期刊
DRUG DISCOVERY TODAY
卷 17, 期 19-20, 页码 1103-1110出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2012.06.001
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资金
- Italian Association for Cancer Research (AIRC) [IG9089]
- Ricerca Sanitaria Regionale (Regione Liguria Government)
Glioblastoma is the most prevalent and malignant form of brain cancer, but the current available multimodality treatments yield poor survival improvement. Thus, innovative therapeutic strategies represent the challenging topic for glioblastoma management. Multidisciplinary advances, supporting current standard of care therapies and investigational trials that reveal potential drug targets for glioblastoma are reviewed. A radical change in glioblastoma therapeutic approaches could arise from the identification of cancer stem cells, putative tumor-initiating cells involved in tumor initiation, progression and resistance, as innovative drug target. Still controversial identification of markers and molecular regulators in glioma tumor-initiating cells and novel approaches targeting these cells are discussed.
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