Article
Engineering, Biomedical
Sijie Wu, Gaodan Liu, Ping Shao, Xingyu Lin, Jiahao Yu, Hanchi Chen, Huiliang Li, Simin Feng
Summary: This study developed a carboxymethyl-modified chitosan/hyaluronic acid thermosensitive hydrogel for sustained transdermal delivery of liposomes. The hydrogel exhibited suitable gel properties and structure, resulting in delayed liposomes release and improved skin retention. The liposome-hydrogel system more efficiently promoted the effects of anti-aging agents on the skin.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Franco Furlani, Arianna Rossi, Maria Aurora Grimaudo, Giada Bassi, Elena Giusto, Filippo Molinari, Florigio Lista, Monica Montesi, Silvia Panseri
Summary: This work presents the development of an injectable nanocomposite system for regenerative medicine, combining chitosan thermosensitive hydrogel and liposomes. The system allows controlled release, enhances cellular uptake, and can form a hydrogel at physiological temperature.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Huan Liu, Xinyu Meng, Lei Li, Yongmei Xia, Xueyi Hu, Yun Fang
Summary: A hydrogel delivery system made of chitosan incorporated fatty acid vesicles was developed for protective sustained release of curcumin. The hydrogel was fluidic at room temperature and could gel rapidly at 37 degrees C. The vesicles remained as nano-vesicles in the gel, effectively reducing the burst effect and enhancing the antioxidant activity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Multidisciplinary
Seung Hun Park, Richard S. Kim, Wesley R. Stiles, Minjoo Jo, Lingxue Zeng, Sunghoon Rho, Yoonji Baek, Jonghan Kim, Moon Suk Kim, Homan Kang, Hak Soo Choi
Summary: Deferoxamine (DFO) is an FDA-approved iron-chelating agent with good therapeutic efficacy, but its short blood half-life poses challenges for patients who require frequent administrations. By integrating crosslinked hyaluronic acid and Pluronic F127 into an injectable hydrogel formulation, a prolonged release of DFO nanochelators is achieved, significantly extending the half-life and demonstrating potential for the treatment of iron overload disorders.
Article
Biochemistry & Molecular Biology
Ashiq Hussain Pandit, Safiya Nisar, Khalid Imtiyaz, Masood Nadeem, Nasreen Mazumdar, M. Moshahid Alam Rizvi, Sharif Ahmad
Summary: The synthesized N,O-CMCS/MAGG hydrogel showed promising applications in localized delivery of anticancer drugs. The hydrogel exhibited pH-responsive swelling behavior, good mechanical properties, excellent self-healing and thixotropic properties due to the reversible Schiff base linkages. The Dox-loaded hydrogel demonstrated significant killing effect against breast cancer cells, indicating its potential in anticancer drug delivery.
Article
Chemistry, Multidisciplinary
Maximilian Regenold, Kan Kaneko, Xuehan Wang, H. Benson Peng, James C. Evans, Pauric Bannigan, Christine Allen
Summary: Triggered drug delivery strategies, such as thermosensitive liposomes, have shown improved targetability for chemotherapeutics. However, most studies have focused on doxorubicin encapsulation, while other drugs could also benefit from this targeted delivery approach.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Polymer Science
Chengjun Peng, Guichun Wang, Yuxiao Wang, Maomao Tang, Xiaodong Ma, Xiangwei Chang, Jian Guo, Shuangying Gui
Summary: This study develops a novel thermosensitive hydrogel delivery system to improve the therapeutic potential of natural active ingredients for periodontitis therapy.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2023)
Article
Chemistry, Physical
Kento Koga, Tatsuaki Tagami, Tetsuya Ozeki
Summary: The study developed gold nanoparticle-coated liposome/doxorubicin for controlled drug release and photothermal effect, showing synergistic therapeutic efficacy on lung cancer cells compared to monotherapy. This approach holds promise for cancer treatment with the use of near-infrared laser irradiation.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2021)
Article
Biochemistry & Molecular Biology
Parinaz Jabbari, Gholam Reza Mahdavinia, Parisa Fathi Rezaei, Bagher Kazemi Heragh, Parisa Labib, Hessam Jafari, Shahrzad Javanshir
Summary: A nanocomposite carrier with double-responsive features was developed by integrating magnetic montmorillonite into a chitosan matrix and crosslinking it with citric acid. The carrier showed high sustained release and antibacterial activity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Marine & Freshwater Biology
Jianan Tong, Huiyun Zhou, Jingjing Zhou, Yawei Chen, Jing Shi, Jieke Zhang, Xinyu Liang, Tianyuan Du
Summary: Chitosan-amino acid thermosensitive hydrogels demonstrate good thermosensitivity and a three-dimensional network structure, with sustained release effects even after the addition of model drugs.
MARINE LIFE SCIENCE & TECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Francisca Casanova, Carla F. Pereira, Alessandra B. Ribeiro, Eduardo M. Costa, Ricardo Freixo, Pedro M. Castro, Joao C. Fernandes, Manuela Pintado, Oscar L. Ramos
Summary: This study investigates the potential use of cellulose nanostructures as carriers for the delivery of curcumin. Surface-modified cellulose showed improved encapsulation and sustained release properties for curcumin. The modified cellulose carriers reduced cytotoxicity and could be a promising drug delivery system.
Article
Chemistry, Physical
Bahar Kanci Bozoglan, Osman Duman, Sibel Tunc
Summary: New OXI-loaded hydrogels with high antifungal activity were developed for onychomycosis treatment. The release of OXI from the hydrogels can be controlled by adjusting the amount of MMT in the hydrogel matrix.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2021)
Article
Engineering, Biomedical
Yunfan Zhang, Xueyu Dou, Lingyun Zhang, Hufei Wang, Ting Zhang, Rushui Bai, Qiannan Sun, Xing Wang, Tingting Yu, Decheng Wu, Bing Han, Xuliang Deng
Summary: In this study, a semi-interpenetrating network composite gel was prepared to fulfill the mechanical and cell compatibility requirements of hydrogels. The gel successfully encapsulated ASA via electrostatic interactions and achieved sustained release, promoting stem cell proliferation and differentiation. In vivo studies confirmed the potential of this gel in bone tissue engineering.
BIOACTIVE MATERIALS
(2022)
Article
Chemistry, Physical
Junyoung Kim, Tae Ho Kim, Jong Hyeon Lee, Young Ah Park, Yu Jin Kang, Hong Geun Ji
Summary: A porous nanocomposite of layered double hydroxide (LDH) nanosheets and chitosan biopolymer was developed for easy uptake and selective release of cosmetic liposome capsules. The nanocomposite exhibited a high BET surface area and porous structure, allowing for controlled release of large liposome particles depending on solution pH and anions. The polymer network effectively blocked liposome release and the nanocomposites could be successfully reused after washing with ethanol.
APPLIED CLAY SCIENCE
(2021)
Article
Engineering, Environmental
Shuxuan Wu, Sheng Deng, Fu Xia, Xu Han, Tianyu Ju, Han Xiao, Xiangjian Xu, Yu Yang, Yonghai Jiang, Beidou Xi
Summary: Novel hydrogels (ASGs) with thermosensitive properties were prepared based on agarose and silica for controlled per sulfate (PS) release. The composition ratio of the hydrogels was adjusted to regulate the gelation time and internal pore structure, which influenced the encapsulated amount and release properties of PS. The ASGs exhibited significant temperature responsiveness and when combined with zero-valent iron, achieved long-lasting degradation of 2,4-dinitrotoluene (2,4-DNT) with improved performance compared to the PS/ZVI system.
JOURNAL OF HAZARDOUS MATERIALS
(2023)