Article
Medicine, General & Internal
Julie M. Donohue, Marian P. Jarlenski, Joo Yeon Kim, Lu Tang, Katherine Ahrens, Lindsay Allen, Anna Austin, Andrew J. Barnes, Marguerite Burns, Chung-Chou H. Chang, Sarah Clark, Evan Cole, Dushka Crane, Peter Cunningham, David Idala, Stefanie Junker, Paul Lanier, Rachel Mauk, Mary Joan McDuffie, Shamis Mohamoud, Nathan Pauly, Logan Sheets, Jeffery Talbert, Kara Zivin, Adam J. Gordon, Susan Kennedy
Summary: The study found that the prevalence of medication use for the treatment of opioid use disorder among Medicaid enrollees in 11 states in the US increased from 2014 through 2018. Further research is needed to understand the situation in other states.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Chemistry, Physical
Simin Liu, Defei Yin, Wei Li, Dongzhi Liu, Xueqin Zhou
Summary: Three new compounds were synthesized by introducing a benzyloxy group to phenylethyl phenylacetate (PPA) and shortening the flexible ester linker. These compounds were found to form supercooled liquids with a supercooling degree of up to 44 degrees C during a heating-cooling cycle. The effects of the benzyloxy group and the flexible linker on the phase transition processes and supercooling degrees were discussed in detail.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Biochemistry & Molecular Biology
Deepika Singh, Priya Singh, Pooja Srivastava, Dipti Kakkar, Mallika Pathak, Anjani Kumar Tiwari
Summary: Serotonin is an important neurotransmitter and hormone that affects mood, anxiety, depression, and sleep. It is one of the most desirable targets for medical chemists and pharmaceutical firms. The 5-HT1A and 5-HT7 receptors are related to psychological conditions such as anxiety, depression, and movement disorders, with the 5-HT7 receptor potentially being a beneficial target for depression treatment.
BIOORGANIC CHEMISTRY
(2023)
Article
Public, Environmental & Occupational Health
Lisa M. Letourneau
Summary: Rural states and communities are facing significant challenges in addressing the ongoing opioid epidemic and implementing strategies for prevention and treatment tailored for their unique needs. Evidence-based approaches and tailored options are crucial for the success of combating this deadly epidemic in rural areas.
PREVENTIVE MEDICINE
(2021)
Article
Medicine, General & Internal
Tara Gomes, Tonya J. Campbell, Sophie A. Kitchen, Ria Garg, Nikki Bozinoff, Siyu Men, Mina Tadrous, Charlotte Munro, Tony Antoniou, Dan Werb, Jennifer Wyman
Summary: A retrospective cohort study in Ontario, Canada during the COVID-19 pandemic found that providing increased take-home doses of opioid agonist therapy was associated with lower risks of treatment interruption and discontinuation. The study did not show a significant increase in opioid-related overdoses over 6 months of follow-up.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2022)
Article
Nanoscience & Nanotechnology
Fahao Ma, Qian Wu, Mu Liu, Liren Zheng, Fengxia Tong, Zeyan Wang, Peng Wang, Yuanyuan Liu, Hefeng Cheng, Ying Dai, Zhaoke Zheng, Yuchen Fan, Baibiao Huang
Summary: Surface engineering plays a crucial role in enhancing the electrocatalytic performance of NiFe-PBA-F catalyst for oxygen evolution reaction (OER). The controlled removal of ligands through surface fluorination provides a pathway for maintaining the framework structure of NiFe-PBA, leading to the creation of more active sites for F-doped NiFeOOH. The lattice oxygen oxidation mechanism proposed for NiFe-PBA-F contributes to a better understanding of the reconstruction process and the OER mechanism.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Mathematics, Applied
Dinesh Kumar, Frederic Ayant, Norbert Suedland, Junesang Choi
Summary: Using Mellin-Barnes contour integrals, we propose a q-extension of the several variable Aleph-function. We then present Riemann Liouville fractional q-integral and q-differential formulae for the q-extended several variable Aleph-function. By using the q-analogue of the Leibniz rule, we provide a formula expressed in terms of an infinite series for the q-extended several variable Aleph-function. The general nature of the formulas presented in this article allows for the reduction to yield identities involving q-extended simpler special functions, such as the q-extended I-function, the q-extended H-function, and the q-extended Meijer's G-function. These results are believed to have applications in quantum mechanics.
Article
Medicine, General & Internal
Elizabeth J. Austin, Jessica Chen, Elsa S. Briggs, Lori Ferro, Paul Barry, Ashley Heald, Joseph O. Merrill, Geoffrey M. Curran, Andrew J. Saxon, John C. Fortney, Anna D. Ratzliff, Emily C. Williams
Summary: This study explores the experiences and perspectives of multidisciplinary primary care (PC) teams in initiating or expanding medication for opioid use disorder (MOUD). The results suggest that PC teams face challenges in providing rapid access to care and engaging patients with MOUD, as well as maintaining clinician confidence. Attitudes towards MOUD expansion vary among PC teams. The study highlights the need for flexibility in appointment scheduling, effective patient engagement, and ongoing training to address evolving opioid-related clinical issues.
Article
Biochemical Research Methods
Dora Ujj, Eszter Kalydi, Milo Malanga, Erzsebet Varga, Tamas Sohajda, Szabolcs Beni, Gabor Benkovics
Summary: This paper describes the application of three single-isomeric cyclodextrin derivatives, Sugammadex, Subetadex, and Sualphadex, as chiral selectors for the first time. Their recognition ability was investigated through chiral capillary electrophoresis on a pool of cathinone and amphetamine derivatives. The size of the cavity and the number of ionizable groups of the selectors influenced their enantioselectivity performance. Subetadex showed the best performance as a chiral selector under acidic pH values, as proven by capillary electrophoresis and NMR measurements.
JOURNAL OF CHROMATOGRAPHY A
(2022)
Article
Medicine, General & Internal
Joshua A. Barocas, Samantha K. Nall, Sarah Axelrath, Courtney Pladsen, Alaina Boyer, Alex H. Kral, Ashley A. Meehan, Alexandra Savinkina, David Peery, Michael Bien, Christine Agnew-Brune, Jesse Goldshear, Joey Chiang, Benjamin P. Linas, Gregg Gonsalves, Ricky N. Bluthenthal, Emily Mosites, NHBS Study Grp
Summary: At least 500,000 people in the US are homeless every night, and over 30% of them also have substance use disorders. Involuntary displacement is a common response to unsheltered homelessness. It is important to understand the health implications of displacement, especially regarding substance use disorder outcomes.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Letter
Medicine, General & Internal
Kao-Ping Chua, Thuy D. D. Nguyen, Jason Zhang, Rena M. M. Conti, Pooja Lagisetty, Amy S. S. Bohnert
Summary: This study utilizes data from a comprehensive database of prescription sales in US retail pharmacies to analyze the patterns of buprenorphine initiation and retention from 2016 to 2022.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Medicine, General & Internal
Ji E. Chang, Berkeley Franz, Jose A. Pagan, Zoe Lindenfeld, Cory E. Cronin
Summary: This cross-sectional study found that safety-net hospitals (SNHs) had lower odds of providing substance use disorder (SUD) services compared to non-SNHs. The findings further suggest that SNHs may face additional barriers to offering SUD programs, highlighting the need for further research to understand these barriers and identify strategies for addressing them.
Editorial Material
Health Care Sciences & Services
Parisa Mortaji, Dale Terasaki, Jaime Moo-Young
Summary: Opioid use disorder has impacted many lives in the US, with medications like buprenorphine shown to decrease mortality in patients. This case study of a 32-year-old woman undergoing multiple surgeries highlights the use of buprenorphine/naloxone, methadone, and a novel microdosing approach. The report aims to provide hospital-based providers with insights on managing peri-operative patients on medications for opioid use disorder.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2021)
Article
Medicine, General & Internal
Madeline C. Frost, Lan Zhang, H. Myra Kim, Lewei (Allison) Lin
Summary: The study found that many patients accessed buprenorphine via telephone, and some were less likely to have any video visits. The results suggest that discontinuing or reducing telephone access may disrupt treatment for many patients, particularly groups with access disparities such as Black patients and those experiencing homelessness.
Article
Medicine, General & Internal
Yu-Tien Hsu, Ya-Wen Chen, David C. Chang, Numa P. Perez, Maggie L. Westfal, Ya-Ching Hung, Cassandra M. Kelleher, Peter T. Masiakos, Chana A. Sacks
Summary: This study analyzed data from emergency departments in New York from 2005 to 2016 and found an annual incidence rate of 18.4 per 100,000 population for nonfatal firearm-related injuries. Although overall trends showed a decrease, over half of the counties saw an increase in injury incidence between 2010 and 2015.
Article
Biochemical Research Methods
Simon D. Brandt, Pierce V. Kavanagh, Folker Westphal, Wolfgang Dreiseitel, Geraldine Dowling, Matthew J. Bowden, James P. B. Williamson
Summary: Synthetic cannabinoid receptor agonists (SCRAs) are a diverse group of molecules considered new psychoactive substances (NPS) designed to explore the cannabinoid receptor system. This study extensively characterized a group of SCRAs with sulfamoyl benzoate, sulfamoyl benzamide, and N-benzoylpiperidine based structures, providing useful analytical profiles for researchers and scientists. The research performed by Stargate International set the stage for the development of these compounds, potentially leading to the emergence of new SCRAs with the quinolin-8-yl head group.
DRUG TESTING AND ANALYSIS
(2021)
Article
Clinical Neurology
Torsten Passie, Hans-Anton Adams, Frank Logemann, Simon D. Brandt, Birgitt Wiese, Matthias Karst
Summary: Ketamine and its enantiomers, particularly the (S)-enantiomer, have distinct psychological effects which can impact psychopathology and neurocognitive function. While (R)-ketamine appears to have fewer dissociative and psychotomimetic effects at subanesthetic doses, (S)-ketamine may induce more negative psychopathology experiences. The study suggests that the ideal composition of ketamine for treating depression should include (R)-ketamine, as it may offer protective effects against negative psychotomimetic effects compared to (S)-ketamine.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Istvan Ujvary, Rachel Christie, Michael Evans-Brown, Ana Gallegos, Rita Jorge, Joanna de Morais, Roumen Sedefov
Summary: Etonitazene and its derivatives, developed in the late 1950s by the Swiss pharmaceutical giant CIBA, are potent analgesics with morphine-like effects. Recently, unscheduled synthetic opioids have emerged on the illicit drug market, leading to fatalities. This class of compounds has inspired research and led to the emergence of new psychoactive substances, impacting chemical neuroscience.
ACS CHEMICAL NEUROSCIENCE
(2021)
Article
Biochemical Research Methods
Simon D. Brandt, Pierce V. Kavanagh, Folker Westphal, Alexander Stratford, Peter Blanckaert, Geraldine Dowling, Matthias Grill, Hannes M. Schwelm, Volker Auwaerter, Stephen J. Chapman
Summary: LSD analogs like MIPLA are being sold on the street market, making it crucial to develop techniques to differentiate them from LSD. This study presents methods using gas chromatography-solid phase infrared spectroscopy and mass spectrometry to distinguish between MIPLA and LAMPA.
DRUG TESTING AND ANALYSIS
(2022)
Article
Biochemistry & Molecular Biology
Matthias J. Richter, Lea Wagmann, Tanja M. Gampfer, Simon D. Brandt, Markus R. Meyer
Summary: The study identified the in vitro phase I/II metabolites of QMPSB and QMPCB and demonstrated the involvement of various monooxygenases and human carboxylesterases in their metabolism. Ester hydrolysis, hydroxylation, and formation of glucuronides and sulfates were observed. Including these metabolites in toxicological screening procedures is recommended based on the results of the in vitro experiments.
Article
Biochemical Research Methods
Simon D. Brandt, Pierce V. Kavanagh, Folker Westphal, Benedikt Pulver, Kathleen Morton, Alexander Stratford, Geraldine Dowling, Adam L. Halberstadt
Summary: The research on the novel LSD derivative 1V-LSD suggests that it has hallucinogenic effects similar to LSD but at lower doses. Further studies on its biotransformation and receptor pharmacology are needed to fully elucidate its mechanism of action.
DRUG TESTING AND ANALYSIS
(2022)
Editorial Material
Biochemical Research Methods
Simon D. Brandt, Michael Collins
DRUG TESTING AND ANALYSIS
(2022)
Article
Biochemical Research Methods
Simon D. Brandt, Pierce Kavanagh, Folker Westphal, Benedikt Pulver, Hannes M. Schwelm, Kyla Whitelock, Alexander Stratford, Volker Auwaerter, Adam L. Halberstadt
Summary: This study characterized a novel lysergamide N,N-diethyl-1-propanoyl-6-(prop-2-en-1-yl)-9,10-didehydroergoline-8 beta-carboxamide (1P-AL-LAD) using various analytical methods. In vitro metabolism studies confirmed that 1P-AL-LAD acted as a prodrug and converted to AL-LAD as the most abundant metabolite. 1P-AL-LAD induced dose-dependent head twitch response (HTR) in mice, similar to other hallucinogenic substances.
DRUG TESTING AND ANALYSIS
(2022)
Article
Biochemical Research Methods
Pierce Kavanagh, Folker Westphal, Benedikt Pulver, Hannes M. Schwelm, Alexander Stratford, Volker Auwaerter, Stephen J. Chapman, Adam L. Halberstadt, Simon D. Brandt
Summary: This study describes the analysis of a novel lysergamides compound, 1cP-AL-LAD, using various chromatographic, mass spectrometric, and spectroscopic methods. The compound was found in both purchased samples and blotters sold online for recreational use. The findings provide valuable information for those interested in the chemistry of lysergamides.
DRUG TESTING AND ANALYSIS
(2023)
Article
Chemistry, Analytical
Matthias J. Richter, Lea Wagmann, Simon D. Brandt, Markus R. Meyer
Summary: The study identified in vitro metabolites of synthetic cannabinoid receptor agonists 2F-QMPSB and SGT-233, and found suitable targets for toxicological screenings. Different enzymes and human carboxylesterases were involved in their metabolism. Various CYP isoforms played important roles in the metabolism of these compounds.
JOURNAL OF ANALYTICAL TOXICOLOGY
(2023)
Article
Neurosciences
Adam L. Halberstadt, Dino Luethi, Marius C. Hoener, Daniel Trachsel, Simon D. Brandt, Matthias E. Liechti
Summary: This study investigated the structure-activity relationships of 4-thio-substituted phenylalkylamines and found that these compounds have psychedelic effects, supporting their classification as psychedelics.
PSYCHOPHARMACOLOGY
(2023)
Article
Biochemical Research Methods
Simon D. Brandt, Pierce V. Kavanagh, Folker Westphal, Benedikt Pulver, Hannes M. Schwelm, Alexander Stratford, Volker Auwaerter, Adam L. Halberstadt
Summary: Preclinical investigations have shown that EIPLA exhibits LSD-like properties and can mimic the effects of known psychedelic drugs, making it important for forensic and clinical research.
DRUG TESTING AND ANALYSIS
(2023)
Review
Biochemical Research Methods
Istvan Ujvary
Summary: Since the early 2000s, the global illicit cannabinoid market has been in turmoil with the emergence of unregulated synthetic cannabinoids and more recently, semi-synthetic cannabinoids made from hemp extracts. The production of these semi-synthetic cannabinoids, such as hexahydrocannabinol (HHC), was triggered by changes in US legislation regarding hemp cultivation. Current large-scale manufacture of HHC is based on hemp-derived CBD extract and involves cyclization and catalytic hydrogenation processes. While preclinical studies have shown THC-like properties in (9R)-HHC, the human pharmacology and metabolism of HHC are still unknown, and there is a lack of (immuno)analytical methods for rapid detection of HHC or its metabolites in urine. This review provides an overview of the legal background, chemistry, analysis, and pharmacology of HHC and related analogs, including HHC acetate (HHC-O).
DRUG TESTING AND ANALYSIS
(2023)
Article
Biochemical Research Methods
Verena Angerer, Yasmin Schmid, Florian Franz, Heike Gnann, Jan Manuel Speer, Anke Gnann, Stephan Helmecke, Armin Buchwald, Simon D. Brandt, Torsten Passie, Matthias E. Liechti, Volker Auwaerter
Summary: Administration of the new psychoactive substance 5,6-methylenedioxy-2-aminoindane (MDAI) to six volunteers revealed that acute subjective effects were qualitatively comparable with 3,4-methylenedioxymethamphetamine (MDMA) based on psychometric measures. Physiological and endocrine measures were also included. In serum and urine, MDAI could be detected for at least 4 and 6 days.
DRUG TESTING AND ANALYSIS
(2023)
Article
Chemistry, Medicinal
Adam K. Klein, Muhammad Chatha, Lauren J. Laskowski, Emilie Anderson, Simon D. Brandt, Stephen J. Chapman, John D. McCorvy, Adam L. Halberstadt
Summary: This study investigated the pharmacological properties of tryptamine derivatives containing N,N-dialkyl substituents and a 4-hydroxy or 4-acetoxy group, revealing their similar potencies at 5-HT2A and 5-HT2B receptors. The compounds acted as full or partial agonists at 5-HT2 subtypes and induced LSD-like head twitches in mice. O-acetylation reduced the in vitro potency of the compounds but had little effect on their in vivo head twitch response potency, suggesting a prodrug mechanism.
ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE
(2021)