Article
Chemistry, Physical
Ola A. El-Gammal, Ashraf A. El-Bindary, Farid Sh Mohamed, Ghada N. Rezk, Mohamed A. El-Bindary
Summary: This study investigates the properties of a novel Schiff base and its complexes with Co(II), Ni(II), and Cu(II) metals using various analysis methods. The research covers structural characterization, thermodynamic properties, DNA binding, antioxidant activity, and antibacterial action. The potential of the compound in combating COVID-19 and prostate cancer is evaluated through its interaction with the SARS-CoV-2 main protease.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Biochemistry & Molecular Biology
Jianfang Dong, Lei Gao, Bo Zhang, Tao Xu, Lei Wang, Jinming Kong, Lianzhi Li
Summary: A mononuclear nickel(II) complex, [Ni(o-van-tris)(2)]·2H(2)O, has been synthesized and structurally characterized. The complex interacts with CT-DNA through hydrogen bond and hydrophobic interactions, showing efficient DNA cleavage activity. Molecular docking studies reveal effective docking of the complex in the major groove of DNA, and the DNA cleavage is concentration dependent and sensitive to ionic strength.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Article
Chemistry, Inorganic & Nuclear
S. Sukkur Saleem, M. Sankarganesh, P. Adwin Jose, J. Dhaveethu Raja
Summary: This study synthesized and characterized a morpholine-based Schiff base ligand and its metal(II) complexes. They exhibited good free radical scavenging and antimicrobial activities, with the metal complexes showing stronger antimicrobial effects. In addition, L and its complexes may interact with DNA through an intercalative mode.
INORGANIC CHEMISTRY COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Hanan B. Howsaui, Amal S. Basaleh, Magda H. Abdellattif, Walid M. Hassan, Mostafa A. Hussien
Summary: Three novel 2-aminopyrazine Schiff bases and their uranyl complexes were synthesized and characterized, with studies on DNA binding and anticancer activities showing promising results. Molecular docking analysis provided insights into interactions with cancer proteins.
Article
Biochemistry & Molecular Biology
Mohammad Ibrahim, Hazrat Un Nabi, Niaz Muhammad, Muhammad Ikram, Momin Khan, Musadiq Ibrahim, Abdullah F. AlAsmari, Metab Alharbi, Abdulrahman Alshammari
Summary: Currently, ongoing studies are exploring the interaction between free radicals and biological systems. This study evaluated the synthesis, characterization, antioxidant properties, DNA binding, and molecular docking of Schiff base ligand and its Ni(II), Co(II), Cu(II), and Zn(II) complexes. The metal complexes showed significant dose-dependent antioxidant activities, but lower than ascorbic acid. The DNA binding constants (K-b) and molecular docking analysis supported the experimental results. The study highlights the importance of synthesis complexes as synthetic antioxidants and anticancer drugs.
Article
Biochemistry & Molecular Biology
Murugesan Sankarganesh, Paul Raj Adwin Jose, Jeyaraj Dhaveethu Raja, Rajadurai Vijay Solomon, Clarence Dorothy Sheela, Shunmugasundaram Gurusamy
Summary: A new octahedral platinum complex [PtLCl4] of Schiff base ligand containing pyrimidine and morpholine skeleton was synthesized and characterized. The compound exhibited interaction with DNA and BSA through electrostatic interactions and static quenching, respectively. The platinum complex showed promising anticancer activity against various cancer cell lines, while also demonstrating good radical scavenging and antimicrobial abilities.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Environmental Sciences
Mohd Afzal, Abdullah Alarifi, Md Saquib Hasnain, Mohd Muddassir
Summary: The synthesis, structural elucidation, and DNA interaction of newly synthesized Cu(II) and Zn(II) complexes were described. Both complexes were found to avidly bind to DNA through surface and groove binding modes, with different intrinsic binding constants. Various experiments confirmed the electrostatic and groove binding modes of the complexes, paving the way for the development of DNA-targeting Cu(II)/Zn(II) metal complexes as chemotherapeutic agents.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Chemistry, Inorganic & Nuclear
Anmol Singh, Subir Kr Maiti, Himadri Priya Gogoi, Pranjit Barman
Summary: Metal complexes of Co(II), Zn(II), and Cu(II) with purine base Schiff base ligands L1 and L2 were synthesized and characterized. The coordination of the ligands to the metal centers and their structural details were confirmed through spectroscopic and DFT studies. The binding modes of oxygen atoms in L1 and L2 complexes were found to be different. Cobalt complexes of L1 and L2 showed high DNA binding activity, with a binding constant in the order of 105 via intercalation mode. Molecular docking study provided insights into the active binding site between the metal complexes and CT-DNA.
Article
Chemistry, Multidisciplinary
Hanan B. Howsaui, Abeer A. Sharfalddin, Magda H. Abdellattif, Amal S. Basaleh, Mostafa A. Hussien
Summary: Novel anti-cancer transition metal complexes were successfully synthesized and characterized using Schiff base derived from 2-aminopyrazine and salicylaldehyde. The complexes exhibited different structures and properties under different metal ions, showing promising anti-cancer activity. The Cu(II) complex showed practical results with HOP-62 cell lines, while the Zn(II) and Co(II) complexes demonstrated non-toxicity at doses up to 370 mg/kg based on LD50 values.
APPLIED SCIENCES-BASEL
(2021)
Article
Chemistry, Applied
Adel Z. El-Sonbati, Mostafa A. Diab, Ahmed K. El-Sayed, Mohamed Abou-Dobara, Sameh A. El-Sayad
Summary: Metal complexes of a Schiff base ligand derived from 2,4-dihydroxybenzaldehyde and p-nitroaniline were synthesized and characterized. The complexes showed antibacterial, antifungal, and cytotoxic activities, and the ligand exhibited high binding affinity to various receptors.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Binesh Kumar, Jai Devi, Amit Dubey, Aisha Tufail, Bharti Taxak
Summary: This research focuses on the synthesis and characterization of metal complexes and their potential as anti-tuberculosis drugs. The study finds that the zinc(II) complex (10) shows high potency in suppressing TB disease and could be a novel drug candidate. The findings provide a new insight for further in vivo investigations.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Inorganic & Nuclear
P. Jyothi, V. Sumalatha, D. Rajitha
Summary: Three Co(II) complexes were synthesized and characterized, showing good DNA binding, antimicrobial, and anticancer activities.
INORGANIC CHEMISTRY COMMUNICATIONS
(2022)
Article
Chemistry, Inorganic & Nuclear
Himadri Priya Gogoi, Pranjit Barman
Summary: A new Schiff base ligand was synthesized via condensation reaction between 4,5-dichloro-o-phenylenediamine and 5-bromosalicylaldehyde. The coordination behavior and nature of bonding of Ni(II), Cu(II), and Zn(II) complexes were characterized using various analytical and spectroscopical methods. The synthesized compounds exhibited antibacterial activity, DNA binding, antioxidant, and anti-inflammatory activity, and their molecular docking analysis correlated well with experimental data.
INORGANICA CHIMICA ACTA
(2023)
Article
Multidisciplinary Sciences
Ghada N. Rezk, Ola A. El -Gammal, Salhah H. Alrefaee, Ismail Althagafi, Ashraf A. El-Bindary, Mohamed A. El-Bindary
Summary: A hydrazone ligand was successfully created by combining hydrazide with 2-Acetylpyridine. Copper (II) hydrazone complexes were synthesized using various copper (II) salts and studied using analytical techniques. The complexes exhibited tridentate behavior and octahedral geometries. Their properties were analyzed through computational calculations and experimental assays, revealing potential antimicrobial and antioxidant effects.
Article
Chemistry, Inorganic & Nuclear
Andrew J. Ressler, Olivia N. Brandt, Ashton Weaver, Jenna E. Poor, Anna Ream, Nicolas A. Summers, Colin D. McMillen, Navindra P. Seeram, William G. Dougherty, Geneive E. Henry
Summary: Three tetranuclear clusters, Zn(II), Ni(II) and Fe(III), were prepared using a new chromene-based Schiff base ligand (H2L). Crystallographic studies revealed that the Zn and Ni clusters have similar structures with a defective dicubane core, while the Fe complex forms a tetranuclear star shaped cluster. The ligand H2L showed significant DNA cleavage ability in the presence of Cu(II) salt.
INORGANICA CHIMICA ACTA
(2023)
Review
Chemistry, Multidisciplinary
Antony Rajendran, Marimuthu Rajendiran, Zhi-Fen Yang, Hong-Xia Fan, Tian-You Cui, Ya-Gang Zhang, Wen-Ying Li
Article
Chemistry, Applied
Hong-Xia Fan, Tian-You Cui, Antony Rajendran, Qing Yang, Jie Feng, Xiu-Ping Yue, Wen-Ying Li
Review
Chemistry, Multidisciplinary
Antony Rajendran, Hong-Xia Fan, Jie Feng, Wen-Ying Li
CHEMISTRY-AN ASIAN JOURNAL
(2020)
Review
Engineering, Chemical
Tian-You Cui, Antony Rajendran, Hong-Xia Fan, Jie Feng, Wen-Ying Li
Summary: Zeolite-based HDS catalysts play a crucial role in alleviating the removal of refractory sulfur compounds through isomerization and cracking abilities. These catalysts can improve HDS efficiency and reduce coke formation, leading to better selectivity in the process.
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2021)
Article
Energy & Fuels
Antony Rajendran, Hong-Xia Fan, Tian-You Cui, Jie Feng, Wen-Ying Li
Summary: This study reports the preparation of a catalyst based on WOx on SnO2 and its performance in desulfurization of model diesel. SnO2 plays a role in adsorbing sulfur compounds and enhancing catalytic performance, with higher surface area SnO2 aiding in the formation of efficient polymeric WOx species.
Article
Green & Sustainable Science & Technology
Antony Rajendran, Hong-Xia Fan, Tian-You Cui, Jie Feng, Wen-Ying Li
Summary: This study reported a novel preparation method for oxidative desulfurization catalysts, which involves the hydrothermal synthesis of mesoporous tin oxide-supported octamolybdates and exhibits higher turnover frequency in the oxidative desulfurization reaction. This catalytic system shows promise in contributing to the establishment of an SOx-free environment.
JOURNAL OF CLEANER PRODUCTION
(2022)
Article
Chemistry, Multidisciplinary
Dao-Cheng Liu, Yu Chen, Jie-Ying Jing, Antony Rajendran, Hong-Cun Bai, Wen-Ying Li
Summary: The study focused on synthesizing Ni/NiAlOx catalysts with a uniform electron-deficient state of Ni to overcome the disadvantages in the hydrogenation process of phenanthrene. Results showed that the catalyst calcinated at 650 degrees C exhibited the highest r(obs) and TOF for phenanthrene hydrogenation, with Ni2+ occupying octahedral sites. Stabilizing the electron-deficient state of surface Ni was found to enhance the saturation performance of phenanthrene hydrogenation.
FRONTIERS IN CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Sengodagounder Muthusamy, Muthukumar Malarvizhi, Eringathodi Suresh
Summary: The AlCl3-catalyzed oxidative cyclization of thiosemicarbazones/triazolothiones with propargylic alcohols provides a diverse set of triazolothiazines in good yields. This synthetic approach offers the advantages of shorter duration at room temperature and atom economical synthesis in an open-air environment.
Article
Chemistry, Applied
Antony Rajendran, Tian-You Cui, Hong-Xia Fan, Meng-Yu Wang, Wen-Ying Li
Summary: The study attempted a straightforward hydrothermal synthesis of NiMoS active phases loaded on SBA-15. Characterization of the catalysts revealed that the one-pot synthesis promoted the generation of dispersed MoS2 layers, leading to improved catalytic activity and ultra-deep sulfur removal in dibenzothiophene hydrodesulfurization.
FUEL PROCESSING TECHNOLOGY
(2022)
Article
Chemistry, Inorganic & Nuclear
Michael Samuel, Rajamanickam Rajasekar, Porkodi Jeyaraman, Selvaganapathy Muthusamy, Vellaichamy Muniyandi, Natarajan Raman
Summary: The study describes the synthesis of novel Knoevenagel condensed copper(II) complexes from Schiff bases of thiosemicarbazide derivatives, characterized using analytical and spectral techniques. DFT calculations confirmed the stability and biological approachability of these compounds, with pharmacokinetic properties suggesting oral administration and intercalative binding with CTDNA.
INORGANICA CHIMICA ACTA
(2022)
Article
Chemistry, Physical
Samuel Michael, Porkodi Jeyaraman, Bhuvaneswari Marimuthu, Rajamanickam Rajasekar, Radha Thanasamy, Karuppiah Arunsunai Kumar, Natarajan Raman
Summary: Novel Cu(II) and Zn(II) complexes [ML(dppz)]Cl2, where L is Schiff bases derived from the condensation of (E)-3-(2-mercaptovinyl)-pentane-2,4-dione and para-substituted anilines, were successfully synthesized and characterized. These complexes exhibited monomeric and cationic properties with square-planar geometry. The compounds showed strong DNA nuclease activity via intercalative binding mechanism, with [CuL1(dppz)]Cl2 demonstrating the highest binding efficacy among all the complexes.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Multidisciplinary
Karuppaiya Palpandi, Chellapandi Bhuvaneswari, Sundaram Ganesh Babu, Natarajan Raman
Summary: A novel metal stannate (Mn2SnO4) nanocube electrocatalyst with outstanding sensing capability and electrochemical properties was synthesized using an ultrasonic-assisted technique. The electrocatalyst exhibited higher cathodic current response, lower detection limit, and good sensitivity for the determination of chloramphenicol.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Organic
Sengodagounder Muthusamy, Muthukumar Malarvizhi, Eringathodi Suresh
Summary: The study presents an unambiguous and precise method for the synthesis of 3,1-benzoxathiin-4-ones/1,3-benzodioxin-4-ones using propargylic alcohols and salicylic/thiosalicylic acids under catalyst-free and open-air conditions. This strategy is shown to be quite general, yielding benzoxathiinones/benzodioxinones in good amounts with various 2-mercapto and 2-hydroxybenzoic acids.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Karuppaiya Palpandi, Natarajan Raman
NEW JOURNAL OF CHEMISTRY
(2020)
Review
Chemistry, Physical
Antony Rajendran, Tian-you Cui, Hong-xia Fan, Zhi-fen Yang, Jie Feng, Wen-ying Li
JOURNAL OF MATERIALS CHEMISTRY A
(2020)
Article
Biochemistry & Molecular Biology
Girgis Obaid, Menitte Eroy, Jie Zhao, Shazia Bano, Mari Mino-Kenudson, Tayyaba Hasan
Summary: The presence of desmoplasia in pancreatic ductal adenocarcinoma (PDAC) is associated with poor treatment outcomes and reduced drug delivery. By analyzing collagen subtypes in PDAC tumors following different treatment regimens, immunofluorescence profiling can predict long-term survival and tumor growth inhibition. This information can aid in personalized treatment and improve patient survival.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Fatemeh Malekpour, Rashin Bahrami, Mahshid Hodjat, Neda Hakimiha, Behnam Bolhari, Aidin Sooratgar, Soheil Niavarzi
Summary: This study investigated the effect of photobiomodulation (PBM) therapy using an 808 nm diode laser on cellular modulation mechanisms in regenerative endodontic procedures (REPs). The results showed that PBM treatment significantly increased cell viability and migration, and enhanced the release of TGF-131 from dentin.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Pranathi Tata, Ramakrishnan Ganesan, Jayati Ray Dutta
Summary: Thin film coatings with potent antibacterial properties are widely used in medical devices, frequently touched surfaces, and food packaging. However, achieving antibacterial performance under both light and dark conditions remains a challenge. In this study, we successfully prepared AgBr-coated ZnO nanorod thin film architecture using a unique surfactant-mediated solution-phase spin-coating approach. The resulting structures showed dual functionality as antimicrobial agents and photosensitizers, effectively enhancing the visible-light photodisinfection efficacy of ZnO nanorods. The concentration of the surfactant-based precursor solution could be modulated to control the AgBr content. Additionally, components like urea and lactic acid were found to enhance the photocatalytic efficiency of the structures.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2024)