期刊
DRUG DISCOVERY TODAY
卷 19, 期 4, 页码 425-432出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2013.10.010
关键词
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资金
- European Union Seventh Framework Program (FP7) [305397]
- European Social Fund (ESF)
- Greek national funds through the Operational Program 'Education and Lifelong Learning' of the National Strategic Reference Framework (NSRF) - Research Funding Program: ERC. Investing in knowledge society through the European Social Fund
- European Social Fund
Several important aspects of the drug discovery process, including target identification, mechanism of action determination and biomarker identification as well as drug repositioning, require complete understanding of the effects of drugs on protein phosphorylation in relevant biological systems. Novel high-throughput phosphoproteomic technologies can be employed to measure these phosphorylation events. In this review, we describe the advantages and limitations of state-of-the-art phosphoproteomic approaches such as mass spectrometry and antibody-based technologies in terms of sample and data throughput as well as data quality. We then discuss how datasets from each technology can be analyzed and how the results can be and have been applied to advance different aspects of the drug discovery process.
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