLOGY

Comparative study of the efficacy of transdermal buprenorphine patches and prolonged-release tramadol tablets for postoperative pain control after spinal fusion surgery: a prospective, randomized controlled non-inferiority trial

(2017) Ho-Joong Kim et al.   EUROPEAN SPINE JOURNAL

Drug Binding Poses Relate Structure with Efficacy in the μ Opioid Receptor

(2017) Katy J. Sutcliffe et al.   JOURNAL OF MOLECULAR BIOLOGY

Converting from Transdermal to Buccal Formulations of Buprenorphine: A Pharmacokinetic Meta-Model Simulation in Healthy Volunteers

(2017) Tony Priestley et al.   PAIN MEDICINE

Effects of buprenorphine on QT intervals in healthy subjects: results of 2 randomized positive- and placebo-controlled trials

(2017) Stephen C. Harris et al.   POSTGRADUATE MEDICINE

Transdermal buprenorphine and fentanyl patches in cancer pain: a network systematic review

(2017) Jin Seok Ahn et al.   Journal of Pain Research

Long-term safety and analgesic efficacy of buprenorphine buccal film in patients with moderate-to-severe chronic pain requiring around-the-clock opioids

(2017) Martin Hale et al.   Journal of Pain Research

Differentiating the Effect of an Opioid Agonist on Cardiac Repolarization From µ-Receptor–mediated, Indirect Effects on the QT Interval: A Randomized, 3-way Crossover Study in Healthy Subjects

(2016) Borje Darpo et al.   CLINICAL THERAPEUTICS

Evaluation of the Pharmacokinetics of Single- and Multiple-dose Buprenorphine Buccal Film in Healthy Volunteers

(2016) Stephen A. Bai et al.   CLINICAL THERAPEUTICS

Intranasal buprenorphine alone and in combination with naloxone: Abuse liability and reinforcing efficacy in physically dependent opioid abusers

(2016) Sharon L. Walsh et al.   DRUG AND ALCOHOL DEPENDENCE

Voriconazole more likely than posaconazole increases plasma exposure to sublingual buprenorphine causing a risk of a clinically important interaction

(2016) Mari Fihlman et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Prediction of Clearance, Volume of distribution, and Half-life of Drugs in Extremely Low to Low Birth Weight Neonates: An Allometric Approach

(2016) Iftekhar Mahmood   EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS

Dose-Dependent Flux of Buprenorphine Following Transdermal Administration in Healthy Subjects

(2016) Yi Wang et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Antidepressant-like Effects of Buprenorphine are Mediated by Kappa Opioid Receptors

(2016) Edgardo Falcon et al.   NEUROPSYCHOPHARMACOLOGY

Efficacy and tolerability of buccal buprenorphine in opioid-experienced patients with moderate to severe chronic low back pain

(2016) Joseph Gimbel et al.   PAIN

Mediation of buprenorphine analgesia by a combination of traditional and truncated mu opioid receptor splice variants

(2016) Steven G. Grinnell et al.   SYNAPSE

Buprenorphine – the unique opioid adjuvant in regional anesthesia

(2016) Juliusz Kosel et al.   Expert Review of Clinical Pharmacology

Management of chronic pain in the elderly: focus on transdermal buprenorphine

(2016) Nalini Vadivelu et al.   Clinical Interventions in Aging

Arrhythmia associated with buprenorphine and methadone reported to the food and drug administration

(2015) David P. Kao et al.   ADDICTION

Pharmacokinetics of Sublingual Buprenorphine and Naloxone in Subjects with Mild to Severe Hepatic Impairment (Child-Pugh Classes A, B, and C), in Hepatitis C Virus-Seropositive Subjects, and in Healthy Volunteers

(2015) Azmi F. Nasser et al.   CLINICAL PHARMACOKINETICS

Effects of a Higher-bioavailability Buprenorphine/Naloxone Sublingual Tablet Versus Buprenorphine/Naloxone Film for the Treatment of Opioid Dependence During Induction and Stabilization: A Multicenter, Randomized Trial

(2015) Erik W. Gunderson et al.   CLINICAL THERAPEUTICS

Novel Buccal Film Formulation of Buprenorphine-Naloxone for the Maintenance Treatment of Opioid Dependence: A 12-Week Conversion Study

(2015) James G. Sullivan et al.   CLINICAL THERAPEUTICS

Pronociceptive and Antinociceptive Effects of Buprenorphine in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude

(2015) K. J. Gerhold et al.   JOURNAL OF NEUROSCIENCE

Multimodal Perineural Analgesia with Combined Bupivacaine-Clonidine-Buprenorphine-Dexamethasone: Safe In Vivo and Chemically Compatible in Solution

(2015) Brian A. Williams et al.   PAIN MEDICINE

Population Pharmacokinetic Model of Sublingual Buprenorphine in Neonatal Abstinence Syndrome

(2015) Chee M. Ng et al.   PHARMACOTHERAPY

Efficacy and tolerability of buccal buprenorphine in opioid-naive patients with moderate to severe chronic low back pain

(2015) Richard L. Rauck et al.   POSTGRADUATE MEDICINE

Influence of UGT2B7, CYP3A4, and OPRM1 Gene Polymorphisms on Transdermal Buprenorphine Pain Control in Patients with Critical Lower Limb Ischemia Awaiting Revascularization

(2015) Francisco Blanco et al.   Pain Practice

BU08073 a buprenorphine analogue with partial agonist activity at μ-receptorsin vitrobut long-lasting opioid antagonist activityin vivoin mice

(2014) T V Khroyan et al.   BRITISH JOURNAL OF PHARMACOLOGY

Safety, Tolerability, and Clinical Effect of Low-Dose Buprenorphine for Treatment-Resistant Depression in Midlife and Older Adults

(2014) Jordan F. Karp et al.   JOURNAL OF CLINICAL PSYCHIATRY

Conversion from High-Dose Full-Opioid Agonists to Sublingual Buprenorphine Reduces Pain Scores and Improves Quality of Life for Chronic Pain Patients

(2014) Danielle Daitch et al.   PAIN MEDICINE

Sublingual Buprenorphine as an Analgesic in Chronic Pain: A Systematic Review

(2014) Joyce Cote et al.   PAIN MEDICINE

Transdermal buprenorphine in the treatment of cancer and non-cancer pain – the results of multicenter studies in Poland

(2014) Anna Przeklasa-Muszyńska et al.   Pharmacological Reports

Dosing considerations with transdermal formulations of fentanyl and buprenorphine for the treatment of cancer pain

(2014) Tracy Skaer   Journal of Pain Research

A meta-analysis of efficacy and tolerability of buprenorphine for the relief of cancer pain

(2014) Cho Naing et al.   SpringerPlus

A randomised controlled trial of sublingual buprenorphine–naloxone film versus tablets in the management of opioid dependence

(2013) N. Lintzeris et al.   DRUG AND ALCOHOL DEPENDENCE

Pharmaceutical and pharmacokinetic characterization of a novel sublingual buprenorphine/naloxone tablet formulation in healthy volunteers

(2013) Andreas Fischer et al.   DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

Reply to

(2013) Waltraud Stromer et al.   EUROPEAN JOURNAL OF ANAESTHESIOLOGY

An alternative way of managing acute pain in patients who are in buprenorphine opioid substitution therapy programs

(2013) Christine A. Huxtable et al.   EUROPEAN JOURNAL OF ANAESTHESIOLOGY

Effects of chronic kidney disease and uremia on hepatic drug metabolism and transport

(2013) Catherine K. Yeung et al.   KIDNEY INTERNATIONAL

A Feasibility Study of Transdermal Buprenorphine Versus Transdermal Fentanyl in the Long-Term Management of Persistent Non-Cancer Pain

(2013) Farzana Mitra et al.   PAIN MEDICINE

Dose Patterns among Patients Using Low-Dose Buprenorphine Patches

(2013) Eva Lesén et al.   PAIN MEDICINE

Influence of Uridine Diphosphate-Glucuronyltransferase 2B7 (UGT2B7) Variants on Postoperative Buprenorphine Analgesia

(2013) José A. Sastre et al.   Pain Practice

Local Anesthetic-like Inhibition of Voltage-gated Na+ Channels by the Partial μ-opioid Receptor Agonist Buprenorphine

(2012) Andreas Leffler et al.   ANESTHESIOLOGY

Buprenorphine 5, 10 and 20 μg/h Transdermal Patch: A Guide to Its Use in Chronic Non-Malignant Pain

(2012) Greg L. Plosker et al.   CNS DRUGS

Respiratory toxicity of buprenorphine results from the blockage of P-glycoprotein-mediated efflux of norbuprenorphine at the blood–brain barrier in mice

(2012) Hisham Alhaddad et al.   CRITICAL CARE MEDICINE

Systematic review of efficacy and safety of buprenorphine versus fentanyl or morphine in patients with chronic moderate to severe pain

(2012) Robert F. Wolff et al.   CURRENT MEDICAL RESEARCH AND OPINION

Corrected QT interval during treatment with methadone and buprenorphine—Relation to doses and serum concentrations

(2012) Marianne Stallvik et al.   DRUG AND ALCOHOL DEPENDENCE

Perioperative pain therapy in opioid abuse

(2012) Waltraud Stromer et al.   EUROPEAN JOURNAL OF ANAESTHESIOLOGY

Pharmacokinetics of transdermal buprenorphine patch in the elderly

(2012) Nabil Al-Tawil et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Once-Weekly Transdermal Buprenorphine Application Results in Sustained and Consistent Steady-State Plasma Levels

(2012) Ram P. Kapil et al.   JOURNAL OF PAIN AND SYMPTOM MANAGEMENT

The pharmacodynamic and pharmacokinetic profile of intranasal crushed buprenorphine and buprenorphine/naloxone tablets in opioid abusers

(2011) Lisa S. Middleton et al.   ADDICTION

Molecular Mechanism of β-Arrestin-Biased Agonism at Seven-Transmembrane Receptors

(2011) Eric Reiter et al.   Annual Review of Pharmacology and Toxicology

Buprenorphine 5, 10 and 20 μg/h Transdermal Patch

(2011) Greg L. Plosker   DRUGS

Efficacy and Safety of Buprenorphine Transdermal System (BTDS) for Chronic Moderate to Severe Low Back Pain: A Randomized, Double-Blind Study

(2011) Deborah Steiner et al.   JOURNAL OF PAIN

Efficacy and Safety of the Seven-Day Buprenorphine Transdermal System in Opioid-Naïve Patients with Moderate to Severe Chronic Low Back Pain: An Enriched, Randomized, Double-Blind, Placebo-Controlled Study

(2011) Deborah J. Steiner et al.   JOURNAL OF PAIN AND SYMPTOM MANAGEMENT

Transdermal buprenorphine plus oral paracetamol vs an oral codeine-paracetamol combination for osteoarthritis of hip and/or knee: a randomised trial

(2011) P.G. Conaghan et al.   OSTEOARTHRITIS AND CARTILAGE

Functional Selectivity at the  -Opioid Receptor: Implications for Understanding Opioid Analgesia and Tolerance

(2011) K. M. Raehal et al.   PHARMACOLOGICAL REVIEWS

Truncated G protein-coupled mu opioid receptor MOR-1 splice variants are targets for highly potent opioid analgesics lacking side effects

(2011) S. Majumdar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Buprenorphine as a safe alternative to methadone in a patient with acquired long QT syndrome: a case report

(2011) I. M. de Jong et al.   Netherlands Heart Journal

Buprenorphine transdermal system in adults with chronic low back pain: A randomized, double-blind, placebo-controlled crossover study, followed by an open-label extension phase

(2010) Allan Gordon et al.   CLINICAL THERAPEUTICS

A Randomized, Double-Blind, Double-Dummy Comparison of the Efficacy and Tolerability of Low-Dose Transdermal Buprenorphine (BuTrans® Seven-Day Patches) With Buprenorphine Sublingual Tablets (Temgesic®) in Patients With Osteoarthritis Pain

(2010) Ian G.V. James et al.   JOURNAL OF PAIN AND SYMPTOM MANAGEMENT

Transdermal Buprenorphine for the Treatment of Chronic Noncancer Pain in the Oldest Old

(2010) Walter Gianni et al.   JOURNAL OF PAIN AND SYMPTOM MANAGEMENT

 -Opioid Receptors: Correlation of Agonist Efficacy for Signalling with Ability to Activate Internalization

(2010) J. McPherson et al.   MOLECULAR PHARMACOLOGY

The role of beta-arrestin2 in the severity of antinociceptive tolerance and physical dependence induced by different opioid pain therapeutics

(2010) Kirsten M. Raehal et al.   NEUROPHARMACOLOGY

Effectiveness of buprenorphine maintenance treatment as compared to a syringe exchange program among buprenorphine misusing opioid-dependent patients

(2010) Mauri Aalto et al.   NORDIC JOURNAL OF PSYCHIATRY

Buprenorphine TTS for children - a review of the drug’s clinical pharmacology

(2010) Erik Michel et al.   PEDIATRIC ANESTHESIA

Current Knowledge of Buprenorphine and Its Unique Pharmacological Profile

(2010) Joseph Pergolizzi et al.   Pain Practice

TheIn VivoResponse of Novel Buprenorphine Metabolites, M1 and M3, to Antiretroviral Inducers and Inhibitors of Buprenorphine Metabolism

(2009) David E. Moody et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Identification of an additional supraspinal component to the analgesic mechanism of action of buprenorphine

(2009) Zhe Ding et al.   BRITISH JOURNAL OF PHARMACOLOGY

Buprenorphine

(2009) Howard A. Heit et al.   CLINICAL JOURNAL OF PAIN

Effects of intravenous patient-controlled analgesia with buprenorphine and morphine alone and in combination during the first 12 postoperative hours: A randomized, double-blind, four-arm trial in adults undergoing abdominal surgery

(2009) Stanislav Oifa et al.   CLINICAL THERAPEUTICS

Effect of Rifampin and Nelfinavir on the Metabolism of Methadone and Buprenorphine in Primary Cultures of Human Hepatocytes

(2009) D. E. Moody et al.   DRUG METABOLISM AND DISPOSITION

Ontogeny of midazolam glucuronidation in preterm infants

(2009) Saskia N. de Wildt et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Interaction of drugs of abuse and maintenance treatments with human P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2)

(2009) Nicolas Tournier et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Pharmacokinetics and dosage adjustment in patients with hepatic dysfunction

(2008) Roger K. Verbeeck   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Clinical update on the pharmacology, efficacy and safety of transdermal buprenorphine

(2008) Hans G. Kress   EUROPEAN JOURNAL OF PAIN

Efficacy and Safety of Transdermal Buprenorphine: A Randomized, Placebo-Controlled Trial in 289 Patients with Severe Cancer Pain

(2008) Philippe Poulain et al.   JOURNAL OF PAIN AND SYMPTOM MANAGEMENT

Equipotent doses to switch from high doses of opioids to transdermal buprenorphine

(2008) Sebastiano Mercadante et al.   SUPPORTIVE CARE IN CANCER

Opioids and the Management of Chronic Severe Pain in the Elderly: Consensus Statement of an International Expert Panel with Focus on the Six Clinically Most Often Used World Health Organization step III Opioids (Buprenorphine, Fentanyl, Hydromorphone, Methadone, Morphine, Oxycodone)

(2008) Joseph Pergolizzi et al.   Pain Practice