期刊
DRUG AND ALCOHOL DEPENDENCE
卷 123, 期 1-3, 页码 48-56出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.drugalcdep.2011.10.013
关键词
Adolescence; Epidemiology; DSM-IV-cannabis use disorders; Etiology; Parental disorder; Family history
资金
- German Federal Ministry of Education and Research (BMBF) [01EB9405/6, 01EB9901/6, EB01016200, 01EB0140, 01EB0440]
- Deutsche Forschungsgemeinschaft (DFG) [LA1148/1-1, WI2246/1-1, WI709/7-1, WI709/8-1]
- Bavarian State Ministry of the Environment and Public Health
Background: A younger age at onset of use of a specific substance is a well-documented risk-factor for a substance use disorder (SUD) related to that specific substance. However, the cross-substance relationship between a younger age at onset of alcohol use (AU) and nicotine use (NU) and the risk of cannabis use disorders (CUD) in adolescence and early adulthood remains unclear. Aims: To identify the sequence of and latency between initial AU/NU and initial cannabis use (CU). To investigate whether younger age at AU- and NU-onset is associated with any and earlier CU-onset and a higher risk of transition from first CU to CUD, taking into account externalizing disorders (ED) and parental substance use disorders as putative influential factors. Methods: Prospective-longitudinal community study with N=3021 subjects (baseline age 14-24) and up to four assessment waves over up to ten years with additional direct parental and family history information. Substance use and CUD were assessed with the DSM-IV/M-CIDI. Results: Most subjects with CU reported AU (99%) and NU (94%). Among users of both substances, 93% reported AU prior to CU (87% for NU). After adjustment for ED and parental substance use disorders younger age at AU-onset was associated with any CU. Younger age at NU-onset was associated with earlier CU initiation. Younger age at AU- and NU-onset was not associated with a higher risk of CUD. Conclusions: The cross-substance relevance of younger age at first AU and NU for the risk of CUD is limited to early CU involvement. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
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