Article
Chemistry, Multidisciplinary
Kamchai Saepang, S. Kevin Li, Doungdaw Chantasart
Summary: This study evaluated the effect of decreasing the formulation pH to increase the positive charges of pramipexole dihydrochloride (PXCl) on its iontophoretic transport across skin. The results showed that the decrease in PXCl delivery at higher valence at pH 3 was mainly due to pH-dependent selectivity of PX ion permeation across the skin and not electroosmosis. Skin permselectivity is a significant factor for iontophoretic transport of PXCl, and reducing formulation pH to increase the positive charges on PX ions did not enhance PXCl delivery.
PHARMACEUTICAL RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Deepanjan Datta, Dhruvisha Sureshbhai Panchal, Venkata Vamsi Krishna Venuganti
Summary: The study demonstrates that a combination of chemical enhancers and tape-stripping techniques significantly increases the permeation of vancomycin hydrochloride (VH) across the skin, leading to enhanced local and systemic treatment of bacterial infections. Results from experiments and pharmacokinetic analysis suggest that this approach could be a promising method for delivering antibiotics through topical route.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Chemistry, Medicinal
Soroush Khamoushian, Tayyebeh Madrakian, Abbas Afkhami, Arash Ghoorchian, Saeid Ghavami, Kamran Tari, Mohammad Reza Samarghandi
Summary: This study introduces deep eutectic solvent (DESs) as novel chemical penetration enhancers (CPEs) for transdermal iontophoresis (IP) delivery of insulin (INS) across rat skin, both in vitro and in vivo.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Review
Medicine, Research & Experimental
Mohammad Dahri, Nima Beheshtizadeh, Nasrin Seyedpour, Amin Nakhostin-Ansari, Faezeh Aghajani, Simin Seyedpour, Moein Masjedi, Fatemeh Farjadian, Reza Maleki, Khosro Adibkia
Summary: Immunotherapy is an important treatment for various diseases, and different approaches using biomaterials and devices have been studied. Transdermal immunotherapy using microneedles is commonly used for cancer, infectious diseases, and allergic and autoimmune disorders. The biomaterials used in transdermal immunotherapy have different shapes, sizes, and sensitivities to external stimuli.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Engineering, Biomedical
Yanjun Li, Jingbo Yang, Ying Zheng, Rui Ye, Bin Liu, Yong Huang, Wei Zhou, Lelun Jiang
Summary: The study introduced a novel iontophoresis-driven porous MA patch (IDPMAP) and a portable iontophoresis-driven device for active transdermal delivery of charged liquid drugs. IDPMAP showed robust drug delivery ability with more advanced controllability and efficiency compared to pristine MA or iontophoresis, offering a platform technique for effective drug delivery in an active-controlled manner.
ACTA BIOMATERIALIA
(2021)
Article
Multidisciplinary Sciences
Joakim Henricson, Folke Sjoberg, Fredrik Iredahl, Tomas Stromberg, Daniel Wilhelms
Summary: This study used polarized reflectance spectroscopy to measure vascular responses to iontophoretically administrated acetylcholine and observed the effects of consecutive current pulses. The results showed that polarized reflectance spectroscopy is well suited for measuring vascular responses to iontophoresis, supporting its further development as a method to study vascular function and pharmacological responses in vivo.
SCIENTIFIC REPORTS
(2022)
Article
Pharmacology & Pharmacy
Mahmoud H. Teaima, Mohamed Azmi Ahmed Mohamed, Randa Tag Abd El Rehem, Saadia A. Tayel, Mohamed A. El-Nabarawi, Shahinaze A. Fouad
Summary: The study enhanced the transdermal delivery of bisoprolol hemifumarate (BH) through differently prepared hydrogels, proving it as a successful alternative route to conventional oral tablets.
Article
Spectroscopy
Kordian Chamerski, Jacek Filipecki, Agnieszka Balinska, Piotr Jelen, Maciej Sitarz
Summary: This study characterized calcium phosphates formed under conditions similar to those in the human eye using SEM/EDS and infrared spectroscopy. The results showed the formation of white spherical precipitates with an unstable nature when extracted from the solution. Elemental analysis revealed a Ca/P ratio similar to hydroxyapatite, and further analysis indicated the presence of calcium phosphate hydration.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Pharmacology & Pharmacy
Mahadi Hasan, Anowara Khatun, Kentaro Kogure
Summary: Biological macromolecular drugs have become a significant therapeutic modality for various diseases due to their high specificity and safety profiles. However, their oral bioavailability and half-lives are limited. Iontophoresis, a method that uses low-level electricity for skin permeation, has been explored for the noninvasive transdermal delivery of these drugs.
Article
Pharmacology & Pharmacy
Amruta A. Dandekar, Madhura Kale, Harsha T. Garimella, Ajay K. Banga
Summary: Application of drugs on compromised skin can alter drug permeation and lead to increased adverse effects. This study examined the in vitro delivery of diclofenac sodium from different brands and generic formulations across normal and compromised skin using microneedles and iontophoresis. The results showed that compromised skin had higher delivery of diclofenac sodium, suggesting increased absorption and systemic exposure of the drug.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Review
Pharmacology & Pharmacy
Ahlam Zaid Alkilani, Jehad Nasereddin, Rania Hamed, Sukaina Nimrawi, Ghaid Hussein, Hadeel Abo-Zour, Ryan F. Donnelly
Summary: Transdermal drug delivery (TDD) is a non-invasive approach that is convenient and easy to use, especially for vulnerable age groups. However, its applicability is limited to drugs with specific physicochemical properties due to the barrier posed by the skin. Various techniques, including chemical and passive methods, have been investigated to enhance drug permeability across the skin. Hybrid approaches combining chemical penetration enhancement technologies with physical technologies are also being intensely researched.
Article
Pharmacology & Pharmacy
Kristyna Dvorakova, Petr Stepanek, Jirina Kroupova, Jarmila Zbytovska
Summary: Transdermal drug delivery is a non-invasive method with advantages over conventional routes of administration. However, the skin barrier needs to be modulated with enhancers, and currently there is a lack of enhancers with low toxicity and reversible effects. A study found that a series of new N-alkylmorpholines showed enhanced transdermal and dermal delivery, with the most effective derivatives having 10-14 carbons. The enhancers interacted predominantly with stratum corneum lipids.
Article
Environmental Sciences
S. A. Naidu, L. Mawii, V. Ranga Rao, G. Anitha, P. Mishra, Bhavani E. Narayanaswamy, V. Anil Kumar, M. V. Ramana Murthy, G. V. M. Gupta
Summary: The study found that the prevalence of microplastics in the Eastern Arabian Sea is mainly due to the degradation of larger items, primarily composed of polypropylene, polyethylene, and nylon, posing a potential risk to marine ecosystems.
MARINE POLLUTION BULLETIN
(2021)
Article
Chemistry, Multidisciplinary
Tae Hyeon Kim, Na Yeon Kim, Hee Uk Lee, Ji Wook Choi, Taewook Kang, Bong Geun Chung
Summary: Cancer is a leading cause of death worldwide, and conventional cancer therapy has limitations. To address these issues, a transdermal drug delivery system based on iontophoresis has been developed. Controlled by a smartphone application, this system significantly enhances drug permeation at the tumor site and reduces systemic side effects.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Immunology
Hadeer Mamdouh Ahmed Eldeeb, Mona F. Ali, Maisa M. A. Mansour, Maha Ahmed Ali Ahmed, Mohamed Z. M. Salem
Summary: This study focused on isolating and identifying fungi from old albumen prints and evaluating their ability to cause deterioration. Four fungal species were identified, and it was found that some of them can cause hydrolysis and oxidation to the prints.
MICROBIAL PATHOGENESIS
(2022)