Article
Multidisciplinary Sciences
Tanner Rathbone, Ilayda Ates, Callie Stuart, Tina Parker, Renee N. Cottle
Summary: This protocol describes a method for isolating primary mouse hepatocytes and delivering CRISPR-Cas9 using electroporation. The method is fast and effective, with high cell viability and transfection efficiency, and has potential applications in studying genetic diseases related to the liver.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2022)
Article
Multidisciplinary Sciences
Schuyler D. Vickers, Dominique C. Saporito, Roberta Leonardi
Summary: Fatty acid beta-oxidation is essential for meeting liver energy demands and maintaining whole-body glucose homeostasis. Measurements of beta-oxidation in liver homogenates may be affected by the addition of high levels of cofactors, but using intact primary hepatocytes can overcome these limitations.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2021)
Article
Environmental Sciences
Seung-Hyun Jeong, Ji-Hun Jang, Hea-Young Cho, Yong-Bok Lee
Summary: This study investigated the subacute toxicity and toxicokinetics of DiBP in male and female rats, finding that 100 mg/kg of DiBP led to modest toxicity in the liver, kidney, lung, and testis, with minimal differences in toxicokinetics between genders. The metabolism of DiBP to MiBP was significant in both male and female rats, with MiBP excretion in urine serving as a major indicator of DiBP exposure.
Article
Psychology, Multidisciplinary
Yifei Li, Juan Li, Zhen Yang, Jie Zhang, Lili Dong, Fusheng Wang, Jingping Zhang
Summary: This study revealed gender differences in anxiety and depression in isolated COVID-19 patients, with males showing a greater tendency for symptoms, especially those infected with colleagues. In contrast, female patients had greater concerns about safe treatment environments and communication with medical staff. Thus, targeted nursing should be implemented to address specific psychological characteristics and nursing needs.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Oncology
Joseph M. Unger, Riha Vaidya, Kathy S. Albain, Michael LeBlanc, Lori M. Minasian, Carolyn C. Gotay, N. Lynn Henry, Michael J. Fisch, Shing M. Lee, Charles D. Blanke, Dawn L. Hershman
Summary: Women have a higher risk of severe adverse events (AEs) from cancer treatment compared to men, especially in immunotherapy. The study found that there are broad-based sex differences in the severity of symptomatic AEs and hematologic AEs across different treatment modalities. Understanding the sex differences in AEs is important, particularly in the context of immunotherapy.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Toxicology
Dong Wang, Wei Zhang, Jie-Xi Ju, Lu-Jia Wang, Ru-Yu Huang, Yan-Fang Xu, Hai-Lin Zhang, Jin-Long Qi
Summary: The study showed significant gender differences in acute toxicity of lipid dosage form amphotericin B, with more severe toxic symptoms and higher mortality observed in female rats compared to male rats. These differences may be attributed to higher drug exposure, longer half-life, lower plasma clearance, and higher drug concentrations in the liver and kidneys of female animals.
TOXICOLOGY LETTERS
(2021)
Article
Medical Laboratory Technology
Jie Gu, Xiong Chen, Zhiming Yang, Yao Bai, Xiaobo Zhang
Summary: This study found gender differences in the microbial spectrum of uropathogens in urolithiasis patients, with females showing higher susceptibility to antibiotics. It is recommended to use appropriate antimicrobial therapies based on gender to prevent the increase of multidrug-resistant bacteria.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Article
Economics
Jan Eckhard
Summary: This study used longitudinal data from the German Socio-Economic Panel to examine the impact of unemployment on the risk of social isolation. The results showed that unemployment had an isolating effect on men, particularly those who experienced long-term unemployment and had limited contact with friends and family. However, there was no such effect found for women, short-term unemployment, or non-participation in civic associations. Additionally, the study found that the financial situation of the unemployed only played a minor role in the isolating impact of unemployment.
WORK EMPLOYMENT AND SOCIETY
(2022)
Article
Medicine, General & Internal
Takumi Tsuchida, Takeshi Wada, Ryuta Nakae, Yu Fujiki, Takahiro Kanaya, Yasuhiro Takayama, Go Suzuki, Yasutaka Naoe, Shoji Yokobori
Summary: Gender differences exist in coagulation function, with women being more hypercoagulable. Traumatic brain injury patients show coagulopathy, but no previous studies have examined the gender differences in detail.
Article
Psychology, Clinical
Sarah Ascienzo, Ginny Sprang, David Royse
Summary: Gender differences in the development and severity of PTSD have been observed, but less is known regarding gender differences in traumatic experiences. This study found that Trauma-focused Cognitive Behavioral Therapy (TF-CBT) effectively reduced overall PTSD symptoms in polytraumatized youth, with females reporting higher symptom levels. Gender differences were also observed during some phases of treatment, with variations across different symptom domains.
PSYCHOLOGICAL TRAUMA-THEORY RESEARCH PRACTICE AND POLICY
(2022)
Article
Medicine, General & Internal
Nathalie Lehnen, Michael Hallek
Summary: This article provides a summary of the current state of knowledge on sex differences in the incidence and outcome of specific malignancies, and explores possible underlying causes. Significant sex-specific differences are found in the incidence, response rates, and mortality for various oncological diseases. The implementation of these sex differences in clinical practice and further investigations on underlying mechanisms will contribute to advanced patient-individualized treatment and optimized outcomes for oncological patients in the future.
Article
Oncology
Austin R. R. Waters, Erin E. E. Kent, Clare Meernik, Darios Getahun, Cecile A. A. Laurent, Lanfang Xu, Sara Mitra, Lawrence H. H. Kushi, Chun Chao, Hazel B. B. Nichols
Summary: This study examines the financial hardship experienced by LGBTQ+ adolescents and young adult cancer survivors. The results reveal that LGBTQ+ individuals have a higher probability of experiencing material and psychological financial hardship compared to non-LGBTQ+ individuals. Qualitative analysis further highlights the specific economic challenges faced by LGBTQ+ individuals, including educational changes, unpaid bills and debt, and housing instability.
CANCER CAUSES & CONTROL
(2023)
Article
Cardiac & Cardiovascular Systems
Roxana Sadeghi, Reza Miri, Naser Kachoueian, Mohammad Sistanizad, Rezvan Hassanpour
Summary: This study aimed to compare the differences in preoperative, intraoperative, and postoperative parameters between genders, as well as the postoperative complications and mortality. The results showed that female patients were older and had more underlying comorbidities, while male patients were more prone to myocardial infarction and had lower ejection fraction. Although there was no difference in the number of vessels involved, men had a higher number of grafts. However, there was no statistically significant difference in postoperative mortality between the two groups.
ARYA ATHEROSCLEROSIS
(2023)
Article
Oncology
Francesca De Felice, Laura D. Locati, Sara Ronchi, Juliette Thariat, Ester Orlandi
Summary: This article discusses the differences in quality of life and financial toxicity between female and male head and neck cancer patients undergoing (chemo)radiotherapy, emphasizing the importance of assessing these differences and proposing interventions and care recommendations.