Article
Pharmacology & Pharmacy
Tamas Agh, Maja Ortner Hadziabdic, Kristina Garuoliene, Anne Gerd Granas, Emma Aarnio, Enrica Menditto, Joao Gregorio, Pilar Barnestein-Fonseca, Vildan Mevsim, Przemyslaw Kardas
Summary: This study aimed to provide an in-depth overview of reimbursed medication adherence enhancing interventions (MAEIs) in European countries and pave the way for future implementation. The survey found that only a small number of European countries currently reimburse MAEIs. Countries with reimbursed interventions had significantly higher GDP per capita compared to those without reimbursement.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Przemyslaw Kardas, Martina Bago, Pilar Barnestein-Fonseca, Kristina Garuolien, Anne Gerd Granas, Joao Gregorio, Maja Ortner Hadziabdi, Barbora Kostalova, Francisca Leiva-Fernandez, Pawel Lewek, Katerina Mala-Ladova, Marie Paule Schneider, Job F. M. van Boven, Daisy Volmer, Ioli Ziampara, Tamas Agh
Summary: This paper reviews reimbursed medication adherence-enhancing interventions (MAEIs) in selected European countries and finds a scarcity of these interventions, emphasizing the need for their more frequent use and reimbursement.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Ophthalmology
Ahnul Ha, Mirinae Jang, Sung Ryul Shim, Chung Young Kim, In Boem Chang, Young Kook Kim
Summary: This study compared the effectiveness of different interventions in improving medication adherence in glaucoma patients through network meta-analysis. The results showed that tailored care was the most effective intervention, and a multifaceted approach could further improve adherence.
Review
Health Care Sciences & Services
Bart P. H. Pouls, Johanna E. Vriezekolk, Charlotte L. Bekker, Annemiek J. Linn, Hein A. W. van Onzenoort, Marcia Vervloet, Sandra van Dulmen, Bart J. F. van den Bemt
Summary: This systematic review found that interactive eHealth interventions are effective in improving medication adherence, especially when using methods such as SMS, interactive voice response, mobile apps, and calls for providing adherence tele-feedback. Strategies such as teaching medication management skills, coordinating medication adherence care between professionals, and facilitating communication between patients and health care providers have shown strong evidence for a positive effect on medication adherence.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2021)
Review
Health Care Sciences & Services
Mieke H. J. Schulte, Jiska J. Aardoom, Lisa Loheide-Niesmann, Leonie L. L. Verstraete, Hans C. Ossebaard, Heleen Riper
Summary: This review investigates the effects of eHealth interventions on medication adherence in patients with COPD or asthma. The results show mixed effects, possibly due to the type, context, and intensity of the interventions, as well as differences in the operationalization and measurement of adherence outcomes. Further research is needed to fully understand the potential of eHealth in optimizing treatment adherence for COPD and asthma.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2021)
Review
Health Care Sciences & Services
Ainslie Forbes, Madeline Rose Keleher, Michael Venditto, Faith Dibiasi
Summary: Patient adherence to and engagement with digital interventions for depression play a crucial role in treatment efficacy. While most patients do not complete all available modules, the average engagement level is relatively high. Higher engagement is positively associated with improved efficacy outcomes.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Review
Psychology, Multidisciplinary
Yan Yee Cherizza Choi, Micah Fineberg, Aikaterini Kassavou
Summary: This study evaluates the effectiveness of remote interventions in supporting medication adherence after stroke. The results indicate that patients who received remote interventions had better medication adherence and improved blood pressure and cholesterol levels. The analysis also suggests that enhancing behavior factors has the most significant impact on adherence behavior and clinical outcomes.
BEHAVIORAL SCIENCES
(2023)
Review
Public, Environmental & Occupational Health
Abraham Tolley, Refaat Hassan, Rohan Sanghera, Kirpal Grewal, Ruige Kong, Baani Sodhi, Saurav Basu
Summary: This study is the first systematic review evaluating interventions to improve medication adherence for chronic diseases in India. The results suggest that patient education and regular follow-up are effective strategies to improve medication adherence. However, further high-quality randomized controlled trials are needed to evaluate these interventions.
FRONTIERS IN PUBLIC HEALTH
(2023)
Review
Ophthalmology
Shannan G. Moore, Grace Richter, Bobeck S. Modjtahedi
Summary: Glaucoma is a leading cause of vision loss and the adherence with topical therapy for glaucoma is a significant challenge. Factors such as medication cost, patient education levels, and ethnicity are associated with lower medication adherence rates. Interventions targeting patient education and personalized action plans have shown efficacy in improving adherence.
OPHTHALMOLOGY AND THERAPY
(2023)
Review
Obstetrics & Gynecology
Anna Davies, Sadie Mullin, Sarah Chapman, Katie Barnard, Danya Bakhbakhi, Rachel Ion, Francesca Neuberger, Judith Standing, Abi Merriel, Abigail Fraser, Christy Burden
Summary: Sub-optimal medication adherence in pregnant women with chronic disease and pregnancy-related indications can have negative effects on maternal and perinatal outcomes. This study aimed to identify effective interventions to promote medication adherence in pregnant and planning pregnancy women and assess their impact on perinatal, maternal disease-related, and adherence outcomes.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Review
Public, Environmental & Occupational Health
Shrey Gohil, Zahra Majd, Jared C. Sheneman, Susan M. Abughosh
Summary: This review summarizes existing literature on interventions to enhance medication adherence for inflammatory bowel disease (IBD) patients and their effectiveness. Multicomponent interventions have achieved the greatest success in promoting medication adherence among IBD patients. Future research should focus on a multidisciplinary approach to design multi-component interventions to optimize treatment adherence and enhance long-term clinical outcomes.
PATIENT EDUCATION AND COUNSELING
(2022)
Review
Infectious Diseases
Laura B. Whiteley, Elizabeth M. Olsen, Kayla K. Haubrick, Enyonam Odoom, Nicholas Tarantino, Larry K. Brown
Summary: Despite the wide range of ART adherence interventions, theory-based behavioral interventions are found to be more effective than non-theory-based interventions. Interventions should be tailored to individuals at highest risk for poor adherence. Digital and mobile ART adherence interventions have the potential to improve dissemination and implementation of evidence-based treatments both nationally and internationally.
CURRENT HIV/AIDS REPORTS
(2021)
Review
Nursing
Chun-Ja Kim, Moonsun Kim, Ga-Young Lee, Eunyoung Park, Elizabeth A. Schlenk
Summary: This study aimed to evaluate the effectiveness of nurse-led interventions on medication adherence, medication knowledge, and clinical outcomes in adults with metabolic syndrome. The findings showed that nurse-led interventions had a moderate impact on enhancing medication adherence and knowledge and improving clinical outcomes. Factors such as intervention duration, delivery mode, and use of multiple strategies influenced the effectiveness of nurse-led medication adherence interventions.
JOURNAL OF CLINICAL NURSING
(2023)
Review
Geriatrics & Gerontology
Zachary A. Marcum, Shangqing Jiang, Jennifer L. Bacci, Todd M. Ruppar
Summary: This meta-analysis found a significant improvement in medication adherence among older adults receiving pharmacist-led interventions. Implementation of pharmacist-led interventions supported by Medicare reimbursement could ensure older adults' access to effective medication adherence support.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2021)
Article
Public, Environmental & Occupational Health
Bibinur Sydykova, Dariga Smailova, Zaituna Khismetova, Marzhan Brimzhanova, Zaure Baigozhina, Hengameh Hosseini, Natalya Latypova, Marina Izmailovich
Summary: This article emphasizes the importance of comprehensive nursing documentation in scientific medicine and discusses the adoption of standardized terminologies in Europe. The study presents findings from a cross-sectional study conducted in Kazakhstan, assessing the utilization of standard operating procedures and nursing documentation in various clinical scenarios.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Pharmacology & Pharmacy
Alexandra L. Dima, Samuel S. Allemann, Jacqueline Dunbar-Jacob, Dyfrig A. Hughes, Bernard Vrijens, Ira B. Wilson
Summary: Measuring medication adherence is complex due to various contexts. The TEOS framework offers a process to operationalize adherence. This study aims to develop recommendations for quantification of medication adherence using self-report, electronic monitoring, and electronic healthcare databases.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Public, Environmental & Occupational Health
David Gillespie, Marijn de Bruin, Dyfrig A. Hughes, Richard Ma, Adam Williams, Fiona Wood, Zoe Couzens, Adam Jones, Kerenza Hood
Summary: This study investigated the factors influencing the use of PrEP and the coverage of condomless anal sex (CAS) by PrEP among men who have sex with men in Wales, UK. The results showed that an STI diagnosis was associated with lower PrEP use and coverage, while older adults had higher PrEP use. Believing that other PrEP users took PrEP as prescribed was associated with lower PrEP coverage. These findings suggest that an STI diagnosis can be an important cue for interventions to improve PrEP coverage, and provide a basis for developing evidence-informed interventions to promote PrEP coverage.
Editorial Material
Medicine, Research & Experimental
Bernie Carter, Lucy Bray, Nadia al-Najjar, Agnes Tort Piella, Catrin Tudur-Smith, Catherine Spowart, Amber Collingwood, Holly Crudgington, Janet Currier, Dyfrig A. Hughes, Eifiona Wood, Rachael Martin, Christopher Morris, Deborah Roberts, Alison Rouncefield-Swales, Heather Sutherland, Victoria Watson, Georgia Cook, Luci Wiggs, Paul Gringras, Deb Pal
Summary: This study reflects on the recruitment challenges faced in a trial examining the effectiveness of antiseizure medications and a sleep behavior intervention in children with Rolandic epilepsy. The study highlights the importance of considering parental preference, involving children in decision-making, and using alternative trial designs. Future studies should prioritize consultation and explore novel methods such as preference trials and discrete choice experiments.
Editorial Material
Nursing
Janel M. Draxler, Todd M. Ruppar
WESTERN JOURNAL OF NURSING RESEARCH
(2023)
Article
Health Care Sciences & Services
Raphaelle A. Guerbaai, Sabina DeGeest, Lori L. Popejoy, Michael Simon, Nathalie I. H. Wellens, Kris Denhaerynck, Franziska Zuniga
Summary: This study investigates the impact of implementation fidelity on unplanned transfers and finds that higher fidelity is associated with lower rates of unplanned hospital transfers. Specifically, higher fidelity to advance care planning is linked to lower rates of unplanned transfers, while lower fidelity in communication tools is linked to higher rates of unplanned transfers. The study also identifies collaborative in-house physicians and staff's perceived need for nurses in extended roles as important moderators for achieving and sustaining high fidelity.
BMC HEALTH SERVICES RESEARCH
(2023)
Article
Health Care Sciences & Services
Betty Steenkamer, Bert Vaes, Ernst Rietzschel, John Crombez, Sabina De Geest, Fabian Demeure, Marijke Gielen, Michel P. Hermans, Stefan Teughels, Peter Vanacker, Thierry van der Schueren, Steven Simoens
Summary: Although population health management is still in its early stages in Belgium, this article aims to raise awareness about its importance in addressing the public health issue of atherosclerotic cardiovascular disease. The study identified several barriers and recommendations for implementing population health management in Belgium, and proposed introducing a population health management approach to secondary prevention of atherosclerotic cardiovascular disease as a proof-of-concept.
BMC HEALTH SERVICES RESEARCH
(2023)
Editorial Material
Pharmacology & Pharmacy
Daniel F. B. Wright, Klarissa A. Sinnappah, Dyfrig A. Hughes
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Najla Chebib, Emily Holmes, Sabrina Maniewicz, Samir Abou-Ayash, Murali Srinivasan, Gerald McKenna, Anastasia Kossioni, Martin Schimmel, Frauke Mueller, Paul Brocklehurst
Summary: This pilot study used discrete choice experiments to investigate older adults' future preferences for dental service provision. The results showed a strong preference for dental examinations to be performed by dentists rather than medical doctors, and a preference for the examinations to take place in dental practices in Switzerland and the UK, and in participants' homes in Greece. Participants in Switzerland and the UK were willing to pay more to ensure the continuity of future service provision at a family dental practice.
Article
Immunology
Kris Denhaerynck, Fabienne Dobbels, Barbora Kostalova, Sabina De Geest
Summary: This study found through meta-analysis that the Basel Assessment of Adherence to Immunosuppressive Medications Scale (BAASIS) has good validity and reliability in assessing medication adherence in transplant recipients.
Review
Medicine, General & Internal
Christian Subbe, Dyfrig A. Hughes, Sally Lewis, Emily A. Holmes, Cor Kalkman, Ralph So, Sumeshni Tranka, John Welch
Summary: This study aims to explore the impact of safer care on health economic considerations for clinicians, providers, and policymakers. The results indicate that limiting the long-term effects of adverse events is crucial for optimizing population health.
Article
Economics
Paulos Gebrehiwet, Lisa Meng, Stacy A. Rudnicki, Phil Sarocco, Jenny Wei, Andrew A. Wolff, Michael Butzner, Adriano Chio, Jinsy A. Andrews, Angela Genge, Dyfrig A. Hughes, Carlayne E. Jackson, Noah Lechtzin, Timothy M. Miller, Jeremy M. Shefner
Summary: This post hoc analysis of the FORTITUDE-ALS study suggests that reldesemtiv showed a modest but significant benefit in health utilities and QALYs compared with placebo in patients with ALS.
JOURNAL OF MEDICAL ECONOMICS
(2023)
Article
Transplantation
Akihiro Kosoku, Tomoaki Iwai, Hiroo Masuda, Kazuya Kabei, Shunji Nishide, Keiko Maeda, Yuki Yoshikawa, Yasutaka Nakamura, Sabina De Geest, Junji Uchida
Summary: This study translated the Basel Assessment of Adherence to Immunosuppressive Medications Scale (BAASIS) into Japanese and developed the Japanese version of BAASIS (J-BAASIS). The J-BAASIS was found to have good reliability and validity based on the analysis of 106 kidney transplant recipients.
TRANSPLANTATION DIRECT
(2023)
Article
Genetics & Heredity
Yankier Pijeira Perez, Eifiona Wood, Dyfrig A. Hughes
Summary: The study investigates the trend in costs of orphan medicinal products (OMPs) in Wales and finds that the costs of OMPs have increased over time, with a significant increase in costs after the marketing exclusivity period expires.
ORPHANET JOURNAL OF RARE DISEASES
(2023)
Article
Health Policy & Services
Victoria Charlton, Michael Distefano, Polly Mitchell, Liz Morrell, Leah Rand, Gabriele Badano, Rachel Baker, Michael Calnan, Kalipso Chalkidou, Anthony Culyer, Daniel Howdon, Dyfrig Hughes, James Lomas, Catherine Max, Christopher Mccabe, James F. O'Mahony, Mike Paulden, Zack Pemberton-Whiteley, Annette Rid, Paul Scuffham, Mark Sculpher, Koonal Shah, Albert Weale, Gry Wester
Summary: This paper offers a clear definition of key terms and distinguishes between different types of normative commitment, providing a novel conceptual framework for the reasoning behind health technology assessment (HTA). Through application to a hypothetical case, it demonstrates how this framework can enhance the transparency and coherence of decision-making and enable accountability.
HEALTH ECONOMICS POLICY AND LAW
(2023)
Article
Health Care Sciences & Services
Sabine Valenta, Janette Ribaut, Lynn Leppla, Juliane Mielke, Alexandra Teynor, Katharina Koehly, Sabine Gerull, Florian Grossmann, Verena Witzig-Braendli, Sabina De Geest
Summary: This study provides a context-driven methodological approach for adapting interventions and tailoring implementation strategies. The importance of a theory-guided adaptation phase is highlighted, emphasizing its integration and budgeting in implementation science projects.
FRONTIERS IN HEALTH SERVICES
(2023)