Article
Psychiatry
Lorenzo Zamboni, Simone Campagnari, Rosaria Giordano, Francesca Fusina, Silvia Carli, Alessio Congiu, Isabella Barbon, Silvia Melchiori, Rebecca Casari, Elisa Tedeschi, Roberta Vesentin, Giuseppe Verlato, Maurizio Valentino Infante, Fabio Lugoboni
Summary: The study aims to compare the effects of two different treatment approaches on nicotine addiction patients, as well as the importance of environmental cues in the smoking cessation process.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Behavioral Sciences
L. M. Cope, A. Gheidi, M. E. Martz, E. R. Duval, H. Khalil, T. Allerton, J. D. Morrow
Summary: Cue-based associative learning is a fundamental component of animal behavior and may be related to addiction liability. Previous research has shown significant individual differences in this type of learning in non-human animals. This study revealed the existence of sign-trackers, goal-trackers, and intermediate responders in humans, with impulsivity being a significant predictor of sign-tracking behavior.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Neurosciences
Noah B. Walker, Yijin Yan, Melissa A. Tapia, Brenton R. Tucker, Leanne N. Thomas, Brianna E. George, Alyssa M. West, Christopher B. Marotta, Henry A. Lester, Dennis A. Dougherty, Katherine M. Holleran, Sara R. Jones, Ryan M. Drenan
Summary: This study demonstrates that selective activation of nAChRs is sufficient for nicotine self-administration. Expression of β2 subunits with enhanced sensitivity to nicotine in VTA neurons supports nicotine reinforcement and enhances dopamine release.
Editorial Material
Substance Abuse
Robert West, Sharon Cox
Summary: The 1988 US Surgeon General's Report on Nicotine Addiction highlighted the addictive nature of tobacco and the role of nicotine in addiction. While the report's main conclusions have held up well over 30 years, it is now understood that different nicotine products vary in addictiveness and there is a need for updated thinking on this topic.
Article
Health Care Sciences & Services
Kar-Hai Chu, Tina B. Hershey, Beth L. Hoffman, Riley Wolynn, Jason B. Colditz, Jaime E. Sidani, Brian A. Primack
Summary: This study examined discussions related to Puff Bar on Twitter and found that the ban of e-cigarette flavors did not reduce interest, but instead shifted the discussion to brands utilizing a legal loophole to continue selling flavored products. The study also identified nicotine dependence and tobacco policy as the main topics of discussion.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2022)
Article
Psychology, Biological
Toni C. Spinella, Sean P. Barrett, Hera E. Schlagintweit
Summary: The study found that dependent and nondependent smokers have different motivations for smoking. Dependent smokers are driven by negative reinforcement, while nondependent smokers are not influenced by it. Therefore, targeting smoking cessation strategies to the unique needs of different types of smokers may improve quit success rates.
EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY
(2021)
Article
Substance Abuse
Ashley N. Gearhardt, Alexandra G. DiFeliceantonio
Summary: There is a debate on whether highly processed foods (HPFs) are addictive. The lack of scientifically grounded criteria to evaluate the addictive nature of HPFs has hindered the resolution of this debate. This article proposes four scientifically valid benchmarks that can be used to evaluate the addictiveness of HPFs and discusses the implications of labeling HPFs as addictive. It concludes that HPFs can meet the criteria to be labeled as addictive substances and their addictive potential may contribute to high public health costs.
Review
Psychology, Clinical
Mariangela Antonelli, Liana Fattore, Luisa Sestito, Daniela Di Giuda, Marco Diana, Giovanni Addolorato
Summary: Repetitive TMS has shown promising results in patients with alcohol, tobacco, and cocaine use disorder, indicating a potential role in the treatment of SUD.
ADDICTIVE BEHAVIORS
(2021)
Article
Environmental Sciences
Jochen Vukas, Nadja Mallock-Ohnesorg, Tobias Ruether, Elke Pieper, Luna Romano-Brandt, Yvonne Stoll, Lukas Hoehne, Nestor Burgmann, Peter Laux, Andreas Luch, Andrea Rabenstein
Summary: Heated tobacco products (HTPs) produce lower emissions of harmful substances compared to tobacco cigarettes, but may also deliver lower levels of nicotine. This study aimed to compare the nicotine delivery and satisfaction of two different HTPs with conventional cigarettes in users who had switched to HTPs. The results showed that both HTPs delivered comparable levels of nicotine, but significantly lower than conventional cigarettes, suggesting a lower addictive potential. Despite the different nicotine delivery, cravings were reduced by all products, indicating that HTPs do not necessarily require high nicotine levels to satisfy cravings like tobacco cigarettes do. These findings were further supported by an ad libitum use study.
Article
Psychology, Clinical
Georgios Mikellides, Panayiota Michael, Lilia Psalta, Artemis Stefani, Teresa Schuhmann, Alexander T. Sack
Summary: The study investigated the long-term effects of accelerated intermittent theta burst stimulation (aiTBS) in smoking cessation, showing that the positive effects on nicotine dependence and tobacco craving lasted for at least one month after treatment, but dissipated after six months. No significant differences were found between the three groups.
INTERNATIONAL JOURNAL OF CLINICAL AND HEALTH PSYCHOLOGY
(2023)
Article
Psychiatry
Tim Van Timmeren, Ruth J. Van Holst, Anna E. Goudriaan
Summary: This study compared the activation of the striatum during reward anticipation between patients with alcohol use disorder (AUD) and gambling disorder (GD) using functional MRI. The results showed hypoactivation of the reward system in AUD patients compared to healthy controls. However, the study did not support the hypothesis that addiction-related cues explain striatal dysfunction.
JOURNAL OF BEHAVIORAL ADDICTIONS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Leila Salhi, Laurence Seidel, Adelin Albert, France Lambert
Summary: The study found that the nicotine dependence level assessed by FTND could complement NCC as an important indicator in periodontal research, and the combination of both could better predict the severity of periodontitis.
JOURNAL OF PERIODONTOLOGY
(2021)
Article
Multidisciplinary Sciences
Hyeji Lee, Yoonji Jeon, Cheolin Yoo, HeeYoung Seon, Jiwon Park, Minho Hwang, Kwangyeol Baek, Dongil Chung
Summary: Smoking is highly addictive and often leads to relapse. The neurobiological changes associated with smoking addiction are well-known, but it is unclear whether these changes persist after long periods of abstinence. This study used resting state EEG to examine the brain activity of chronic smokers, successful quitters, and never-smokers. The results showed that both smokers and successful quitters had decreased theta power compared to never-smokers, indicating the persistent effect of smoking on the brain. Additionally, other EEG features in the alpha frequency band were found to differ between active smokers and never-smokers, but not between successful quitters and never-smokers, suggesting that these changes may be reversible after long-term abstinence.
SCIENTIFIC REPORTS
(2023)
Article
Computer Science, Artificial Intelligence
Shivam Kalhan, Marta I. Garrido, Robert Hester, A. David Redish
Summary: Dysfunction in learning and motivational systems is believed to contribute to addictive behaviors. Previous models have limitations in explaining the key features of addictive behaviors, but this study proposes a novel mathematical model that combines dopamine's role in learning and motivation to simulate addictive behaviors accurately. The model also explains some key characteristics of addictive behaviors.
Article
Clinical Neurology
Maylen Perez Diaz, Jean-Baptiste Pochon, Dara G. Ghahremani, Andy C. Dean, Paul Faulkner, Nicole Petersen, Rachel F. Tyndale, Andrea Donis, Diana Paez, Citlaly Cahuantzi, Gerhard S. Hellemann, Edythe D. London
Summary: The study found that women reported stronger craving for cigarettes than men, regardless of smoking condition. Nicotine dependence was positively associated with craving, with no sex differences in this association. There was a negative association of right anterior insula thickness with craving in women only.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Substance Abuse
Katie Witkiewitz, Elena R. Stein, Victoria R. Votaw, Kevin A. Hallgren, Benjamin C. Gibson, Cassandra L. Boness, Matthew R. Pearson, Stephen A. Maisto
Summary: This study aims to validate the utility of addiction cycle domains in predicting treatment outcomes and recovery among individuals with alcohol use disorder (AUD). The results showed that relief drinking/negative emotionality and reward drinking/incentive salience were significantly associated with treatment outcomes. Measurement of addiction cycle domains varied across different sociodemographic groups.
PSYCHOLOGY OF ADDICTIVE BEHAVIORS
(2023)
Article
Substance Abuse
Antonio Verdejo-Garcia, Tara Rezapour, Emily Giddens, Arash Khojasteh Zonoozi, Parnian Rafei, Jamie Berry, Alfonso Caracuel, Marc L. Copersino, Matt Field, Eric L. Garland, Valentina Lorenzetti, Leandro Malloy-Diniz, Victoria Manning, Ely M. Marceau, David L. Pennington, Justin C. Strickland, Reinout Wiers, Rahia Fairhead, Alexandra Anderson, Morris Bell, Wouter J. Boendermaker, Samantha Brooks, Raimondo Bruno, Salvatore Campanella, Janna Cousijn, W. Miles Cox, Andrew C. Dean, Karen D. Ersche, Ingmar Franken, Brett Froeliger, Pedro Gamito, Thomas E. Gladwin, Priscila D. Goncalves, Katrijn Houben, Joanna Jacobus, Andrew Jones, Anne M. Kaag, Johannes Lindenmeyer, Elly McGrath, Talia Nardo, Jorge Oliveira, Charlotte R. Pennington, Kelsey Perrykkad, Hugh Piercy, Claudia Rupp, Mieke H. J. Schulte, Lindsay M. Squeglia, Petra Staiger, Dan J. Stein, Jeff Stein, Maria Stein, William W. Stoops, Mary Sweeney, Katie Witkiewitz, Steven P. Woods, Richard Yi, Min Zhao, Hamed Ekhtiari
Summary: This study used a Delphi approach to reach consensus on recommendations for developing and applying cognitive training and remediation interventions for substance use disorders. Through two rounds of surveys, experts reached consensus on the targets, approaches, active ingredients, and modes of delivery for these interventions. The study indicates that intervention measures based on validated techniques and flexible delivery methods can effectively improve cognitive deficits in the treatment of substance use disorders.
Article
Substance Abuse
Victoria R. R. Votaw, Katie Witkiewitz, M. Lee Van Horn, Richard C. C. Crist, Timothy Pond, Henry R. R. Kranzler
Summary: This study aimed to investigate whether a single-nucleotide polymorphism (rs2832407) in GRIK1 moderates the effects of topiramate treatment for drinking reduction. The results showed that topiramate treatment was effective in reducing daily heavy drinking and desire to drink, and this effect was not influenced by the rs2832407*C-allele homozygotes.
Article
Psychology, Biological
Cassandra L. Boness, Katie Witkiewitz
Summary: This article discusses the overlap between alcohol use disorder treatment and etiologic maintenance mechanisms, suggesting areas for further research and potential improvements in treatment efficacy. By leveraging these overlapping processes, it may be possible to identify treatment targets and enhance the effectiveness of existing treatments.
EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY
(2023)
Article
Substance Abuse
Cassandra L. L. Boness, Victoria R. R. Votaw, Meredith W. W. Francis, Ashley L. L. Watts, Sarah H. H. Sperry, Christopher S. S. Kleva, Linda Nellis, Yoanna McDowell, Antoine B. B. Douaihy, Kenneth J. J. Sher, Katie Witkiewitz
Summary: This paper discusses the evolution of conceptualizations and diagnostic criteria for alcohol use disorder (AUD) in the United States, influenced by sociopolitical factors. It provides four examples of how DSM-defined alcoholism, abuse/dependence, and AUD have been influenced by sociopolitical factors. The importance of recognizing and understanding these sociopolitical factors in the application of AUD diagnoses is emphasized. Furthermore, a roadmap is offered to improve the diagnosis of AUD, focusing on falsifiability, acknowledging researchers' assumptions about human behavior, and collaboration across subfields. Such efforts have the potential to minimize sociopolitical influences in the development of diagnostic criteria and maximize the treatment utility of diagnoses.
ADDICTION RESEARCH & THEORY
(2023)
Article
Medicine, Research & Experimental
Kevin E. Vowles, Katie Witkiewitz, Erik Clarke, Zachary Schmidt, Brian Borsari, Karlyn E. Edwards, J. Richard Korecki, David Moniz-Lewis, Juliana A. Bondzie, Chloe Mullins, Claire Thoreson, Joannalyn Delacruz, Consuelo H. Wilkins, Sarah Nelson, Jennifer Delventura, Ryan Henderson, Andrea Katz, William Hua, Erin Watson, Catherine Baxley, Bernard R. Canlas, Tiffany Pendleton, Ellen Herbst, Steven Batki
Summary: This study aims to evaluate the efficacy of an integrated behavioral treatment for chronic pain and opioid use disorder. A randomized controlled trial will be conducted with veterans who have chronic pain and are on a stable dose of buprenorphine. The results of this study will provide valuable insights for the development of integrated treatments for chronic pain and opioid use disorder.
CONTEMPORARY CLINICAL TRIALS
(2023)
Article
Substance Abuse
Christine Vinci, Steven K. Sutton, Min-Jeong Yang, Sana Baban, Rachel Sauls, Katie Witkiewitz, Karen O. Brandon, Marina Unrod, Thomas H. Brandon, David W. Wetter
Summary: This pilot study evaluated the feasibility and acceptability of a mindfulness-based intervention for addressing both smoking and alcohol use. The results showed that the intervention had comparable outcomes to cognitive behavioral therapy (CBT) in reducing tobacco and alcohol use. Future research should conduct large-scale trials to evaluate the efficacy of this intervention.
DRUG AND ALCOHOL DEPENDENCE
(2023)
Article
Psychology, Clinical
Kevin A. Hallgren, Gantt P. Galloway, Katie Witkiewitz, Paul Linde, Bob Nix, John E. Mendelson
Summary: This study investigated the 90-day treatment retention and changes in blood alcohol concentration (BAC) in a large cohort receiving AUD telehealth. The results showed that most patients had good retention rates during the 90-day treatment period, and there was a significant reduction in estimated daily peak BAC. This suggests that telehealth is a viable approach for promoting drinking reductions in AUD treatment.
AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE
(2023)
Article
Psychology, Multidisciplinary
Katie Witkiewitz, Kevin E. Vowles
Summary: Chronic pain and substance use disorders (SUDs) are prevalent and persisting issues, with a significant proportion of the adult population being affected by them. Accessing evidence-based treatments for both conditions is challenging, but ongoing research is shedding light on the mechanisms and co-occurrence of chronic pain and substance use. Integrated behavioral treatments based on acceptance and mindfulness are being developed and tested, and there are increasing efforts in research funding, training, dissemination, and implementation of evidence-based treatments.
CURRENT DIRECTIONS IN PSYCHOLOGICAL SCIENCE
(2023)
Review
Substance Abuse
Rory A. Pfund, Shelby A. King, David P. Forman, James M. Zech, Meredith K. Ginley, Samuel C. Peter, Nicholas W. McAfee, Katie Witkiewitz, James P. Whelan
Summary: The objective of this study was to examine the effect of cognitive behavioral techniques on gambling-related harms, psychological symptoms, and quality of life. The results showed that cognitive behavioral techniques significantly reduced anxiety and depression symptoms, and improved the quality of life. However, further research is needed to explore the relationships between gambling harms, psychological symptoms, and quality of life.
PSYCHOLOGY OF ADDICTIVE BEHAVIORS
(2023)
Review
Psychology, Clinical
Cassandra L. L. Boness, Victoria R. R. Votaw, Frank J. J. Schwebel, David I. K. Moniz-Lewis, R. Kathryn McHugh, Katie Witkiewitz
Summary: Cognitive behavioral therapy (CBT) is an effective treatment for substance use disorders (SUDs), particularly during the early follow-up period.
CLINICAL PSYCHOLOGY-SCIENCE AND PRACTICE
(2023)
Article
Public, Environmental & Occupational Health
Verlin W. Joseph, David I. K. Moniz-Lewis, Dylan K. K. Richards, Matthew R. R. Pearson, Jason B. B. Luoma, Katie Witkiewitz
Summary: This study examined the role of shame in substance use treatment settings and found that it is a major barrier to successful recovery. The Internalized Shame Scale (ISS) was used to measure shame and the findings supported its consistent measurement across different time points and treatment conditions. Although there were significant reductions in shame after treatment, no differences were found between the two treatment approaches. Further research is necessary to understand how different treatment components impact shame reduction in individuals with substance use disorder.
Article
Public, Environmental & Occupational Health
Michael F. Rayo, Daria Faulkner, David Kline, Thomas Thornhill, Samuel Malloy, Dante Della Vella, Dane A. Morey, Net Zhang, Gregg Gonsalves
Summary: The FAAST program is an innovative approach for improving the detection of new cases of infectious disease. This study evaluates a Bayesian search algorithm to target hotspots of SARS-CoV-2 transmission in multiple locations in Columbus, Ohio, with the goal of detecting the most cases over time.
JMIR PUBLIC HEALTH AND SURVEILLANCE
(2023)
Article
Substance Abuse
Katie Witkiewitz, Megan Kirouac, James W. Baurley, Christopher S. McMahan
Summary: This study analyzed data from the Project MATCH and COMBINE studies to explore baseline predictors of drinking patterns. The findings suggest that prior drinking patterns are the most consistent predictors of future drinking patterns. Social network drinking, AUD severity, mental health symptoms, and constructs based on the addiction cycle were associated with patterns of drinking prior to treatment. Addiction cycle constructs, AUD severity, purpose in life, social network, legal history, craving, and motivation were associated with drinking during and following treatment.
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
(2023)
Article
Substance Abuse
H. M. Hebden, V. R. Votaw, L. Herchenroeder, K. Witkiewitz, E. W. Yeung
Summary: A valid measure for identifying reward and relief drinking subgroups in college students with binge drinking has been established. This could be useful for precision prevention efforts targeting individuals in the high-reward/low-relief and high-reward/high-relief subgroups.
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
(2023)