Review
Biology
Helena Korpelainen, Maria Pietilainen
Summary: We explored various traits that promote plant invasions, such as life history traits, genetic variation patterns, competitive and dispersal abilities, phenotypic plasticity, resistance, tolerance, and allelopathic interactions. External factors, including abiotic and biotic constraints, also play a significant role in invasion success. The introduction of invasive species is often associated with human activities, and their adaptation may not be reflected in their geographical distribution. However, repeated introductions and novel mutations can compensate for a lack of adaptation. As a case study, we used data from the Global Invasive Species Database to identify factors contributing to invasiveness, such as human-assisted dispersal, preference for disturbed habitats, and being used as ornamentals. We found that invasive species commonly have mixed reproduction systems, providing flexibility for spreading and establishment.
Article
Biotechnology & Applied Microbiology
Martin De Cecco, Daniel N. Galbraith, Lisa L. McDermott
Summary: ADCs are increasingly important in the fight against cancer, with a vast array of choices to consider in their design. Understanding the structure-function relationship of molecules is crucial for achieving clinical success, and the breadth of ADC applications is expected to continue expanding.
EXPERT OPINION ON BIOLOGICAL THERAPY
(2021)
Article
Computer Science, Artificial Intelligence
Shengju Qian, Yi Zhu, Wenbo Li, Mu Li, Jiaya Jia
Summary: This work investigates the importance of good tokenizers in computer vision from an information trade-off perspective. The proposed Modulation across Tokens (MoTo) and TokenProp regularization objective provide better design strategies, leading to improved performance and intriguing properties with negligible computational overhead. These findings emphasize the commonly-omitted designs of tokenizers in vision transformer.
IEEE TRANSACTIONS ON PATTERN ANALYSIS AND MACHINE INTELLIGENCE
(2023)
Article
Education & Educational Research
Berry M. O'Donovan, Birgit den Outer, Margaret Price, Andy Lloyd
Summary: The study identified attributes of good feedback from the perspective of recipients through 32 interviews with student participants. The findings highlighted the complex interdependency and contextual nature of key influences on students' perspectives, emphasizing the importance of considering factors beyond technical aspects for increasing student engagement and satisfaction with feedback.
STUDIES IN HIGHER EDUCATION
(2021)
Article
Chemistry, Multidisciplinary
Shu-Yu Chen, Martin Zacharias
Summary: Protein-protein interactions (PPIs) play a crucial role in biological processes and are targeted for therapeutic interventions. This study investigates known stabilizers and their interaction with PPIs using molecular dynamics simulations and pocket detection. The findings suggest that a dual-binding mechanism is important for effective stabilization, and a computational compound identification workflow is proposed. The study demonstrates the potential of in silico discovery of PPI stabilizers for therapeutic applications.
ACS CENTRAL SCIENCE
(2023)
Review
Parasitology
Martin K. Nielsen
Summary: Fecal egg counting techniques have been essential in parasitology research and clinical practice for over a century, but current issues such as lack of consensus on diagnostic parameters evaluation and confusing use of terminology exist. Clear guidelines are needed for validating fecal egg counting techniques in veterinary parasitology, emphasizing what should be evaluated, how studies could be designed, and how to appropriately analyze data.
VETERINARY PARASITOLOGY
(2021)
Article
Geriatrics & Gerontology
Anna Nivestam, Albert Westergren, Maria Haak
Summary: This study aimed to explore older adults' views on what makes them feel good. Through qualitative and quantitative research design, it was found that leisure activities were most frequently mentioned, followed by productivity activities, and self-care activities were seldom reported. There were significant differences in the activities reported as making them feel good based on gender, marital status, and health status.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2023)
Article
Neurosciences
Qian Yang, Yan Hong, Ting Zhao, Hongjun Song, Guo-Li Ming
Summary: Human neurogenesis mainly occurs in embryonic, fetal, and neonatal stages, generating diverse neural cell types that form the human nervous system. Brain organoids derived from human pluripotent stem cells can recapitulate major developmental processes during neurogenesis and exhibit human-specific features, offering unprecedented opportunities for studying human neurodevelopment.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Hospitality, Leisure, Sport & Tourism
Lan Xue, Xi Y. Leung, Shihan (David) Ma
Summary: The purpose of this study is to explore the characteristics of being a good guest from the perspective of Airbnb hosts. The study analyzed 10,068 reviews posted by Airbnb hosts using a mixed method approach. A framework was developed to summarize the characteristics of being a good guest at different levels. The findings suggest that Airbnb is considered a consumption space that emphasizes effective interaction between hosts and guests.
ANNALS OF TOURISM RESEARCH
(2022)
Article
Multidisciplinary Sciences
Janos Abonyi, Adam Ipkovich, Gyula Dorgo, Karoly Heberger
Summary: Non-negative matrix factorization (NMF) efficiently reduces high dimensionality for many-objective ranking problems. The key idea is that NMF aggregates the objectives so that the Pareto front can be applied, while the Sum of Ranking Differences (SRD) method selects the objectives that have a detrimental effect on the aggregation, and validates the findings. The results illustrate that PCA incorporates negatively correlated objectives into the same principal component, while NMF only allows non-negative correlations, which enable the proper use of the Pareto front.
Article
Anthropology
Meredith G. Marten, Allysha P. Winburn, Benjamin R. Burgen, Spencer K. Seymour, Taylor Walkup
Summary: Forensic anthropology has faced fundamental disciplinary issues in estimating population affinity, pursuing objectivity, and addressing bias in medicolegal contexts, leading to concerns about its future. However, a study found that there is broad consensus among forensic anthropologists on the training, experiences, perspectives, and practices important for being a good forensic anthropologist. Disagreements primarily arose regarding the issue of neutrality, with generational differences noted.
AMERICAN ANTHROPOLOGIST
(2023)
Article
Management
Shunyuan Zhang, Dokyun Lee, Param Vir Singh, Kannan Srinivasan
Summary: The study reveals an increase in Airbnb property occupancy after the acquisition of verified images, indicating the importance of good images in boosting property demand. By analyzing various image attributes, differences between verified and unverified images were identified, offering insights for Airbnb photographers and hosts on image optimization.
MANAGEMENT SCIENCE
(2022)
Article
Food Science & Technology
Lilian Pungas
Summary: Against the backdrop of multiple crises within-and due to-the current industrial agri-food system, the concept of food democracy calls for socially just and environmentally friendly food systems. This article sheds light on the aspects of food democracy within Food Self-Provisioning (FSP) practices in Eastern Estonia, highlighting subtle, informal, and mundane forms of democratic practices and everyday resistance. The study concludes with a plea for alliances between marginalized elderly rural food producers and urban food activists to create more democratic, just, and ecologically sound food systems.
FRONTIERS IN SUSTAINABLE FOOD SYSTEMS
(2023)
Article
Education & Educational Research
Richard P. Kipling, William A. V. Stiles, Micael de Andrade-Lima, Neil MacKintosh, Meirion W. Roberts, Cate L. Williams, Peter C. Wootton-Beard, Sarah J. Watson-Jones
Summary: Online postgraduate courses often use discussion forums for engagement and interaction. This study analyzed feedback and interviews from part-time postgraduate distance learners to evaluate their perceptions of discussion forums. The findings revealed the complex interactions between the costs and benefits of forums.
DISTANCE EDUCATION
(2023)
Review
Nanoscience & Nanotechnology
Niranjan Chatterjee, Piyush Kumar, Krishan Kumar, Santosh K. Misra
Summary: Carbon nanoparticles (CNPs) have been widely used in biology for sensing, imaging, and therapy due to their biocompatibility and unique properties. This article discusses the correlations between synthesis, characterization, and utilization of CNPs, and explores their applications in various biological activities. The insights gained from this study can lead to the development of new CNPs with improved applications and evaluation methods, ultimately benefiting human needs in the future.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2022)
Article
Oncology
Anette Sommer, Charlotte Kopitz, Christoph A. Schatz, Carl F. Nising, Christoph Mahlert, Hans-Georg Lerchen, Beatrix Stelte-Ludwig, Stefanie Hammer, Simone Greven, Joachim Schuhmacher, Manuela Braun, Ruprecht Zierz, Sabine Wittemer-Rump, Axel Harrenga, Frank Dittmer, Frank Reetz, Heiner Apeler, Rolf Jautelat, Hung Huynh, Karl Ziegelbauer, Bertolt Kreft
Article
Chemistry, Multidisciplinary
Hans-Georg Lerchen, Sven Wittrock, Beatrix Stelte-Ludwig, Anette Sommer, Sandra Berndt, Nils Griebenow, Anne-Sophie Rebstock, Sarah Johannes, Yolanda Cancho-Grande, Christoph Mahlert, Simone Greven, Carsten Terjung
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2018)
Article
Oncology
Julia C. Meier, Bernard Haendler, Henrik Seidel, Philip Groth, Robert Adams, Karl Ziegelbauer, Bertolt Kreft, Georg Beckmann, Anette Sommer, Charlotte Kopitz
Article
Chemistry, Multidisciplinary
Hans-Georg Lerchen, Beatrix Stelte-Ludwig, Sandra Berndt, Anette Sommer, Lisa Dietz, Anne-Sophie Rebstock, Sarah Johannes, Leo Marx, Hannah Joerissen, Christoph Mahlert, Simone Greven
CHEMISTRY-A EUROPEAN JOURNAL
(2019)
Article
Oncology
Katrine Wickstroem, Urs B. Hagemann, Alexander Kristian, Christine Ellingsen, Anette Sommer, Heidrun Ellinger-Ziegelbauer, Uta Wirnitzer, Else-Marie Hagelin, Aasmund Larsen, Roger Smeets, Roger M. Bjerke, Jenny Karlsson, Olav B. Ryan, Antje M. Wengner, Lars Linden, Dominik Mumberg, Alan S. Cuthbertson
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2019)
Article
Oncology
Sung-Bae Kim, Funda Meric-Bernstam, Aparna Kalyan, Aleksei Babich, Rong Liu, Takahiko Tanigawa, Anette Sommer, Motonobu Osada, Frank Reetz, Dirk Laurent, Sabine Wittemer-Rump, Jordan Berlin
Meeting Abstract
Hematology
Anilkumar Gopalakrishnapillai, Allison Kaeding, Christoph Schatz, Anette Sommer, Soheil Meshinchi, E. Anders Kolb, Sonali Barwe
Article
Biochemical Research Methods
Hans-Georg Lerchen, Beatrix Stelte-Ludwig, Anette Sommer, Sandra Berndt, Anne-Sophie Rebstock, Sarah Johannes, Christoph Mahlert, Simone Greven, Lisa Dietz, Hannah Joerissen
BIOCONJUGATE CHEMISTRY
(2020)
Article
Oncology
Dennis Kirchhoff, Beatrix Stelte-Ludwig, Hans-Georg Lerchen, Antje Margret Wengner, Oliver von Ahsen, Pascale Buchmann, Stephan Marsch, Christoph Mahlert, Simone Greven, Lisa Dietz, Michael Erkelenz, Ruprecht Zierz, Sandra Johanssen, Dominik Mumberg, Anette Sommer
Article
Oncology
Vincent Chen, Shigeki Umemura, Yumin Han, Renuka Raman, Robin Tucker, Joeffrey Chahine, In-Kyu Kim, Christoph Schatz, Sabine Zitzmann-Kolbe, Anette Sommer, Masanori Onda, Trevor Lee, Yongfeng He, Giuseppe Giaccone
Summary: This study demonstrates that anetumab ravtansine inhibits the growth of MSLN positive thymic carcinoma cells both in vitro and in vivo. The results show that ARav has potential as a novel therapy for thymic carcinoma, especially in cases where traditional therapies have limited effectiveness.
BRITISH JOURNAL OF CANCER
(2022)
Article
Oncology
Anette Sommer, Sandra Berndt, Hans-Georg Lerchen, Sabrina Forveille, Allan Sauvat, Dominik Mumberg, Guido Kroemer, Oliver Kepp
Summary: The study characterizes the mode of action of antibody-drug conjugates (ADCs) and finds that they can activate immune responses and induce immunogenic cell death, contributing to their antineoplastic effects.
Article
Biochemical Research Methods
Niels Boehnke, Markus Berger, Nils Griebenow, Antje Rottmann, Michael Erkelenz, Stefanie Hammer, Sandra Berndt, Judith Guenther, Antje M. Wengner, Beatrix Stelte-Ludwig, Christoph Mahlert, Simone Greven, Lisa Dietz, Hannah Jorissen, Naomi Barak, Ulf Boemer, Roman C. Hillig, Uwe Eberspaecher, Jorg Weiske, Anja Giese, Dominik Mumberg, Carl Friedrich Nising, Hilmar Weinmann, Anette Sommer
Summary: A new class of NAMPT inhibitors as ADC payloads was developed, optimizing their structures to create highly potent effector chemistries. The optimized NAMPTi-ADCs demonstrated potent in vivo antitumor efficacy with a very good selectivity profile.
BIOCONJUGATE CHEMISTRY
(2022)
Article
Cell Biology
Richard E. Beatson, Ana C. Parente-Pereira, Leena Halim, Domenico Cozzetto, Caroline Hull, Lynsey M. Whilding, Olivier Martinez, Chelsea A. Taylor, Jana Obajdin, Kim Ngan Luu Hoang, Benjamin Draper, Ayesha Iqbal, Tom Hardiman, Tomasz Zabinski, Francis Man, Rafael T. M. de Rosales, Jinger Xie, Fred Aswad, Daniela Achkova, Chung-Yang Ricardo Joseph, Sara Ciprut, Antonella Adami, Helge G. Roider, Holger Hess-Stumpp, Balazs Gyorffy, Jelmar Quist, Anita Grigoriadis, Anette Sommer, Andrew N. J. Tutt, David M. Davies, John Maher
Summary: Expanding circulating Vγ9Vδ2 T cells in specific culture medium can enhance the therapeutic efficacy and activity of γδT cells in cancer immunotherapy, particularly showing potential treatment activity in leukemia and solid tumor models.
CELL REPORTS MEDICINE
(2021)
Meeting Abstract
Oncology
Hans-Georg Lerchen, Sven Wittrock, Nils Griebenow, Mario Lobell, Anne-Sophie Rebstock, Yolanda Cancho-Grande, Beatrix Stelte-Ludwig, Christoph Mahlert, Simone Greven, Anette Sommer, Sandra Berndt, Carsten Terjung, Heiner Apeler, Bertolt Kreft, Rolf Jautelat
Article
Neurosciences
Christian Barucker, Anette Sommer, Georg Beckmann, Murat Eravci, Anja Harmeier, Carola G. Schipke, Damian Brockschnieder, Thomas Dyrks, Veit Althoff, Paul E. Fraser, Lili-Naz Hazrati, Peter St George-Hyslop, John C. S. Breitner, Oliver Peters, Gerhard Multhaup
JOURNAL OF ALZHEIMERS DISEASE
(2015)
Review
Pharmacology & Pharmacy
Karlie R. Sharma, Christine M. Colvis, Griffih P. Rodgers, Douglas M. Sheeley
Summary: There are many genes within the druggable genome that have not been studied, and the US National Institutes of Health's program provides resources to explore these genes, with the potential for rapid impact on human health.
DRUG DISCOVERY TODAY
(2024)
Review
Pharmacology & Pharmacy
Mohammad Sameer Khan, B. H. Jaswanth Gowda, Waleed H. Almalki, Tanuja Singh, Amirhossein Sahebkar, Prashant Kesharwani
Summary: Mitochondria-specific functional liposomes hold great potential for cancer therapy. This review discusses the association between mitochondria and tumor formation, as well as the advantages of liposomes in delivering drugs to mitochondria.
DRUG DISCOVERY TODAY
(2024)
Review
Pharmacology & Pharmacy
Choong Yong Ung, Cristina Correia, Hu Li, Christopher M. Adams, Jennifer J. Westendorf, Shizhen Zhu
Summary: With increasing human life expectancy, the global medical burden of chronic diseases is growing. Chronic diseases often involve malfunctioning of multiple organs, and understanding the interorgan crosstalk is crucial to understanding the etiology of chronic diseases. Researchers have proposed the locked-state model (LoSM) and cutting-edge systems biology and artificial intelligence strategies to decipher chronic multiorgan locked states. The findings have important clinical implications for improving treatments for chronic diseases.
DRUG DISCOVERY TODAY
(2024)
