Article
Biology
Weiyin Huang, Shuang Chen, Lin Sun, Hubin Wwang, Hongqun Qiao
Summary: The study investigated the intestinal permeability of lamivudine using Caco-2 cells monolayer and single-pass intestinal perfusion, revealing a passive diffusion absorption mechanism possibly related to efflux transporters. Lamivudine was classified as a moderate-permeability drug in the Biopharmaceutics Classification System.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Zhixiang Liu, Tong An, Rui Yuan, Maoxiong Tian, Linlin Yuan, Tong Zhang, Gang Cheng
Summary: This study investigated the applicability of mPEG-PR as a novel non-absorbable indicator in the in situ single-pass intestinal perfusion (SPIP) experiment. The results showed that mPEG-PR was a stable and accurate method for correcting water flux and predicting the fraction dose absorbed in human.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Xi Tang, Hui Feng, Jie Gao, Ruohong Bi, Lin Pan, Yi Shi, Yunfeng Han, Xianrong Lai
Summary: This study investigated the intestinal absorption characteristics of berberine hydrochloride (BBH) under different perfusion conditions in rats. The results showed that BBH is absorbed through passive diffusion in a neutral environment of pH 7.4, and the jejunum is the most efficient segment for absorption.
TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH
(2022)
Article
Chemistry, Analytical
Weiwei Tang, Yuejie Zhang, Ping Li, Bin Li
Summary: In this study, an integrated strategy combining quadruple single-pass intestinal perfusion (Q-SPIP) technique and matrix-assisted laser desorption ionization mass spectrometry imaging (MALDI MSI) was developed for in situ visualization and assessment of drug absorption and interaction in rat intestines. The Q-SPIP model enabled simultaneous perfusion of four individual segments of each rat intestine, providing rich data for analysis. The optimized MALDI MSI approach accurately visualized the drug distribution and absorption in rat intestinal tissue. The findings demonstrate the utility and versatility of Q-SPIP coupled with MALDI MSI in studying transporter-mediated intestinal drug absorption and interaction.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Weiwei Tang, Yuejie Zhang, Ping Li, Bin Li
Summary: Visualization and characterization of intestinal membrane transporter-mediated drug absorption and interaction are challenging. A new integrated strategy using quadruple single-pass intestinal perfusion (Q-SPIP) technique coupled with matrix-assisted laser desorption ionization mass spectrometry imaging (MALDI MSI) was developed for in situ visualization and assessment of drug absorption and interaction in rat intestines. The utility and versatility of this strategy were demonstrated through the examination of P-glycoprotein (P-gp)-mediated intestinal absorption of berberine (BBR) and its combination with natural products possessing inhibitory potency against P-gp.
ANALYTICAL CHEMISTRY
(2023)
Article
Optics
A. Fisher, Y. Park, M. Lenz, A. Ody, R. Agustsson, T. Hodgetts, A. Murokh, P. Musumeci
Summary: The terahertz gap is a region in the electromagnetic spectrum where high power radiation sources are scarce but the demand for scientific and industrial applications is increasing. This study demonstrates the use of a circular waveguide and a strongly tapered helical undulator to efficiently extract resonant energy from a short electron beam, resulting in an average energy efficiency of about 10%.
Review
Chemistry, Multidisciplinary
Kai Cai, Xuewu Zhang, Xiao-chen Bai
Summary: Single-pass transmembrane receptors (SPTMRs) are a diverse group of membrane proteins involved in essential cellular processes. Understanding their mechanisms of action has been challenging due to the lack of full-length structures in different functional states. Recent developments in cryo-electron microscopy have led to significant progress in studying the structures of SPTMRs, improving our understanding of their function and mechanisms.
Article
Materials Science, Multidisciplinary
Jing Peng, Xicai Fan, Gabriel A. Goenaga, Catherine M. Weiss, Christopher Andrew Neal, Nelly Cantillo, Thomas A. Zawodzinski Jr
Summary: A comprehensive understanding of the pretreatment effects on perfluorosulfonic acid membranes is crucial for their application in vanadium redox flow batteries. Boiling pretreatment can modify the physicochemical and transport properties of the membranes, resulting in increased water and acid uptake, as well as higher conductivity. This is mainly attributed to the morphology change induced by the pretreatment, which includes a larger swelling volume and more continuous water channels. The trade-off between membrane conductance and vanadium transport across the membrane is driven by the propensity to absorb solution components and their intrinsic mobility.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Computer Science, Software Engineering
Ege Ciklabakkal, Adrien Gruson, Iliyan Georgiev, Derek Nowrouzezahrai, Toshiya Hachisuka
Summary: Resampling is the process of selecting samples from a set of candidates to achieve a distribution that is approximately proportional to a desired target. Recent research has explored its application to Monte Carlo integration, resulting in powerful and practical importance sampling methods. Existing resampling methods have the limitation of not being able to generate stratified samples. We propose two complementary techniques to efficiently achieve stratified resampling.
COMPUTER GRAPHICS FORUM
(2022)
Article
Chemistry, Medicinal
Liqing Chai, Rongrong Wang, Yan Wang, Wenju Guo, Ning Li, Hengtong Zuo, Yidan Wang, Danyu Duan, Guolian Ren, Bin Zheng, Ruili Wang, Shuqiu Zhang
Summary: The study found that time-dependent pharmacokinetics of artemisinin drugs were mainly caused by the increased intestinal first-pass effect rather than hepatic first-pass effect or systemic metabolism. In contrast, dihydroartemisinin did not exhibit time-dependent pharmacokinetics.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Polymer Science
Tilen Kosir, Janko Slavic
Summary: Three-dimensional printing by material extrusion allows for the production of fully functional dynamic piezoelectric sensors in a single process, eliminating the need for additional assembly steps. However, these 3D-printed sensors have higher electrical resistance due to material limitations, resulting in a limited usable frequency range. This research presents an analytical model for determining the usable frequency range of 3D-printed piezoelectric sensors with resistive electrodes, and experimental results confirm the accuracy of the model. This research opens up possibilities for designing the electrical and dynamic characteristics of future intelligent dynamic systems printed in a single process.
Article
Pharmacology & Pharmacy
David Dahlgren, Tobias Olander, Markus Sjoblom, Mikael Hedeland, Hans Lennernas
Summary: Paracellular permeation enhancers were found to increase the mucosal permeability of hydrophilic peptides with low molecular mass compared to those with a transcellular mechanism-of-action. Additionally, luminal hypotonicity primarily affects paracellular solute transport in the mucosal crypt region.
ACTA PHARMACEUTICA SINICA B
(2021)
Article
Optics
Dongdi Zhao, Yongpeng Zhao, Huaiyu Cui, Bo An, Lei Li, Yunsong Bai
Summary: In this paper, the influence of delay time on the double-pass amplified 46.9 nm laser was studied using a high-precision polished SiC slice as a rear mirror. The temporal and spatial characteristics of the output laser were measured to investigate the effect of delay time. The energy of double-pass amplified laser ranged from 510 vJ to 890 vJ.
CHINESE OPTICS LETTERS
(2023)
Article
Engineering, Environmental
E. Valadez-Renteria, J. Oliva, K. P. Padmasree, A. I. Oliva, V. Rodriguez-Gonzalez
Summary: In this research, the performance of Ce0.8Sm0.15Nd0.05O2-d (CSNO) powders immobilized on recycled single use packets for the removal of furosemide (FUR) drug by physical adsorption was investigated. The results showed that CSNO powders exhibited a high adsorption capacity for FUR, reaching 95.1% removal rate in just 4 minutes of reaction. The composite material of plastic packet and CSNO powder also showed efficient adsorption of FUR, with a maximum adsorption capacity of 20.7 mg/g.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2023)
Article
Geochemistry & Geophysics
Andreas Theodosiou, Marcel Kleinherenbrink, Paco Lopez-Dekker
Summary: Estimating sea surface height with cross-track interferometry requires high sensitivity due to the small magnitude of the ocean surface signal. A squinted line of sight, combined with a helix satellite formation, can optimize the baselines to meet the requirements. This article presents a model to evaluate the performance of a formation-flying cross-track interferometer using a squinted line of sight. Case studies demonstrate that the system can accurately estimate surface elevation at submesoscales and resolve spatial scales up to 47 km.
IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING
(2023)
Article
Pharmacology & Pharmacy
Nazila Fathi Maroufi, Vahid Vahedian, Seyed Ali Miresmaeili Mazrakhondi, Wesam Kooti, Hosein Ajami Khiavy, Roya Bazzaz, Fatemeh Ramezani, Seyed Mohammadbagher Pirouzpanah, Marjan Ghorbani, Maryam Akbarzadeh, Hamed Hajipour, Saeed Ghanbarzadeh, Mehdi Sabzichi
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Mehran Mesgari-Abbasi, Hadi Valizadeh, Navideh Mirzakhani, Tohid Vahdatpour
Summary: This study investigates the effects of small peptides, including di- and tri-peptides containing proline, glycine, and leucine, on enzymes and histopathology of the liver in mice with diabetes. The results suggest that the dipeptides Ala-His, Leu-Gly, and Pro-Gly-Pro have stronger protective effects against diabetes-induced changes in liver enzymes and histology.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Article
Plant Sciences
Fatemeh Ebrahimi, Javad Mahmoudi, Mohammadali Torbati, Pouran Karimi, Hadi Valizadeh
JOURNAL OF ETHNOPHARMACOLOGY
(2020)
Review
Chemistry, Multidisciplinary
Mehdi Azizi, Hassan Dianat-Moghadam, Roya Salehi, Masoud Farshbaf, Disha Iyengar, Samaresh Sau, Arun K. Iyer, Hadi Valizadeh, Mohammad Mehrmohammadi, Michael R. Hamblin
ADVANCED FUNCTIONAL MATERIALS
(2020)
Article
Chemistry, Medicinal
Parvin Zakeri-Milani, Ali Shirani, Ali Nokhodchi, Samad Farkhani, Samaneh Mohammadi, Javid Mojarrad, Mohammad Mahmoudian, Tooba Gholikhani, Masoud Farshbaf, Hadi Valizadeh
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
(2020)
Review
Pharmacology & Pharmacy
Fahimeh Zahednezhad, Parvin Zakeri-Milani, Javid Shahbazi Mojarrad, Hadi Valizadeh
EXPERT OPINION ON DRUG DELIVERY
(2020)
Article
Pharmacology & Pharmacy
Mitra Alami-Milani, Parvin Zakeri-Milani, Hadi Valizadeh, Marzieh Fathi, Sara Salatin, Roya Salehi, Mitra Jelvehgari
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
(2020)
Article
Pharmacology & Pharmacy
Mohammad Mahmoudian, Hadi Valizadeh, Raimar Lobenberg, Parvin Zakeri-Milani
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
(2020)
Review
Pharmacology & Pharmacy
Seyed Hossein Kiaie, Solmaz Mojarad-Jabali, Farnaz Khaleseh, Saeideh Allahyari, Elham Taheri, Parvin Zakeri-Milani, Hadi Valizadeh
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2020)
Review
Pharmacology & Pharmacy
Somayeh Mahdinloo, Seyed Hossein Kiaie, Ala Amiri, Salar Hemmati, Hadi Valizadeh, Parvin Zakeri-Milani
ACTA PHARMACEUTICA SINICA B
(2020)
Article
Chemistry, Physical
Zahra Naderloo, Ali Shayanfar, Parvin Zakeri-Milani, Hadi Valizadeh
JOURNAL OF MOLECULAR LIQUIDS
(2020)
Article
Pharmacology & Pharmacy
Maryam Saadat, Sevda Jafari, Parvin Zakeri-Milani, Javid Shahbazi-Mojarrad, Hadi Valizadeh
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2020)
Article
Chemistry, Multidisciplinary
Mehdi Azizi, Hadi Valizadeh, Mehdi Shahgolzari, Mehdi Talebi, Elahe Baybordi, Mohammad Reza Dadpour, Roya Salehi, Mohammad Mehrmohammadi
Review
Pharmacology & Pharmacy
Mohammad Mahmoudian, Solmaz Maleki Dizaj, Sara Salatin, Raimar Lobenberg, Maryam Saadat, Ziba Islambulchilar, Hadi Valizadeh, Parvin Zakeri-Milani
Summary: Lipid-based nano-drug delivery systems (LBNDDSs), such as solid lipid nanoparticles (SLNs), have shown great potential in oral drug delivery due to their tunable properties. However, the susceptibility of SLNs to lipolysis poses challenges in developing more efficient delivery systems. This paper highlights factors affecting the digestion rate/level of SLNs in the gastrointestinal tract, providing valuable insights for researchers aiming to develop controlled drug delivery systems for oral applications.
EXPERT OPINION ON DRUG DELIVERY
(2021)
Article
Pharmacology & Pharmacy
Fatemeh Ebrahimi, Mohammadali Torbati, Javad Mahmoudi, Hadi Valizadeh
JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES
(2020)
