期刊
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
卷 34, 期 4, 页码 413-418出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/03639040701662495
关键词
neutron capture therapy; redistribution; release; local delivery
Gadolinium neutron capture therapy (Gd-NCT) is a promising approach to right cancer. One key factor for the success of Gd-NCT is to deliver and maintain a sufficient amount of Gd inside tumors. A large amount of Gd can be readily introduced into tumors by direct intratumor injection. However, an innovative approach is needed to maintain the Gd in the tumors. We encapsulated a Gd compound into a liposome formulation and then dispersed the liposomes into a thermo-sensitive polymeric gel. In murine tumor models, we showed that this liposome-in-thermo-sensitive gel system significantly extended the retention of the Gd compound in tumors. This similar concept may be applied to prolong the retention of other cytotoxic chemicals in tumors, and thus, improve their anti-tumor efficacy.
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