期刊
DRUG DELIVERY
卷 17, 期 8, 页码 561-572出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/10717544.2010.500635
关键词
Hyaluronic acid; 5-fluorouracil; PLGA nanoparticles; cancer; targeted delivery
资金
- ICMR, New Delhi, India
The present investigation was aimed to develop and explore the prospective of engineered PLGA nanoparticles as vehicles for targeted delivery of 5-fluorouracil (5-FU). Nanoparticles of 5-FU-loaded hyaluronic acid-poly(ethylene glycol)-poly(lactide-co-glycolide) (HA-PEG-PLGA-FU) copolymer were prepared and characterized by FTIR, NMR, transmission electron microscopy, particle size analysis, DSC, and X-ray diffractometer measurement studies. The nanoparticulate formulation was evaluated for in vitro release, hemolytic toxicity, and hematological toxicity. Cytotoxicity studies were performed on Ehrlich ascites tumor (EAT) cell lines using MTT cell proliferation assay. Biodistribution studies of
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