Article
Biochemistry & Molecular Biology
Tsz Cheung Chong, Iris L. K. Wong, Jiahua Cui, Man Chun Law, Xuezhen Zhu, Xuesen Hu, Jason W. Y. Kan, Clare S. W. Yan, Tak Hang Chan, Larry M. C. Chow
Summary: This study identified Ac15(Az8)(2) as a potent and non-toxic BCRP inhibitor that can reverse BCRP-mediated drug resistance and inhibit tumor growth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Farbod Bahreini, Elham Rayzan, Nima Rezaei
Summary: Breast cancer, a multifactorial disease, may have an increased risk due to alterations in microRNA sequences. miR-SNPs are potential biomarkers for early detection of breast cancer.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Zsolt Safar, Gabor Kecskemeti, Judit Molnar, Anita Kurunczi, Zoltan Szabo, Tamas Janaky, Emese Kis, Peter Krajcsi
Summary: BCRP/ABCG2 is a key factor in the pharmacokinetics of substrate drugs. Membranes from different expression systems show variation in substrate correlation and dynamic range, but good consistency in IC50 values.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Sonali Mehendale-Munj, Shivangi Sawant
Summary: Breast Cancer Resistance Protein (BCRP) is an efflux transporter responsible for causing multidrug resistance. BCRP expels potent antineoplastic drugs, leading to resistance and failure in cancer treatment. The regulation and expression of BCRP play important roles in maintaining the balance of xenobiotics and nutrients, impacting cancer therapies.
CURRENT DRUG TARGETS
(2021)
Article
Medicine, Research & Experimental
Bianca Vora, Deanna J. Brackman, Ling Zou, Maria Garcia-Cremades, Marina Sirota, Radojka M. Savic, Kathleen M. Giacomini
Summary: The study revealed that the p.Q141K genotype and renal function affected the half-life of oxypurinol and serum uric acid levels, while real-world data showed that patients treated with clinical BCRP inhibitors had higher levels of uric acid.
CTS-CLINICAL AND TRANSLATIONAL SCIENCE
(2021)
Article
Pharmacology & Pharmacy
Chiara Casotti, Claudia Maria Hattinger, Maria Pia Patrizio, Silvia Luppi, Leonardo Fantoni, Michela Pasello, Katia Scotlandi, Toni Ibrahim, Massimo Serra
Summary: In this study, an innovative mmNGS approach was used to investigate SNPs associated with MTX resistance in HGOS cell lines. The results showed that allele changes in TP53, SLC19A1, and MTHFR were functionally involved in the development of MTX resistance. In addition, a fusion transcript of DHFR and MSH3 was identified in the cells with the highest MTX resistance level.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Oncology
Jing Zhang, Jing Hu, Weiwei Li, Chunyan Zhang, Peng Su, Yan Wang, Wei Sun, Xiao Wang, Li Li, Xiaojuan Wu
Summary: BCRP is an independent risk factor for BCa and its expression is regulated by 17 alpha-PG in mPR alpha-positive cells through the PI3K/Akt/mTOR pathway. Rapamycin may enhance the therapeutic effects of certain chemotherapy agents in mPR alpha-positive BCa cells with BCRP overexpression.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Lydia Kuhnert, Robert Kuhnert, Menyhart B. Sarosi, Cathleen Lakoma, Birte K. Scholz, Peter Loennecke, Evamarie Hey-Hawkins, Walther Honscha
Summary: Chemotherapy is often hindered by multidrug resistance, and the inhibition of ABCG2 efflux transporter shows promise in overcoming drug resistance. This study successfully enhanced the affinity of baicalein towards ABCG2 by replacing the phenyl ring with a meta-carborane and adding three methoxy substituents. The modified compound demonstrated significant inhibitory effects on ABCG2-mediated drug resistance and holds potential for the development of efficient ABCG2 inhibitors.
MOLECULAR ONCOLOGY
(2023)
Article
Chemistry, Analytical
Jialun He, Xiaolong Li, Lei Liao, Wenjiao Zhou, Bingying Jiang
Summary: A non-enzymatic and label-free sensing method is developed for accurate and ultrasensitive differentiation of SNP in the K-ras gene, showing high sensitivity with a detection limit of 3.63 fM and high selectivity to discriminate MtDNA from a mixture with a concentration ratio of WtDNA to MtDNA as high as 5000:1. This approach has the potential application for future clinical diagnostics by analyzing target MtDNA in diluted serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Genetics & Heredity
Moumita Mukherjee, Satyajit Ghosh, Srikanta Goswami
Summary: This study explores the potential effects of SNPs on miRNA-target mRNA interactions in PDAC. Through rigorous analytical methods, common and rare variants were identified that may interfere with miRNA-mediated gene regulation in the disease. The results provide insights into the role of genetic variations in modulating miRNA function in PDAC.
Review
Chemistry, Multidisciplinary
Marcelino Varona, Jared L. Anderson
Summary: Detection of mutations and single-nucleotide polymorphisms is crucial for diagnostic applications, and Loop-mediated isothermal amplification (LAMP) is a powerful tool for this purpose. However, traditional LAMP lacks the ability to distinguish single-nucleotide differences within target sequences. Various approaches have been developed to address this limitation, including primer design modifications and probe-based detection methods.
Article
Biochemistry & Molecular Biology
Chao-Yun Cai, Qiu-Xu Teng, Megumi Murakami, Suresh V. Ambudkar, Zhe-Sheng Chen, Vijaya L. Korlipara
Summary: A series of 22 quinazolinamine derivatives with potent inhibitory activities on BCRP and P-gp were synthesized. Compound 22 was identified as a dual BCRP and P-gp inhibitor, while compound 33 showed BCRP inhibitory activity. These compounds changed the localization of BCRP and P-gp, inhibiting the efflux of anticancer drugs by the two ABC transporters. Compounds 22 and 33 also stimulated ATP hydrolysis, increasing the accumulation of mitoxantrone in BCRP-overexpressing cells.
Article
Chemistry, Analytical
Shanshan Zhai, Yao Yang, Yuhua Wu, Jun Li, Yunjing Li, Gang Wu, Jingang Liang, Hongfei Gao
Summary: This study developed a specific and sensitive detection method for the cauliflower mosaic virus 35s (CaMV35S) promoter in genetically modified (GM) crops using the nuclease-dead Cas9 (dCas9)/sgRNA system and a clustered regularly interspaced short palindromic repeats (CRISPR)/dCas9-mediated enzyme-linked immunosorbent assay (ELISA). The proposed method offers a specific, sensitive, rapid, and cost-effective detection platform for molecular diagnoses.
Article
Hematology
Hadeer Aly Abbassy, Mayada Aly Moussa, Rahma Mohamed Abd Elmoniem, Salma Alaa Eldin Imbaby
Summary: Breast cancer resistance protein (BCRP) is an ABC transporter that plays a crucial role in protecting cells from toxic compounds. Genetic variations, such as single nucleotide polymorphisms (SNPs), may affect gene expression and increase the risk of developing multiple myeloma (MM). This study suggests that the SNP-C421A of the ABCG-2 gene could be a potential predictor for MM risk.
INDIAN JOURNAL OF HEMATOLOGY AND BLOOD TRANSFUSION
(2022)
Article
Oncology
Xue Wang, Zihui Zhao, Xueqing Han, Yutong Zhang, Yitong Zhang, Fenglan Li, Hui Li
Summary: This study successfully identified 42 prognostic modules for breast cancer through constructing co-expression networks and integrating gene expression profiles and clinical data. The risk values carried by genes in these modules were found to classify high-risk and low-risk groups of patients, and 16 genes were identified as potential biological markers related to breast cancer.
FRONTIERS IN ONCOLOGY
(2021)
Letter
Pediatrics
Gideon Koren, Katarina Aleksa
Article
Pharmacology & Pharmacy
Dana Barchel, Orit Stolar, Tal De-Haan, Tomer Ziv-Baran, Naama Saban, Danny Or Fuchs, Gideon Koren, Matitiahu Berkovitch
FRONTIERS IN PHARMACOLOGY
(2019)
Article
Instruments & Instrumentation
Merav Jacobson Bensky, Irit Ayalon-Dangur, Roi Ayalon-Dangur, Eviatar Naamany, Anat Gafter-Gvili, Gideon Koren, Shachaf Shiber
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2019)
Meeting Abstract
Biophysics
Brett Baggett, Kevin Murphy, Yueming Cao, Nilufer Turan, YiChun Lu, Lorraine Schofield, Tae Yun Kim, Dmitry Terentyev, Bum Rak Choi, John Sedivy, Gideon Koren
BIOPHYSICAL JOURNAL
(2019)
Article
Pharmacology & Pharmacy
Gideon Koren, Galia Norton, Kira Radinsky, Varda Shalev
CLINICAL DRUG INVESTIGATION
(2019)
Article
Medicine, Legal
Gideon Koren, Elad Bellaish, Karen Maman
JOURNAL OF FORENSIC SCIENCES
(2019)
Article
Chemistry, Multidisciplinary
Ho-Seok Kwak, Jung-Yeol Han, Gideon Koren, Sang-Hee Jo, Ki-Hyun Kim
APPLIED SCIENCES-BASEL
(2019)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ayelet Akselrod-Ballin, Michal Chorev, Yoel Shoshan, Adam Spiro, Alon Hazan, Roie Melamed, Ella Barkan, Esma Herzel, Shaked Naor, Ehud Karavani, Gideon Koren, Yaara Goldscbmidt, Varda Shalev, Michal Rosen-Zvi, Michal Guindy
Article
Pharmacology & Pharmacy
Walaa A. Abualsunun, Cigdem Sahin, Carolyn L. Cummins, Micheline Piquette-Miller
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2020)
Review
Substance Abuse
Eliza R. McColl, Micheline Piquette-Miller
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
(2020)
Article
Developmental Biology
Eliza R. McColl, Micheline Piquette-Miller
Summary: Maternal immune activation (MIA) has been linked to neurodevelopmental disorders in offspring. This study demonstrated that poly(I:C)-mediated MIA affects placental proteome in a sexually dimorphic manner, with enrichment of mTOR signaling in male placentas. Inhibition of mTORC1 and activation of AMPK in response to MIA decreased membrane localization of EAAT2 and ASCT1, suggesting a potential treatment target for MIA-related placental amino acid transport changes.
Article
Pharmacology & Pharmacy
Kamelia Mirdamadi, Jacinda Kwok, Ori Nevo, Howard Berger, Micheline Piquette-Miller
Summary: Th-17 cytokines have an impact on the expression and activity of placental transporters, potentially affecting fetal exposure to endogenous and exogenous substances.
Article
Pharmacology & Pharmacy
Miles J. Luke, Nina Krupetsky, Helen Liu, Clara Korenvain, Natalie Crown, Sameera Toenjes, Beth A. Sproule, Micheline Piquette-Miller, Lisa M. Guirguis, Lisa M. McCarthy
Summary: By analyzing internal factors that influence pharmacists' ability to implement PGx testing, the study found that pharmacists' professional identities, practice environments, self-confidence, and beliefs in the benefits of PGx impact their provision of PGx testing services. Potential interventions to improve the implementation of PGx testing include preparing pharmacists for managing an increased patient load, helping pharmacists navigate the software and technology requirements associated with PGx services, and streamlining workflows and documentation requirements.
Article
Pharmacology & Pharmacy
Kim L. R. Brouwer, Raymond Evers, Elizabeth Hayden, Shuiying Hu, Cindy Yanfei Li, Henriette E. Meyer zu Schwabedissen, Sibylle Neuhoff, Stefan Oswald, Micheline Piquette-Miller, Chitra Saran, Noora Sjostedt, Jason A. Sprowl, Simone H. Stahl, Wei Yue
Summary: Membrane transport proteins play crucial roles in the absorption, disposition, efficacy, and toxicity of many drugs. The regulation of these proteins involves various mechanisms and factors that can alter their levels, localization, and function. Understanding the impact of transporter regulation on drug disposition is important for predicting therapeutic outcomes and improving clinical treatments.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Pharmacology & Pharmacy
Valerio Taggi, Mario Riera Romo, Micheline Piquette-Miller, Henriette E. Meyer zu Schwabedissen, Sibylle Neuhoff
Summary: Drug transporters are crucial for maintaining chemical balance and homeostasis in tissues, as well as for the absorption, distribution, and elimination of clinically important drugs. Diseases can alter the expression and function of drug transporters. However, there is limited knowledge on transporter regulation in critical protective barriers, which requires further research.