期刊
DRUG AND ALCOHOL DEPENDENCE
卷 122, 期 1-2, 页码 93-99出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.drugalcdep.2011.09.014
关键词
Impulsivity; Negative urgency; Translational research; Substance abuse; Amphetamine; Self-administration
资金
- NIH [F31 DA028018, P50 DA05312, T32 DA007304]
- University of Kentucky Center on Drug and Alcohol Research
- American Psychological Association Science Directorate
- American Psychological Association Division 28
- Graduate School at the University of Kentucky
Background: Laboratory tasks that measure various facets of impulsivity derived from self-report questionnaires are important for elucidating the behavioral consequences of impulsivity in humans and for back-translating these facets to non-human species. Negative urgency, or mood-based rash action, is a self-report facet of impulsivity linked to problem substance use; however, a valid behavioral task is lacking. Methods: The current studies were designed to bridge self-report questionnaire and behavioral measures of negative urgency in humans and to determine if this could be back-translated to rats. Results: Humans scoring high in negative urgency showed greater behavioral responding and increased frustration following unexpected reward omission on a monetary-based task compared to subjects low in negative urgency. Rats also showed elevated responding for either sucrose pellets or intravenous amphetamine following unexpected reward omission. Conclusion: These results suggest that impulsive behavior engendered by unexpected reward omission may represent a valid behavioral model of negative urgency linked to substance abuse. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
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