Destination Known: Targeted Drug Delivery in Atherosclerosis and Thrombosis

Delayed targeting of CD39 to activated platelet GPIIb/IIIa via a single-chain antibody: breaking the link between antithrombotic potency and bleeding?

(2013) J. D. Hohmann et al.   BLOOD

Executive Summary: Heart Disease and Stroke Statistics—2013 Update

(2013) Alan S. Go et al.   CIRCULATION

A Novel Mouse Model of Atherosclerotic Plaque Instability for Drug Testing and Mechanistic/Therapeutic Discoveries Using Gene and MicroRNA Expression Profiling

(2013) Yung-Chih Chen et al.   CIRCULATION RESEARCH

Potential therapeutic role of microRNAs in ischemic heart disease

(2013) Annalisa Caroli et al.   Journal of Cardiology

Phase II Randomized Study of Trastuzumab Emtansine Versus Trastuzumab Plus Docetaxel in Patients With Human Epidermal Growth Factor Receptor 2–Positive Metastatic Breast Cancer

(2013) Sara A. Hurvitz et al.   JOURNAL OF CLINICAL ONCOLOGY

Fibrinolysis or Primary PCI in ST-Segment Elevation Myocardial Infarction

(2013) Paul W. Armstrong et al.   NEW ENGLAND JOURNAL OF MEDICINE

Atherosclerotic geometries exacerbate pathological thrombus formation poststenosis in a von Willebrand factor-dependent manner

(2013) Erik Westein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Challenges in Development of Targeted Liposomal Therapeutics

(2012) Rupa R. Sawant et al.   AAPS Journal

Nonviral gene therapy targeting cardiovascular system

(2012) Cheng-Huang Su et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Targeted microbubbles in the experimental and clinical setting

(2012) Ahmed Alzaraa et al.   AMERICAN JOURNAL OF SURGERY

Antibody-Drug Conjugates in Cancer Therapy

(2012) Eric L. Sievers et al.   Annual Review of Medicine

Targeted nanoparticle delivery overcomes off-target immunostimulatory effects of oligonucleotides and improves therapeutic efficacy in chronic lymphocytic leukemia

(2012) B. Yu et al.   BLOOD

Platelets increase the proliferation of ovarian cancer cells

(2012) M. S. Cho et al.   BLOOD

A humanized single-chain antibody against beta 3 integrin inhibits pulmonary metastasis by preferentially fragmenting activated platelets in the tumor microenvironment

(2012) W. Zhang et al.   BLOOD

Microparticles: major transport vehicles for distinct microRNAs in circulation

(2012) P. Diehl et al.   CARDIOVASCULAR RESEARCH

Novel Single-Chain Antibody-Targeted Microbubbles for Molecular Ultrasound Imaging of Thrombosis

(2012) Xiaowei Wang et al.   CIRCULATION

2012 ACCF/AHA/ACP/AATS/PCNA/SCAI/STS Guideline for the Diagnosis and Management of Patients With Stable Ischemic Heart Disease: Executive Summary

(2012) Stephan D. Fihn et al.   CIRCULATION

Platelets Contribute to the Pathogenesis of Experimental Autoimmune Encephalomyelitis

(2012) Harald F. Langer et al.   CIRCULATION RESEARCH

Gene Therapy for Heart Failure

(2012) Lisa Tilemann et al.   CIRCULATION RESEARCH

HDL drug carriers for targeted therapy

(2012) Xing Liu et al.   CLINICA CHIMICA ACTA

Strategies to deliver microRNAs as potential therapeutics in the treatment of cardiovascular pathology

(2012) Dimitry A. Chistiakov et al.   DRUG DELIVERY

Drug Conjugates Such as Antibody Drug Conjugates (ADCs), Immunotoxins and Immunoliposomes Challenge Daily Clinical Practice

(2012) Wolf-Dieter Janthur et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Gemtuzumab Ozogamicin: Time to Resurrect?

(2012) Farhad Ravandi et al.   JOURNAL OF CLINICAL ONCOLOGY

Doxil® — The first FDA-approved nano-drug: Lessons learned

(2012) Yechezkel (Chezy) Barenholz   JOURNAL OF CONTROLLED RELEASE

Ticagrelor Versus Prasugrel in Acute Coronary Syndrome Patients With High On-Clopidogrel Platelet Reactivity Following Percutaneous Coronary Intervention

(2012) Dimitrios Alexopoulos et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

2013 ACCF/AHA Guideline for the Management of ST-Elevation Myocardial Infarction

(2012) Patrick T. O'Gara et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Shear-stress sensitive lenticular vesicles for targeted drug delivery

(2012) Margaret N. Holme et al.   Nature Nanotechnology

Platelets: active players in the pathogenesis of arthritis and SLE

(2012) Eric Boilard et al.   Nature Reviews Rheumatology

The Shear Stress of Busting Blood Clots

(2012) David M. Wootton et al.   NEW ENGLAND JOURNAL OF MEDICINE

Trastuzumab Emtansine for HER2-Positive Advanced Breast Cancer

(2012) Sunil Verma et al.   NEW ENGLAND JOURNAL OF MEDICINE

Shear-Activated Nanotherapeutics for Drug Targeting to Obstructed Blood Vessels

(2012) N. Korin et al.   SCIENCE

GPIIb/IIIa inhibitors: From bench to bedside and back to bench again

(2012) Paul C. Armstrong et al.   THROMBOSIS AND HAEMOSTASIS

Enzymatic Antibody Tagging: Toward a Universal Biocompatible Targeting Tool

(2012) Hang T. Ta et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Preparation and Characterization of a Lovastatin-Loaded Protein-Free Nanostructured Lipid Carrier Resembling High-Density Lipoprotein and Evaluation of its Targeting to Foam Cells

(2011) Xiao Gu et al.   AAPS PHARMSCITECH

An Activation-Specific Platelet Inhibitor That Can Be Turned On/Off by Medically Used Hypothermia

(2011) Denijal Topcic et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Profiling of circulating microRNAs: from single biomarkers to re-wired networks

(2011) A. Zampetaki et al.   CARDIOVASCULAR RESEARCH

MicroRNA-24 Regulates Vascularity After Myocardial Infarction

(2011) Jan Fiedler et al.   CIRCULATION

Enzymatic Single-Chain Antibody Tagging

(2011) H.T. Ta et al.   CIRCULATION RESEARCH

Recent Advances in Understanding of the Immunological Off-Target Effects of siRNA

(2011) Marta Olejniczak et al.   CURRENT GENE THERAPY

Repeated and targeted transfer of angiogenic plasmids into the infarcted rat heart via ultrasound targeted microbubble destruction enhances cardiac repair

(2011) Hiroko Fujii et al.   EUROPEAN HEART JOURNAL

Impact of polyplex micelles installed with cyclic RGD peptide as ligand on gene delivery to vascular lesions

(2011) H Kagaya et al.   GENE THERAPY

The Evolving Role of HDL in the Treatment of High-Risk Patients with Cardiovascular Disease

(2011) H. Bryan Brewer   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Preparation andin vitroevaluation of anti-VCAM-1-Fab′-conjugated liposomes for the targeted delivery of the poorly water-soluble drug celecoxib

(2011) Dong Il Kang et al.   JOURNAL OF MICROENCAPSULATION

Use of secondary prevention drugs for cardiovascular disease in the community in high-income, middle-income, and low-income countries (the PURE Study): a prospective epidemiological survey

(2011) Salim Yusuf et al.   LANCET

Inhibition of miR-33a/b in non-human primates raises plasma HDL and lowers VLDL triglycerides

(2011) Katey J. Rayner et al.   NATURE

Progress and challenges in translating the biology of atherosclerosis

(2011) Peter Libby et al.   NATURE

MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins

(2011) Kasey C. Vickers et al.   NATURE CELL BIOLOGY

Atherosclerosis: current pathogenesis and therapeutic options

(2011) Christian Weber et al.   NATURE MEDICINE

Activated Platelets in Carotid Artery Thrombosis in Mice Can Be Selectively Targeted with a Radiolabeled Single-Chain Antibody

(2011) Timo Heidt et al.   PLoS One

Specific penetration and accumulation of a homing peptide within atherosclerotic plaques of apolipoprotein E-deficient mice

(2011) J. Hamzah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polymer-based therapeutics: nanoassemblies and nanoparticles for management of atherosclerosis

(2011) Daniel R. Lewis et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Controllable inhibition of cellular uptake of oxidized low-density lipoprotein: Structure–function relationships for nanoscale amphiphilic polymers

(2010) Nicole M. Iverson et al.   Acta Biomaterialia

Nanostructured lipid carriers constituted from high-density lipoprotein components for delivery of a lipophilic cardiovascular drug

(2010) Wen-Li Zhang et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Immunoliposomes That Target Endothelium In Vitro Are Dependent on Lipid Raft Formation

(2010) Rico C. Gunawan et al.   MOLECULAR PHARMACEUTICS

Antiplatelet therapies for the treatment of cardiovascular disease

(2010) Alan D. Michelson   NATURE REVIEWS DRUG DISCOVERY

miR-33 links SREBP-2 induction to repression of sterol transporters

(2010) T. J. Marquart et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Light-Activated Theranostic Nanoagent for Targeted Macrophage Ablation in Inflammatory Atherosclerosis

(2010) Jason R. McCarthy et al.   Small

Magnetically targeted thrombolysis with recombinant tissue plasminogen activator bound to polyacrylic acid-coated nanoparticles

(2009) Yunn-Hwa Ma et al.   BIOMATERIALS

Diagnostic Ultrasound Combined With Glycoprotein IIb/IIIa–Targeted Microbubbles Improves Microvascular Recovery After Acute Coronary Thrombotic Occlusions

(2009) Feng Xie et al.   CIRCULATION

A Necessary Role of miR-221 and miR-222 in Vascular Smooth Muscle Cell Proliferation and Neointimal Hyperplasia

(2009) Xiaojun Liu et al.   CIRCULATION RESEARCH

Targeting VEGF-encapsulated immunoliposomes to MI heart improves vascularity and cardiac function

(2009) Robert C. Scott et al.   FASEB JOURNAL

MicroRNA Expression Signature and the Role of MicroRNA-21 in the Early Phase of Acute Myocardial Infarction

(2009) Shimin Dong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeted lipid-coated nanoparticles: Delivery of tumor necrosis factor-functionalized particles to tumor cells

(2009) Sylvia K.E. Messerschmidt et al.   JOURNAL OF CONTROLLED RELEASE

A shear gradient–dependent platelet aggregation mechanism drives thrombus formation

(2009) Warwick S Nesbitt et al.   NATURE MEDICINE

Targeting atherosclerosis by using modular, multifunctional micelles

(2009) D. Peters et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA-92a Controls Angiogenesis and Functional Recovery of Ischemic Tissues in Mice

(2009) A. Bonauer et al.   SCIENCE

Ultrasound Mediated Destruction of DNA-Loaded Microbubbles for Enhancement of Cell-Based Therapies

(2009) Flordeliza S. Villanueva   JACC-Cardiovascular Imaging

Ultrasound-Targeted Gene Delivery Induces Angiogenesis After a Myocardial Infarction in Mice

(2009) Hiroko Fujii et al.   JACC-Cardiovascular Imaging

Intramural Delivery of Rapamycin With α v β 3 -Targeted Paramagnetic Nanoparticles Inhibits Stenosis After Balloon Injury

(2008) Tillmann Cyrus et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Magnetic Resonance Imaging Contrast Agent Targeted Toward Activated Platelets Allows In Vivo Detection of Thrombosis and Monitoring of Thrombolysis

(2008) C. von zur Muhlen et al.   CIRCULATION

Gene delivery into ischemic myocardium by double-targeted lipoplexes with anti-myosin antibody and TAT peptide

(2008) Y T Ko et al.   GENE THERAPY

Targeted drug delivery to mesothelioma cells using functionally selected internalizing human single-chain antibodies

(2008) F. An et al.   MOLECULAR CANCER THERAPEUTICS

MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts

(2008) Thomas Thum et al.   NATURE

Antiangiogenic Synergism of Integrin-Targeted Fumagillin Nanoparticles and Atorvastatin in Atherosclerosis

(2008) Patrick M. Winter et al.   JACC-Cardiovascular Imaging

Novel Single-Chain Fv′ Formats for the Generation of Immunoliposomes by Site-Directed Coupling

(2007) Sylvia K. E. Messerschmidt et al.   BIOCONJUGATE CHEMISTRY