Article
Physiology
Catherine Fortier, Charles-Antoine Garneau, Mathilde Pare, Hasan Obeid, Nadege Cote, Karine Duval, Remi Goupil, Mohsen Agharazii
Summary: The acute administration of nitroglycerin leads to a significant reduction in pulse wave velocity of muscular arteries without affecting aortic pulse wave velocity. This results in an unfavorable change in the AB-PWV and AF-PWV ratios, potentially increasing pulse pressure transmission into the microcirculation.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Roberto Castelli, Antonio Gidaro, Gavino Casu, Pierluigi Merella, Nicia I. Profili, Mattia Donadoni, Margherita Maioli, Alessandro P. Delitala
Summary: Aging leads to significant changes in the structural proprieties of the arterial wall, such as loss of elasticity and reduced compliance. Arterial hypertension, diabetes mellitus, and chronic kidney disease are major factors contributing to these changes. Arterial stiffness, evaluated by non-invasive methods like pulse wave velocity, is crucial in assessing vessel elasticity. Early assessment of stiffness is important as it can precede clinical signs of cardiovascular disease. While there is no specific pharmacological target for arterial stiffness, managing its risk factors can improve arterial wall elasticity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Nian Wang, Runliu Wu, Paul B. Comish, Rui Kang, Daolin Tang
Summary: Sepsis 3.0 defines sepsis as life-threatening organ dysfunction caused by the host's uncontrolled response to infection, while the BET protein family is recognized as a significant regulator of inflammation and immune response in sepsis. BET inhibitors have shown promising therapeutic effects in experimental sepsis models.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Adam Z. Spitz, Evripidis Gavathiotis
Summary: In this article, recent studies on the activation of BAX protein are discussed, providing structure-function insights and identifying regulatory surfaces that control BAX activation. The development of small molecule modulators is emphasized as a novel approach towards understanding and targeting BAX for therapeutic purposes.
TRENDS IN PHARMACOLOGICAL SCIENCES
(2022)
Article
Neurosciences
M. A. G. Martens, F. A. Kennedy McConnell, N. Filippini, C. E. Mackay, P. J. Harrison, E. M. Tunbridge
Summary: Dopamine has complex effects on cerebral circulation, and its regulation by COMT can influence regional cerebral blood flow. This study found that COMT genotype and the COMT inhibitor tolcapone both affect cerebral perfusion, with different regions of the brain being influenced by each factor.
Article
Acoustics
Alexander Nowak, L. Flavio Campanile, Alexander Hasse
Summary: Semi-active vibration reduction techniques control system parameters like stiffness to dissipate energy more efficiently, with localized stiffness changes yielding larger vibration attenuation compared to spatially homogeneous modulation, which results in a pseudo-active effect.
JOURNAL OF SOUND AND VIBRATION
(2021)
Article
Biochemistry & Molecular Biology
Jhana O. Hendrickx, Elke Calus, Peter Paul De Deyn, Debby Van Dam, Guido R. Y. De Meyer
Summary: With the increase in the world's population, the prevalence of age-related disorders such as cardiovascular disease and dementia is expected to rise. Recent studies have shown a potential link between arterial stiffness, hypertension, and Alzheimer's disease. In this study, the effects of pharmacological induction of arterial stiffness and hypertension on the progression of Alzheimer's disease in mouse models were examined. While the treatment led to increased arterial stiffness and hypertension, it did not further impair cognitive function or cerebral pathology associated with Alzheimer's disease. The short treatment duration may have limited the observed effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Neng Wang, Shengqi Wang, Xuan Wang, Yifeng Zheng, Bowen Yang, Juping Zhang, Bo Pan, Jianli Gao, Zhiyu Wang
Summary: Tumor-associated macrophages (TAMs) are key players in the tumor microenvironment and reprogramming them has become a focus for targeted therapy. Various pharmacological approaches have been shown to be effective in deleting or reprogramming TAMs, including chemokine-chemokine receptor blockers and exosomal or nanoparticle-based targeting delivery systems.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Ming-Yue Wu, Er-Jin Wang, Du Feng, Min Li, Richard D. Ye, Jia-Hong Lu
Summary: Autophagy is closely related to autoimmune diseases, with potential therapeutic effects of autophagy modulators in treating these diseases, which require further research and exploration.
ACTA PHARMACEUTICA SINICA B
(2021)
Review
Biochemistry & Molecular Biology
Anmol Sharma, Heena Khan, Thakur Gurjeet Singh, Amarjot Kaur Grewal, Agnieszka Najda, Malgorzata Kawecka-Radomska, Mohamed Kamel, Ahmed E. Altyar, Mohamed M. Abdel-Daim
Summary: The ubiquitin-proteasome pathway is crucial in regulating various biological functions and plays a significant role in tumor development. Inhibiting specific enzymes within this pathway can be an effective treatment for cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Marthe T. van Daal, Gert Folkerts, Johan Garssen, Saskia Braber
Summary: The increase in noncommunicable diseases (NCDs) is largely attributed to lifestyle factors, particularly dietary habits. High intake of saturated fatty acids and low intake of dietary fiber are linked to the rise in NCDs, while a low intake of saturated fats and a high intake of dietary fiber have a protective effect. Nutritional components can activate specific receptors which modulate the immune system, potentially offering insights for preventing and treating NCDs.
PHARMACOLOGICAL REVIEWS
(2021)
Article
Medicine, General & Internal
Laurence Guy Howes, Tanya Unni, Ameer Hamza, Jan B. Howes, Rohan Jayasinghe, Anna Kablak-Ziembicka, Mark Butlin
Summary: Antioxidants can reduce arterial stiffness, but the previous effects were weak. This study found that the combination therapy of sulfur-containing antioxidants with ascorbic acid had a significant effect on the stiffness index, which was stronger than previous studies.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Immunology
Chiel van Geffen, Constantin Heiss, Astrid Deissler, Saeed Kolahian
Summary: In this article, we summarize and critically discuss different pharmacological approaches to modulate the generation, activation, and recruitment of MDSCs in vitro and in vivo, and their potential role in future immunosuppressive therapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Respiratory System
Eva L. Peters, Harm Jan Bogaard, Anton Vonk Noordegraaf, Frances S. de Man
Summary: Pulmonary hypertension is a fatal condition characterized by elevated pulmonary pressures and right heart failure. Neurohormonal imbalance in patients with pulmonary arterial hypertension (PAH) is associated with worse prognosis and survival. However, the development of neurohormonal modulation strategies in PAH patients is limited by lack of insight into the changes in the neurohormonal system and difficulties in translating findings from animal models to human trials.
EUROPEAN RESPIRATORY JOURNAL
(2021)
Review
Biochemistry & Molecular Biology
Nicole Wagner, Kay-Dietrich Wagner
Summary: Peroxisome proliferator activated receptors (PPARs) are ligand-activated transcription factors that play important roles in glucose and lipid metabolism. They are also involved in reducing inflammation and atherosclerosis. Different types of PPARs have specific synthetic agonists, which are used to treat dyslipidemia and Type 2 diabetes mellitus. The safety of PPAR activators in cardiovascular diseases is still controversial.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Jeremy Lagrange, Morel E. Worou, Jean-Baptiste Michel, Alexandre Raoul, Melusine Didelot, Vincent Muczynski, Paulette Legendre, Francois Plenat, Guillaume Gauchotte, Marc-Damien Lourenco-Rodrigues, Olivier D. Christophe, Peter J. Lenting, Patrick Lacolley, Cecile Denis, Veronique Regnault
Summary: VWF induces VSMC proliferation through A2 domain binding to LRP4 receptor and integrin alpha(v)beta(3) signaling. These findings provide new insights into the mechanisms that drive physiological repair and pathological hyperplasia of the arterial vessel wall.
CARDIOVASCULAR RESEARCH
(2022)
Review
Cardiac & Cardiovascular Systems
Alexandre Persu, Piotr Dobrowolski, Heather L. Gornik, Jeffrey W. Olin, David Adlam, Michel Azizi, Pierre Boutouyrie, Rosa Maria Bruno, Marion Boulanger, Jean-Baptiste Demoulin, Santhi K. Ganesh, Tomasz J. Guzik, Magdalena Januszewicz, Jason C. Kovacic, Mariusz Kruk, Peter de Leeuw, Bart L. Loeys, Marco Pappaccogli, Melanie H. A. M. Perik, Emmanuel Touze, Patricia Van der Niepen, Daan J. L. Van Twist, Ewa Warchol-Celinska, Aleksander Prejbisz, Andrzej Januszewicz
Summary: Fibromuscular dysplasia (FMD) is a non-atherosclerotic vascular disease that predominantly affects women. Its exact cause is still poorly understood, but it is likely to involve a combination of genetic and environmental factors, leading to arterial fibrosis, cellular hyperplasia, and distortion of the arterial wall architecture. FMD can affect various arteries throughout the body, not just the renal and cerebrovascular arteries.
CARDIOVASCULAR RESEARCH
(2022)
Article
Peripheral Vascular Disease
Benjamin Kably, Eliane M. Billaud, Audrey Derobertmasure, Anne Blanchard, Pierre Boutouyrie, Michel Azizi
Summary: Urinary measurement of AcSDKP can serve as a reliable method for assessing adherence to ACEI treatment, showing good consistency and correlation with ACEI metabolite concentrations.
JOURNAL OF HYPERTENSION
(2022)
Article
Nutrition & Dietetics
Jeremy Bellien, Erwan Bozec, Frederic Bounoure, Hakim Khettab, Julie Malloizel-Delaunay, Mohamed Skiba, Michele Iacob, Nathalie Donnadieu, Aude Coquard, Beatrice Morio, Brigitte Laillet, Jean-Paul Rigaudiere, Jean-Michel Chardigny, Christelle Monteil, Cathy Vendeville, Alain Mercier, Anne-Francoise Cailleux, Anne Blanchard, Jacques Amar, Leopold K. Fezeu, Bruno Pannier, Alessandra Bura-Riviere, Pierre Boutouyrie, Robinson Joannides
Summary: This study assessed the cardiovascular and metabolic effects of camelina oil in hypertensive patients with metabolic syndrome. The results showed that camelina oil supplementation did not improve vascular function but adversely affected glucose metabolism.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Peripheral Vascular Disease
Agnieszka Latosinska, Rosa Maria Bruno, Marco Pappaccogli, Alessandra Bacca, Christophe Beauloye, Pierre Boutouyrie, Hakim Khettab, Jan A. Staessen, Stefano Taddei, Laurent Toubiana, Miikka Vikkula, Harald Mischak, Alexandre Persu
Summary: This study investigates the use of urinary proteomics in the diagnosis of FMD and develops a classifier to distinguish FMD patients from healthy controls and other diseases. Furthermore, the study finds a positive correlation between the proteomic score and the arterial geometry and mechanics in FMD patients.
Article
Physiology
Silvia Seoni, Simeon Beeckman, Yanlu Li, Soren Aasmul, Umberto Morbiducci, Roel Baets, Pierre Boutouyrie, Filippo Molinari, Nilesh Madhu, Patrick Segers
Summary: The study demonstrated the use of template matching and matrix profile for assessing signal quality and developing automated classifiers, showing the potential for future real-time implementation. Both methods were able to generate quality metrics on par with expert assessment, indicating their suitability for automated grading of LDV signal quality.
FRONTIERS IN PHYSIOLOGY
(2022)
Letter
Medicine, General & Internal
Alice V. Stanton, Frederic Leroy, Christopher Elliott, Neil Mann, Patrick Wall, Stefaan De Smet
Article
Acoustics
Federica Poli, Catherine Fortier, Hakim Khettab, Francesco Faita, Saverio Vitali, Giacomo Aringhieri, Lorenzo Ghiadoni, Stefano Taddei, Laurence Amar, Aurelien Lorthioir, Pierre Boutouyrie, Rosa Maria Bruno
Summary: Ultrahigh-frequency ultrasound is a useful tool for studying human small muscular arteries and understanding arterial aging. The Carotid Studio software is a valid and reproducible tool for analyzing UHFUS scans of digital arteries.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Pierre Boutouyrie
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Review
Medicine, General & Internal
Junior Justin, Antoine Fayol, Rosa-Maria Bruno, Hakim Khettab, Pierre Boutouyrie
Summary: High blood pressure is the leading cause of death worldwide, with approximately 1.5 billion people suffering from hypertension in 2010. The guidelines for hypertension management by Canadian, American, International, and European organizations provide the basic principles, but they differ in the definition, measurement, and treatment of blood pressure.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Guillaume Drevin, Marie Briet, Caroline Bazzoli, Emmanuel Gyan, Aline Schmidt, Herve Dombret, Corentin Orvain, Aurelien Giltat, Christian Recher, Norbert Ifrah, Philippe Guardiola, Mathilde Hunault-Berger, Chadi Abbara
Summary: This study aimed to assess the pharmacokinetics of daunorubicin in patients with acute myeloid leukemia and determine the optimal population PK study design. The results showed significant inter-individual variability in the PK profile of daunorubicin. A practical optimal population design with five sampling times per subject was proposed for future studies.
Article
Peripheral Vascular Disease
Pierre Boutouyrie, Antoine Fayol, Catherine Fortier, Hakim Khettab, Catalin Cristian, Umit Gencer, David Fouassier, Elie Mousseaux, Audrey Derobertmasure, Carole Leguy, Rosa-Maria Bruno
Summary: This study investigates the cardiovascular consequences of long-term microgravity on large arteries. The results show that changes in arterial properties differ according to the arterial territory and structure type. Furthermore, head-down bed rest (HDBR) leads to an increase in arterial stiffness, which does not completely recover after HDBR. These findings highlight the importance of considering the long-term cardiovascular effects of microgravity.
JOURNAL OF HYPERTENSION
(2022)
Article
Cardiac & Cardiovascular Systems
Salma Adham, Anne Legrand, Rosa-Maria Bruno, Clarisse Billon, Violaine Dalens, Pierre Boutouyrie, Jean-Michael Mazzella, Sonia Gueguen, Michael Frank, Tristan Mirault, Xavier Jeunemaitre
Summary: Most vEDS patients have arterial lesions, primarily in medium-size arteries (MSA). DN variants are associated with a higher prevalence of arterial lesions, especially in supra-aortic trunks, while HI variants are more likely to have both arterial and aortic lesions. Patients with DN variants have a higher frequency of MSA lesions.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Oncology
Morgane Cellier, Delphine Bourneau-Martin, Chadi Abbara, Alexandre Crosnier, Laurence Lagarce, Anne-Sophie Garnier, Marie Briet
Summary: Tyrosine kinase inhibitors, such as imatinib, dasatinib, nilotinib, bosutinib, and ponatinib, have significantly improved survival and quality of life in hematological cancers. However, these drugs may cause adverse drug effects on the kidney due to their activity against tyrosine kinases expressed in the kidney. A study using the WHO global safety database found signals of renal failure, fluid retention, nephrotic syndrome, and renal artery stenosis associated with these tyrosine kinase inhibitors.
Article
Cardiac & Cardiovascular Systems
Aboubakari Nambiema, Quentin Lisan, Julien Vaucher, Marie-Cecile Perier, Pierre Boutouyrie, Nicolas Danchin, Frederique Thomas, Catherine Guibout, Geoffroy Solelhac, Raphael Heinzer, Xavier Jouven, Pedro Marques-Vidal, Jean-Philippe Empana
Summary: The study found that higher healthy sleep scores and improvement over time were associated with a lower risk of coronary heart disease and stroke in the community.
EUROPEAN HEART JOURNAL
(2023)
