Article
Oncology
Zhiqian Zhang, Xu Huang, Enlin Wang, Yugang Huang, Rongcun Yang
Summary: The study revealed that two subsets of murine Gr1(+)CD11b(+) cells, B220(+) and B220(-), have differing effects on tumor metastasis and cancer cell motility. IL-6 signaling pathway plays opposing roles in the expansion of B220(-) MDSCs and B220(+) counterparts, indicating potential therapeutic implications for inducing MDSCs to B220(+) cells in cancer therapy.
Article
Biotechnology & Applied Microbiology
Rahul Mallick, Erika Gurzeler, Pyry I. Toivanen, Tiina Nieminen, Seppo Yla-Herttuala
Summary: VEGF-B186R127S induces vascular growth in mouse heart by recruiting EPCs. It is a novel therapeutic agent for cardiac therapeutic angiogenesis to rescue myocardial tissue after an ischemic insult.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Polymer Science
Ana C. Manjua, Joaquim M. S. Cabral, Frederico Castelo Ferreira, Carla A. M. Portugal
Summary: This work demonstrates the ability to remotely control the paracrine performance of MSCs in secreting VEGF-A by modulation of an external magnetic field. Higher magnetic field intensity is associated with increased cell death and poor angiogenic effect. Dynamic magnetic field and higher frequency stimulation improve the angiogenic performance of endothelial cells.
Article
Biochemistry & Molecular Biology
Hayan Kwon, Ja-Young Kwon, Jeeun Song, Yong-Sun Maeng
Summary: Research has shown that offspring exposed to preeclampsia (PE) in utero have decreased lymphangiogenic activities in lymphatic endothelial progenitor cells (LEPCs) both in vitro and in vivo, along with decreased expression of pro-lymphangiogenic genes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Elzbieta Zarychta, Barbara Ruszkowska-Ciastek, Kornel Bielawski, Piotr Rhone
Summary: This study examined the utility of SDF-1 alpha and selected vasculo-angiogenic parameters in predicting disease relapse in invasive breast cancer patients. The combination of SDF-1 alpha lower than 42 pg/dL and a number of circulating EPCs lower than 9.68 cells/μL showed strong diagnostic power for predicting disease relapse.
Article
Multidisciplinary Sciences
Adrian Moure, Guillermo Vilanova, Hector Gomez
Summary: This study investigates the complex interactions between interstitial flow and the affinity for matrix binding of different chemokine isoforms using a computational model. The results demonstrate that changing the matrix affinity of the chemokine isoform can invert the effect of interstitial flow on angiogenesis. These findings provide insight into the intricate mechanisms of angiogenesis in the tumor microenvironment.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Walker D. Short, Emily Steen, Aditya Kaul, Xinyi Wang, Oluyinka O. Olutoye, Hima V. Vangapandu, Natalie Templeman, Alexander J. Blum, Chad M. Moles, Daria A. Narmoneva, Timothy M. Crombleholme, Manish J. Butte, Paul L. Bollyky, Sundeep G. Keswani, Swathi Balaji
Summary: This study found that overexpression of IL-10 in dermal wounds recruits EPCs, increases vascular structures, and accelerates re-epithelialization.
Article
Engineering, Biomedical
Kevin T. Campbell, Matthew B. Curtis, Joshua M. Massey, Kajetan Wysoczynski, Dustin J. Hadley, Steve C. George, Eduardo A. Silva
Summary: Lymphatic dysfunction is associated with the progression of several vascular disorders, and there are limited strategies currently available to promote new lymphatic vasculature. This study isolated lymphatic endothelial progenitor cells from human umbilical cord blood and found that they have the potential to promote lymphatic sprouts, highlighting the therapeutic potential of these cells. Delivery of lymphatic EPCs using alginate hydrogels also showed promise for possible therapeutic applications.
ACTA BIOMATERIALIA
(2021)
Article
Endocrinology & Metabolism
Mary P. Udumula, Sharif Sakr, Sajad Dar, Ayesha B. Alvero, Rouba Ali-Fehmi, Eman Abdulfatah, Jing Li, Jun Jiang, Amy Tang, Thomas Buekers, Robert Morris, Adnan Munkarah, Shailendra Giri, Ramandeep Rattan
Summary: The study reveals that the ovarian cancer microenvironment can regulate the metabolism and function of CD11b(+)Gr1(+) myeloid cells, with inhibition of glutamine metabolic pathway reducing their activity and the immunosuppressive tumor microenvironment. Targeting glutamine metabolism has the potential to enhance immunotherapy success in ovarian cancer.
MOLECULAR METABOLISM
(2021)
Article
Multidisciplinary Sciences
Yoshiya Asano, Daisuke Okano, Michiya Matsusaki, Tetsuro Watabe, Yasuhiro Yoshimatsu, Mitsuru Akashi, Hiroshi Shimoda
Summary: In this study, an artificial vascular tissue constructed by human adipose tissue-derived stromal cells (hASCs) and HUVECs (ASCVT) showed higher vascular network density and expression of angiogenesis-related factors. Subcutaneous transplantation of ASCVT into nude mice resulted in the formation of functional vessel networks within 4 weeks.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Chang-Yu Song, Sunny Li-Yun Chang, Chih-Yang Lin, Chun-Hao Tsai, Shang-Yu Yang, Yi-Chin Fong, Yu-Wen Huang, Shih-Wei Wang, Wei-Cheng Chen, Chih-Hsin Tang
Summary: New treatments for chondrosarcoma are crucial due to its poor prognosis, and factors like PDGF and visfatin play significant roles in tumor development and angiogenesis. Research has shown that visfatin promotes chondrosarcoma angiogenesis by modulating miR-1264 expression, potentially offering a new therapeutic approach for the treatment of chondrosarcoma.
Review
Biochemistry & Molecular Biology
Lucio Diaz-Flores, Ricardo Gutierrez, Maria Pino Garcia, Miriam Gonzalez-Gomez, Lucio Diaz-Flores, Jose Luis Carrasco, Juan Francisco Madrid, Aixa Rodriguez Bello
Summary: Perivascular cells, including pericytes and CD34+ stromal cells/telocytes, play an important role in angiogenesis. The behavior and changes of these cells differ depending on the type of angiogenesis, involving various cell-to-cell interactions and signaling pathways. Perivascular cells and CD34+ stromal cells/telocytes have important functions in vessel development and tissue repair, while their involvement in intussusceptive angiogenesis is limited.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Materials Science, Multidisciplinary
Ana C. Manjua, Joaquim M. S. Cabral, Carla A. M. Portugal, Frederico Castelo Ferreira
Summary: This study demonstrates the use of external magnetic fields to stimulate mesenchymal stromal cells (MSCs) and increase the production of vascular endothelial growth factor-A (VEGF-A). The magnetic stimulation significantly enhances MSCs angiogenic potential and guides their morphology and alignment, leading to an increase in new vessel formation in both in vitro and in vivo models. Ultimately, this research reveals the potential to manipulate cellular processes through short-term magnetic stimulation.
SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS
(2021)
Review
Biochemistry & Molecular Biology
Melissa Garcia-Caballero, Liliana Sokol, Anne Cuypers, Peter Carmeliet
Summary: The dynamic crosstalk between different components of the tumor microenvironment plays a critical role in cancer progression and metastasis. Angiogenesis is crucial for tumor growth, but abnormal blood vessels can lead to hypoxia and acidosis in the tumor microenvironment. Cancer and stromal cells can alter their metabolism to meet high energy demands and promote tumor proliferation. Recent studies have shown that the metabolism of tumor endothelial cells is reprogrammed and targeting these metabolic pathways can affect blood vessel formation. Therefore, metabolic antiangiogenic therapies combined with immunotherapies offer a clinical opportunity for cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Yanfen Cui, Hui Liu, Zhaosong Wang, He Zhang, Jianfei Tian, Zhiyong Wang, Weijie Song, Hui Guo, Liming Liu, Ruinan Tian, Xiaoyan Zuo, Sixin Ren, Fei Zhang, Ruifang Niu
Summary: High fructose intake is associated with increased risk of multiple cancers. Fructose can enhance the biological function of vascular endothelial cells (VECs) and promote angiogenesis by activating the Akt and Src signaling pathways. It can also upregulate production of reactive oxygen species (ROS) in colorectal cancer cells, indirectly enhancing the function of VECs. These findings have been validated in clinical colorectal cancer tissues and mouse models.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
