Article
Chemistry, Multidisciplinary
Shuaikai Ren, Chunxin Wang, Liang Guo, Congcong Xu, Yan Wang, Changjiao Sun, Haixin Cui, Xiang Zhao
Summary: Microcapsules with uniform size and tailored dimensions were prepared using emulsification and solvent evaporation methods in this study for the construction of controlled-release drug carriers. Morphology and structure of the microcapsules could be tailored by regulating the preparation conditions, and the release rate of protein could be controlled by adjusting the pore size. This controlled-release novel microcapsule carrier system shows great potential for biomedical applications.
Article
Pharmacology & Pharmacy
Soumyarwit Manna, Anna M. Donnell, Rafaela Q. Caixeta Faraj, Blanca I. Riemann, Christopher D. Riemann, James J. Augsburger, Zelia M. Correa, Rupak K. Banerjee
Summary: The research demonstrates that chitosan and poly(lactic-co-glycolic) acid-based methotrexate intravitreal micro-implants show promising pharmacokinetics and low toxicity in normal rabbit eyes, maintaining therapeutic concentrations for 56 days. Histopathologic evaluation reveals no signs of toxicity, and the micro-implants remain stationary at their implantation site.
Article
Pharmacology & Pharmacy
Alessia Romeo, Teresa Musumeci, Claudia Carbone, Angela Bonaccorso, Simona Corvo, Gabriella Lupo, Carmelina Daniela Anfuso, Giovanni Puglisi, Rosario Pignatello
Summary: The study proposes a novel method to improve the bioavailability of ferulic acid through nanoformulations, specifically polymeric nanoparticles. Various tests and analyses demonstrated the potential application of these nanoformulations in ocular drug delivery.
Article
Pharmacology & Pharmacy
Carolina Castaneda-Fernandez, Rosa Maria Chavez-Santos, Mayra Silva-Miranda, Clara Espitia-Pinzon, Roberto Martinez, Anna Kozina
Summary: This study systematically investigates the challenges of encapsulating rifampicin in polymeric reservoirs and proposes optimization techniques to improve drug loading. The particle solidification stage is found to be the most crucial step, and the recovery and washing process significantly affect the encapsulation efficiency. Fabricating multiple emulsions can enhance encapsulation, although the resulting particles may be relatively large and porous.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Polymer Science
Roberta Bussons Rodrigues Valerio, Nilvan Alves da Silva, Jose Ribamar Paiva Junior, Anderson Valerio Chaves, Bruno Peixoto de Oliveira, Nagila Freitas Souza, Selene Maia de Morais, Jose Cleiton Sousa dos Santos, Flavia Oliveira Monteiro da Silva Abreu
Summary: Cardanol, the main constituent of technical cashew nut shell liquid, was encapsulated in nanoparticles using biocompatible and stable polysaccharide systems to enhance its antioxidant potential, demonstrating better protection and targeted activities in various sectors such as pharmaceutical, nutraceutical, and biomedical.
Article
Polymer Science
Stavroula G. Nanaki, Evi Christodoulou, Nikolaos D. Bikiaris, Afroditi Kapourani, Konstantinos N. Kontogiannopoulos, Souzan Vergkizi-Nikolakaki, Panagiotis Barmpalexis
Summary: The aim of the study was to prepare a leflunomide sustained release transdermal delivery system for psoriasis treatment. Using SDAEM-modified CS resulted in improved wetting and solubilization properties, better in vitro dissolution profile characteristics, and enhanced antibacterial properties in the LFD-loaded NPs. Embedding the NPs in polymeric thin-film patches resulted in sustained drug release for up to approximately twelve days, with CS-SDAEM NPs showing the most promising formulation approach.
Article
Polymer Science
Amaraporn Wongrakpanich, Nichakan Khunkitchai, Yanisa Achayawat, Jiraphong Suksiriworapong
Summary: This study developed ketorolac microparticles using hyaluronic acid stabilized poly(lactide-co-glycolide) (PLGA), poly(lactide) (PLA), and their blend for osteoarthritis treatment. Different emulsification techniques and polymer compositions influenced the microparticle characteristics, with probe sonication resulting in smaller size and broader size distribution than high-speed stirring. The microparticles showed biphasic drug release over 35 days and demonstrated potential for treating osteoarthritis.
Article
Chemistry, Physical
Noe Escareno, Natalia Hassan, Marcelo J. Kogan, Josue Juarez, Antonio Topete, Adrian Daneri-Navarro
Summary: Nanoparticle-based drug delivery systems combined with high-affinity targeting ligands provide a sophisticated landscape in cancer theranostics. Antibodies, due to their high diversity and specificity, are extensively used to provide bioactivity to nanoparticulate systems. However, controlled assembly of nanoparticles with targeting ligands remains a challenge.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Article
Chemistry, Medicinal
Yusuke Oe, Shinichi Ogino, Masanori Kobayashi, Hiroyuki Kojima, Takayuki Terukina, Takanori Kanazawa, Hiromu Kondo
Summary: This study developed a sustained release testosterone formulation for the treatment of fecal incontinence. The formulation effectively affected both the internal and external anal sphincters with a sufficient safety profile.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Majd Alrashdan, Ziad A. Shraideh, Samer R. Abulateefeh
Summary: This study developed a novel injectable long-acting carvedilol-ISFD, which exhibited tunable extended-release behavior by choosing the appropriate grade of polymer. The PLGA-based ISFD formulations demonstrated excellent release behaviors and were able to extend the release of carvedilol over 30 days.
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Suhair Sunoqrot, Mohammad Niazi, Mohammad A. Al-Natour, Malak Jaber, Luay Abu-Qatouseh
Summary: This study developed a nanoparticle formulation of coal tar (CT) based on biocompatible poly(lactide-co-glycolide) (PLGA) for the treatment of psoriasis. The CT-loaded PLGA nanoparticles showed high loading efficiency, small particle size, and colloidal stability. Compared to crude CT, the CT nanoparticles significantly reduced cytotoxicity, staining ability, and improved washability.
Article
Pathology
Christos Poulios, Varvara Karagkiozaki, Dorothea Kapoukranidou, Zena Chakim, Thomas Zarampoukas, Nikolaos Foroglou, Stergios Logothetidis
Summary: In recent years, there has been a growing interest in using nanomaterials in medicine. It is crucial to assess their safety before their clinical application, and pathology can play a significant role in this process. This study compared the in vivo toxicity effects of poly-(lactic-co-glycolic acid) nanoparticles with and without a chitosan shell, both loaded with curcumin. The findings suggest that nanoparticles with chitosan coating have significantly less, if any, toxic effects compared to those without chitosan.
Article
Pharmacology & Pharmacy
Wenting Lin, Tao Xu, Zhongzhi Wang, Jianghan Chen
Summary: The study synthesized AMB-loaded thermogel for the treatment of cryptococcal meningitis, demonstrating its sustained release, reduced neurotoxicity, and improved therapeutic effect compared to traditional AMB solution, indicating the potential of the PLGA-PEG-PLGA thermogel as a biocompatible carrier for intrathecal drug delivery.
Review
Chemistry, Multidisciplinary
Lianmeng Liu, Wenlong Liang, Yabo Zhang, Qiang Fu
Summary: As natural organisms, microorganisms have limitations that prevent them from meeting the requirements of commercial applications. Nanoencapsulation, a technology that encapsulates microorganisms and gives their cells additional properties, has been developed and applied rapidly in recent years. Different materials and strategies have been used for nanoencapsulation, providing beneficial microorganisms with advantages such as protection, functionalization, and controlled release. Nanoencapsulation technology differs from traditional encapsulation technologies in many aspects.
Article
Biochemistry & Molecular Biology
Yirong Wang, Li Guo, Jiao Liu, Xiaofei Huang, Xinxin Wang, Xiaolong Guo, Xinguo You, Wenhui Li, Lili Li, Tongyi Sun, Yuanyuan Gao
Summary: Wound treatment is a common healthcare issue, and Tylotoin, a peptide derived from salamander, has shown skin wound healing properties. However, its degradation and administration limitations hinder its use. In this study, Chitosan-PLGA-Tylotoin nanoparticles were developed to deliver Tylotoin for wound healing. The nanoparticles demonstrated good antibacterial properties, biocompatibility, and sustained release of Tylotoin, leading to improved wound healing in vitro and in vivo.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)