Review
Pharmacology & Pharmacy
Hossein Omidian, Niloofar Babanejad, Yadollah Omidi
Summary: The primary tools to alleviate the opioid epidemic in the USA include strict laws on opioid prescriptions, tracking opioid medications, and boosting public awareness. While abuse-deterrent opioids have helped lower opioid abuse, there are still pending post-marketing studies and some products have been recalled or terminated. There is a strong need for nonaddictive opioids and alternative non-opioid options for acute pain management.
DRUG DISCOVERY TODAY
(2022)
Review
Biochemistry & Molecular Biology
Ke Zhang Reid, Brendan Matthew Lemezis, Tien-Chi Hou, Rong Chen
Summary: Chronic exposure to drugs of abuse leads to significant changes in gene expression and neural activity, which are associated with drug-seeking and taking behavior. Opioid receptor gene expression is commonly dysregulated across various abused substances, and its regulation involves epigenetic mechanisms such as DNA and histone modifications, as well as non-coding RNAs. Additionally, drugs of abuse can target various epigenetic regulatory networks to modulate opioid receptor gene expression. Manipulating epigenetic processes shows therapeutic potential in treating substance use disorder.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Erin J. Stringfellow, Tse Yang Lim, Keith Humphreys, Catherine DiGennaro, Celia Stafford, Elizabeth Beaulieu, Jack Homer, Wayne Wakeland, Benjamin Bearnot, R. Kathryn McHugh, John Kelly, Lukas Glos, Sara L. Eggers, Reza Kazemi, Mohammad S. Jalali
Summary: Opioid overdose deaths remain a major public health crisis. Our analysis shows that strategies including reducing fentanyl-related overdose risk, increasing naloxone distribution, and providing recovery support for individuals in remission can significantly reduce fatal opioid overdoses.
Article
Chemistry, Analytical
Kathryn J. Vannoy, Nicole E. Tarolla, Philip J. Kauffmann, Rebecca B. Clark, Jeffrey E. Dick
Summary: We present a facile method for the detection of methamphetamine in aerosols by trapping them in a soap bubble wall for electroanalysis. By changing the microwire material, we are able to control the wetting parameters of the bubble wall, which significantly affects the voltammetric behavior in this system.
ANALYTICAL CHEMISTRY
(2022)
Article
Neurosciences
T. R. Baird, H. Akbarali, W. L. Dewey, H. Elder, M. Kang, S. A. Marsh, M. R. Peace, J. L. Poklis, E. J. Santos, S. S. Negus
Summary: The study found that tianeptine has a lower abuse potential compared to commonly abused opioids in rats, as it exhibits resistance to tolerance and dependence. However, tianeptine does produce acute adverse effects similar to opioid agonists, including motor impairment, constipation, and respiratory depression.
PSYCHOPHARMACOLOGY
(2022)
Article
Engineering, Biomedical
Holly A. Knapp, Blaire A. Sobolewski, Jesse C. Dean
Summary: This study investigated the effects of augmented and disrupted feedback on the relationship between pelvis dynamics and foot placement in gait. The results showed that augmented feedback strengthened this relationship, while disrupted feedback did not significantly weaken it.
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
(2021)
Article
Medicine, General & Internal
J. Deanna Wilson, Kaleab Z. Abebe, Kevin Kraemer, Jane Liebschutz, Jessica Merlin, Elizabeth Miller, David Kelley, Julie Donohue
Summary: This study identified two trajectories of opioid prescribing patterns in opioid-naive youths, with high-risk trajectory associated with older age and longer, more potent initial prescriptions. Even short and low-dose opioid prescriptions can be associated with risks of persistent opioid use for youths.
Article
Ophthalmology
Cindy Ung, Yoshihiro Yonekawa, Jennifer F. Waljee, Vidhya Gunaseelan, Yen-Ling Lai, Maria A. Woodward
Summary: In patients who underwent ophthalmic surgery, the rate of new persistent opioid use was 3.4% in those who had prior opioid exposure compared to 0.6% in opioid-naive patients. For patients who had an initial perioperative opioid prescription, a prescription size of 150 morphine milligram equivalents or more was associated with an increased odds of refill.
Article
Chemistry, Inorganic & Nuclear
Maryam Bazargan, Masoud Mirzaei, Amirhassan Amiri, Joel T. Mague
Summary: A series of 2D polyoxometalate-based frameworks were synthesized and characterized. These frameworks have a unique 2D layer structure suitable for surface binding of common drugs. The ability of these frameworks as sorbents for the extraction and quantification of opioid drugs was also investigated.
INORGANIC CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Piotr F. J. Lipinski, Joanna Matalinska
Summary: The design of multitarget analgesics is a strategy in the search for safe and effective analgesic drugs. These drugs are intended to target multiple molecular targets involved in pain modulation. This article summarizes attempts to use fentanyl or its substructures as a scaffold for attaching fragments related to non-opioid receptors. The non-opioid targets include various proteins. The article reviews the chemistry, pharmacological properties, and structure-activity relationships of these attempts, and discusses future research directions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Criminology & Penology
Richard Rosenfeld, Joel Wallman, Randolph Roth
Summary: The study found that the opioid-related overdose death rate is positively associated with homicide rates in the United States, indicating a link between violent dynamics of street drug markets and substance abuse. However, further research is needed to understand the mechanisms connecting opioid demand and homicide.
JOURNAL OF RESEARCH IN CRIME AND DELINQUENCY
(2021)
Article
Criminology & Penology
Jessica Roberts Williams, Susan Girdler, Weston Williams, Martha Grace Cromeens
Summary: This study found an association between IPT and opioid misuse, but not with use. The relationship between sexual assault and opioid misuse was confounded by exposure to other types of IPT. Intimate partner violence was associated with opioid misuse among men, while adverse childhood experiences were associated with misuse among women. The interaction between intimate partner violence and sexual assault increased odds of opioid use among women.
JOURNAL OF INTERPERSONAL VIOLENCE
(2021)
Article
Neurosciences
Kelly E. Dunn, Cecilia L. Bergeria, Andrew S. Huhn, Traci J. Speed, Chung Jung Mun, Ryan Vandrey, Claudia M. Campbell
Summary: The study found no consistent dose-effect relationship of dronabinol on hydromorphone, with analgesia improvement only observed at a specific dosage. The combination of low doses had the lowest abuse risk, while higher doses were associated with increased risk of abuse and adverse events. Opioid responders showed higher subjective effects and abuse risk compared to nonresponders.
NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Denis Agniel, Gabriel A. Brat, Jayson S. Marwaha, Kathe Fox, Daniel Knecht, Harold L. Paz, Mark C. Bicket, Brian Yorkgitis, Nathan Palmer, Isaac Kohane
Summary: This cohort study found that family members of patients who received prescription opioid refills after surgery had an increased risk of opioid misuse and chronic opioid use.
Review
Pediatrics
Malema Ahrari, Samina Ali, Lisa Hartling, Kathryn Dong, Amy L. Drendel, Terry P. Klassen, Kurt Schreiner, Michele P. Dyson
Summary: Studies suggest a potential association between short-term therapeutic opioid exposure and future nonmedical opioid use or opioid use disorder, but the risk factors remain contradictory and unclear. Healthcare providers should carefully consider pain management options and educate patients about the appropriate use of opioids to prevent misuse.
Article
Behavioral Sciences
Rebecca S. Hofford, Mark A. Prendergast, Michael T. Bard
BEHAVIOURAL BRAIN RESEARCH
(2015)
Article
Psychology, Biological
Virginia G. Weiss, Rebecca S. Hofford, Justin R. Yates, Faith C. Jennings, Michael T. Bardo
EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY
(2015)
Article
Substance Abuse
Rebecca S. Hofford, Joshua S. Beckmann, Michael T. Bardo
DRUG AND ALCOHOL DEPENDENCE
(2016)
Article
Neurosciences
Rebecca S. Hofford, Jonathan J. Chow, Joshua S. Beckmann, Michael T. Bardo
PSYCHOPHARMACOLOGY
(2017)
Article
Behavioral Sciences
Rebecca S. Hofford, Mark A. Prendergast, Michael T. Bardo
BEHAVIOURAL BRAIN RESEARCH
(2018)
Article
Substance Abuse
M. L. Shawn Bates, Rebeca S. Hofford, Michael A. Emery, Paul J. Wellman, Shoshana Eitan
DRUG AND ALCOHOL DEPENDENCE
(2018)
Article
Neurosciences
Aaron P. Smith, Rebecca S. Hofford, Thomas R. Zentall, Joshua S. Beckmann
PSYCHOPHARMACOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Shannon L. Cole, Rebecca S. Hofford, Daniel J. Evert, Paul J. Wellman, Shoshana Eitan
Article
Behavioral Sciences
Rebecca S. Hofford, Mahesh Darna, Carrie E. Wilmouth, Linda P. Dwoskin, Michael T. Bardo
BEHAVIOURAL BRAIN RESEARCH
(2014)
Article
Substance Abuse
J. William Barwatt, Rebecca S. Hofford, Michael A. Emery, M. L. Shawn Bates, Paul J. Wellman, Shoshana Eitan
DRUG AND ALCOHOL DEPENDENCE
(2013)
Article
Neurosciences
Rebecca S. Hofford, Scott J. Russo, Drew D. Kiraly
EUROPEAN JOURNAL OF NEUROSCIENCE
(2019)
Article
Neurosciences
Munir Gunes Kutlu, Lillian J. Brady, Emily G. Peck, Rebecca S. Hofford, Jordan T. Yorgason, Cody A. Siciliano, Drew D. Kiraly, Erin S. Calipari
JOURNAL OF NEUROSCIENCE
(2018)
Article
Biochemistry & Molecular Biology
Lillian J. Brady, Rebecca S. Hofford, Jennifer Tat, Erin S. Calipari, Drew D. Kiraly
ACS CHEMICAL NEUROSCIENCE
(2019)
Article
Substance Abuse
Lindsey R. Hammerslag, Rebecca S. Hofford, Qiwen Kang, Richard J. Kryscio, Joshua S. Beclunann, Michael T. Bardo
DRUG AND ALCOHOL DEPENDENCE
(2020)
Article
Biochemistry & Molecular Biology
Nicholas L. Mervosh, Rashaun Wilson, Navin Rauniyar, Rebecca S. Hofford, Munir Gunes Kutlu, Erin S. Calipari, TuKiet T. Lam, Drew D. Kiraly