Article
Multidisciplinary Sciences
Caner Caglar, Jeffrey Friedman
Summary: Activation of PPP1R17 neurons in Leptin-deficient mice does not increase food intake as hypothesized, but instead decreases it, suggesting these neurons play a role in limiting overconsumption. The neurons in the DMH expressing PPP1R17 are indirectly affected by Leptin and serve to constrain binge eating behavior.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Endocrinology & Metabolism
Rizaldy C. Zapata, Dinghong Zhang, Dongmin Yoon, Chanond A. Nasamran, Daisy R. Chilin-Fuentes, Avraham Libster, Besma S. Chaudry, Mariela Lopez-Valencia, Devasena Ponnalagu, Harpreet Singh, Michael Petrascheck, Olivia Osborn
Summary: Clic1 inhibition reduces food intake and body weight in mouse models, suggesting it as a potential therapeutic target for obesity treatment.
MOLECULAR METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Shota Yamamoto, Hiroki Noguchi, Asuka Takeda, Ryosuke Arakaki, Maimi Uchishiba, Junki Imaizumi, Saki Minato, Shuhei Kamada, Tomohiro Kagawa, Atsuko Yoshida, Takako Kawakita, Yuri Yamamoto, Kanako Yoshida, Masafumi Kon, Nobuo Shinohara, Takeshi Iwasa
Summary: PCOS is a common condition in reproductive-age females, often exacerbated by obesity. Recent studies have found that oxytocin can reduce weight gain and food intake, making it a potential treatment for obese PCOS patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Danielle Renzi, Takara Stanley, Jessica Waxler, Hang Lee, Barbara Pober, Marianne Nordstrom
Summary: This study investigated the relationship between predicted dietary intake and body weight differences in adults with Williams syndrome. The study found that deviations in dietary intake and behaviors related to food were associated with increased body mass index (BMI) and weight gain.
FOOD & NUTRITION RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Liya Kerem, Elizabeth A. Lawson
Summary: This review comprehensively describes both the central and peripheral effects of oxytocin on eating behavior and metabolism, as well as discussing the association between endogenous oxytocin levels and weight status, metabolic syndrome, and bone health. The review also highlights the potential of intranasal oxytocin as a therapeutic option for obesity treatment and the challenges of translating oxytocin research into clinical care.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Tito Borner, Caroline E. Geisler, Samantha M. Fortin, Richard Cosgrove, Jorge Alsina-Fernandez, Mridula Dogra, Sarah Doebley, Marcos J. Sanchez-Navarro, Rosa M. Leon, Jane Gaisinsky, Arianna White, Ankur Bamezai, Misgana Y. Ghidewon, Harvey J. Grill, Richard C. Crist, Benjamin C. Reiner, Minrong Ai, Ricardo J. Samms, Bart C. De Jonghe, Matthew R. Hayes
Summary: GIPR signaling blocks emesis and attenuates illness behaviors induced by GLP-1R activation while maintaining reduced food intake, weight loss, and improved glucose tolerance. The hindbrain AP/NTS is crucial for processing GLP-1R ligand-induced effects on food intake and weight suppression, as well as emetic stimuli.
Article
Food Science & Technology
Marko Ugrica, Nicole Gehring, Pieter Giesbertz, Eva-Maria Pastor-Arroyo, Hannelore Daniel, Carsten A. Wagner, Isabel Rubio-Aliaga
Summary: This study investigates the effects of high phosphate diet on body composition and energy metabolism parameters. The results show that mice fed a high phosphate diet have slower weight gain, increased lean-to-fat mass ratio, and fasting hypoglycemia. This research provides important insights into the impact of high phosphate intake on the body.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Public, Environmental & Occupational Health
Hlengiwe P. Madlala, Nelia P. Steyn, Emma Kalk, Mary-Anne Davies, Dorothy Nyemba, Thokozile R. Malaba, Ushma Mehta, Gregory Petro, Andrew Boulle, Landon Myer
Summary: This study examined the dietary intake of pregnant women in South Africa and its associations with maternal overweight/obesity and gestational weight gain. The findings suggest that diet modification may promote healthy weight in pregnant women, both with and without HIV.
Article
Public, Environmental & Occupational Health
Andrew G. Rundle, Kathryn M. Neckerman, Suzanne E. Judd, Natalie Colabianchi, Kari A. Moore, James W. Quinn, Jana A. Hirsch, Gina S. Lovasi
Summary: This study provides additional longitudinal evidence that residential neighborhood features that support pedestrian activity are associated with lower adiposity.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Microbiology
Christa N. Cheatham, Kevin L. Gustafson, Zachary L. McAdams, Giedre M. Turner, Rebecca A. Dorfmeyer, Aaron C. Ericsson
Summary: Obesity is a major health issue and burden on the healthcare system. The gut microbiome plays a role in body weight regulation and feeding behavior. This research aimed to investigate whether differences in the gut microbiome were associated with differences in intake, fecal energy loss, and fetal growth.
Review
Nutrition & Dietetics
Yasuyuki Nagasawa
Summary: Sodium intake has dual effects on non-dialysis chronic kidney disease and dialysis patients, affecting nutritional status, blood pressure, and mortality. Restricting sodium intake can decrease mortality by balancing the negative and positive effects it has on these patients.
Article
Endocrinology & Metabolism
Signe Schmidt, Christian S. Frandsen, Thomas F. Dejgaard, Dorte Vistisen, Thorhallur Halldorsson, Sjudur F. Olsen, Jens-Erik B. Jensen, Sten Madsbad, Henrik U. Andersen, Kirsten Norgaard
Summary: Liraglutide treatment led to decreased fat and lean body mass, as well as reduced intake of added sugars, while no significant difference in total daily energy intake was observed between liraglutide- and placebo-treated participants.
DIABETES OBESITY & METABOLISM
(2022)
Review
Endocrinology & Metabolism
Candice A. Myers
Summary: This review summarizes recent research on the impact of the built environment, specifically the neighborhood food environment, on dietary intake and obesity. While there is some evidence of certain features of the neighborhood food environment influencing health behaviors and outcomes, the research presents mixed evidence overall.
CURRENT DIABETES REPORTS
(2023)
Article
Physiology
Clinton T. Elfers, James E. Blevins, Elizabeth A. Lawson, Richard Pittner, David Silva, Alex Kiselyov, Christian L. Roth
Summary: The study demonstrated the efficacy of oxytocin analog ASK1476 in reducing food intake and body weight in experimental animals, showing a stronger dose response and similar reduction in food intake compared to native oxytocin.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Kevin D. Hall, Juen Guo, Amber B. Courville, James Boring, Robert Brychta, Kong Y. Chen, Valerie Darcey, Ciaran G. Forde, Ahmed M. Gharib, Isabelle Gallagher, Rebecca Howard, Paule V. Joseph, Lauren Milley, Ronald Ouwerkerk, Klaudia Raisinger, Irene Rozga, Alex Schick, Michael Stagliano, Stephan Torres, Mary Walter, Peter Walter, Shanna Yang, Stephanie T. Chung
Summary: In an inpatient, randomized controlled crossover trial, participants consumed 550-700 fewer calories per day when following a plant-based, low-fat diet with a high glycemic load compared with an animal-based, low-carbohydrate diet with a low glycemic load; weight loss was comparable between the two diets and there were no significant differences in hunger or enjoyment of the meals.