期刊
DRUG AND ALCOHOL DEPENDENCE
卷 129, 期 3, 页码 240-246出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.drugalcdep.2013.02.024
关键词
Conditioned place preference; Social interaction; Amphetamine; Concurrent choice; Development; Adolescence; Differential housing
资金
- NIH [P50 DA05312, R01 DA12964, T32 DA016176]
Background: Social interaction can serve as a natural reward that attenuates drug reward in rats; however, it is unknown if age or housing conditions alter the choice between social interaction and drug. Methods: Individually- and pair-housed adolescent and adult male rats were tested using conditioned place preference (CPP) in separate experiments in which: (1) social interaction was conditioned against no social interaction; (2) amphetamine (AMPH; 1 mg/kg, s.c.) was conditioned against saline; or (3) social interaction was conditioned against AMPH. Results: Social interaction CPP was obtained only in individually-housed adolescents, whereas AMPH CPP was obtained in both individually-housed adolescents and adults; however, the effect of AMPH was not statistically significant in pair-housed adults. When allowed to choose concurrently between compartments paired with either social interaction or AMPH, individually-housed adolescents preferred the compartment paired with social interaction, whereas pair-housed adolescents preferred the compartment paired with AMPH. Regardless of housing condition, adults showed a similar preference for the compartments paired with either social interaction or AMPH. Conclusions: Although some caution is needed in interpreting cross-experiment comparisons, the overall results suggest that individually-housed adolescents were most sensitive to the rewarding effect of social interaction, and this hypersensitivity to social reward effectively competed with AMPH reward. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
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