Challenges in exploring the cytochrome P450 system as a source of variation in canine drug pharmacokinetics

Proximal Duodenal Perforation in Three Dogs Following Deracoxib Administration

(2014) J. Brad Case et al.   JOURNAL OF THE AMERICAN ANIMAL HOSPITAL ASSOCIATION

Mass Spectrometry-Based Quantification of CYP Enzymes to Establish In Vitro/In Vivo Scaling Factors for Intestinal and Hepatic Metabolism in Beagle Dog

(2012) Aki T. Heikkinen et al.   PHARMACEUTICAL RESEARCH

Pharmacogenetics of drugs withdrawn from the market

(2012) Wei Zhang et al.   PHARMACOGENOMICS

Expression of the aryl hydrocarbon receptor pathway and cyclooxygenase-2 in dog tumors

(2012) M. Giantin et al.   RESEARCH IN VETERINARY SCIENCE

Comparison of Cytochrome P450 2D6 and Variants in Terms of Drug Oxidation Rates and Substrate Inhibition

(2011) Toshiro Niwa et al.   CURRENT DRUG METABOLISM

Role of the cytochrome P450 enzyme system in veterinary pharmacokinetics: where are we now? Where are we going?

(2011) Leposava Antonovic et al.   Future Medicinal Chemistry

Personalizing medicine with clinical pharmacogenetics

(2011) Stuart A. Scott   GENETICS IN MEDICINE

Antitumor effects of deracoxib treatment in 26 dogs with transitional cell carcinoma of the urinary bladder

(2011) Sarah K. McMillan et al.   JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION

The effects of concurrent administration of cytochrome P-450 inhibitors on the pharmacokinetics of oral methadone in healthy dogs

(2011) Butch KuKanich et al.   VETERINARY ANAESTHESIA AND ANALGESIA

Stereo-Selective Metabolism of Methadone by Human Liver Microsomes and cDNA-Expressed Cytochrome P450s: A Reconciliation

(2010) Yan Chang et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Expression and Characterization of Dog Cytochrome P450 2A13 and 2A25 in Baculovirus-Infected Insect Cells

(2010) D. Zhou et al.   DRUG METABOLISM AND DISPOSITION

Cytochrome P450-mediated hepatic metabolism of new fluorescent substrates in cats and dogs

(2010) C. D. Van BEUSEKOM et al.   JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS

Population pharmacokinetics of mavacoxib in osteoarthritic dogs

(2010) S. R. COX et al.   JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS

Detection of the CYP1A2 1117C > T polymorphism in 14 dog breeds

(2010) J. S. ARETZ et al.   JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS

Genetic Polymorphism and Toxicology—With Emphasis on Cytochrome P450

(2010) Inger Johansson et al.   TOXICOLOGICAL SCIENCES

Hormonal gene regulation through DNA methylation and demethylation

(2010) Alexander Kouzmenko et al.   Epigenomics

Insights into the Substrate Specificity, Inhibitors, Regulation, and Polymorphisms and the Clinical Impact of Human Cytochrome P450 1A2

(2009) Shu-Feng Zhou et al.   AAPS Journal

Major Genomic Events and Their Consequences for Vertebrate Evolution and Endocrinology

(2009) Dan Larhammar et al.   Annals of the New York Academy of Sciences

Polymorphism of Human Cytochrome P450 2D6 and Its Clinical Significance

(2009) Shu-Feng Zhou   CLINICAL PHARMACOKINETICS

Substrate Specificity, Regulation, and Polymorphism of Human Cytochrome P450 2B6

(2009) Sui-Lin Mo et al.   CURRENT DRUG METABOLISM

Current Cytochrome P450 Phenotyping Methods Applied to Metabolic Drug-Drug Interaction Prediction in Dogs

(2009) B. M. Mills et al.   DRUG METABOLISM AND DISPOSITION

Structure, function, regulation and polymorphism and the clinical significance of human cytochrome P450 1A2

(2009) Shu-Feng Zhou et al.   DRUG METABOLISM REVIEWS

Molecular genetics and epigenetics of the cytochrome P450 gene family and its relevance for cancer risk and treatment

(2009) Cristina Rodriguez-Antona et al.   HUMAN GENETICS

Canine CYP2B11 metabolizes and is inhibited by anesthetic agents often co-administered in dogs

(2009) M. T. BARATTA et al.   JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS

Epigenetic and microRNA-dependent control of cytochrome P450 expression: a gap between DNA and protein

(2009) Alvin Gomez et al.   PHARMACOGENOMICS

Pharmacogenetic and Metabolic Differences Between Dog Breeds: Their Impact on Canine Medicine and the Use of the Dog as a Preclinical Animal Model

(2008) Steven Fleischer et al.   AAPS Journal

CYP2B6: New Insights into a Historically Overlooked Cytochrome P450 Isozyme

(2008) Hongbing Wang et al.   CURRENT DRUG METABOLISM

Drugs Behave as Substrates, Inhibitors and Inducers of Human Cytochrome P450 3A4

(2008) Shu-Feng Zhou   CURRENT DRUG METABOLISM

Evaluation of Escherichia coli Membrane Preparations of Canine CYP1A1, 2B11, 2C21, 2C41, 2D15, 3A12, and 3A26 with Coexpressed Canine Cytochrome P450 Reductase

(2008) C. W. Locuson et al.   DRUG METABOLISM AND DISPOSITION

In Vitro Drug-Drug Interaction Screens for Canine Veterinary Medicines: Evaluation of Cytochrome P450 Reversible Inhibition

(2008) D. Aidasani et al.   DRUG METABOLISM AND DISPOSITION

Characterization of Substrate Specificity of Dog CYP1A2 Using CYP1A2-Deficient and Wild-Type Dog Liver Microsomes

(2008) M. Mise et al.   DRUG METABOLISM AND DISPOSITION

Aberrant Splicing Caused by Single Nucleotide Polymorphism c.516G>T [Q172H], a Marker of CYP2B6*6, Is Responsible for Decreased Expression and Activity of CYP2B6 in Liver

(2008) M. H. Hofmann et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Canine ABCB1 and macrocyclic lactones: Heartworm prevention and pharmacogenetics

(2008) Katrina L. Mealey   VETERINARY PARASITOLOGY

Differential expression ofCYP3A12andCYP3A26mRNAs in canine liver and intestine

(2008) K. L. Mealey et al.   XENOBIOTICA

Species Differences in In Vitro and In Vivo Small Intestinal Metabolism of CYP3A Substrates

(2007) Hiroshi Komura et al.   JOURNAL OF PHARMACEUTICAL SCIENCES