Article
Oncology
Wen Zhao, Lujia Jin, Peng Chen, Dingchang Li, Wenxing Gao, Guanglong Dong
Summary: Immunotherapy has become a major treatment method for metastatic or recurrent solid tumors, including colorectal cancer. In colorectal cancer patients, immune checkpoint inhibitor (ICI)-based immunotherapy has shown satisfactory safety and efficacy. Other immunotherapies such as CAR-T cells and cancer vaccines have also contributed to the development of colorectal cancer treatment.
Article
Biochemistry & Molecular Biology
Shanshan Luo, Chuiyu Kong, Danyu Ye, Xingeng Liu, Yu Wang, Guoliang Meng, Yi Han, Liping Xie, Yong Ji
Summary: Hydrogen sulfide (H2S) is a gasotransmitter that regulates physiological and pathological activities. S-sulfhydration, involving the formation of protein persulfides, explains the multiple functions of H2S. Investigating protein persulfides can provide insights into the potential functions of H2S.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Review
Oncology
Arafat Shabbir, Arsenije Kojadinovic, Tabinda Shafiq, Prabhjot S. Mundi
Summary: Genomic alterations in the RET receptor tyrosine kinase are actionable driver events in various cancers. RET point mutations and fusions are implicated in medullary thyroid cancer, differentiated thyroid cancer, and lung cancer. Recent clinical trials have shown promising response rates with highly selective RET inhibitors, leading to accelerated approval of selpercatinib and pralsetinib in 2020. Resistance to these inhibitors can occur through secondary drug resistance mutations or alternate bypass mechanisms, highlighting the need for combinatorial drug strategies.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2023)
Review
Endocrinology & Metabolism
Jose Miguel Hinojosa-Amaya, Cesar Ernesto Lam-Chung, Daniel Cuevas-Ramos
Summary: Corticotroph tumors are pituitary neoplasms arising from the Tpit lineage, with functioning CTs causing Cushing's disease and non-functioning or silent CTs and Crooke's cell subtypes more frequently manifesting as macroadenomas. Tumorigenesis involves disruption of cell-cycle regulators through genetic, epigenetic, and post-transcriptional mechanisms, potentially becoming therapeutic targets. Treatment options include targeted therapies like EGFR inhibitors and HSP90 inhibitors, as well as BRAF inhibitors for specific mutations.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Oncology
Jameel Muzaffar, Shahla Bari, Kedar Kirtane, Christine H. Chung
Summary: Head and neck squamous cell carcinoma (HNSCC) is the most common cancer in the head and neck region, with smoking, excessive drinking, and HPV infection as the main risk factors. While the prognosis of non-metastatic HNSCC continues to improve, the treatment of metastatic disease remains challenging.
Article
Business
Dennis Herhausen, Stefan F. Bernritter, Eric W. T. Ngai, Ajay Kumar, Dursun Delen
Summary: Decision-making in marketing has undergone significant changes in the past decade, with increasing attention being paid to the applications of machine learning. While machine learning brings intelligence and efficiency to marketing, it also presents challenges. This article provides an overview of machine learning applications in marketing and proposes future research directions.
JOURNAL OF BUSINESS RESEARCH
(2024)
Review
Oncology
Zhan Wang, Peng Sun, Zhiyong Li, Shaowen Xiao
Summary: Head and neck cancer is a significant global health issue, and traditional treatments often have limited success. Oncolytic virotherapy offers a new approach by genetically modifying viruses to target and kill cancer cells while sparing healthy ones. Clinical trials have shown encouraging results, and combining oncolytic viruses with other treatments has demonstrated promise.
Review
Oncology
Tomohiro Enokida, Makoto Tahara
Summary: Electrochemotherapy (ECT) is a new treatment modality for head and neck cancer, combining locally applied electric pulses with antineoplastic agents. It has shown promising efficacy and tolerable safety profile in clinical studies, making it a potential strategy for heavily pre-treated HNC patients. Efforts to improve its efficacy and expand its application are ongoing, with the combination of ECT with novel therapies like immune checkpoint inhibitors showing theoretical promise. Extensive, well-organized clinical studies and updated consensus guidelines are needed to bring this hopeful treatment to challenging situations in HNC patients.
Article
Polymer Science
Mahshid Hafezi, Saied Nouri Khorasani, Mohadeseh Zare, Rasoul Esmaeely Neisiany, Pooya Davoodi
Summary: Cartilage tissue engineering aims to develop new biomimetic cartilage to replace injured tissue, using novel engineering and biological approaches. In recent years, advanced hydrogels have been designed and synthesized to improve network crosslinking and self-recovery of implanted scaffolds.
Review
Immunology
Chunmei Hu, Min Liu, Yutao Li, Yi Zhao, Amit Sharma, Haotian Liu, Ingo G. H. Schmidt-Wolf
Summary: Head and neck cancer (HNC) is the sixth most prevalent type of cancer globally, with head and neck squamous cell carcinoma (HNSCC) being the majority. Clinical therapies for HNSCC include surgery, radiation therapy, chemotherapy, immunotherapy, targeted therapy, and multimodal treatments. However, CAR-T immunotherapy in solid tumors, particularly HNSCCs, lags behind due to various challenges. This review aims to explore the advancement of CAR-T cell therapy in treating HNSCCs.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Green & Sustainable Science & Technology
Abbas Elhambakhsh, Nguyen Van Duc Long, Pradeep Lamichhane, Volker Hessel
Summary: This paper provides a comprehensive elucidation of the principal concepts, procedures, benefits, and drawbacks of plasma-based biomass conversion processes to produce hydrogen. It surveys the impact of process variations and catalysts reported in recent research and introduces new directions for plasma applications of biomass.
Review
Pharmacology & Pharmacy
Nanxi Chen, Jianfeng Sun, Zhenhua Zhu, Adam P. Cribbs, Bo Xiao
Summary: This article introduces the extraction, construction strategies, and therapeutic effects of plant-derived exosome-like NPs (PDENs) in various diseases. It also discusses the future direction and challenges of this technology.
EXPERT OPINION ON DRUG DELIVERY
(2022)
Review
Medicine, General & Internal
David A. Bond, Peter Martin, Kami J. Maddocks
Summary: The increasing number of approved therapies for relapsed mantle cell lymphoma (MCL) provides patients with effective treatment options, but also increases the complexity in prioritization and sequencing of these therapies. Various options including chemo-immunotherapy, BTK inhibitors, Lenalidomide, bortezomib, Venetoclax, and CAR-T therapies are available for relapsed MCL, each with their own toxicity profiles, mechanisms of action and efficacy. Future directions in research include exploring combination treatment strategies and new therapies.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, Research & Experimental
Chenyue Zhang, Chenxing Zhang, Kai Wang, Haiyong Wang
Summary: Small cell lung cancer (SCLC) is a difficult-to-treat malignancy with poor prognosis. Recent advancements in targeted therapy and immune checkpoint inhibitors have shown promise in SCLC treatment. However, improving the efficacy and reducing the toxicity of immune checkpoint inhibitors, as well as identifying reliable biomarkers, remain challenging and require further investigation.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Materials Science, Multidisciplinary
Thembinkosi Donald Malevu, Richard Opio Ocaya, Ho Soonmin, Toitoi Amos Nhlapo
Summary: Metal halide perovskite photocatalysts (MHPPs) have unique electronic and optical properties that make them attractive for a variety of photocatalytic applications. Their exceptional properties can be controlled by adjusting the size of the halide ion or cation. MHPPs have shown promise in solar energy conversion, water splitting, and air purification, but practical applications face challenges in synthesis and stability. This comprehensive review discusses the properties, applications, and challenges of MHPPs, and proposes future research directions.
CRITICAL REVIEWS IN SOLID STATE AND MATERIALS SCIENCES
(2023)