期刊
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
卷 35, 期 4, 页码 387-395出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/03639040802363704
关键词
risperidone; formulation considerations; brain targeting; transmucosal delivery; nasal ciliotoxicity
Risperidone nanoemulsion (NE) and mucoadhesive NE formulations were successfully prepared by the spontaneous emulsification method (titration method) using Capmul MCM as the oily phase on the basis of solubility studies. The NE formulation containing 8% oil, 44% Smix, 48% (wt/wt) aqueous phase that displayed an optical transparency of 99.82%, globule size of 15.5 2.12 nm, and polydispersity of 0.172 0.02 was selected for the incorporation of mucoadhesive components. The mucoadhesive formulation that contained 0.5% by weight of chitosan displayed highest diffusion coefficient that followed Higuchi model was free from nasal ciliotoxicity and stable for 3 months.
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