High-resolution mass spectrometric metabolite profiling of a novel synthetic designer drug, N-(adamantan-1-yl)-1-(5-fluoropentyl)-1H-indole-3-carboxamide (STS-135), using cryopreserved human hepatocytes and assessment of metabolic stability with human liv

Metabolism of synthetic cannabinoids PB-22 and its 5-fluoro analog, 5F-PB-22, by human hepatocyte incubation and high-resolution mass spectrometry

(2014) Ariane Wohlfarth et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Metabolism of RCS-8, a synthetic cannabinoid with cyclohexyl structure, in human hepatocytes by high-resolution MS

(2014) Ariane Wohlfarth et al.   Bioanalysis

First Characterization of AKB-48 Metabolism, a Novel Synthetic Cannabinoid, Using Human Hepatocytes and High-Resolution Mass Spectrometry

(2013) Adarsh S. Gandhi et al.   AAPS Journal

LC/ESI-MS/MS method for quantification of 28 synthetic cannabinoids in neat oral fluid and its application to preliminary studies on their detection windows

(2013) Stefan Kneisel et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Qualitative Confirmation of 9 Synthetic Cannabinoids and 20 Metabolites in Human Urine Using LC–MS/MS and Library Search

(2013) Ariane Wohlfarth et al.   ANALYTICAL CHEMISTRY

First Metabolic Profile of XLR-11, a Novel Synthetic Cannabinoid, Obtained by Using Human Hepatocytes and High-Resolution Mass Spectrometry

(2013) A. Wohlfarth et al.   CLINICAL CHEMISTRY

Synthetic cannabinoid use associated with acute kidney injury*

(2013) Stephen L. Thornton et al.   CLINICAL TOXICOLOGY

Identification and quantification of synthetic cannabinoids in ‘spice-like’ herbal mixtures: A snapshot of the German situation in the autumn of 2012

(2013) Nico Langer et al.   Drug Testing and Analysis

The 12-month prevalence and nature of adverse experiences resulting in emergency medical presentations associated with the use of synthetic cannabinoid products

(2013) Adam R. Winstock et al.   HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL

K2 Toxicity: Fatal Case of Psychiatric Complications Following AM2201 Exposure

(2013) Amy L. Patton et al.   JOURNAL OF FORENSIC SCIENCES

Characteristics of the designer drug and synthetic cannabinoid receptor agonist AM-2201 regarding its chemistry and metabolism

(2013) Melanie Hutter et al.   JOURNAL OF MASS SPECTROMETRY

Cannabinoids in disguise: Δ9-Tetrahydrocannabinol-like effects of tetramethylcyclopropyl ketone indoles

(2013) Jenny L. Wiley et al.   NEUROPHARMACOLOGY

In vivoandin vitrometabolism of the synthetic cannabinoid JWH-200

(2013) Nik De Brabanter et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Human metabolites of synthetic cannabinoids JWH-018 and JWH-073 bind with high affinity and act as potent agonists at cannabinoid type-2 receptors

(2013) Maheswari Rajasekaran et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Monohydroxylated metabolites of the K2 synthetic cannabinoid JWH-073 retain intermediate to high cannabinoid 1 receptor (CB1R) affinity and exhibit neutral antagonist to partial agonist activity

(2012) Lisa K. Brents et al.   BIOCHEMICAL PHARMACOLOGY

A Major Glucuronidated Metabolite of JWH-018 Is a Neutral Antagonist at CB1 Receptors

(2012) Kathryn A. Seely et al.   CHEMICAL RESEARCH IN TOXICOLOGY

AKI Associated with Synthetic Cannabinoids: A Case Series

(2012) G. K. Bhanushali et al.   Clinical Journal of the American Society of Nephrology

‘Legal Highs’ – novel and emerging psychoactive drugs: a chemical overview for the toxicologist

(2012) Simon Gibbons   CLINICAL TOXICOLOGY

The detection of the urinary metabolites of 1-[(5-fluoropentyl)-1H-indol-3-yl]-(2-iodophenyl)methanone (AM-694), a high affinity cannabimimetic, by gas chromatography - mass spectrometry

(2012) Andrej Grigoryev et al.   Drug Testing and Analysis

Analysis of 30 synthetic cannabinoids in oral fluid using liquid chromatography-electrospray ionization tandem mass spectrometry

(2012) Stefan Kneisel et al.   Drug Testing and Analysis

Detection of urinary metabolites of AM-2201 and UR-144, two novel synthetic cannabinoids

(2012) Tim Sobolevsky et al.   Drug Testing and Analysis

URB-754: A new class of designer drug and 12 synthetic cannabinoids detected in illegal products

(2012) Nahoko Uchiyama et al.   FORENSIC SCIENCE INTERNATIONAL

The Identification of the Urinary Metabolites of 3-(4-Methoxybenzoyl)-1-Pentylindole (RCS-4), a Novel Cannabimimetic, by Gas Chromatography-Mass Spectrometry

(2012) P. Kavanagh et al.   JOURNAL OF ANALYTICAL TOXICOLOGY

Detection of JWH-018 and JWH-073 by UPLC-MS-MS in Postmortem Whole Blood Casework

(2012) K. G. Shanks et al.   JOURNAL OF ANALYTICAL TOXICOLOGY

Determination of 22 synthetic cannabinoids in human hair by liquid chromatography–tandem mass spectrometry

(2012) Melanie Hutter et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

LC–MS/MS method for the quantitation of metabolites of eight commonly-used synthetic cannabinoids in human urine – An Australian perspective

(2012) Andrew D. de Jager et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

High-throughput bioanalytical method for analysis of synthetic cannabinoid metabolites in urine using salting-out sample preparation and LC–MS/MS

(2012) Enrique G. Yanes et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Identification of the major urinary metabolites in man of seven synthetic cannabinoids of the aminoalkylindole type present as adulterants in ‘herbal mixtures’ using LC-MS/MS techniques

(2012) M. Hutter et al.   JOURNAL OF MASS SPECTROMETRY

Spice drugs are more than harmless herbal blends: A review of the pharmacology and toxicology of synthetic cannabinoids

(2012) Kathryn A. Seely et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Quantitative Measurement of JWH-018 and JWH-073 Metabolites Excreted in Human Urine

(2011) Cindy L. Moran et al.   ANALYTICAL CHEMISTRY

Solid-Phase Extraction and Quantitative Measurement of Omega and Omega-1 Metabolites of JWH-018 and JWH-073 in Human Urine

(2011) Krishna C. Chimalakonda et al.   ANALYTICAL CHEMISTRY

Conjugation of Synthetic Cannabinoids JWH-018 and JWH-073, Metabolites by Human UDP-Glucuronosyltransferases

(2011) K. C. Chimalakonda et al.   DRUG METABOLISM AND DISPOSITION

The detection of the urinary metabolites of 3-[(adamantan-1-yl)carbonyl]-1-pentylindole (AB-001), a novel cannabimimetic, by gas chromatography-mass spectrometry

(2011) Andrej Grigoryev et al.   Drug Testing and Analysis

Chromatography–mass spectrometry studies on the metabolism of synthetic cannabinoids JWH-018 and JWH-073, psychoactive components of smoking mixtures

(2011) Andrej Grigoryev et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Gas and liquid chromatography–mass spectrometry studies on the metabolism of the synthetic phenylacetylindole cannabimimetic JWH-250, the psychoactive component of smoking mixtures

(2011) Andrej Grigoryev et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Myocardial Infarction Associated With Use of the Synthetic Cannabinoid K2

(2011) A. Mir et al.   PEDIATRICS

Beyond THC: The New Generation of Cannabinoid Designer Drugs

(2011) Liana Fattore et al.   Frontiers in Behavioral Neuroscience

In vitro phase I metabolism of the synthetic cannabimimetic JWH-018

(2010) Annette Wintermeyer et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Detection of JWH-018 metabolites in smoking mixture post-administration urine

(2010) Tim Sobolevsky et al.   FORENSIC SCIENCE INTERNATIONAL

Monitoring of herbal mixtures potentially containing synthetic cannabinoids as psychoactive compounds

(2010) Sebastian Dresen et al.   JOURNAL OF MASS SPECTROMETRY

An Automated Liquid Chromatography-Mass Spectrometry Process to Determine Metabolic Stability Half-Life and Intrinsic Clearance of Drug Candidates by Substrate Depletion

(2008) Colleen A. McNaney et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES